NP-MRD: Showing NP-Card for tenuifolin D (NP0043240)

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Record Information

Version

1.0

Created at

2021-06-21 00:42:22 UTC

Updated at

2021-06-30 00:18:49 UTC

NP-MRD ID

NP0043240

Secondary Accession Numbers

None

Natural Product Identification

Common Name

tenuifolin D

Provided By

JEOL Database JEOL Logo

Description

Tenuifolin D belongs to the class of organic compounds known as kaurane diterpenoids. These are diterpene alkaloids with a structure that is based on the kaurane skeleton. Kaurane is a tetracyclic compound that arises by cyclisation of a pimarane precursor followed by rearrangement. It possesses a [3,2,1]-bicyclic ring system with C15-C16 bridge connected to C13, forming the five-membered ring D. tenuifolin D is found in Isodon tenuifolius. It was first documented in 2002 (PMID: 33651529). Based on a literature review a small amount of articles have been published on Tenuifolin D (PMID: 33079503) (PMID: 26389513) (PMID: 26389498) (PMID: 26389454) (PMID: 33851450) (PMID: 24702811).

Structure

MOL 3D MOL SDF 3D SDF PDB SMILES InChI


  Mrv1652306212102423D          

 67 70  0  0  0  0            999 V2000
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M  END

     RDKit          3D

 67 70  0  0  0  0  0  0  0  0999 V2000
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M  END


  Mrv1652306212102423D          

 67 70  0  0  0  0            999 V2000
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M  END
> <DATABASE_ID>
NP0043240

> <DATABASE_NAME>
NP-MRD

> <SMILES>
[H]O[C@]1([H])C(=C([H])[H])[C@@]2([H])C([H])([H])[C@@]11[C@@]([H])(O[H])C([H])([H])[C@]3([H])C(C([H])([H])[H])(C([H])([H])[H])[C@@]([H])(O[H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])[H])[C@@]3(C([H])([H])[H])[C@]1([H])[C@@]([H])(OC(=O)C([H])([H])[H])C2([H])[H]

> <INCHI_IDENTIFIER>
InChI=1S/C24H36O7/c1-11-14-7-15(30-12(2)25)20-23(6)16(8-18(28)24(20,10-14)21(11)29)22(4,5)17(27)9-19(23)31-13(3)26/h14-21,27-29H,1,7-10H2,2-6H3/t14-,15+,16-,17+,18+,19+,20+,21-,23+,24+/m1/s1

> <INCHI_KEY>
OTPQVCJGZXJUEW-KNGCFTRFSA-N

> <FORMULA>
C24H36O7

> <MOLECULAR_WEIGHT>
436.545

> <EXACT_MASS>
436.246103499

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
67

> <JCHEM_AVERAGE_POLARIZABILITY>
46.08096852481913

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1R,2S,4R,6S,8S,9R,10S,11S,13S,15R)-8-(acetyloxy)-2,6,15-trihydroxy-5,5,9-trimethyl-14-methylidenetetracyclo[11.2.1.0^{1,10}.0^{4,9}]hexadecan-11-yl acetate

> <ALOGPS_LOGP>
1.39

> <JCHEM_LOGP>
0.3494933749999996

> <ALOGPS_LOGS>
-2.77

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.48327045156243

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.864159562541872

> <JCHEM_PKA_STRONGEST_BASIC>
-2.9631257463644527

> <JCHEM_POLAR_SURFACE_AREA>
113.29

> <JCHEM_REFRACTIVITY>
111.4063

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
7.39e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1R,2S,4R,6S,8S,9R,10S,11S,13S,15R)-8-(acetyloxy)-2,6,15-trihydroxy-5,5,9-trimethyl-14-methylidenetetracyclo[11.2.1.0^{1,10}.0^{4,9}]hexadecan-11-yl acetate

> <JCHEM_VEBER_RULE>
0

$$$$

     RDKit          3D

 67 70  0  0  0  0  0  0  0  0999 V2000
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 26 62  1  1
 29 64  1  0
 29 65  1  0
  3 34  1  1
  4 35  1  0
  4 36  1  0
  5 37  1  1
 22 53  1  0
 22 54  1  0
 22 55  1  0
 12 42  1  0
 12 43  1  0
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 23 56  1  0
 23 57  1  0
 23 58  1  0
 20 52  1  0
 30 66  1  6
  1 32  1  0
  1 33  1  0
 16 46  1  0
 16 47  1  0
 16 48  1  0
  8 38  1  0
  8 39  1  0
  8 40  1  0
 27 63  1  0
 31 67  1  0
M  END

