NP-MRD: Showing NP-Card for aphanalide K (NP0043484)

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Record Information

Version

1.0

Created at

2021-06-21 00:52:58 UTC

Updated at

2021-06-30 00:19:11 UTC

NP-MRD ID

NP0043484

Secondary Accession Numbers

None

Natural Product Identification

Common Name

aphanalide K

Provided By

JEOL Database JEOL Logo

Description

(1S,2R,3S,8R,10R,11R,12S,15R,16S,17R,18R)-15-(furan-3-yl)-10,17,18-trihydroxy-2,7,7,11,16-pentamethyl-5,13-dioxo-6-oxatetracyclo[9.7.0.0²,⁸.0¹²,¹⁶]Octadecan-3-yl acetate belongs to the class of organic compounds known as limonoids. These are highly oxygenated, modified terpenoids with a prototypical structure either containing or derived from a precursor with a 4,4,8-trimethyl-17-furanylsteroid skeleton. All naturally occurring citrus limonoids contain a furan ring attached to the D-ring, at C-17, as well as oxygen containing functional groups at C-3, C-4, C-7, C-16 and C-17. aphanalide K is found in Aphanamixis grandifolia. It was first documented in 2002 (PMID: 29437326). Based on a literature review a significant number of articles have been published on (1S,2R,3S,8R,10R,11R,12S,15R,16S,17R,18R)-15-(furan-3-yl)-10,17,18-trihydroxy-2,7,7,11,16-pentamethyl-5,13-dioxo-6-oxatetracyclo[9.7.0.0²,⁸.0¹²,¹⁶]Octadecan-3-yl acetate (PMID: 27466641) (PMID: 27253005) (PMID: 26389468) (PMID: 26389426).

Structure

MOL 3D MOL SDF 3D SDF PDB SMILES InChI


  Mrv1652306212102523D          

 75 79  0  0  0  0            999 V2000
    2.1074   -3.7691    2.9404 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6320   -2.8373    1.8925 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4329   -1.9346    2.1036 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0611   -3.1188    0.6912 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4533   -2.3299   -0.4600 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.2226   -3.2688   -1.3848 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.3129   -4.3020   -1.9555 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2072   -5.4521   -1.5621 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6192   -3.7612   -2.9811 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2296   -3.4783   -2.7319 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.2563   -2.8193   -4.0395 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5423   -4.8119   -2.6041 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0258   -2.5739   -1.4413 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.3960   -1.9619   -1.4556 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.7558   -1.2013   -0.1850 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.7084   -2.1257    0.9034 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8011    0.0022    0.0718 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.0405    1.0101   -1.0861 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1761    0.6349    1.4791 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.3424    1.6077    1.3686 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4920    1.2699    1.1087 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9388    3.0427    1.5949 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4100    2.9484    1.6784 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.2320    4.0989    2.4009 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3874    4.8213    1.9750 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6195    5.7926    2.9190 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6844    5.7297    3.8975 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1536    4.7124    3.5782 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1258    1.5205    2.2339 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4534    1.4600    3.7621 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3360    1.0443    2.0232 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.6185   -0.0180    2.9460 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6625    0.5453    0.5989 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.7144    1.6252   -0.3215 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6630   -0.5637    0.1539 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.1824   -1.5345   -1.0413 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.6872   -0.7169   -2.2483 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2899   -4.8046    2.6418 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6299   -3.5846    3.8833 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0391   -3.5932    3.0884 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2040   -1.5927   -0.1635 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0076   -3.7969   -0.8293 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7250   -2.7340   -2.1976 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0340   -3.4282   -4.9051 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3442   -2.7041   -4.0730 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1974   -1.8387   -4.1998 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6259   -4.6683   -2.6577 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3255   -5.3147   -1.6560 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2510   -5.5062   -3.4010 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0093   -3.2852   -0.6031 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1244   -2.7747   -1.5649 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5322   -1.3150   -2.3253 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7911   -0.8492   -0.2616 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4943   -2.6963    0.8332 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1004    1.2779   -1.1660 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4929    1.9431   -0.9855 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7830    0.6116   -2.0641 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4853   -0.1610    2.1664 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2531    3.6647    0.7520 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4085    3.4007    2.5151 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0349    3.0140    0.6545 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9752    4.6571    1.0829 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3635    6.5688    3.0318 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9620    4.5491    4.2784 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4827    0.4259    4.1252 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3050    1.9871    4.3512 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4279    1.8962    4.0027 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0184    1.8619    2.2818 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5285   -0.3446    2.7859 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6733    0.1372    0.6326 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4919    2.1660   -0.0938 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6140   -1.2457    1.0127 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9092   -0.1192   -2.7164 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5015   -0.0434   -1.9644 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1022   -1.3477   -3.0375 H   0  0  0  0  0  0  0  0  0  0  0  0
  7  8  2  0  0  0  0
 14 15  1  0  0  0  0
 20 21  2  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
 35 17  1  0  0  0  0
 29 30  1  1  0  0  0
  7  9  1  0  0  0  0
 31 32  1  0  0  0  0
  5 36  1  0  0  0  0
 15 16  1  0  0  0  0
 13 10  1  0  0  0  0
 13 50  1  1  0  0  0
  9 10  1  0  0  0  0
 33 34  1  0  0  0  0
 35 33  1  0  0  0  0
 36 37  1  6  0  0  0
 17 19  1  0  0  0  0
 10 11  1  6  0  0  0
 29 31  1  0  0  0  0
 10 12  1  0  0  0  0
 24 28  2  0  0  0  0
 31 33  1  0  0  0  0
 29 19  1  0  0  0  0
 36 13  1  0  0  0  0
 28 27  1  0  0  0  0
 27 26  1  0  0  0  0
 26 25  2  0  0  0  0
 25 24  1  0  0  0  0
  6  7  1  0  0  0  0
 35 72  1  1  0  0  0
  6  5  1  0  0  0  0
 36 35  1  0  0  0  0
 17 18  1  6  0  0  0
 19 20  1  0  0  0  0
  5  4  1  0  0  0  0
 20 22  1  0  0  0  0
  4  2  1  0  0  0  0
 22 23  1  0  0  0  0
  2  3  2  0  0  0  0
 23 29  1  0  0  0  0
  2  1  1  0  0  0  0
 13 14  1  0  0  0  0
 19 58  1  1  0  0  0
  6 42  1  0  0  0  0
  6 43  1  0  0  0  0
  5 41  1  1  0  0  0
 14 51  1  0  0  0  0
 14 52  1  0  0  0  0
 31 68  1  1  0  0  0
 33 70  1  1  0  0  0
 22 59  1  0  0  0  0
 22 60  1  0  0  0  0
 23 61  1  6  0  0  0
 30 65  1  0  0  0  0
 30 66  1  0  0  0  0
 30 67  1  0  0  0  0
 32 69  1  0  0  0  0
 16 54  1  0  0  0  0
 34 71  1  0  0  0  0
 37 73  1  0  0  0  0
 37 74  1  0  0  0  0
 37 75  1  0  0  0  0
 11 44  1  0  0  0  0
 11 45  1  0  0  0  0
 11 46  1  0  0  0  0
 12 47  1  0  0  0  0
 12 48  1  0  0  0  0
 12 49  1  0  0  0  0
 28 64  1  0  0  0  0
 26 63  1  0  0  0  0
 25 62  1  0  0  0  0
 15 53  1  6  0  0  0
 18 55  1  0  0  0  0
 18 56  1  0  0  0  0
 18 57  1  0  0  0  0
  1 38  1  0  0  0  0
  1 39  1  0  0  0  0
  1 40  1  0  0  0  0
M  END

