NP-MRD: Showing NP-Card for (+)-Matrine N-oxide (NP0055158)

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Record Information

Version

2.0

Created at

2022-04-28 01:17:38 UTC

Updated at

2022-04-28 01:17:38 UTC

NP-MRD ID

NP0055158

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(+)-Matrine N-oxide

Description

Oxymatrine belongs to the class of organic compounds known as matrine alkaloids. These are lupin alkaloids with a structure based on the matrine skeleton, a four-ring skeleton that based on a saturated dipyrido[2,1-f:3',2',1'-Ij][1,6]naphthyridin-10-one skeleton. (+)-Matrine N-oxide is found in Ammothamnus lehmanni, Ammothamnus songoricus, Corydalis yanhusuo , Daphniphyllum oldhami, Genista aucheri, Sophora alopecuroides, Sophora davidii, Sophora flavescens , Sophora flavescens var. angustifolia , Sophora moorcroftiana Benth. , Sophora pachycarpa Schrenk., Sophora subprostate, Sophora subprostrata, Sophora tonkinensis, Sophora viciifolia and Sophorae flavescentis. (+)-Matrine N-oxide was first documented in 2021 (PMID: 35252223). Based on a literature review a small amount of articles have been published on Oxymatrine (PMID: 35335977) (PMID: 35432866) (PMID: 35310033) (PMID: 35290143).

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 43 46  0  0  0  0  0  0  0  0999 V2000
    2.7800    2.8713    1.0590 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6499    1.6549    0.7669 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8566    0.7851    0.9924 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5708   -0.4967    0.2006 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3061   -1.0694    0.8567 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0846   -0.3044    0.4999 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.3623   -0.7535   -0.7141 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.1202   -2.2080   -0.8503 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0662   -2.6996   -0.0114 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2694   -1.9155   -0.5564 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0269   -0.5308   -0.1226 N   0  0  2  0  0  4  0  0  0  0  0  0
   -1.8586   -0.5676    1.1943 O   0  0  0  0  0  1  0  0  0  0  0  0
   -3.1842    0.3014   -0.3933 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0022    1.5891    0.4185 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5618    1.9435    0.5909 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8093    1.4768   -0.6512 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.5964    1.9766   -0.5265 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4510    1.1030    0.2533 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9262   -0.0007   -0.8728 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.8392    0.5033    2.0547 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7751    1.2721    0.6539 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3787   -1.2268    0.3845 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4043   -0.2751   -0.8578 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5063   -0.9679    1.9657 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2935   -2.1351    0.6565 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4411   -0.2534    1.4211 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0003   -0.4493   -1.5992 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9704   -2.8665   -0.7042 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2184   -2.3824   -1.9172 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9320   -2.4975    1.0518 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2326   -3.7458   -0.2774 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2507   -1.9031   -1.6522 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2088   -2.2335   -0.1080 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0892   -0.2080   -0.0188 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2091    0.5096   -1.4686 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5740    1.5477    1.3636 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4746    2.3864   -0.1993 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4707    3.0670    0.5743 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1024    1.6178    1.5205 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2762    2.0672   -1.4959 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0084    2.1937   -1.5313 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5580    2.9567    0.0110 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2098   -0.1329   -1.9616 H   0  0  0  0  0  0  0  0  0  0  0  0
 11 12  1  1
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18  6  1  0
  6  5  1  0
  5  4  1  0
  4  3  1  0
  3  2  1  0
  2  1  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
  7 19  1  0
 10 11  1  0
 19 11  1  0
 19 16  1  0
  2 18  1  0
 13 34  1  0
 13 35  1  0
 14 36  1  0
 14 37  1  0
 15 38  1  0
 15 39  1  0
 16 40  1  6
 17 41  1  0
 17 42  1  0
  6 26  1  1
  5 24  1  0
  5 25  1  0
  4 22  1  0
  4 23  1  0
  3 20  1  0
  3 21  1  0
  7 27  1  6
  8 28  1  0
  8 29  1  0
  9 30  1  0
  9 31  1  0
 10 32  1  0
 10 33  1  0
 19 43  1  6
M  CHG  2  11   1  12  -1
M  END