HEADER    PROTEIN                                 21-JUN-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   21-JUN-21         0                                  
HETATM    1  C   UNK     0      -4.430  -2.864  -0.564  0.00  0.00           C+0
HETATM    2  C   UNK     0      -3.227  -2.462  -0.133  0.00  0.00           C+0
HETATM    3  C   UNK     0      -2.963  -1.660   1.115  0.00  0.00           C+0
HETATM    4  C   UNK     0      -3.101  -0.165   0.830  0.00  0.00           C+0
HETATM    5  C   UNK     0      -2.218   0.335  -0.334  0.00  0.00           C+0
HETATM    6  O   UNK     0      -2.920   0.106  -1.588  0.00  0.00           O+0
HETATM    7  C   UNK     0      -3.784   1.079  -1.994  0.00  0.00           C+0
HETATM    8  C   UNK     0      -4.406   0.692  -3.300  0.00  0.00           C+0
HETATM    9  O   UNK     0      -4.026   2.115  -1.392  0.00  0.00           O+0
HETATM   10  C   UNK     0      -0.818  -0.357  -0.476  0.00  0.00           C+0
HETATM   11  C   UNK     0       0.436   0.504   0.088  0.00  0.00           C+0
HETATM   12  C   UNK     0       0.216   0.889   1.570  0.00  0.00           C+0
HETATM   13  C   UNK     0       0.612   1.833  -0.755  0.00  0.00           C+0
HETATM   14  O   UNK     0      -0.422   2.788  -0.423  0.00  0.00           O+0
HETATM   15  C   UNK     0      -0.807   3.646  -1.409  0.00  0.00           C+0
HETATM   16  C   UNK     0      -1.839   4.601  -0.890  0.00  0.00           C+0
HETATM   17  O   UNK     0      -0.349   3.677  -2.543  0.00  0.00           O+0
HETATM   18  C   UNK     0       1.947   2.555  -0.494  0.00  0.00           C+0
HETATM   19  C   UNK     0       3.158   1.670  -0.737  0.00  0.00           C+0
HETATM   20  O   UNK     0       3.207   1.369  -2.134  0.00  0.00           O+0
HETATM   21  C   UNK     0       3.126   0.352   0.086  0.00  0.00           C+0
HETATM   22  C   UNK     0       3.444   0.637   1.566  0.00  0.00           C+0
HETATM   23  C   UNK     0       4.280  -0.554  -0.432  0.00  0.00           C+0
HETATM   24  C   UNK     0       1.741  -0.362  -0.145  0.00  0.00           C+0
HETATM   25  C   UNK     0       1.624  -1.745   0.530  0.00  0.00           C+0
HETATM   26  C   UNK     0       0.502  -2.561  -0.106  0.00  0.00           C+0
HETATM   27  O   UNK     0       0.881  -2.801  -1.466  0.00  0.00           O+0
HETATM   28  C   UNK     0      -0.872  -1.878  -0.005  0.00  0.00           C+0
HETATM   29  C   UNK     0      -1.496  -1.989   1.398  0.00  0.00           C+0
HETATM   30  C   UNK     0      -1.907  -2.751  -0.792  0.00  0.00           C+0
HETATM   31  O   UNK     0      -1.908  -2.470  -2.176  0.00  0.00           O+0
HETATM   32  H   UNK     0      -4.531  -3.453  -1.471  0.00  0.00           H+0
HETATM   33  H   UNK     0      -5.338  -2.619  -0.020  0.00  0.00           H+0
HETATM   34  H   UNK     0      -3.603  -1.963   1.950  0.00  0.00           H+0
HETATM   35  H   UNK     0      -2.838   0.380   1.744  0.00  0.00           H+0
HETATM   36  H   UNK     0      -4.154   0.067   0.627  0.00  0.00           H+0
HETATM   37  H   UNK     0      -2.113   1.407  -0.209  0.00  0.00           H+0
HETATM   38  H   UNK     0      -3.630   0.577  -4.061  0.00  0.00           H+0
HETATM   39  H   UNK     0      -5.095   1.479  -3.621  0.00  0.00           H+0
HETATM   40  H   UNK     0      -4.969  -0.237  -3.181  0.00  0.00           H+0
HETATM   41  H   UNK     0      -0.615  -0.404  -1.558  0.00  0.00           H+0
HETATM   42  H   UNK     0      -0.812   1.198   1.765  0.00  0.00           H+0
HETATM   43  H   UNK     0       0.460   0.084   2.263  0.00  0.00           H+0
HETATM   44  H   UNK     0       0.818   1.746   1.874  0.00  0.00           H+0
HETATM   45  H   UNK     0       0.545   1.569  -1.819  0.00  0.00           H+0
HETATM   46  H   UNK     0      -2.455   4.954  -1.721  0.00  0.00           H+0
HETATM   47  H   UNK     0      -1.343   5.447  -0.409  0.00  0.00           H+0
HETATM   48  H   UNK     0      -2.497   4.099  -0.175  0.00  0.00           H+0
HETATM   49  H   UNK     0       2.003   3.428  -1.157  0.00  0.00           H+0
HETATM   50  H   UNK     0       1.970   2.974   0.518  0.00  0.00           H+0
HETATM   51  H   UNK     0       4.072   2.231  -0.504  0.00  0.00           H+0
HETATM   52  H   UNK     0       3.258   2.208  -2.625  0.00  0.00           H+0
HETATM   53  H   UNK     0       4.484   0.970   1.678  0.00  0.00           H+0
HETATM   54  H   UNK     0       3.327  -0.259   2.184  0.00  0.00           H+0
HETATM   55  H   UNK     0       2.832   1.427   1.997  0.00  0.00           H+0
HETATM   56  H   UNK     0       4.474  -1.395   0.242  0.00  0.00           H+0
HETATM   57  H   UNK     0       5.218   0.011  -0.505  0.00  0.00           H+0
HETATM   58  H   UNK     0       4.063  -0.964  -1.425  0.00  0.00           H+0
HETATM   59  H   UNK     0       1.741  -0.563  -1.228  0.00  0.00           H+0
HETATM   60  H   UNK     0       2.550  -2.311   0.392  0.00  0.00           H+0
HETATM   61  H   UNK     0       1.472  -1.661   1.610  0.00  0.00           H+0
HETATM   62  H   UNK     0       0.469  -3.544   0.379  0.00  0.00           H+0
HETATM   63  H   UNK     0       0.085  -2.839  -2.033  0.00  0.00           H+0
HETATM   64  H   UNK     0      -1.063  -1.329   2.147  0.00  0.00           H+0
HETATM   65  H   UNK     0      -1.405  -3.012   1.791  0.00  0.00           H+0
