Record Information |
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Version | 1.0 |
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Created at | 2022-02-14 20:22:14 UTC |
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Updated at | 2022-03-10 22:22:08 UTC |
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NP-MRD ID | NP0044235 |
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Secondary Accession Numbers | None |
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Natural Product Identification |
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Common Name | Phosphoric acid |
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Description | Phosphoric acid or free phosphate, also known as H3PO4, belongs to the class of inorganic compounds known as non-metal phosphates. These are inorganic non-metallic compounds containing a phosphate as its largest oxoanion. Phosphate is a moderately acidic compound (based on its pKa). When phosphorous pentoxide is dissolved in water it produces phosphoric acid. Phosphoric acid is a colorless, odorless phosphorus-containing inorganic acid with a bland taste. Phosphate, in the form of phosphoric acid, phosphate ions (H2PO4 or HPO4 – at neutral pH) or various salts of phosphate, exists in all living species, ranging from bacteria to plants to humans. Free orthophosphate anions can be released by the hydrolysis of the phosphoanhydride bonds in ATP or ADP. These phosphorylation and dephosphorylation reactions are the immediate storage and source of energy for many metabolic processes. ATP and ADP are often referred to as high-energy phosphates. An important occurrence of phosphates in biological systems is as the structural material of bone and teeth. These structures are made of crystalline calcium phosphate in the form of hydroxyapatite. Vitamin D, which helps stimulate bone growth and stability, stimulates phosphate absorption, an effect reported to precede its action on calcium ion transport. Phosphate supplementation of the diet of rodents has been shown to lead to reduction in the incidence of dental caries and different phosphates have different powers in reducing the cariogenic potential of the carbohydrates in a diet. Food-grade phosphoric acid (additive E338) is used to acidify foods and beverages such as various colas and jams, providing a tangy or sour taste. Soft drinks containing phosphoric acid, including Coca-Cola, are sometimes called phosphate sodas or phosphates. Phosphoric acid also has the potential to contribute to the formation of kidney stones, especially in those who have had kidney stones previously (PMID:25364887 ). Phosphate, in the form of phosphoric acid, is one of the simple acids found in cannabis plant (PMID: 6991645 ). |
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Structure | InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4) |
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Synonyms | Value | Source |
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[PO(OH)3] | ChEBI | Acide phosphorique | ChEBI | Acidum phosphoricum | ChEBI | H3PO4 | ChEBI | Orthophosphoric acid | ChEBI | Phosphorsaeureloesungen | ChEBI | Phosphorsaeure | ChEBI | Phosphoric acid | Kegg | Orthophosphate | Generator | Phosphate | ChEBI | Diphosphate tetrasodium | HMDB | Marphos | HMDB | NFB | HMDB | ortho- Phosphoric acid | HMDB | Phosphoric acid (acd/name 4.0) | HMDB | Sodium pyrophosphate | HMDB | Sodium pyrophosphate decahydrate | HMDB | Sodium pyrophosphate decahydrate biochemica | HMDB | Sonac | HMDB | Tetra-sodium pyrophosphate | HMDB | Tetrasodium pyrophosphate 10-hydrate | HMDB | Tetrasodium pyrophosphate decahydrate | HMDB | White phosphoric acid | HMDB | K-Etchant | MeSH, HMDB | Uni-etch | MeSH, HMDB | Concise etchant | MeSH, HMDB | Condact | MeSH, HMDB | Hydrogen phosphoric acid | Generator | Dihydrogen phosphate | HMDB | Hydrogen phosphate | HMDB |
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Chemical Formula | H3O4P |
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Average Mass | 97.9952 Da |
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Monoisotopic Mass | 97.97690 Da |
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IUPAC Name | phosphoric acid |
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Traditional Name | phosphoric acid |
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CAS Registry Number | 1339-32-8 |
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SMILES | OP(O)(O)=O |
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InChI Identifier | InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4) |
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InChI Key | NBIIXXVUZAFLBC-UHFFFAOYSA-N |
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Experimental Spectra |
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| Not Available | Predicted Spectra |
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| Not Available | Chemical Shift Submissions |
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Species of Origin | |
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Chemical Taxonomy |
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Description | Belongs to the class of inorganic compounds known as non-metal phosphates. These are inorganic non-metallic compounds containing a phosphate as its largest oxoanion. |
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Kingdom | Inorganic compounds |
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Super Class | Homogeneous non-metal compounds |
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Class | Non-metal oxoanionic compounds |
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Sub Class | Non-metal phosphates |
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Direct Parent | Non-metal phosphates |
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Alternative Parents | |
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Substituents | - Non-metal phosphate
- Inorganic oxide
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Molecular Framework | Not Available |
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External Descriptors | |
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Physical Properties |
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State | Not Available |
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Experimental Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Predicted Properties | |
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General References | - Castrillo JI, Zeef LA, Hoyle DC, Zhang N, Hayes A, Gardner DC, Cornell MJ, Petty J, Hakes L, Wardleworth L, Rash B, Brown M, Dunn WB, Broadhurst D, O'Donoghue K, Hester SS, Dunkley TP, Hart SR, Swainston N, Li P, Gaskell SJ, Paton NW, Lilley KS, Kell DB, Oliver SG: Growth control of the eukaryote cell: a systems biology study in yeast. J Biol. 2007;6(2):4. doi: 10.1186/jbiol54. [PubMed:17439666 ]
- Turner CE, Elsohly MA, Boeren EG: Constituents of Cannabis sativa L. XVII. A review of the natural constituents. J Nat Prod. 1980 Mar-Apr;43(2):169-234. doi: 10.1021/np50008a001. [PubMed:6991645 ]
- Gardner A, Hobson R: Variations in acid-etch patterns with different acids and etch times. Am J Orthod Dentofacial Orthop. 2001 Jul;120(1):64-7. doi: 10.1067/mod.2001.114643. [PubMed:11455380 ]
- Takeda E, Taketani Y, Sawada N, Sato T, Yamamoto H: The regulation and function of phosphate in the human body. Biofactors. 2004;21(1-4):345-55. doi: 10.1002/biof.552210167. [PubMed:15630224 ]
- Yan L, Zhu S, Ji X, Lu W: Proton hopping in phosphoric acid solvated nafion membrane: a molecular simulation study. J Phys Chem B. 2007 Jun 14;111(23):6357-63. doi: 10.1021/jp071005m. Epub 2007 May 23. [PubMed:17518491 ]
- Torres-Rodriguez C, Navarro AB, Sanchez-Sanchez P, Gonzalez-Lopez S: Selective removal of mineral and organic components of bovine enamel by phosphoric acid. J Adhes Dent. 2012 Aug;14(4):329-34. doi: 10.3290/j.jad.a22714. [PubMed:22282755 ]
- Qaseem A, Dallas P, Forciea MA, Starkey M, Denberg TD: Dietary and pharmacologic management to prevent recurrent nephrolithiasis in adults: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2014 Nov 4;161(9):659-67. doi: 10.7326/M13-2908. [PubMed:25364887 ]
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