Record Information |
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Version | 1.0 |
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Created at | 2022-02-14 20:40:12 UTC |
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Updated at | 2022-03-10 22:21:05 UTC |
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NP-MRD ID | NP0044259 |
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Secondary Accession Numbers | None |
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Natural Product Identification |
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Common Name | Guanosine diphosphate mannose |
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Description | Guanosine diphosphate mannose, also known as gdpmannose or GDP-alpha-D-mannose, belongs to the class of organic compounds known as purine nucleotide sugars. These are purine nucleotides bound to a saccharide derivative through the terminal phosphate group. Guanosine diphosphate mannose is a strong basic compound (based on its pKa). Guanosine diphosphate mannose exists in all living species, ranging from bacteria to humans. Within humans, guanosine diphosphate mannose participates in a number of enzymatic reactions. In particular, guanosine diphosphate mannose can be biosynthesized from D-mannose 1-phosphate through its interaction with the enzyme mannose-1-phosphate guanyltransferase beta. In addition, guanosine diphosphate mannose can be converted into GDP-4-dehydro-6-deoxy-D-mannose; which is catalyzed by the enzyme GDP-mannose 4,6 dehydratase. In humans, guanosine diphosphate mannose is involved in the metabolic disorder called fructosuria. Outside of the human body, Guanosine diphosphate mannose has been detected, but not quantified in, several different foods, such as other bread, feijoa, chanterelles, cherimoya, and romaine lettuces. This could make guanosine diphosphate mannose a potential biomarker for the consumption of these foods. The alpha-anomer of GDP-D-mannose. Guanosine diphosphate mannose is expected to be in Cannabis as all living plants are known to produce and metabolize it. |
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Structure | NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)C(=O)N1 InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 |
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Synonyms | Value | Source |
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GDP-D-Mannose | ChEBI | GDPmannose | ChEBI | Guanosine 5'-(trihydrogen diphosphate), mono-alpha-D-mannopyranosyl ester | ChEBI | Guanosine diphosphomannose | ChEBI | Guanosine pyrophosphate mannose | ChEBI | GDP-alpha-D-Mannose | Kegg | Guanosine 5'-(trihydrogen diphosphate), mono-a-D-mannopyranosyl ester | Generator | Guanosine 5'-(trihydrogen diphosphate), mono-α-D-mannopyranosyl ester | Generator | Guanosine 5'-(trihydrogen diphosphoric acid), mono-a-D-mannopyranosyl ester | Generator | Guanosine 5'-(trihydrogen diphosphoric acid), mono-alpha-D-mannopyranosyl ester | Generator | Guanosine 5'-(trihydrogen diphosphoric acid), mono-α-D-mannopyranosyl ester | Generator | Guanosine pyrophosphoric acid mannose | Generator | GDP-a-D-Mannose | Generator | GDP-Α-D-mannose | Generator | Guanosine diphosphoric acid mannose | Generator | GDP Mannose | HMDB | GDP-Glucose | HMDB | GDP-Mannose | HMDB | Pyrophosphate mannose, guanosine | HMDB | Diphosphomannose, guanosine | HMDB | Mannose, guanosine diphosphate | HMDB | Diphosphate mannose, guanosine | HMDB | Mannose, guanosine pyrophosphate | HMDB | Mannose, GDP | HMDB | Guanosine 5'-(trihydrogen diphosphate) p'-mannosyl ester | HMDB | Guanosine 5'-(trihydrogen pyrophosphate) mono-D-mannosyl ester | HMDB | Guanosine 5'-(trihydrogen pyrophosphate) monomannopyranosyl ester | HMDB | Guanosine 5'-(trihydrogen pyrophosphate) monomannosyl ester | HMDB | Guanosine 5'-diphosphate D-mannose | HMDB | Guanosine 5'-pyrophosphate D-mannosyl ester | HMDB | Guanosine 5'-pyrophosphate alpha-D-mannosyl ester | HMDB | Guanosine 5'-pyrophosphate α-D-mannosyl ester | HMDB | Guanosine 5’-(trihydrogen diphosphate) p’-mannosyl ester | HMDB | Guanosine 5’-(trihydrogen pyrophosphate) mono-D-mannosyl ester | HMDB | Guanosine 5’-(trihydrogen pyrophosphate) monomannopyranosyl ester | HMDB | Guanosine 5’-(trihydrogen pyrophosphate) monomannosyl ester | HMDB | Guanosine 5’-diphosphate D-mannose | HMDB | Guanosine 5’-pyrophosphate D-mannosyl ester | HMDB | Guanosine 5’-pyrophosphate α-D-mannosyl ester | HMDB | Guanosine diphosphate mannose | HMDB |
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Chemical Formula | C16H25N5O16P2 |
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Average Mass | 605.3411 Da |
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Monoisotopic Mass | 605.07715 Da |
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IUPAC Name | [({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})phosphinic acid |
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Traditional Name | guanosine diphosphomannose |
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CAS Registry Number | 20236-92-4 |
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SMILES | NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)C(=O)N1 |
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InChI Identifier | InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 |
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InChI Key | MVMSCBBUIHUTGJ-GDJBGNAASA-N |
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Experimental Spectra |
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| Not Available | Predicted Spectra |
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| Spectrum Type | Description | Depositor ID | Depositor Organization | Depositor | Deposition Date | View |
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1D NMR | 13C NMR Spectrum (1D, 25 MHz, D2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 100 MHz, D2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 252 MHz, D2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 1000 MHz, D2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 50 MHz, D2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 200 MHz, D2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 75 MHz, D2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 300 MHz, D2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 101 MHz, D2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 400 MHz, D2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 126 MHz, D2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 500 MHz, D2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 151 MHz, D2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 600 MHz, D2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 176 MHz, D2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 700 MHz, D2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 201 MHz, D2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 800 MHz, D2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 226 MHz, D2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 900 MHz, D2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum |
| Chemical Shift Submissions |
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| Not Available | Species |
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Species of Origin | |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as purine nucleotide sugars. These are purine nucleotides bound to a saccharide derivative through the terminal phosphate group. |
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Kingdom | Organic compounds |
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Super Class | Nucleosides, nucleotides, and analogues |
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Class | Purine nucleotides |
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Sub Class | Purine nucleotide sugars |
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Direct Parent | Purine nucleotide sugars |
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Alternative Parents | |
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Substituents | - Purine nucleotide sugar
- Purine ribonucleoside diphosphate
- Purine ribonucleoside monophosphate
- Pentose phosphate
- Pentose-5-phosphate
- Glycosyl compound
- N-glycosyl compound
- Monosaccharide phosphate
- Organic pyrophosphate
- Imidazopyrimidine
- Purine
- Hydroxypyrimidine
- Monoalkyl phosphate
- Monosaccharide
- N-substituted imidazole
- Organic phosphoric acid derivative
- Oxane
- Phosphoric acid ester
- Alkyl phosphate
- Pyrimidine
- Heteroaromatic compound
- Tetrahydrofuran
- Imidazole
- Azole
- Secondary alcohol
- Polyol
- Oxacycle
- Organoheterocyclic compound
- Azacycle
- Organic oxygen compound
- Alcohol
- Organic oxide
- Primary alcohol
- Hydrocarbon derivative
- Organonitrogen compound
- Organooxygen compound
- Organic nitrogen compound
- Organopnictogen compound
- Aromatic heteropolycyclic compound
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Molecular Framework | Aromatic heteropolycyclic compounds |
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External Descriptors | |
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Physical Properties |
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State | Not Available |
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Experimental Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Predicted Properties | |
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