| Description | Biochanin A, also known as olmelin or pratensol, belongs to the class of organic compounds known as 4'-o-methylisoflavones. These are isoflavones with methoxy groups attached to the C4' atom of the isoflavone backbone. Thus, biochanin a is considered to be a flavonoid lipid molecule. The enzyme isoflavone-7-O-beta-glucoside 6"-O-malonyltransferase uses malonyl-CoA and biochanin A 7-O-β-D-glucoside to produce CoA and biochanin A 7-O-(6-O-malonyl-β-D-glucoside). The enzyme biochanin-A reductase uses dihydrobiochanin A and NADP+ to produce biochanin A, NADPH, and H+. Biochanin A is an O-methylated isoflavone. Biochanin A is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Outside of the human body, Biochanin A is found, on average, in the highest concentration within a few different foods, such as milk (cow), peanuts, and soy beans and in a lower concentration in beers. Biochanin A has also been detected, but not quantified in, several different foods, such as lingonberries, savoy cabbages, garlics, garden rhubarbs, and red rices. This could make biochanin a a potential biomarker for the consumption of these foods. Biochanin A is classified as a phytoestrogen and has putative benefits in dietary cancer prophylaxis. It is a natural organic compound in the class of phytochemicals known as flavonoids. Biochanin A is a potentially toxic compound. It has also been found to be a weak inhibitor of fatty acid amide hydrolase in vitro. Biochanin A is found in Albizia procera , Anaxagorea luzonensis, Anaxagorea luzonensis A.GRAY, Andira inermis , Andira parviflora, Andira surinamensis, Astragalus adsurgens, Baptisia alba, Baptisia calycosa, Baptisia sphaerocarpa, Baptisia tinctoria , Bolusanthus speciosus, Bolusanthus specious, Brassica oleracea , Cicer anatolicum, Cicer bijugum, Cicer canariensis, Cicer chorassanicum, Cicer cuneatum, Cicer echinospermum, Cicer flexuosum, Cicer judaicum, Cicer judicum, Cicer macracanthum, Cicer microphyllum, Cicer mogolatvicum, Cicer montbretii, Cicer nuristanicum, Cicer oxyodon, Cicer pinnatifidum, Cicer pungens, Cicer rechingeri, Cicer reticulatum, Cicer songaricum, Cicer tragacanthoides, Cicer yamashitae, Hedysarum multijugum, Crotalaria thebaica, Cullen corylifolium, Dalbergia frutescens, Dalbergia lanceolaria , Dalbergia monetaria, Dalbergia nigrescens, Dalbergia nitidula , Dalbergia odorifera , Dalbergia oliveri, Dalbergia parviflora , Dalbergia sissoides, Dalbergia sissoo, Dalbergia spruceana, Dalbergia volubilis , Dermatophyllum secundiflorum, Echinospartum horridum, Euchresta formosana, Moghania philippinensis, Flemingia prostrata, Gynerium sagittatum , Halotydeus destructor, Haplormosia monophylla, Homo sapiens (Urine), Iris pseudacorus, Knema furfuracea, Maclura tricuspidata, Medicago truncatula, Millettia dielsiana, Monopteryx uaucu, Myristica malabarica, Myroxylon peruiferum , Ononis spinosa , Ormosia henryi, Pericopsis elata , Pericopsis laxiflora , Pericopsis mooniana, Podocarpus amarus, Sundacarpus amarus, Pueraria montana, Pueraria montana var. lobata, Pycnanthus angolensis, Serratula strangulata, Sophora mollis , Sophora secundiflora , Sophora japonica , Swartzia polyphylla, Syzygium jambos, Taxus chinensis, Taxus fuana, Taxus yunnanensis, Thermopsis macrophylla, Thermopsis rhombifolia, Trifolium alpestre, Trifolium apertum, Trifolium aureum, Trifolium canescens, Trifolium caucasicum, Trifolium echinatum, Trifolium incarnatum, Trifolium medium, Trifolium pannonicum , Trifolium pratense , Trifolium repens , Trifolium repensl, Trifolium riograndense, Trifolium rubens, Trifolium subterraneum, Trifolium trichocephalum, Trigonella foenum-graecum, Virola caducifolia, Virola cadudifolia, Vitis vinifera and Wisteria brachybotrys. Biochanin A was first documented in 2006 (PMID: 16903077). Biochanin A can be found in red clover in soy, in alfalfa sprouts, in peanuts, in chickpea (Cicer arietinum) and in other legumes (PMID: 18565930) (PMID: 16651441) (PMID: 16598420). |
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