     RDKit          3D

 75 79  0  0  0  0  0  0  0  0999 V2000
    2.1074   -3.7691    2.9404 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6320   -2.8373    1.8925 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4329   -1.9346    2.1036 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0611   -3.1188    0.6912 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4533   -2.3299   -0.4600 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.2226   -3.2688   -1.3848 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3129   -4.3020   -1.9555 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2072   -5.4521   -1.5621 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6192   -3.7612   -2.9811 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2296   -3.4783   -2.7319 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.2563   -2.8193   -4.0395 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5423   -4.8119   -2.6041 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0258   -2.5739   -1.4413 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.3960   -1.9619   -1.4556 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7558   -1.2013   -0.1850 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.7084   -2.1257    0.9034 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8011    0.0022    0.0718 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.0405    1.0101   -1.0861 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1761    0.6349    1.4791 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.3424    1.6077    1.3686 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4920    1.2699    1.1087 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9388    3.0427    1.5949 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4100    2.9484    1.6784 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.2320    4.0989    2.4009 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3874    4.8213    1.9750 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6195    5.7926    2.9190 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6844    5.7297    3.8975 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1536    4.7124    3.5782 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1258    1.5205    2.2339 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4534    1.4600    3.7621 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3360    1.0443    2.0232 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.6185   -0.0180    2.9460 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6625    0.5453    0.5989 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.7144    1.6252   -0.3215 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6630   -0.5637    0.1539 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.1824   -1.5345   -1.0413 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.6872   -0.7169   -2.2483 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2899   -4.8046    2.6418 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6299   -3.5846    3.8833 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0391   -3.5932    3.0884 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2040   -1.5927   -0.1635 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0076   -3.7969   -0.8293 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7250   -2.7340   -2.1976 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0340   -3.4282   -4.9051 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3442   -2.7041   -4.0730 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1974   -1.8387   -4.1998 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6259   -4.6683   -2.6577 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3255   -5.3147   -1.6560 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2510   -5.5062   -3.4010 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0093   -3.2852   -0.6031 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1244   -2.7747   -1.5649 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5322   -1.3150   -2.3253 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7911   -0.8492   -0.2616 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4943   -2.6963    0.8332 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1004    1.2779   -1.1660 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4929    1.9431   -0.9855 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7830    0.6116   -2.0641 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4853   -0.1610    2.1664 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2531    3.6647    0.7520 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4085    3.4007    2.5151 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0349    3.0140    0.6545 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9752    4.6571    1.0829 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3635    6.5688    3.0318 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9620    4.5491    4.2784 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4827    0.4259    4.1252 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3050    1.9871    4.3512 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4279    1.8962    4.0027 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0184    1.8619    2.2818 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5285   -0.3446    2.7859 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6733    0.1372    0.6326 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4919    2.1660   -0.0938 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6140   -1.2457    1.0127 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9092   -0.1192   -2.7164 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5015   -0.0434   -1.9644 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1022   -1.3477   -3.0375 H   0  0  0  0  0  0  0  0  0  0  0  0
  7  8  2  0
 14 15  1  0
 20 21  2  0
 15 17  1  0
 23 24  1  0
 35 17  1  0
 29 30  1  1
  7  9  1  0
 31 32  1  0
  5 36  1  0
 15 16  1  0
 13 10  1  0
 13 50  1  1
  9 10  1  0
 33 34  1  0
 35 33  1  0
 36 37  1  6
 17 19  1  0
 10 11  1  6
 29 31  1  0
 10 12  1  0
 24 28  2  0
 31 33  1  0
 29 19  1  0
 36 13  1  0
 28 27  1  0
 27 26  1  0
 26 25  2  0
 25 24  1  0
  6  7  1  0
 35 72  1  1
  6  5  1  0
 36 35  1  0
 17 18  1  6
 19 20  1  0
  5  4  1  0
 20 22  1  0
  4  2  1  0
 22 23  1  0
  2  3  2  0
 23 29  1  0
  2  1  1  0
 13 14  1  0
 19 58  1  1
  6 42  1  0
  6 43  1  0
  5 41  1  1
 14 51  1  0
 14 52  1  0
 31 68  1  1
 33 70  1  1
 22 59  1  0
 22 60  1  0
 23 61  1  6
 30 65  1  0
 30 66  1  0
 30 67  1  0
 32 69  1  0
 16 54  1  0
 34 71  1  0
 37 73  1  0
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 11 44  1  0
 11 45  1  0
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 12 47  1  0
 12 48  1  0
 12 49  1  0
 28 64  1  0
 26 63  1  0
 25 62  1  0
 15 53  1  6
 18 55  1  0
 18 56  1  0
 18 57  1  0
  1 38  1  0
  1 39  1  0
  1 40  1  0
M  END


