NP-MRD: Showing NP-Card for Spiromaterpene A (NP0044677)

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Record Information

Version

2.0

Created at

2022-02-24 21:11:51 UTC

Updated at

2022-02-24 21:11:51 UTC

NP-MRD ID

NP0044677

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Spiromaterpene A

Description

Based on a literature review very few articles have been published on (1S)-1,4-dimethyl-7-(propan-2-yl)-1,2,3,5-tetrahydroazulen-5-one.

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 36 37  0  0  0  0  0  0  0  0999 V2000
   -1.6536   -2.8712   -0.9868 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8115   -1.7224   -0.5936 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4376   -0.7919    0.2054 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9630    0.4761    0.4614 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3590    0.9430    0.4809 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4833    0.3227   -0.0122 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8016    0.9116    0.3345 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.6220    1.1883   -0.8927 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5970   -0.0988    1.1680 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5016   -0.8060   -0.8062 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4881   -1.7308   -1.0751 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7950   -2.6670   -1.8354 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1208    1.3610    0.7359 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.2977    2.2531   -0.4758 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3015    0.4245    0.8626 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7091   -0.9478    0.9379 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2205   -3.3381   -1.9153 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6564   -3.5845   -0.1349 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6739   -2.5430   -1.2249 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5423    1.9036    0.9322 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6700    1.7980    0.9641 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4022    1.9377   -0.5921 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1986    0.2732   -1.1707 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0136    1.5756   -1.7407 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2123   -0.1522    2.2017 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6435    0.3052    1.2023 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5783   -1.0839    0.6551 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4659   -0.9665   -1.2758 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9742    1.9825    1.6322 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0583    3.0314   -0.3318 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5160    1.6281   -1.3484 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3084    2.7529   -0.6597 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9780    0.4909   -0.0267 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9002    0.6257    1.7786 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3578   -1.7439    0.5362 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4359   -1.1371    2.0098 H   0  0  0  0  0  0  0  0  0  0  0  0
  8  7  1  0
  7  9  1  0
  7  6  1  0
  6 10  2  0
 10 11  1  0
 11 12  2  0
 11  2  1  0
  2  1  1  0
  2  3  2  0
  3 16  1  0
 16 15  1  0
 15 13  1  0
 13 14  1  0
 13  4  1  0
  4  5  2  0
  5  6  1  0
  4  3  1  0
  8 22  1  0
  8 23  1  0
  8 24  1  0
  7 21  1  1
  9 25  1  0
  9 26  1  0
  9 27  1  0
 10 28  1  0
  1 17  1  0
  1 18  1  0
  1 19  1  0
 16 35  1  0
 16 36  1  0
 15 33  1  0
 15 34  1  0
 13 29  1  1
 14 30  1  0
 14 31  1  0
 14 32  1  0
  5 20  1  0
M  END


  Mrv1652302242222112D          

 16 17  0  0  1  0            999 V2000
    4.3699    3.1868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6713    2.4188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4871    2.2958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1569    1.7738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5149    1.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1569    0.2872    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6713   -0.3578    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3526    0.1036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1690   -0.7007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7076    0.6180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9230    0.3631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4380    1.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9230    1.6979    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.6680    2.4826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7076    1.4430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3526    1.9574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  6  0  0  0
 13 15  1  0  0  0  0
 10 15  1  0  0  0  0
 15 16  2  0  0  0  0
  4 16  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0044677

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(C)C1=CC(=O)C(C)=C2CC[C@H](C)C2=C1

> <INCHI_IDENTIFIER>
InChI=1S/C15H20O/c1-9(2)12-7-14-10(3)5-6-13(14)11(4)15(16)8-12/h7-10H,5-6H2,1-4H3/t10-/m0/s1

> <INCHI_KEY>
RAFZQRWGNALMOP-JTQLQIEISA-N

> <FORMULA>
C15H20O

> <MOLECULAR_WEIGHT>
216.324

> <EXACT_MASS>
216.151415264

> <JCHEM_ACCEPTOR_COUNT>
1

> <JCHEM_ATOM_COUNT>
36

> <JCHEM_AVERAGE_POLARIZABILITY>
26.261497263992187

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1S)-1,4-dimethyl-7-(propan-2-yl)-1,2,3,5-tetrahydroazulen-5-one