HETATM   66  H   UNK     0      -1.684  -3.818  -0.661  0.00  0.00           H+0
HETATM   67  H   UNK     0      -2.458  -1.672  -2.297  0.00  0.00           H+0
CONECT    1    2   32   33                                                  
CONECT    2    3   30    1                                                  
CONECT    3    2   29    4   34                                             
CONECT    4    3    5   35   36                                             
CONECT    5    6    4   10   37                                             
CONECT    6    5    7                                                       
CONECT    7    6    9    8                                                  
CONECT    8    7   38   39   40                                             
CONECT    9    7                                                            
CONECT   10   11   41   28    5                                             
CONECT   11   10   12   13   24                                             
CONECT   12   11   42   43   44                                             
CONECT   13   11   14   18   45                                             
CONECT   14   13   15                                                       
CONECT   15   14   17   16                                                  
CONECT   16   15   46   47   48                                             
CONECT   17   15                                                            
CONECT   18   19   13   49   50                                             
CONECT   19   20   18   21   51                                             
CONECT   20   19   52                                                       
CONECT   21   22   23   24   19                                             
CONECT   22   21   53   54   55                                             
CONECT   23   21   56   57   58                                             
CONECT   24   25   21   11   59                                             
CONECT   25   24   26   60   61                                             
CONECT   26   25   28   27   62                                             
CONECT   27   26   63                                                       
CONECT   28   26   10   30   29                                             
CONECT   29   28    3   64   65                                             
CONECT   30   28    2   31   66                                             
CONECT   31   30   67                                                       
CONECT   32    1                                                            
CONECT   33    1                                                            
CONECT   34    3                                                            
CONECT   35    4                                                            
CONECT   36    4                                                            
CONECT   37    5                                                            
CONECT   38    8                                                            
CONECT   39    8                                                            
CONECT   40    8                                                            
CONECT   41   10                                                            
CONECT   42   12                                                            
CONECT   43   12                                                            
CONECT   44   12                                                            
CONECT   45   13                                                            
CONECT   46   16                                                            
CONECT   47   16                                                            
CONECT   48   16                                                            
CONECT   49   18                                                            
CONECT   50   18                                                            
CONECT   51   19                                                            
CONECT   52   20                                                            
CONECT   53   22                                                            
CONECT   54   22                                                            
CONECT   55   22                                                            
CONECT   56   23                                                            
CONECT   57   23                                                            
CONECT   58   23                                                            
CONECT   59   24                                                            
CONECT   60   25                                                            
CONECT   61   25                                                            
CONECT   62   26                                                            
CONECT   63   27                                                            
CONECT   64   29                                                            
CONECT   65   29                                                            
CONECT   66   30                                                            
CONECT   67   31                                                            
MASTER        0    0    0    0    0    0    0    0   67    0  140    0
END