  Mrv1652306212102523D          

 75 79  0  0  0  0            999 V2000
    2.1074   -3.7691    2.9404 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6320   -2.8373    1.8925 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4329   -1.9346    2.1036 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0611   -3.1188    0.6912 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4533   -2.3299   -0.4600 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.2226   -3.2688   -1.3848 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.3129   -4.3020   -1.9555 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2072   -5.4521   -1.5621 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6192   -3.7612   -2.9811 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2296   -3.4783   -2.7319 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.2563   -2.8193   -4.0395 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5423   -4.8119   -2.6041 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0258   -2.5739   -1.4413 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.3960   -1.9619   -1.4556 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.7558   -1.2013   -0.1850 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.7084   -2.1257    0.9034 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8011    0.0022    0.0718 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.0405    1.0101   -1.0861 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1761    0.6349    1.4791 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.3424    1.6077    1.3686 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4920    1.2699    1.1087 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9388    3.0427    1.5949 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4100    2.9484    1.6784 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.2320    4.0989    2.4009 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3874    4.8213    1.9750 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6195    5.7926    2.9190 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6844    5.7297    3.8975 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1536    4.7124    3.5782 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1258    1.5205    2.2339 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4534    1.4600    3.7621 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3360    1.0443    2.0232 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.6185   -0.0180    2.9460 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6625    0.5453    0.5989 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.7144    1.6252   -0.3215 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6630   -0.5637    0.1539 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.1824   -1.5345   -1.0413 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.6872   -0.7169   -2.2483 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2899   -4.8046    2.6418 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6299   -3.5846    3.8833 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0391   -3.5932    3.0884 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2040   -1.5927   -0.1635 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0076   -3.7969   -0.8293 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7250   -2.7340   -2.1976 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0340   -3.4282   -4.9051 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3442   -2.7041   -4.0730 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1974   -1.8387   -4.1998 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6259   -4.6683   -2.6577 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3255   -5.3147   -1.6560 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2510   -5.5062   -3.4010 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0093   -3.2852   -0.6031 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1244   -2.7747   -1.5649 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5322   -1.3150   -2.3253 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7911   -0.8492   -0.2616 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4943   -2.6963    0.8332 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1004    1.2779   -1.1660 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4929    1.9431   -0.9855 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7830    0.6116   -2.0641 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4853   -0.1610    2.1664 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2531    3.6647    0.7520 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4085    3.4007    2.5151 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0349    3.0140    0.6545 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9752    4.6571    1.0829 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3635    6.5688    3.0318 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9620    4.5491    4.2784 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4827    0.4259    4.1252 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3050    1.9871    4.3512 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4279    1.8962    4.0027 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0184    1.8619    2.2818 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5285   -0.3446    2.7859 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6733    0.1372    0.6326 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4919    2.1660   -0.0938 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6140   -1.2457    1.0127 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9092   -0.1192   -2.7164 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5015   -0.0434   -1.9644 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1022   -1.3477   -3.0375 H   0  0  0  0  0  0  0  0  0  0  0  0
  7  8  2  0  0  0  0
 14 15  1  0  0  0  0
 20 21  2  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
 35 17  1  0  0  0  0
 29 30  1  1  0  0  0
  7  9  1  0  0  0  0
 31 32  1  0  0  0  0
  5 36  1  0  0  0  0
 15 16  1  0  0  0  0
 13 10  1  0  0  0  0
 13 50  1  1  0  0  0
  9 10  1  0  0  0  0
 33 34  1  0  0  0  0
 35 33  1  0  0  0  0
 36 37  1  6  0  0  0
 17 19  1  0  0  0  0
 10 11  1  6  0  0  0
 29 31  1  0  0  0  0
 10 12  1  0  0  0  0
 24 28  2  0  0  0  0
 31 33  1  0  0  0  0
 29 19  1  0  0  0  0
 36 13  1  0  0  0  0
 28 27  1  0  0  0  0
 27 26  1  0  0  0  0
 26 25  2  0  0  0  0
 25 24  1  0  0  0  0
  6  7  1  0  0  0  0
 35 72  1  1  0  0  0
  6  5  1  0  0  0  0
 36 35  1  0  0  0  0
 17 18  1  6  0  0  0
 19 20  1  0  0  0  0
  5  4  1  0  0  0  0
 20 22  1  0  0  0  0
  4  2  1  0  0  0  0
 22 23  1  0  0  0  0
  2  3  2  0  0  0  0
 23 29  1  0  0  0  0
  2  1  1  0  0  0  0
 13 14  1  0  0  0  0
 19 58  1  1  0  0  0
  6 42  1  0  0  0  0
  6 43  1  0  0  0  0
  5 41  1  1  0  0  0
 14 51  1  0  0  0  0
 14 52  1  0  0  0  0
 31 68  1  1  0  0  0
 33 70  1  1  0  0  0
 22 59  1  0  0  0  0
 22 60  1  0  0  0  0
 23 61  1  6  0  0  0
 30 65  1  0  0  0  0
 30 66  1  0  0  0  0
 30 67  1  0  0  0  0
 32 69  1  0  0  0  0
 16 54  1  0  0  0  0
 34 71  1  0  0  0  0
 37 73  1  0  0  0  0
 37 74  1  0  0  0  0
 37 75  1  0  0  0  0
 11 44  1  0  0  0  0
 11 45  1  0  0  0  0
 11 46  1  0  0  0  0
 12 47  1  0  0  0  0
 12 48  1  0  0  0  0
 12 49  1  0  0  0  0
 28 64  1  0  0  0  0
 26 63  1  0  0  0  0
 25 62  1  0  0  0  0
 15 53  1  6  0  0  0
 18 55  1  0  0  0  0
 18 56  1  0  0  0  0
 18 57  1  0  0  0  0
  1 38  1  0  0  0  0
  1 39  1  0  0  0  0
  1 40  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0043484

