NP-MRD: Showing NP-Card for Epigallocatechin 3-O-p-coumarate (NP0056138)

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Record Information

Version

2.0

Created at

2022-04-28 02:00:20 UTC

Updated at

2022-04-28 02:00:20 UTC

NP-MRD ID

NP0056138

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Epigallocatechin 3-O-p-coumarate

Description

(-)-Epigallocatechin 3-p-coumaroate, also known as 3-O-p-coumaroylepigallocatechin, belongs to the class of organic compounds known as epigallocatechins. Epigallocatechins are compounds containing epigallocatechin or a derivative. Epigallocatechin is a flavan-3-ol containing a benzopyran-3,5,7-triol linked to a 3,4,5-hydroxyphenyl moiety (-)-Epigallocatechin 3-p-coumaroate is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Outside of the human body, (-)-Epigallocatechin 3-p-coumaroate is found, on average, in the highest concentration within tea. Epigallocatechin 3-O-p-coumarate is found in Camellia sinensis . This could make (-)-epigallocatechin 3-p-coumaroate a potential biomarker for the consumption of these foods.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv0541 02241209182D          

 33 36  0  0  0  0            999 V2000
   -3.0054    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7198   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7198   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0054   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2909   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2909   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5764    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5764   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8620   -1.2375    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.8620   -0.4125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.1475    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5670    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1475    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5670   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2814    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2814    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4343    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0054   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9959   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5670    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9959    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1475   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5670   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5670   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1475   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8620   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8620   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1475   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5670   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5670   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1475   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2814   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1475   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  6  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  7  6  1  0  0  0  0
  6  5  2  0  0  0  0
  5  8  1  0  0  0  0
  7 10  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  6  0  0  0
 13 11  2  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 12 16  2  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 21  1  0  0  0  0
  2 17  1  0  0  0  0
  4 18  1  0  0  0  0
  9 31  1  6  0  0  0
 15 19  1  0  0  0  0
 12 20  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 22 27  1  0  0  0  0
 22 28  1  0  0  0  0
 28 29  2  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  2  0  0  0  0
 25 33  1  0  0  0  0
M  END

     RDKit          3D

 53 56  0  0  0  0  0  0  0  0999 V2000
    0.8548    1.8266    1.9797 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7519    0.8185    1.2356 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8044    0.4890    0.2640 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8876    1.2266    0.1321 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9680    0.9710   -0.7986 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9698   -0.0901   -1.6546 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0132   -0.3273   -2.5460 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0757    0.5516   -2.5509 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1411    0.3620   -3.4187 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1159    1.6356   -1.7046 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0507    1.8221   -0.8395 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3891    0.0412    1.3737 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4184    0.3567    2.3185 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.3857   -0.7977    3.3332 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6110   -2.0369    2.5600 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8500   -3.1591    2.6549 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2259   -3.2654    3.4925 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1829   -4.2628    1.8564 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2556   -4.2203    0.9921 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5686   -5.3131    0.2153 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0345   -3.0769    0.8930 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6999   -1.9996    1.6802 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4237   -0.8218    1.6436 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7651    0.4293    1.6781 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.7481    1.1005    0.3591 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4351    0.4150   -0.7942 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4140    1.0292   -2.0414 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0885    0.2624   -3.1458 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7102    2.3670   -2.1700 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6988    3.0221   -3.4165 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0259    3.0660   -1.0202 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3275    4.4097   -1.1187 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0423    2.4418    0.2088 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7005   -0.3753   -0.3633 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9466    2.0990    0.7960 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1563   -0.7793   -1.6639 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0269   -1.1643   -3.2295 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.1825    0.7532   -4.3511 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.9639    2.3198   -1.7225 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1019    2.6763   -0.1857 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1785    1.2714    2.8962 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4192   -0.8042    3.8203 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2455   -0.6917    4.0305 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5044   -2.5150    4.0836 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5789   -5.1499    1.9331 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3354   -5.3273   -0.4237 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8770   -3.0516    0.2116 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4032    1.0787    2.3480 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2033   -0.6277   -0.7008 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0437    0.6034   -4.0876 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4764    2.5602   -4.2806 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3174    4.8727   -2.0149 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2887    2.9788    1.1205 H   0  0  0  0  0  0  0  0  0  0  0  0
  9  8  1  0
  8  7  2  0
  7  6  1  0
  6  5  2  0
  5  4  1  0
  4  3  2  0
  3  2  1  0
  2  1  2  0
  2 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 22  2  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  1  0
 27 29  2  0
 29 30  1  0
 29 31  1  0
 31 32  1  0
 31 33  2  0
 22 21  1  0
 21 19  2  0
 19 20  1  0
 19 18  1  0
 18 16  2  0
 16 17  1  0
  5 11  1  0
 11 10  2  0
 10  8  1  0
 24 13  1  0
 33 25  1  0
 16 15  1  0
  9 38  1  0
  7 37  1  0
  6 36  1  0
  4 35  1  0
  3 34  1  0
 13 41  1  1
 14 42  1  0
 14 43  1  0
 24 48  1  1
 26 49  1  0
 28 50  1  0
 30 51  1  0
 32 52  1  0
 33 53  1  0
 21 47  1  0
 20 46  1  0
 18 45  1  0
 17 44  1  0
 11 40  1  0
 10 39  1  0
M  END