RDKit          3D

67 70  0  0  0  0  0  0  0  0999 V2000
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 27 63  1  0
 31 67  1  0
M  END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₄H₃₆O₇

Average Mass

436.5450 Da

Monoisotopic Mass

436.24610 Da

IUPAC Name

(1R,2S,4R,6S,8S,9R,10S,11S,13S,15R)-8-(acetyloxy)-2,6,15-trihydroxy-5,5,9-trimethyl-14-methylidenetetracyclo[11.2.1.0^{1,10}.0^{4,9}]hexadecan-11-yl acetate

Traditional Name

(1R,2S,4R,6S,8S,9R,10S,11S,13S,15R)-8-(acetyloxy)-2,6,15-trihydroxy-5,5,9-trimethyl-14-methylidenetetracyclo[11.2.1.0^{1,10}.0^{4,9}]hexadecan-11-yl acetate

CAS Registry Number

Not Available

SMILES

[H]O[C@]1([H])C(=C([H])[H])[C@@]2([H])C([H])([H])[C@@]11[C@@]([H])(O[H])C([H])([H])[C@]3([H])C(C([H])([H])[H])(C([H])([H])[H])[C@@]([H])(O[H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])[H])[C@@]3(C([H])([H])[H])[C@]1([H])[C@@]([H])(OC(=O)C([H])([H])[H])C2([H])[H]

InChI Identifier

InChI=1S/C24H36O7/c1-11-14-7-15(30-12(2)25)20-23(6)16(8-18(28)24(20,10-14)21(11)29)22(4,5)17(27)9-19(23)31-13(3)26/h14-21,27-29H,1,7-10H2,2-6H3/t14-,15+,16-,17+,18+,19+,20+,21-,23+,24+/m1/s1

InChI Key

OTPQVCJGZXJUEW-KNGCFTRFSA-N

Experimental Spectra

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, C₅D₅N, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, C₅D₅N, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, C₅D₅N, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, C₅D₅N, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, C₅D₅N, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, C₅D₅N, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, C₅D₅N, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, C₅D₅N, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, C₅D₅N, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, C₅D₅N, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, C₅D₅N, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, C₅D₅N, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, C₅D₅N, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, C₅D₅N, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, C₅D₅N, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, C₅D₅N, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, C₅D₅N, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, C₅D₅N, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, C₅D₅N, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, C₅D₅N, simulated)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Predicted Spectra

Not Available

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Isodon tenuifolius	JEOL database	Yang, J. -H., et al, J. Nat. Prod. 76, 256 (2013)

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as kaurane diterpenoids. These are diterpene alkaloids with a structure that is based on the kaurane skeleton. Kaurane is a tetracyclic compound that arises by cyclisation of a pimarane precursor followed by rearrangement. It possesses a [3,2,1]-bicyclic ring system with C15-C16 bridge connected to C13, forming the five-membered ring D.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Diterpenoids