> <DATABASE_NAME>
NP-MRD

> <SMILES>
[H]O[C@]1([H])C([H])([H])[C@]2([H])[C@@](C([H])([H])[H])([C@@]3([H])[C@@]([H])(O[H])[C@]([H])(O[H])[C@@]4(C([H])([H])[H])[C@]([H])(C5=C([H])OC([H])=C5[H])C([H])([H])C(=O)[C@@]4([H])[C@]13C([H])([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])C([H])([H])C(=O)OC2(C([H])([H])[H])C([H])([H])[H]

> <INCHI_IDENTIFIER>
InChI=1S/C28H38O9/c1-13(29)36-19-11-20(32)37-25(2,3)17-10-18(31)28(6)22-16(30)9-15(14-7-8-35-12-14)26(22,4)24(34)21(33)23(28)27(17,19)5/h7-8,12,15,17-19,21-24,31,33-34H,9-11H2,1-6H3/t15-,17-,18+,19-,21+,22+,23+,24-,26-,27+,28-/m0/s1

> <INCHI_KEY>
NMUNZRHSVIUJQI-ORPHTWIOSA-N

> <FORMULA>
C28H38O9

> <MOLECULAR_WEIGHT>
518.603

> <EXACT_MASS>
518.251582804

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
75

> <JCHEM_AVERAGE_POLARIZABILITY>
53.32632542847364

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1S,2R,3S,8R,10R,11R,12S,15R,16S,17R,18R)-15-(furan-3-yl)-10,17,18-trihydroxy-2,7,7,11,16-pentamethyl-5,13-dioxo-6-oxatetracyclo[9.7.0.0^{2,8}.0^{12,16}]octadecan-3-yl acetate

> <ALOGPS_LOGP>
2.12

> <JCHEM_LOGP>
0.813183452

> <ALOGPS_LOGS>
-3.46

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.503575591467854

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.466304570782604

> <JCHEM_PKA_STRONGEST_BASIC>
-2.877523973265071

> <JCHEM_POLAR_SURFACE_AREA>
143.5

> <JCHEM_REFRACTIVITY>
129.4582

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
1.79e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1S,2R,3S,8R,10R,11R,12S,15R,16S,17R,18R)-15-(furan-3-yl)-10,17,18-trihydroxy-2,7,7,11,16-pentamethyl-5,13-dioxo-6-oxatetracyclo[9.7.0.0^{2,8}.0^{12,16}]octadecan-3-yl acetate