  Mrv1652304282203172D          

 19 22  0  0  1  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  3  2  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  5  4  1  1  0  0  0
  5  6  1  0  0  0  0
  6  1  1  1  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  9  8  1  6  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  1  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  4 13  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
  8 17  1  0  0  0  0
 17 18  2  0  0  0  0
  4 19  1  1  0  0  0
M  CHG  2   4   1  19  -1
M  END
> <DATABASE_ID>
NP0055158

> <DATABASE_NAME>
NP-MRD

> <SMILES>
[O-][N@+]12CCC[C@H]3CN4[C@H](CCCC4=O)[C@@H](CCC1)[C@@H]23

> <INCHI_IDENTIFIER>
InChI=1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-,17+/m0/s1

> <INCHI_KEY>
XVPBINOPNYFXID-JARXUMMXSA-N

> <FORMULA>
C15H24N2O2

> <MOLECULAR_WEIGHT>
264.369

> <EXACT_MASS>
264.183778021

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
43

> <JCHEM_AVERAGE_POLARIZABILITY>
29.460545891590648

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1R,2R,9S,13R,17S)-6-oxo-7,13-diazatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadecan-13-ium-13-olate

> <ALOGPS_LOGP>
-0.33

> <JCHEM_LOGP>
-0.04844787133333345

> <ALOGPS_LOGS>
-2.24

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_BASIC>
3.8188790175929146

> <JCHEM_POLAR_SURFACE_AREA>
43.370000000000005

> <JCHEM_REFRACTIVITY>
73.4934

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.52e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1R,2R,9S,13R,17S)-6-oxo-7,13-diazatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadecan-13-ium-13-olate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 28-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   28-APR-22         0                                  
HETATM    1  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -1.334  -0.770   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -1.334  -2.310   0.000  0.00  0.00           C+0
HETATM    4  N   UNK     0       0.000  -3.080   0.000  0.00  0.00           N+1
HETATM    5  C   UNK     0       1.334  -2.310   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       2.667   0.000   0.000  0.00  0.00           C+0
HETATM    8  N   UNK     0       4.001  -0.770   0.000  0.00  0.00           N+0
HETATM    9  C   UNK     0       4.001  -2.310   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       2.667  -3.080   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       2.667  -4.620   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       1.334  -5.390   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       0.000  -4.620   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       5.335  -3.080   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       6.668  -2.310   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       6.668  -0.770   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       5.335  -0.000   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0       5.335   1.540   0.000  0.00  0.00           O+0
HETATM   19  O   UNK     0      -1.334  -3.850   0.000  0.00  0.00           O-1
CONECT    1    2    6                                                       
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5   13   19                                             
CONECT    5    4    6   10                                                  
CONECT    6    5    1    7                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9   17                                                  
CONECT    9    8   10   14                                                  
CONECT   10    9    5   11                                                  
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12    4                                                       
CONECT   14    9   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16    8   18                                                  
CONECT   18   17                                                            
CONECT   19    4                                                            
MASTER        0    0    0    0    0    0    0    0   19    0   44    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₅H₂₄N₂O₂

Average Mass

264.3690 Da

Monoisotopic Mass

264.18378 Da

IUPAC Name

(1R,2R,9S,13R,17S)-6-oxo-7,13-diazatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadecan-13-ium-13-olate

Traditional Name

(1R,2R,9S,13R,17S)-6-oxo-7,13-diazatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadecan-13-ium-13-olate

CAS Registry Number

Not Available

SMILES

[O-][N@+]12CCC[C@H]3CN4[C@H](CCCC4=O)[C@@H](CCC1)[C@@H]23

InChI Identifier

InChI=1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-,17+/m0/s1

InChI Key

XVPBINOPNYFXID-JARXUMMXSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Ammothamnus lehmanni	Plant	KNApSAcK
Ammothamnus songoricus	Plant	KNApSAcK
Corydalis yanhusuo	Plant	KNApSAcK
Daphniphyllum oldhamii	Plant	KNApSAcK
Genista aucheri	Plant	KNApSAcK
Sophora alopecuroides	Plant	KNApSAcK
Sophora davidii	LOTUS Database	35616633
Sophora flavescens	Plant	KNApSAcK
Sophora flavescens var. angustifolia	Plant	KNApSAcK
Sophora moorcroftiana Benth.	Plant	KNApSAcK
Sophora pachycarpa Schrenk.	Plant	KNApSAcK
Sophora subprostate	Plant	KNApSAcK
Sophora subprostrata	Plant	KNApSAcK
Sophora tonkinensis	Plant	KNApSAcK
Sophora viciifolia	Plant	KNApSAcK
Sophorae flavescentis	-	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as matrine alkaloids. These are lupin alkaloids with a structure based on the matrine skeleton, a four-ring skeleton that based on a saturated dipyrido[2,1-f:3',2',1'-Ij][1,6]naphthyridin-10-one skeleton.