  Mrv0541 02241209182D          

 33 36  0  0  0  0            999 V2000
   -3.0054    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7198   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7198   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0054   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2909   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2909   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5764    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5764   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8620   -1.2375    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.8620   -0.4125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.1475    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5670    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1475    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5670   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2814    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2814    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4343    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0054   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9959   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5670    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9959    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1475   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5670   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5670   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1475   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8620   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8620   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1475   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5670   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5670   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1475   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2814   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1475   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  6  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  7  6  1  0  0  0  0
  6  5  2  0  0  0  0
  5  8  1  0  0  0  0
  7 10  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  6  0  0  0
 13 11  2  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 12 16  2  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 21  1  0  0  0  0
  2 17  1  0  0  0  0
  4 18  1  0  0  0  0
  9 31  1  6  0  0  0
 15 19  1  0  0  0  0
 12 20  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 22 27  1  0  0  0  0
 22 28  1  0  0  0  0
 28 29  2  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  2  0  0  0  0
 25 33  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0056138

> <DATABASE_NAME>
NP-MRD

> <SMILES>
OC1=CC=C(\C=C\C(=O)O[C@@H]2CC3=C(O[C@@H]2C2=CC(O)=C(O)C(O)=C2)C=C(O)C=C3O)C=C1

> <INCHI_IDENTIFIER>
InChI=1S/C24H20O9/c25-14-4-1-12(2-5-14)3-6-22(30)32-21-11-16-17(27)9-15(26)10-20(16)33-24(21)13-7-18(28)23(31)19(29)8-13/h1-10,21,24-29,31H,11H2/b6-3+/t21-,24-/m1/s1

> <INCHI_KEY>
HKPGWUPXXPIOAN-XMTAIGAMSA-N

> <FORMULA>
C24H20O9

> <MOLECULAR_WEIGHT>
452.4102

> <EXACT_MASS>
452.110732238

> <JCHEM_ACCEPTOR_COUNT>
8

> <JCHEM_AVERAGE_POLARIZABILITY>
44.99520287366981

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
6

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl (2E)-3-(4-hydroxyphenyl)prop-2-enoate

> <ALOGPS_LOGP>
3.11

> <JCHEM_LOGP>
4.221867089999999

> <ALOGPS_LOGS>
-4.55

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
9.096644185956437

> <JCHEM_PKA_STRONGEST_ACIDIC>
8.567886379256885

> <JCHEM_PKA_STRONGEST_BASIC>
-4.918121429453382

> <JCHEM_POLAR_SURFACE_AREA>
156.91

> <JCHEM_REFRACTIVITY>
117.5292

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
1.29e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl (2E)-3-(4-hydroxyphenyl)prop-2-enoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 24-FEB-12   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-FEB-12         0                                  
HETATM    1  C   UNK     0      -5.610   0.000   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -6.944  -0.770   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -6.944  -2.310   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -5.610  -3.080   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -4.276  -2.310   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -4.276  -0.770   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0      -2.943   0.000   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0      -2.943  -3.080   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -1.609  -2.310   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -1.609  -0.770   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      -0.275   0.000   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       1.058   2.310   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      -0.275   1.540   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       1.058  -0.770   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       2.392   0.000   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       2.392   1.540   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0      -8.277   0.000   0.000  0.00  0.00           O+0
HETATM   18  O   UNK     0      -5.610  -4.620   0.000  0.00  0.00           O+0
HETATM   19  O   UNK     0       3.726  -0.770   0.000  0.00  0.00           O+0
HETATM   20  O   UNK     0       1.058   3.850   0.000  0.00  0.00           O+0
HETATM   21  O   UNK     0       3.726   2.310   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0      -0.275  -7.700   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       1.058  -8.470   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       1.058 -10.010   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      -0.275 -10.780   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      -1.609 -10.010   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      -1.609  -8.470   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      -0.275  -6.160   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       1.058  -5.390   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       1.058  -3.850   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0      -0.275  -3.080   0.000  0.00  0.00           O+0
HETATM   32  O   UNK     0       2.392  -3.080   0.000  0.00  0.00           O+0
HETATM   33  O   UNK     0      -0.275 -12.320   0.000  0.00  0.00           O+0
CONECT    1    2    6                                                       
CONECT    2    1    3   17                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5   18                                                  
CONECT    5    4    6    8                                                  
CONECT    6    1    7    5                                                  
CONECT    7    6   10                                                       
CONECT    8    5    9                                                       
CONECT    9    8   10   31                                                  
CONECT   10    7    9   11                                                  
CONECT   11   10   13   14                                                  
CONECT   12   13   16   20                                                  
CONECT   13   11   12                                                       
CONECT   14   11   15                                                       
CONECT   15   14   16   19                                                  
CONECT   16   12   15   21                                                  
CONECT   17    2                                                            
CONECT   18    4                                                            
CONECT   19   15                                                            
CONECT   20   12                                                            
CONECT   21   16                                                            
CONECT   22   23   27   28                                                  
CONECT   23   22   24                                                       
CONECT   24   23   25                                                       
CONECT   25   24   26   33                                                  
CONECT   26   25   27                                                       
CONECT   27   26   22                                                       
CONECT   28   22   29                                                       
CONECT   29   28   30                                                       
CONECT   30   29   31   32                                                  
CONECT   31    9   30                                                       
CONECT   32   30                                                            
CONECT   33   25                                                            
MASTER        0    0    0    0    0    0    0    0   33    0   72    0
END

