Np mrd loader

Record Information
Version2.0
Created at2021-06-19 18:20:17 UTC
Updated at2021-06-29 23:52:01 UTC
NP-MRD IDNP0026471
Secondary Accession NumbersNone
Natural Product Identification
Common Name3,6,8-trihydroxy-1-methylxanthone. Norlichexanthone
Provided ByJEOL DatabaseJEOL Logo
DescriptionNorlichexanthone is a secondary metabolite. Secondary metabolites are metabolically or physiologically non-essential metabolites that may serve a role as defense or signalling molecules. In some cases they are simply molecules that arise from the incomplete metabolism of other secondary metabolites. 3,6,8-trihydroxy-1-methylxanthone. Norlichexanthone is found in Lecanora iseana, Lecanora reuteri, Penicillium griseofulvum, Senna obtusifolia and Wardomyces anomalus. 3,6,8-trihydroxy-1-methylxanthone. Norlichexanthone was first documented in 2003 (PMID: 14613627). Based on a literature review a small amount of articles have been published on norlichexanthone (PMID: 22061662) (PMID: 21568875) (PMID: 33643823) (PMID: 31874327).
Structure
Thumb
Synonyms
ValueSource
1,3,6-Trihydroxy-8-methyl-9H-xanthen-9-oneChEBI
Chemical FormulaC14H10O5
Average Mass258.2290 Da
Monoisotopic Mass258.05282 Da
IUPAC Name1,3,6-trihydroxy-8-methyl-9H-xanthen-9-one
Traditional Namenorlichexanthone
CAS Registry NumberNot Available
SMILES
[H]OC1=C([H])C(O[H])=C2C(=O)C3=C(C([H])=C(O[H])C([H])=C3OC2=C1[H])C([H])([H])[H]
InChI Identifier
InChI=1S/C14H10O5/c1-6-2-7(15)4-10-12(6)14(18)13-9(17)3-8(16)5-11(13)19-10/h2-5,15-17H,1H3
InChI KeyAQZHBCDRWFMXIN-UHFFFAOYSA-N
Experimental Spectra
Spectrum TypeDescriptionDepositor EmailDepositor OrganizationDepositorDeposition DateView
1D NMR13C NMR Spectrum (1D, 300 MHz, acetone-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 300 MHz, acetone-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 100 MHz, acetone-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 100 MHz, acetone-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 200 MHz, acetone-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 200 MHz, acetone-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 400 MHz, acetone-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 400 MHz, acetone-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 500 MHz, acetone-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 500 MHz, acetone-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 600 MHz, acetone-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 600 MHz, acetone-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 700 MHz, acetone-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 700 MHz, acetone-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 800 MHz, acetone-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 800 MHz, acetone-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 900 MHz, acetone-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 900 MHz, acetone-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 1000 MHz, acetone-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 1000 MHz, acetone-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
Predicted Spectra
Not Available
Chemical Shift Submissions
Not Available
Species
Species of Origin
Species NameSourceReference
Lecanora iseana-
Lecanora reuteri-
Penicillium griseofulvumLOTUS Database
Senna obtusifoliaLOTUS Database
Wardomyces anomalusJEOL database
    • Abdel-Lateff, A., et al, J. Nat. Prod. 66, 706 (2003)
Species Where Detected
Species NameSourceReference
Penicillium griseofulvum (a mutant strain)KNApSAcK Database
Chemical Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as xanthones. These are polycyclic aromatic compounds containing a xanthene moiety conjugated to a ketone group at carbon 9. Xanthene is a tricyclic compound made up of two benzene rings linearly fused to each other through a pyran ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzopyrans
Sub Class1-benzopyrans
Direct ParentXanthones
Alternative Parents
Substituents
  • Xanthone
  • Chromone
  • 1-hydroxy-4-unsubstituted benzenoid
  • 1-hydroxy-2-unsubstituted benzenoid
  • Pyranone
  • Pyran
  • Benzenoid
  • Heteroaromatic compound
  • Vinylogous acid
  • Polyol
  • Oxacycle
  • Hydrocarbon derivative
  • Organic oxide
  • Organooxygen compound
  • Organic oxygen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Physical Properties
StateNot Available
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP2.64ALOGPS
logP3.21ChemAxon
logS-2.9ALOGPS
pKa (Strongest Acidic)7.26ChemAxon
pKa (Strongest Basic)-3.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area86.99 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity67.8 m³·mol⁻¹ChemAxon
Polarizability25.49 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
HMDB IDNot Available
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDNot Available
KNApSAcK IDC00002969
Chemspider ID4444976
KEGG Compound IDC10087
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem CompoundNot Available
PDB IDNot Available
ChEBI ID7632
Good Scents IDNot Available
References
General References
  1. Wang QX, Bao L, Yang XL, Guo H, Yang RN, Ren B, Zhang LX, Dai HQ, Guo LD, Liu HW: Polyketides with antimicrobial activity from the solid culture of an endolichenic fungus Ulocladium sp. Fitoterapia. 2012 Jan;83(1):209-14. doi: 10.1016/j.fitote.2011.10.013. Epub 2011 Oct 28. [PubMed:22061662 ]
  2. Fotie J, Nkengfack AE, Rukunga G, Tolo F, Peter MG, Heydenreich M, Fomum ZT: In-vivo antimalarial activity of some oxygenated xanthones. Ann Trop Med Parasitol. 2003 Oct;97(7):683-8. doi: 10.1179/000349803225002390. [PubMed:14613627 ]
  3. Ikeda M, Kurotobi Y, Namikawa A, Kuranuki S, Matsuura N, Sato M, Igarashi Y, Nakamura T, Oikawa T: Norlichexanthone isolated from fungus P16 promotes the secretion and expression of adiponectin in cultured ST-13 adipocytes. Med Chem. 2011 Jul;7(4):250-6. doi: 10.2174/157340611796150950. [PubMed:21568875 ]
  4. Wang K, Chen Y, Gao S, Wang M, Ge M, Yang Q, Liao M, Xu L, Chen J, Zeng Z, Chen H, Zhang XK, Lin T, Zhou H: Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting ER alpha to inhibit RANKL signaling. Acta Pharm Sin B. 2021 Feb;11(2):442-455. doi: 10.1016/j.apsb.2020.09.012. Epub 2020 Sep 28. [PubMed:33643823 ]
  5. Akinfala TO, Houbraken J, Sulyok M, Adedeji AR, Odebode AC, Krska R, Ezekiel CN: Moulds and their secondary metabolites associated with the fermentation and storage of two cocoa bean hybrids in Nigeria. Int J Food Microbiol. 2020 Mar 2;316:108490. doi: 10.1016/j.ijfoodmicro.2019.108490. Epub 2019 Dec 14. [PubMed:31874327 ]
  6. Abdel-Lateff, A., et al. (2003). Abdel-Lateff, A., et al, J. Nat. Prod. 66, 706 (2003). J. Nat. Prod..