> <JCHEM_VEBER_RULE>
0

$$$$

     RDKit          3D

 75 79  0  0  0  0  0  0  0  0999 V2000
    2.1074   -3.7691    2.9404 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6320   -2.8373    1.8925 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4329   -1.9346    2.1036 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0611   -3.1188    0.6912 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4533   -2.3299   -0.4600 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.2226   -3.2688   -1.3848 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3129   -4.3020   -1.9555 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2072   -5.4521   -1.5621 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6192   -3.7612   -2.9811 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2296   -3.4783   -2.7319 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.2563   -2.8193   -4.0395 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5423   -4.8119   -2.6041 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0258   -2.5739   -1.4413 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.3960   -1.9619   -1.4556 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7558   -1.2013   -0.1850 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.7084   -2.1257    0.9034 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8011    0.0022    0.0718 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.0405    1.0101   -1.0861 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1761    0.6349    1.4791 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.3424    1.6077    1.3686 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4920    1.2699    1.1087 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9388    3.0427    1.5949 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4100    2.9484    1.6784 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.2320    4.0989    2.4009 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3874    4.8213    1.9750 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6195    5.7926    2.9190 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6844    5.7297    3.8975 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1536    4.7124    3.5782 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1258    1.5205    2.2339 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4534    1.4600    3.7621 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3360    1.0443    2.0232 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.6185   -0.0180    2.9460 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6625    0.5453    0.5989 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.7144    1.6252   -0.3215 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6630   -0.5637    0.1539 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.1824   -1.5345   -1.0413 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.6872   -0.7169   -2.2483 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2899   -4.8046    2.6418 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6299   -3.5846    3.8833 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0391   -3.5932    3.0884 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2040   -1.5927   -0.1635 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0076   -3.7969   -0.8293 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7250   -2.7340   -2.1976 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0340   -3.4282   -4.9051 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3442   -2.7041   -4.0730 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1974   -1.8387   -4.1998 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6259   -4.6683   -2.6577 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3255   -5.3147   -1.6560 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2510   -5.5062   -3.4010 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0093   -3.2852   -0.6031 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1244   -2.7747   -1.5649 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5322   -1.3150   -2.3253 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7911   -0.8492   -0.2616 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4943   -2.6963    0.8332 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1004    1.2779   -1.1660 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4929    1.9431   -0.9855 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7830    0.6116   -2.0641 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4853   -0.1610    2.1664 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2531    3.6647    0.7520 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4085    3.4007    2.5151 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0349    3.0140    0.6545 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9752    4.6571    1.0829 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3635    6.5688    3.0318 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9620    4.5491    4.2784 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4827    0.4259    4.1252 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3050    1.9871    4.3512 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4279    1.8962    4.0027 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0184    1.8619    2.2818 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5285   -0.3446    2.7859 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6733    0.1372    0.6326 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4919    2.1660   -0.0938 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6140   -1.2457    1.0127 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9092   -0.1192   -2.7164 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5015   -0.0434   -1.9644 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1022   -1.3477   -3.0375 H   0  0  0  0  0  0  0  0  0  0  0  0
  7  8  2  0
 14 15  1  0
 20 21  2  0
 15 17  1  0
 23 24  1  0
 35 17  1  0
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  7  9  1  0
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 36 13  1  0
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 20 22  1  0
  4  2  1  0
 22 23  1  0
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 23 29  1  0
  2  1  1  0
 13 14  1  0
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  6 42  1  0
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  1 38  1  0
  1 39  1  0
  1 40  1  0
M  END

