NP-MRD: Showing NP-Card for Cabucine (NP0050842)

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Record Information

Version

2.0

Created at

2022-04-27 22:14:48 UTC

Updated at

2022-04-27 22:14:48 UTC

NP-MRD ID

NP0050842

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Cabucine

Description

Cabucine belongs to the class of organic compounds known as yohimbine alkaloids. These are alkaloids containing the pentacyclic yohimban skeleton. The Yohimbinoid alkaloids contain a carbocyclic ring E arising through C-17 to C-18 bond formation in a corynantheine precursor. Cabucine is found in Cabucala madagascariensis, Petchia ceylanica, Rauvolfia media and Rauwolfia media. Based on a literature review very few articles have been published on Cabucine.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652304282200142D          

 28 32  0  0  1  0            999 V2000
    5.7299    1.2347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4079    0.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3397   -0.0576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5936   -0.4097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9157    0.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9838    0.8826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2229    1.2015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6845    0.5764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1127   -0.1288    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8740    0.7301    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.6018    1.5090    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1402    2.1341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9508    1.9803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7913    1.6627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2529    1.0376    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.5250    0.2588    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.3356    0.1050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9866   -0.3663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1761   -0.2126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0961    0.5662    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4423    1.1913    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.1702    1.9701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2588   -1.1451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0693   -1.2989    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7204   -1.7702    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9925   -2.5491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1540    1.1166    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2221    1.9388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  1  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
 10  8  1  6  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 11 14  1  0  0  0  0
 15 14  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  1  6  0  0  0
 10 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 15 21  1  0  0  0  0
 21 22  1  1  0  0  0
 18 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
  2 27  1  0  0  0  0
 27 28  1  0  0  0  0
M  END

     RDKit          3D

 54 58  0  0  0  0  0  0  0  0999 V2000
   -1.3727   -4.1019    0.8199 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8495   -2.7819    0.8220 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1726   -2.4192    0.7146 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0290   -3.3325    0.6057 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6002   -1.0426    0.7233 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8717   -0.7254    0.6204 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3440    0.5964    0.6233 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4227    1.6942    0.6420 C   0  0  1  0  0  0  0  0  0  0  0  0
   -4.1990    2.0541    2.0821 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1482    1.1797   -0.0301 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.1807    2.2536   -0.3239 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8707    1.7537   -0.5739 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7217    1.0903   -1.8322 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6906    0.6954   -2.0956 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5300    0.6183   -0.8733 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0261    0.7617    0.3932 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0208    0.6427    1.2740 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1545    0.4262    0.6120 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4559    0.2349    1.0293 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4491    0.0279    0.0905 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2043    0.0017   -1.2691 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2002   -0.2062   -2.2160 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5488   -0.4053   -1.7985 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8976    0.1950   -1.6648 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8786    0.4056   -0.7381 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4185    1.0050    0.5585 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.2118   -0.2828    0.6241 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6389    0.0658    0.8473 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.3683   -4.0770    0.3131 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1992   -4.5198    1.8193 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0069   -4.7457    0.1787 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6076   -1.5276    0.5270 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8984    2.4919    0.0480 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9506    2.8546    2.3289 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3960    1.2101    2.7761 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1717    2.4075    2.2992 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4888    0.7312   -0.9978 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5195    2.7759   -1.2665 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1097    3.0469    0.4439 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3909    0.2085   -1.8986 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1168    1.8026   -2.6114 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1225    1.4397   -2.8152 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7180   -0.2991   -2.6116 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9866    0.6996    2.3314 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7181    0.2442    2.0992 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.4886   -0.1262    0.3974 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.1917   -0.7297   -2.6222 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.9737    0.5358   -1.3892 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.5876   -1.1597   -0.9744 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6284    0.1879   -2.7133 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6604    1.5714    1.4765 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8327   -0.8139    1.5302 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9905   -0.9038   -0.2398 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7115    0.4603    1.9048 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  8 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  1  0
 21 24  1  0
 24 25  2  0
 16 26  1  0
 26 27  1  0
 27 28  1  0
 28  5  1  0
 28 10  1  0
 26 12  1  0
 25 15  1  0
 25 18  1  0
  1 29  1  0
  1 30  1  0
  1 31  1  0
  6 32  1  0
  8 33  1  6
  9 34  1  0
  9 35  1  0
  9 36  1  0
 10 37  1  6
 11 38  1  0
 11 39  1  0
 13 40  1  0
 13 41  1  0
 14 42  1  0
 14 43  1  0
 17 44  1  0
 19 45  1  0
 20 46  1  0
 23 47  1  0
 23 48  1  0
 23 49  1  0
 24 50  1  0
 26 51  1  1
 27 52  1  0
 27 53  1  0
 28 54  1  1
M  END