Direct Parent

Kaurane diterpenoids

Alternative Parents

Substituents

Kaurane diterpenoid
Dicarboxylic acid or derivatives
Cyclic alcohol
Secondary alcohol
Carboxylic acid ester
Polyol
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Alcohol
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.39	ALOGPS
logP	0.35	ChemAxon
logS	-2.8	ALOGPS
pKa (Strongest Acidic)	13.86	ChemAxon
pKa (Strongest Basic)	-3	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	113.29 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	111.41 m³·mol⁻¹	ChemAxon
Polarizability	46.08 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

29420429

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

71579051

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Authors unspecified: Curcumin (Curcuma, Turmeric) and Cancer (PDQ(R)): Health Professional Version. 2002. [PubMed:33651529 ]
Authors unspecified: Cancer Therapy Interactions With Foods and Dietary Supplements (PDQ(R)): Health Professional Version. 2002. [PubMed:33079503 ]
Authors unspecified: Planning the Transition to End-of-Life Care in Advanced Cancer (PDQ(R)): Health Professional Version. 2002. [PubMed:26389513 ]
Authors unspecified: Childhood Central Nervous System Germ Cell Tumors Treatment (PDQ(R)): Health Professional Version. 2002. [PubMed:26389498 ]
Authors unspecified: Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies Treatment (PDQ(R)): Health Professional Version. 2002. [PubMed:26389454 ]
Koganezawa N, Sekino Y, Kawakami H, Fuchino H, Kawahara N, Shirao T: NMDA receptor-dependent and -independent effects of natural compounds and crude drugs on synaptic states as revealed by drebrin imaging analysis. Eur J Neurosci. 2021 Jun;53(11):3548-3560. doi: 10.1111/ejn.15231. Epub 2021 Apr 27. [PubMed:33851450 ]
Zhou YH, Zhang SY, Guo Q, Chai XY, Jiang Y, Tu PF: Chemical investigation of the roots of Polygala sibirica L. Chin J Nat Med. 2014 Mar;12(3):225-8. doi: 10.1016/S1875-5364(14)60038-8. [PubMed:24702811 ]
Ma B, Li X, Li J, Zhang Q, Liu Y, Yang X, Sun J, Yao D, Liu L, Liu X, Ying H: Quantitative analysis of tenuifolin concentrations in rat plasma and tissue using LCMS/MS: application to pharmacokinetic and tissue distribution study. J Pharm Biomed Anal. 2014 Jan;88:191-200. doi: 10.1016/j.jpba.2013.07.012. Epub 2013 Jul 23. [PubMed:24055855 ]
Zhang H, Han T, Zhang L, Yu CH, Wan DG, Rahman K, Qin LP, Peng C: Effects of tenuifolin extracted from radix polygalae on learning and memory: a behavioral and biochemical study on aged and amnesic mice. Phytomedicine. 2008 Aug;15(8):587-94. doi: 10.1016/j.phymed.2007.12.004. Epub 2008 Mar 4. [PubMed:18289838 ]
Diome C, Mitaine-Offer AC, Miyamoto T, Delaude C, Mirjolet JF, Duchamp O, Lacaille-Dubois MA: Saponins from the roots of Nylandtia spinosa. J Nat Prod. 2007 Oct;70(10):1680-2. doi: 10.1021/np0703186. Epub 2007 Oct 11. [PubMed:17927264 ]
Yang, J. -H., et al. (2013). Yang, J. -H., et al, J. Nat. Prod. 76, 256 (2013). J. Nat. Prod..

Showing NP-Card for tenuifolin D (NP0043240)

MOL for NP0043240 (tenuifolin D)

3D MOL for NP0043240 (tenuifolin D)

3D SDF for NP0043240 (tenuifolin D)

3D-SDF for NP0043240 (tenuifolin D)

PDB for NP0043240 (tenuifolin D)

3D PDB for NP0043240 (tenuifolin D)

SMILES for NP0043240 (tenuifolin D)

INCHI for NP0043240 (tenuifolin D)

Structure for NP0043240 (tenuifolin D)

3D Structure for NP0043240 (tenuifolin D)