HEADER    PROTEIN                                 21-JUN-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   21-JUN-21         0                                  
HETATM    1  C   UNK     0       2.107  -3.769   2.940  0.00  0.00           C+0
HETATM    2  C   UNK     0       2.632  -2.837   1.893  0.00  0.00           C+0
HETATM    3  O   UNK     0       3.433  -1.935   2.104  0.00  0.00           O+0
HETATM    4  O   UNK     0       2.061  -3.119   0.691  0.00  0.00           O+0
HETATM    5  C   UNK     0       2.453  -2.330  -0.460  0.00  0.00           C+0
HETATM    6  C   UNK     0       3.223  -3.269  -1.385  0.00  0.00           C+0
HETATM    7  C   UNK     0       2.313  -4.302  -1.956  0.00  0.00           C+0
HETATM    8  O   UNK     0       2.207  -5.452  -1.562  0.00  0.00           O+0
HETATM    9  O   UNK     0       1.619  -3.761  -2.981  0.00  0.00           O+0
HETATM   10  C   UNK     0       0.230  -3.478  -2.732  0.00  0.00           C+0
HETATM   11  C   UNK     0      -0.256  -2.819  -4.040  0.00  0.00           C+0
HETATM   12  C   UNK     0      -0.542  -4.812  -2.604  0.00  0.00           C+0
HETATM   13  C   UNK     0       0.026  -2.574  -1.441  0.00  0.00           C+0
HETATM   14  C   UNK     0      -1.396  -1.962  -1.456  0.00  0.00           C+0
HETATM   15  C   UNK     0      -1.756  -1.201  -0.185  0.00  0.00           C+0
HETATM   16  O   UNK     0      -1.708  -2.126   0.903  0.00  0.00           O+0
HETATM   17  C   UNK     0      -0.801   0.002   0.072  0.00  0.00           C+0
HETATM   18  C   UNK     0      -1.040   1.010  -1.086  0.00  0.00           C+0
HETATM   19  C   UNK     0      -1.176   0.635   1.479  0.00  0.00           C+0
HETATM   20  C   UNK     0      -2.342   1.608   1.369  0.00  0.00           C+0
HETATM   21  O   UNK     0      -3.492   1.270   1.109  0.00  0.00           O+0
HETATM   22  C   UNK     0      -1.939   3.043   1.595  0.00  0.00           C+0
HETATM   23  C   UNK     0      -0.410   2.948   1.678  0.00  0.00           C+0
HETATM   24  C   UNK     0       0.232   4.099   2.401  0.00  0.00           C+0
HETATM   25  C   UNK     0       1.387   4.821   1.975  0.00  0.00           C+0
HETATM   26  C   UNK     0       1.619   5.793   2.919  0.00  0.00           C+0
HETATM   27  O   UNK     0       0.684   5.730   3.898  0.00  0.00           O+0
HETATM   28  C   UNK     0      -0.154   4.712   3.578  0.00  0.00           C+0
HETATM   29  C   UNK     0      -0.126   1.521   2.234  0.00  0.00           C+0
HETATM   30  C   UNK     0      -0.453   1.460   3.762  0.00  0.00           C+0
HETATM   31  C   UNK     0       1.336   1.044   2.023  0.00  0.00           C+0
HETATM   32  O   UNK     0       1.619  -0.018   2.946  0.00  0.00           O+0
HETATM   33  C   UNK     0       1.663   0.545   0.599  0.00  0.00           C+0
HETATM   34  O   UNK     0       1.714   1.625  -0.322  0.00  0.00           O+0
HETATM   35  C   UNK     0       0.663  -0.564   0.154  0.00  0.00           C+0
HETATM   36  C   UNK     0       1.182  -1.535  -1.041  0.00  0.00           C+0
HETATM   37  C   UNK     0       1.687  -0.717  -2.248  0.00  0.00           C+0
HETATM   38  H   UNK     0       2.290  -4.805   2.642  0.00  0.00           H+0
HETATM   39  H   UNK     0       2.630  -3.585   3.883  0.00  0.00           H+0
HETATM   40  H   UNK     0       1.039  -3.593   3.088  0.00  0.00           H+0
HETATM   41  H   UNK     0       3.204  -1.593  -0.164  0.00  0.00           H+0
HETATM   42  H   UNK     0       4.008  -3.797  -0.829  0.00  0.00           H+0
HETATM   43  H   UNK     0       3.725  -2.734  -2.198  0.00  0.00           H+0
HETATM   44  H   UNK     0       0.034  -3.428  -4.905  0.00  0.00           H+0
HETATM   45  H   UNK     0      -1.344  -2.704  -4.073  0.00  0.00           H+0
HETATM   46  H   UNK     0       0.197  -1.839  -4.200  0.00  0.00           H+0
HETATM   47  H   UNK     0      -1.626  -4.668  -2.658  0.00  0.00           H+0
HETATM   48  H   UNK     0      -0.326  -5.315  -1.656  0.00  0.00           H+0
HETATM   49  H   UNK     0      -0.251  -5.506  -3.401  0.00  0.00           H+0
HETATM   50  H   UNK     0       0.009  -3.285  -0.603  0.00  0.00           H+0
HETATM   51  H   UNK     0      -2.124  -2.775  -1.565  0.00  0.00           H+0
HETATM   52  H   UNK     0      -1.532  -1.315  -2.325  0.00  0.00           H+0
HETATM   53  H   UNK     0      -2.791  -0.849  -0.262  0.00  0.00           H+0
HETATM   54  H   UNK     0      -2.494  -2.696   0.833  0.00  0.00           H+0
HETATM   55  H   UNK     0      -2.100   1.278  -1.166  0.00  0.00           H+0
HETATM   56  H   UNK     0      -0.493   1.943  -0.986  0.00  0.00           H+0
HETATM   57  H   UNK     0      -0.783   0.612  -2.064  0.00  0.00           H+0
HETATM   58  H   UNK     0      -1.485  -0.161   2.166  0.00  0.00           H+0
HETATM   59  H   UNK     0      -2.253   3.665   0.752  0.00  0.00           H+0
HETATM   60  H   UNK     0      -2.409   3.401   2.515  0.00  0.00           H+0
HETATM   61  H   UNK     0      -0.035   3.014   0.655  0.00  0.00           H+0
HETATM   62  H   UNK     0       1.975   4.657   1.083  0.00  0.00           H+0
HETATM   63  H   UNK     0       2.364   6.569   3.032  0.00  0.00           H+0
HETATM   64  H   UNK     0      -0.962   4.549   4.278  0.00  0.00           H+0
HETATM   65  H   UNK     0      -0.483   0.426   4.125  0.00  0.00           H+0
HETATM   66  H   UNK     0       0.305   1.987   4.351  0.00  0.00           H+0
HETATM   67  H   UNK     0      -1.428   1.896   4.003  0.00  0.00           H+0
HETATM   68  H   UNK     0       2.018   1.862   2.282  0.00  0.00           H+0
HETATM   69  H   UNK     0       2.529  -0.345   2.786  0.00  0.00           H+0
HETATM   70  H   UNK     0       2.673   0.137   0.633  0.00  0.00           H+0
HETATM   71  H   UNK     0       2.492   2.166  -0.094  0.00  0.00           H+0
HETATM   72  H   UNK     0       0.614  -1.246   1.013  0.00  0.00           H+0
HETATM   73  H   UNK     0       0.909  -0.119  -2.716  0.00  0.00           H+0
HETATM   74  H   UNK     0       2.502  -0.043  -1.964  0.00  0.00           H+0
HETATM   75  H   UNK     0       2.102  -1.348  -3.038  0.00  0.00           H+0
CONECT    1    2   38   39   40                                             
CONECT    2    4    3    1                                                  
CONECT    3    2                                                            
CONECT    4    5    2                                                       
CONECT    5   36    6    4   41                                             
CONECT    6    7    5   42   43                                             
CONECT    7    8    9    6                                                  
CONECT    8    7                                                            
CONECT    9    7   10                                                       
CONECT   10   13    9   11   12                                             
CONECT   11   10   44   45   46                                             
CONECT   12   10   47   48   49                                             
CONECT   13   10   50   36   14                                             
CONECT   14   15   13   51   52                                             
CONECT   15   14   17   16   53                                             
CONECT   16   15   54                                                       
CONECT   17   15   35   19   18                                             
CONECT   18   17   55   56   57                                             
CONECT   19   17   29   20   58                                             
CONECT   20   21   19   22                                                  
CONECT   21   20                                                            
CONECT   22   20   23   59   60                                             
CONECT   23   24   22   29   61                                             
CONECT   24   23   28   25                                                  
CONECT   25   26   24   62                                                  
CONECT   26   27   25   63                                                  
CONECT   27   28   26                                                       
CONECT   28   24   27   64                                                  
CONECT   29   30   31   19   23                                             
CONECT   30   29   65   66   67                                             
CONECT   31   32   29   33   68                                             
CONECT   32   31   69                                                       
CONECT   33   34   35   31   70                                             
CONECT   34   33   71                                                       
CONECT   35   17   33   72   36                                             
CONECT   36    5   37   13   35                                             
CONECT   37   36   73   74   75                                             
CONECT   38    1                                                            
CONECT   39    1                                                            
CONECT   40    1                                                            
CONECT   41    5                                                            
CONECT   42    6                                                            
CONECT   43    6                                                            
CONECT   44   11                                                            
CONECT   45   11                                                            
CONECT   46   11                                                            
CONECT   47   12                                                            
CONECT   48   12                                                            
CONECT   49   12                                                            
CONECT   50   13                                                            
CONECT   51   14                                                            
CONECT   52   14                                                            
CONECT   53   15                                                            
CONECT   54   16                                                            
CONECT   55   18                                                            
CONECT   56   18                                                            
CONECT   57   18                                                            
CONECT   58   19                                                            
CONECT   59   22                                                            
CONECT   60   22                                                            
CONECT   61   23                                                            
CONECT   62   25                                                            
CONECT   63   26                                                            
CONECT   64   28                                                            
CONECT   65   30                                                            
CONECT   66   30                                                            
CONECT   67   30                                                            
CONECT   68   31                                                            
CONECT   69   32                                                            
CONECT   70   33                                                            
CONECT   71   34                                                            
CONECT   72   35                                                            
CONECT   73   37                                                            
CONECT   74   37                                                            
CONECT   75   37                                                            
MASTER        0    0    0    0    0    0    0    0   75    0  158    0
END