  Mrv1652304282200142D          

 28 32  0  0  1  0            999 V2000
    5.7299    1.2347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4079    0.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3397   -0.0576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5936   -0.4097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9157    0.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9838    0.8826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2229    1.2015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6845    0.5764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1127   -0.1288    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8740    0.7301    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.6018    1.5090    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1402    2.1341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9508    1.9803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7913    1.6627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2529    1.0376    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.5250    0.2588    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.3356    0.1050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9866   -0.3663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1761   -0.2126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0961    0.5662    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4423    1.1913    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.1702    1.9701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2588   -1.1451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0693   -1.2989    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7204   -1.7702    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9925   -2.5491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1540    1.1166    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2221    1.9388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  1  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
 10  8  1  6  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 11 14  1  0  0  0  0
 15 14  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  1  6  0  0  0
 10 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 15 21  1  0  0  0  0
 21 22  1  1  0  0  0
 18 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
  2 27  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0050842

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC(=O)C1=CO[C@@H](C)[C@H]2CN3CCC4=C(NC5=CC=C(OC)C=C45)[C@@H]3C[C@H]12

> <INCHI_IDENTIFIER>
InChI=1S/C22H26N2O4/c1-12-17-10-24-7-6-14-16-8-13(26-2)4-5-19(16)23-21(14)20(24)9-15(17)18(11-28-12)22(25)27-3/h4-5,8,11-12,15,17,20,23H,6-7,9-10H2,1-3H3/t12-,15-,17+,20-/m0/s1

> <INCHI_KEY>
DTDADHMBRZKXSC-IEGSVRCHSA-N

> <FORMULA>
C22H26N2O4

> <MOLECULAR_WEIGHT>
382.46

> <EXACT_MASS>
382.189257325

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
54

> <JCHEM_AVERAGE_POLARIZABILITY>
43.00320697591677

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
methyl (1S,15R,16S,20S)-7-methoxy-16-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-2(10),4,6,8,18-pentaene-19-carboxylate

> <ALOGPS_LOGP>
3.12

> <JCHEM_LOGP>
2.3950551253333336

> <ALOGPS_LOGS>
-3.75

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_ACIDIC>
16.650388039918678

> <JCHEM_PKA_STRONGEST_BASIC>
7.210778372663201

> <JCHEM_POLAR_SURFACE_AREA>
63.790000000000006

> <JCHEM_REFRACTIVITY>
106.2996

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
6.85e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
methyl (1S,15R,16S,20S)-7-methoxy-16-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-2(10),4,6,8,18-pentaene-19-carboxylate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 28-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   28-APR-22         0                                  
HETATM    1  C   UNK     0      10.696   2.305   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      11.961   1.427   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      11.834  -0.108   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      10.441  -0.765   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       9.176   0.113   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       9.303   1.648   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       7.883   2.243   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       6.878   1.076   0.000  0.00  0.00           C+0
HETATM    9  N   UNK     0       7.677  -0.240   0.000  0.00  0.00           N+0
HETATM   10  C   UNK     0       5.365   1.363   0.000  0.00  0.00           C+0
HETATM   11  N   UNK     0       4.857   2.817   0.000  0.00  0.00           N+0
HETATM   12  C   UNK     0       5.862   3.984   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       7.375   3.697   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       3.344   3.104   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       2.339   1.937   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       2.847   0.483   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       4.360   0.196   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       1.842  -0.684   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       0.329  -0.397   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0      -0.179   1.057   0.000  0.00  0.00           O+0
HETATM   21  C   UNK     0       0.826   2.224   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       0.318   3.678   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       2.350  -2.138   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0       3.863  -2.425   0.000  0.00  0.00           O+0
HETATM   25  O   UNK     0       1.345  -3.304   0.000  0.00  0.00           O+0
HETATM   26  C   UNK     0       1.853  -4.758   0.000  0.00  0.00           C+0
HETATM   27  O   UNK     0      13.354   2.084   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0      13.481   3.619   0.000  0.00  0.00           C+0
CONECT    1    2    6                                                       
CONECT    2    1    3   27                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6    9                                                  
CONECT    6    5    1    7                                                  
CONECT    7    6    8   13                                                  
CONECT    8    7    9   10                                                  
CONECT    9    8    5                                                       
CONECT   10    8   11   17                                                  
CONECT   11   10   12   14                                                  
CONECT   12   11   13                                                       
CONECT   13   12    7                                                       
CONECT   14   11   15                                                       
CONECT   15   14   16   21                                                  
CONECT   16   15   17   18                                                  
CONECT   17   16   10                                                       
CONECT   18   16   19   23                                                  
CONECT   19   18   20                                                       
CONECT   20   19   21                                                       
CONECT   21   20   15   22                                                  
CONECT   22   21                                                            
CONECT   23   18   24   25                                                  
CONECT   24   23                                                            
CONECT   25   23   26                                                       
CONECT   26   25                                                            
CONECT   27    2   28                                                       
CONECT   28   27                                                            
MASTER        0    0    0    0    0    0    0    0   28    0   64    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₂H₂₆N₂O₄