View in JSmol

Synonyms

Value	Source
(-)-Epigallocatechin 3-p-coumaroic acid	Generator
(-)-Epigallocatechin 3-O-p-coumaroate	HMDB
3-O-p-Coumaroylepigallocatechin	HMDB
Epigallocatechin 3-O-p-coumarate	HMDB
Epigallocatechin 3-O-p-coumaric acid	Generator
Epigallocatechin 3-p-coumaric acid	Generator

Chemical Formula

C₂₄H₂₀O₉

Average Mass

452.4102 Da

Monoisotopic Mass

452.11073 Da

IUPAC Name

(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl (2E)-3-(4-hydroxyphenyl)prop-2-enoate

Traditional Name

(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl (2E)-3-(4-hydroxyphenyl)prop-2-enoate

CAS Registry Number

Not Available

SMILES

OC1=CC=C(\C=C\C(=O)O[C@@H]2CC3=C(O[C@@H]2C2=CC(O)=C(O)C(O)=C2)C=C(O)C=C3O)C=C1

InChI Identifier

InChI=1S/C24H20O9/c25-14-4-1-12(2-5-14)3-6-22(30)32-21-11-16-17(27)9-15(26)10-20(16)33-24(21)13-7-18(28)23(31)19(29)8-13/h1-10,21,24-29,31H,11H2/b6-3+/t21-,24-/m1/s1

InChI Key

HKPGWUPXXPIOAN-XMTAIGAMSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Camellia sinensis	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as epigallocatechins. Epigallocatechins are compounds containing epigallocatechin or a derivative. Epigallocatechin is a flavan-3-ol containing a benzopyran-3,5,7-triol linked to a 3,4,5-hydroxyphenyl moiety.

Kingdom

Organic compounds

Super Class

Phenylpropanoids and polyketides

Class

Flavonoids

Sub Class

Flavans

Direct Parent

Epigallocatechins

Alternative Parents

Substituents

Epigallocatechin
3'-hydroxyflavonoid
4'-hydroxyflavonoid
5-hydroxyflavonoid
7-hydroxyflavonoid
Hydroxyflavonoid
Coumaric acid ester
Coumaric acid or derivatives
Hydroxycinnamic acid or derivatives
Cinnamic acid or derivatives
Cinnamic acid ester
Benzopyran
Chromane
1-benzopyran
Pyrogallol derivative
Benzenetriol
Styrene
1-hydroxy-2-unsubstituted benzenoid
Phenol
1-hydroxy-4-unsubstituted benzenoid
Alkyl aryl ether
Fatty acid ester
Monocyclic benzene moiety
Benzenoid
Fatty acyl
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Carboxylic acid ester
Carboxylic acid derivative
Polyol
Organoheterocyclic compound
Oxacycle
Monocarboxylic acid or derivatives
Ether
Carbonyl group
Organooxygen compound
Organic oxide
Organic oxygen compound
Hydrocarbon derivative
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Flavans, Flavanols and Leucoanthocyanidins (LMPK12020117 )

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.11	ALOGPS
logP	4.22	ChemAxon
logS	-4.6	ALOGPS
pKa (Strongest Acidic)	8.57	ChemAxon
pKa (Strongest Basic)	-4.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	8	ChemAxon
Hydrogen Donor Count	6	ChemAxon
Polar Surface Area	156.91 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	117.53 m³·mol⁻¹	ChemAxon
Polarizability	45 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

HMDB0038362

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB017701

KNApSAcK ID

C00008905

Chemspider ID

4976697

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

6474788

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Not Available

Showing NP-Card for Epigallocatechin 3-O-p-coumarate (NP0056138)

MOL for NP0056138 (Epigallocatechin 3-O-p-coumarate)

3D MOL for NP0056138 (Epigallocatechin 3-O-p-coumarate)

3D SDF for NP0056138 (Epigallocatechin 3-O-p-coumarate)

3D-SDF for NP0056138 (Epigallocatechin 3-O-p-coumarate)

PDB for NP0056138 (Epigallocatechin 3-O-p-coumarate)

3D PDB for NP0056138 (Epigallocatechin 3-O-p-coumarate)

SMILES for NP0056138 (Epigallocatechin 3-O-p-coumarate)

INCHI for NP0056138 (Epigallocatechin 3-O-p-coumarate)

Structure for NP0056138 (Epigallocatechin 3-O-p-coumarate)

3D Structure for NP0056138 (Epigallocatechin 3-O-p-coumarate)