RDKit          3D

75 79  0  0  0  0  0  0  0  0999 V2000
    2.1074   -3.7691    2.9404 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6320   -2.8373    1.8925 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4329   -1.9346    2.1036 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0611   -3.1188    0.6912 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4533   -2.3299   -0.4600 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.2226   -3.2688   -1.3848 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3129   -4.3020   -1.9555 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2072   -5.4521   -1.5621 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6192   -3.7612   -2.9811 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2296   -3.4783   -2.7319 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.2563   -2.8193   -4.0395 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5423   -4.8119   -2.6041 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0258   -2.5739   -1.4413 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.3960   -1.9619   -1.4556 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7558   -1.2013   -0.1850 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.7084   -2.1257    0.9034 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8011    0.0022    0.0718 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.0405    1.0101   -1.0861 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1761    0.6349    1.4791 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.3424    1.6077    1.3686 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4920    1.2699    1.1087 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9388    3.0427    1.5949 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4100    2.9484    1.6784 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.2320    4.0989    2.4009 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3874    4.8213    1.9750 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6195    5.7926    2.9190 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6844    5.7297    3.8975 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1536    4.7124    3.5782 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1258    1.5205    2.2339 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4534    1.4600    3.7621 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3360    1.0443    2.0232 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.6185   -0.0180    2.9460 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6625    0.5453    0.5989 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.7144    1.6252   -0.3215 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6630   -0.5637    0.1539 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.1824   -1.5345   -1.0413 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.6872   -0.7169   -2.2483 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2899   -4.8046    2.6418 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6299   -3.5846    3.8833 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0391   -3.5932    3.0884 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2040   -1.5927   -0.1635 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0076   -3.7969   -0.8293 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7250   -2.7340   -2.1976 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0340   -3.4282   -4.9051 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3442   -2.7041   -4.0730 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1974   -1.8387   -4.1998 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6259   -4.6683   -2.6577 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3255   -5.3147   -1.6560 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2510   -5.5062   -3.4010 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0093   -3.2852   -0.6031 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1244   -2.7747   -1.5649 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5322   -1.3150   -2.3253 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7911   -0.8492   -0.2616 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4943   -2.6963    0.8332 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1004    1.2779   -1.1660 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4929    1.9431   -0.9855 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7830    0.6116   -2.0641 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4853   -0.1610    2.1664 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2531    3.6647    0.7520 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4085    3.4007    2.5151 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0349    3.0140    0.6545 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9752    4.6571    1.0829 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3635    6.5688    3.0318 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9620    4.5491    4.2784 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4827    0.4259    4.1252 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3050    1.9871    4.3512 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4279    1.8962    4.0027 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0184    1.8619    2.2818 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5285   -0.3446    2.7859 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6733    0.1372    0.6326 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4919    2.1660   -0.0938 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6140   -1.2457    1.0127 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9092   -0.1192   -2.7164 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5015   -0.0434   -1.9644 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1022   -1.3477   -3.0375 H   0  0  0  0  0  0  0  0  0  0  0  0
  7  8  2  0
 14 15  1  0
 20 21  2  0
 15 17  1  0
 23 24  1  0
 35 17  1  0
 29 30  1  1
  7  9  1  0
 31 32  1  0
  5 36  1  0
 15 16  1  0
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  9 10  1  0
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  2  3  2  0
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  2  1  1  0
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  6 42  1  0
  6 43  1  0
  5 41  1  1
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 18 55  1  0
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 18 57  1  0
  1 38  1  0
  1 39  1  0
  1 40  1  0
M  END

