Np mrd loader

Record Information
Version2.0
Created at2021-06-19 17:13:31 UTC
Updated at2021-06-29 23:49:39 UTC
NP-MRD IDNP0024985
Secondary Accession NumbersNone
Natural Product Identification
Common Name5,4'-dihydroxy-7-methoxyflavone
Provided ByJEOL DatabaseJEOL Logo
DescriptionGenkwanin, also known as 7-methylapigenin, belongs to the class of organic compounds known as 7-o-methylated flavonoids. These are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, genkwanin is considered to be a flavonoid. Genkwanin is a secondary metabolite. Secondary metabolites are metabolically or physiologically non-essential metabolites that may serve a role as defense or signalling molecules. In some cases they are simply molecules that arise from the incomplete metabolism of other secondary metabolites. 5,4'-dihydroxy-7-methoxyflavone is found in Actinobole uliginosum, Ageratina pichinchensis, Alnus alnobetula, Aquilaria sinensis, Aquilegia oxysepala, Arnica cordifolia, Arnica venosa, Artemisia afra, Artemisia diffusa, Artemisia gmelinii, Artemisia oliveriana, Artemisia pontica, Artemisia princeps, Artemisia transiliensis, Baccharis genistelloides, Baccharis trinervis, Bahiopsis triangularis, Ballota hirsuta, Brickellia cavanillesii, Brickellia vernicosa, Calibrachoa parviflora, Callicarpa americana, Campanula armena, Castanea sativa, Chromolaena odorata, Cinnamomum kotoense, Cistus inflatus, Cistus ladanifer, Cistus laurifolius, Cyclotrichium niveum, Daphne bholua, Daphne feddei, Daphne gnidium, Daphne laureola, Dracocephalum multicaule, Equisetum arvense, Ericameria laricifolia, Eriodictyon sessilifolium, Eupatorium capillifolium, Eupatorium serotinum, Frullania teneriffae, Gymnocarpium robertianum, Gyrinops walla, Isodon enanderianus, Isodon eriocalyx, Isodon scoparius, Isodon umbrosus, Kaempferia parviflora, Klasea flavescens, Lavandula dentata, Leonurus japonicus, Leonurus sibiricus, Leonurus turkestanicus, Lycopus europaeus, Lycopus virginicus, Mentha pulegium, Mimosa tenuiflora, Mirabilis viscosa, Monticalia vaccinioides, Nepeta septemcrenata, Notholaena greggii, Notholaena rosei, Notholaena sulphurea, Ocimum basilicum L. , Ocimum selloi, Origanum akhadarense, Origanum boissieri, Origanum calcaratum, Origanum dictamnus , Origanum floribundum, Origanum hypercifolium, Origanum intercedens, Origanum majorana , Origanum micranthum, Origanum microphyllum, Origanum onites , Origanum syriacum , Origanum vulgare , Origanum vulgare subsp. Glandulosum , Origanum vulgare subsp. Hirtum , Oroxylum indicum, Phlomis herba-venti, Pinus morrisonicola, Pityrogramma ebenea, Plazia daphnoides, Populus grandidentata, Populus laurifolia, Populus tremuloides, Prunus cerasoides, Prunus leveilleana, Prunus yedoensis, Pycnanthus angolensis, Salvia candelabrum, Salvia moorcroftiana, Rosmarinus officinalis , Salvia sapinea, Satureja cuneifolia, Solanum paludosum, Streptomyces avermitilis, Symphyopappus compressus, Syphopappus polystachyus, Thymus herba-barona, Thymus vulgaris, Tinospora crispa , Vachellia constricta, Vernonanthura nudiflora, Vernonia fasciculata, Veronica cupressoides, Wikstroemia canescens, Xanthorrhoea preissii, Xerochrysum bracteatum and Zinnia citrea. 5,4'-dihydroxy-7-methoxyflavone was first documented in 2011 (PMID: 22379361). Based on a literature review a small amount of articles have been published on Genkwanin (PMID: 23831487) (PMID: 24059652) (PMID: 34315132) (PMID: 34099770).