Kingdom

Organic compounds

Super Class

Alkaloids and derivatives

Class

Lupin alkaloids

Sub Class

Matrine alkaloids

Direct Parent

Matrine alkaloids

Alternative Parents

Substituents

Matrine
Quinolizidinone
Diazanaphthalene
Quinolizidine
Naphthyridine
Piperidinone
Delta-lactam
Piperidine
Trialkyl amine oxide
Tertiary carboxylic acid amide
Lactam
Carboxamide group
Azacycle
Organoheterocyclic compound
Trisubstituted n-oxide
Carboxylic acid derivative
N-oxide
Organic nitrogen compound
Organic oxygen compound
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Organonitrogen compound
Carbonyl group
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-0.33	ALOGPS
logP	-0.048	ChemAxon
logS	-2.2	ALOGPS
pKa (Strongest Basic)	3.82	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	43.37 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	73.49 m³·mol⁻¹	ChemAxon
Polarizability	29.46 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00007758

Chemspider ID

29273181

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Oxymatrine

METLIN ID

Not Available

PubChem Compound

24864132

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Hu D, Chen X, Li D, Zhang H, Duan Y, Huang Y: Sustained Release of Co-Amorphous Matrine-Type Alkaloids and Resveratrol with Anti-COVID-19 Potential. Pharmaceutics. 2022 Mar 10;14(3). pii: pharmaceutics14030603. doi: 10.3390/pharmaceutics14030603. [PubMed:35335977 ]
Kikuchi T, Ogawa M, Okamura T, Gee AD, Zhang MR: Rapid 'on-column' preparation of hydrogen [(11)C]cyanide from [(11)C]methyl iodide via [(11)C]formaldehyde. Chem Sci. 2022 Mar 8;13(12):3556-3562. doi: 10.1039/d1sc07033a. eCollection 2022 Mar 24. [PubMed:35432866 ]
Aryal B, Raut BK, Bhattarai S, Bhandari S, Tandan P, Gyawali K, Sharma K, Ranabhat D, Thapa R, Aryal D, Ojha A, Devkota HP, Parajuli N: Potential Therapeutic Applications of Plant-Derived Alkaloids against Inflammatory and Neurodegenerative Diseases. Evid Based Complement Alternat Med. 2022 Mar 9;2022:7299778. doi: 10.1155/2022/7299778. eCollection 2022. [PubMed:35310033 ]
Li S, Feng G, Zhang M, Zhang X, Lu J, Feng C, Zhu F: Oxymatrine attenuates TNBS-induced colinutis in rats through TLR9/Myd88/NF-kappaB signal pathway. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221078866. doi: 10.1177/09603271221078866. [PubMed:35290143 ]
Das A, Kashyap O, Singh A, Shree J, Namdeo KP, Bodakhe SH: Oxymatrine Protects TGFbeta1-Induced Retinal Fibrosis in an Animal Model of Glaucoma. Front Med (Lausanne). 2022 Feb 18;8:750342. doi: 10.3389/fmed.2021.750342. eCollection 2021. [PubMed:35252223 ]

Showing NP-Card for (+)-Matrine N-oxide (NP0055158)

MOL for NP0055158 ((+)-Matrine N-oxide)

3D MOL for NP0055158 ((+)-Matrine N-oxide)

3D SDF for NP0055158 ((+)-Matrine N-oxide)

3D-SDF for NP0055158 ((+)-Matrine N-oxide)

PDB for NP0055158 ((+)-Matrine N-oxide)

3D PDB for NP0055158 ((+)-Matrine N-oxide)

SMILES for NP0055158 ((+)-Matrine N-oxide)

INCHI for NP0055158 ((+)-Matrine N-oxide)

Structure for NP0055158 ((+)-Matrine N-oxide)

3D Structure for NP0055158 ((+)-Matrine N-oxide)