View in JSmol

Synonyms

Value	Source
(1S,2R,3S,8R,10R,11R,12S,15R,16S,17R,18R)-15-(Furan-3-yl)-10,17,18-trihydroxy-2,7,7,11,16-pentamethyl-5,13-dioxo-6-oxatetracyclo[9.7.0.0,.0,]octadecan-3-yl acetic acid	Generator

Chemical Formula

C₂₈H₃₈O₉

Average Mass

518.6030 Da

Monoisotopic Mass

518.25158 Da

IUPAC Name

(1S,2R,3S,8R,10R,11R,12S,15R,16S,17R,18R)-15-(furan-3-yl)-10,17,18-trihydroxy-2,7,7,11,16-pentamethyl-5,13-dioxo-6-oxatetracyclo[9.7.0.0^{2,8}.0^{12,16}]octadecan-3-yl acetate

Traditional Name

(1S,2R,3S,8R,10R,11R,12S,15R,16S,17R,18R)-15-(furan-3-yl)-10,17,18-trihydroxy-2,7,7,11,16-pentamethyl-5,13-dioxo-6-oxatetracyclo[9.7.0.0^{2,8}.0^{12,16}]octadecan-3-yl acetate

CAS Registry Number

Not Available

SMILES

[H]O[C@]1([H])C([H])([H])[C@]2([H])[C@@](C([H])([H])[H])([C@@]3([H])[C@@]([H])(O[H])[C@]([H])(O[H])[C@@]4(C([H])([H])[H])[C@]([H])(C5=C([H])OC([H])=C5[H])C([H])([H])C(=O)[C@@]4([H])[C@]13C([H])([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])C([H])([H])C(=O)OC2(C([H])([H])[H])C([H])([H])[H]

InChI Identifier

InChI=1S/C28H38O9/c1-13(29)36-19-11-20(32)37-25(2,3)17-10-18(31)28(6)22-16(30)9-15(14-7-8-35-12-14)26(22,4)24(34)21(33)23(28)27(17,19)5/h7-8,12,15,17-19,21-24,31,33-34H,9-11H2,1-6H3/t15-,17-,18+,19-,21+,22+,23+,24-,26-,27+,28-/m0/s1

InChI Key

NMUNZRHSVIUJQI-ORPHTWIOSA-N

Experimental Spectra

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, DMSO-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, DMSO-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, DMSO-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, DMSO-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, DMSO-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, DMSO-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, DMSO-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, DMSO-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, DMSO-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, DMSO-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, DMSO-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, DMSO-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, DMSO-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, DMSO-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, DMSO-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, DMSO-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, DMSO-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, DMSO-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, DMSO-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, DMSO-d6, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Predicted Spectra

Not Available

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Aphanamixis grandifolia	JEOL database	Zhang, Y., et al, J. Nat. Prod. 76, 1191 (2013)

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as limonoids. These are highly oxygenated, modified terpenoids with a prototypical structure either containing or derived from a precursor with a 4,4,8-trimethyl-17-furanylsteroid skeleton. All naturally occurring citrus limonoids contain a furan ring attached to the D-ring, at C-17, as well as oxygen containing functional groups at C-3, C-4, C-7, C-16 and C-17.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Triterpenoids

Direct Parent

Limonoids

Alternative Parents

Substituents

Limonoid skeleton
Caprolactone
Oxepane
Dicarboxylic acid or derivatives
Cyclic alcohol
Heteroaromatic compound
Furan
Carboxylic acid ester
Ketone
Lactone
Secondary alcohol
Oxacycle
Carboxylic acid derivative
Organoheterocyclic compound
Polyol
Organic oxygen compound
Hydrocarbon derivative
Organic oxide
Alcohol
Organooxygen compound
Carbonyl group
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.12	ALOGPS
logP	0.81	ChemAxon
logS	-3.5	ALOGPS
pKa (Strongest Acidic)	13.47	ChemAxon
pKa (Strongest Basic)	-2.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	143.5 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	129.46 m³·mol⁻¹	ChemAxon
Polarizability	53.33 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

58826819

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

71726253

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Authors unspecified: Childhood Cancer Genomics (PDQ(R)): Health Professional Version. 2002. [PubMed:27466641 ]
Authors unspecified: Thyroid Cancer Screening (PDQ(R)): Patient Version. 2002. [PubMed:29437326 ]
Authors unspecified: Childhood Vascular Tumors Treatment (PDQ(R)): Patient Version. 2002. [PubMed:27253005 ]
Authors unspecified: Stomach (Gastric) Cancer Prevention (PDQ(R)): Patient Version. 2002. [PubMed:26389468 ]
Authors unspecified: Childhood Central Nervous System Atypical Teratoid/Rhabdoid Tumor Treatment (PDQ(R)): Health Professional Version. 2002. [PubMed:26389426 ]
Zhang, Y., et al. (2013). Zhang, Y., et al, J. Nat. Prod. 76, 1191 (2013). J. Nat. Prod..

Showing NP-Card for aphanalide K (NP0043484)

MOL for NP0043484 (aphanalide K)

3D MOL for NP0043484 (aphanalide K)

3D SDF for NP0043484 (aphanalide K)

3D-SDF for NP0043484 (aphanalide K)

PDB for NP0043484 (aphanalide K)

3D PDB for NP0043484 (aphanalide K)

SMILES for NP0043484 (aphanalide K)

INCHI for NP0043484 (aphanalide K)

Structure for NP0043484 (aphanalide K)

3D Structure for NP0043484 (aphanalide K)