> <ALOGPS_LOGP>
4.25

> <JCHEM_LOGP>
3.4594055100000007

> <ALOGPS_LOGS>
-3.23

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_BASIC>
-4.509563583945726

> <JCHEM_POLAR_SURFACE_AREA>
17.07

> <JCHEM_REFRACTIVITY>
69.85170000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.28e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1S)-7-isopropyl-1,4-dimethyl-2,3-dihydro-1H-azulen-5-one

> <JCHEM_VEBER_RULE>
1

$$$$

HEADER    PROTEIN                                 24-FEB-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-FEB-22         0                                  
HETATM    1  C   UNK     0       8.157   5.949   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       8.720   4.515   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      10.243   4.286   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       7.760   3.311   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       8.428   1.924   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       7.760   0.536   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0       8.720  -0.668   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0       6.258   0.193   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       5.916  -1.308   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       5.054   1.154   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       3.590   0.678   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       2.684   1.924   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       3.590   3.169   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       3.114   4.634   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       5.054   2.694   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       6.258   3.654   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5   16                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7    8                                                  
CONECT    7    6                                                            
CONECT    8    6    9   10                                                  
CONECT    9    8                                                            
CONECT   10    8   11   15                                                  
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14   15                                                  
CONECT   14   13                                                            
CONECT   15   13   10   16                                                  
CONECT   16   15    4                                                       
MASTER        0    0    0    0    0    0    0    0   16    0   34    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₅H₂₀O

Average Mass

216.3240 Da

Monoisotopic Mass

216.15142 Da

IUPAC Name

(1S)-1,4-dimethyl-7-(propan-2-yl)-1,2,3,5-tetrahydroazulen-5-one

Traditional Name

(1S)-7-isopropyl-1,4-dimethyl-2,3-dihydro-1H-azulen-5-one

CAS Registry Number

Not Available

SMILES

CC(C)C1=CC(=O)C(C)=C2CC[C@H](C)C2=C1

InChI Identifier

InChI=1S/C15H20O/c1-9(2)12-7-14-10(3)5-6-13(14)11(4)15(16)8-12/h7-10H,5-6H2,1-4H3/t10-/m0/s1

InChI Key

RAFZQRWGNALMOP-JTQLQIEISA-N

Experimental Spectra

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, Dimethylsulfoxide-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, Dimethylsulfoxide-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 150 MHz, Dimethylsulfoxide-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 175 MHz, Dimethylsulfoxide-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, Dimethylsulfoxide-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 225 MHz, Dimethylsulfoxide-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, Dimethylsulfoxide-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 250 MHz, Dimethylsulfoxide-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, Dimethylsulfoxide-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, Dimethylsulfoxide-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, Dimethylsulfoxide-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, Dimethylsulfoxide-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, Dimethylsulfoxide-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, Dimethylsulfoxide-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, Dimethylsulfoxide-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, Dimethylsulfoxide-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, Dimethylsulfoxide-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, Dimethylsulfoxide-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, Dimethylsulfoxide-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, Dimethylsulfoxide-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Spiromastix sp.	Linington's dataset npmrd_submissions_20220207	34161733

Chemical Taxonomy

Classification

Not classified

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	4.25	ALOGPS
logP	3.46	ChemAxon
logS	-3.2	ALOGPS
pKa (Strongest Basic)	-4.5	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	1	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	17.07 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	69.85 m³·mol⁻¹	ChemAxon
Polarizability	26.26 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

110417256

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Showing NP-Card for Spiromaterpene A (NP0044677)

MOL for NP0044677 (Spiromaterpene A)

3D MOL for NP0044677 (Spiromaterpene A)

3D SDF for NP0044677 (Spiromaterpene A)

3D-SDF for NP0044677 (Spiromaterpene A)

PDB for NP0044677 (Spiromaterpene A)

3D PDB for NP0044677 (Spiromaterpene A)

SMILES for NP0044677 (Spiromaterpene A)

INCHI for NP0044677 (Spiromaterpene A)

Structure for NP0044677 (Spiromaterpene A)

3D Structure for NP0044677 (Spiromaterpene A)