Average Mass

382.4600 Da

Monoisotopic Mass

382.18926 Da

IUPAC Name

methyl (1S,15R,16S,20S)-7-methoxy-16-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-2(10),4,6,8,18-pentaene-19-carboxylate

Traditional Name

methyl (1S,15R,16S,20S)-7-methoxy-16-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-2(10),4,6,8,18-pentaene-19-carboxylate

CAS Registry Number

Not Available

SMILES

COC(=O)C1=CO[C@@H](C)[C@H]2CN3CCC4=C(NC5=CC=C(OC)C=C45)[C@@H]3C[C@H]12

InChI Identifier

InChI=1S/C22H26N2O4/c1-12-17-10-24-7-6-14-16-8-13(26-2)4-5-19(16)23-21(14)20(24)9-15(17)18(11-28-12)22(25)27-3/h4-5,8,11-12,15,17,20,23H,6-7,9-10H2,1-3H3/t12-,15-,17+,20-/m0/s1

InChI Key

DTDADHMBRZKXSC-IEGSVRCHSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Cabucala madagascariensis	Plant	KNApSAcK
Petchia ceylanica	LOTUS Database	35616633
Rauvolfia media	LOTUS Database	35616633
Rauwolfia media	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as yohimbine alkaloids. These are alkaloids containing the pentacyclic yohimban skeleton. The Yohimbinoid alkaloids contain a carbocyclic ring E arising through C-17 to C-18 bond formation in a corynantheine precursor.

Kingdom

Organic compounds

Super Class

Alkaloids and derivatives

Class

Yohimbine alkaloids

Sub Class

Not Available

Direct Parent

Yohimbine alkaloids

Alternative Parents

Substituents

Ajmalicine-skeleton
18-oxayohimban
Corynanthean skeleton
Yohimbine alkaloid
Pyridoindole
Beta-carboline
3-alkylindole
Indole
Indole or derivatives
Anisole
Alkyl aryl ether
Aralkylamine
Piperidine
Benzenoid
Methyl ester
Vinylogous ester
Heteroaromatic compound
Pyrrole
Enoate ester
Alpha,beta-unsaturated carboxylic ester
Amino acid or derivatives
Carboxylic acid ester
Tertiary aliphatic amine
Tertiary amine
Carboxylic acid derivative
Oxacycle
Ether
Azacycle
Organoheterocyclic compound
Monocarboxylic acid or derivatives
Amine
Hydrocarbon derivative
Organic nitrogen compound
Carbonyl group
Organic oxygen compound
Organopnictogen compound
Organic oxide
Organonitrogen compound
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

yohimban alkaloid (CHEBI:3287 )
Indole alkaloids (C10904 )

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.12	ALOGPS
logP	2.4	ChemAxon
logS	-3.8	ALOGPS
pKa (Strongest Acidic)	16.65	ChemAxon
pKa (Strongest Basic)	7.21	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	63.79 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	106.3 m³·mol⁻¹	ChemAxon
Polarizability	43 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00001696

Chemspider ID

391331

KEGG Compound ID

C10904

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

443030

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Not Available

Showing NP-Card for Cabucine (NP0050842)

MOL for NP0050842 (Cabucine)

3D MOL for NP0050842 (Cabucine)

3D SDF for NP0050842 (Cabucine)

3D-SDF for NP0050842 (Cabucine)

PDB for NP0050842 (Cabucine)

3D PDB for NP0050842 (Cabucine)

SMILES for NP0050842 (Cabucine)

INCHI for NP0050842 (Cabucine)

Structure for NP0050842 (Cabucine)

3D Structure for NP0050842 (Cabucine)