Structure
Thumb
Synonyms
ValueSource
5,4'-Dihydroxy-7-methoxyflavoneChEBI
7-MethylapigeninChEBI
Apigenin 7-methyl etherChEBI
5,4'-Dihydroxy-7-methoxy-flavoneHMDB
GengkwaninHMDB
Chemical FormulaC16H12O5
Average Mass284.2635 Da
Monoisotopic Mass284.06847 Da
IUPAC Name5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one
Traditional Namegenkwanin
CAS Registry NumberNot Available
SMILES
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=O)C2=C(O[H])C([H])=C(OC([H])([H])[H])C([H])=C2O1
InChI Identifier
InChI=1S/C16H12O5/c1-20-11-6-12(18)16-13(19)8-14(21-15(16)7-11)9-2-4-10(17)5-3-9/h2-8,17-18H,1H3
InChI KeyJPMYFOBNRRGFNO-UHFFFAOYSA-N
Experimental Spectra
Spectrum TypeDescriptionDepositor EmailDepositor OrganizationDepositorDeposition DateView
1D NMR13C NMR Spectrum (1D, 400 MHz, DMSO-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 400 MHz, DMSO-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 100 MHz, DMSO-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 100 MHz, DMSO-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 200 MHz, DMSO-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 200 MHz, DMSO-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 300 MHz, DMSO-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 300 MHz, DMSO-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 500 MHz, DMSO-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 500 MHz, DMSO-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 600 MHz, DMSO-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 600 MHz, DMSO-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 700 MHz, DMSO-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 700 MHz, DMSO-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 800 MHz, DMSO-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 800 MHz, DMSO-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 900 MHz, DMSO-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 900 MHz, DMSO-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 1000 MHz, DMSO-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 1000 MHz, DMSO-d6, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
Predicted Spectra
Not Available
Chemical Shift Submissions
Not Available
Species
Species of Origin
Species NameSourceReference
Acacia constrictaKNApSAcK Database
Actinobole uliginosumLOTUS Database
Ageratina pichinchensisPlant
Alnus viridisLOTUS Database
Aquilaria sinensisLOTUS Database
Aquilegia oxysepalaLOTUS Database
Arnica cordifoliaLOTUS Database
Arnica venosaLOTUS Database
Artemisia afraLOTUS Database
Artemisia capillarisKNApSAcK Database
Artemisia diffusaLOTUS Database
Artemisia gmeliniiLOTUS Database
Artemisia oliverianaLOTUS Database
Artemisia ponticaLOTUS Database
Artemisia princepsLOTUS Database
Artemisia transiliensisLOTUS Database
Baccharis genistelloidesLOTUS Database
Baccharis trinervisLOTUS Database
Bahiopsis triangularisLOTUS Database
Ballota hirsutaLOTUS Database
Brickellia cavanillesiiLOTUS Database
Brickellia vernicosaLOTUS Database
Calibrachoa parvifloraLOTUS Database
Callicarpa americanaLOTUS Database
Campanula armenaLOTUS Database
Castanea sativaLOTUS Database
Cheilanthes albomarginataKNApSAcK Database
Cheilanthes rufaKNApSAcK Database
Chromolaena odorataLOTUS Database
Cinnamomum kotoenseLOTUS Database
Cistus inflatusLOTUS Database
Cistus ladaniferLOTUS Database
Cistus laurifoliusLOTUS Database
Cyclotrichium niveumLOTUS Database
Daphne bholuaLOTUS Database
Daphne feddeiLOTUS Database
Daphne genkwaKNApSAcK Database
Daphne gnidiumLOTUS Database
Daphne laureolaLOTUS Database
Dracocephalum multicauleLOTUS Database
Equisetum arvenseLOTUS Database
Ericameria laricifoliaLOTUS Database
Eriodictyon sessilifoliumLOTUS Database
Eupatorium capillifoliumLOTUS Database
Eupatorium serotinumLOTUS Database
Frullania teneriffaeLOTUS Database
Glycyrrhiza glabraKNApSAcK Database
Glycyrrhiza inflataKNApSAcK Database
Glycyrrhiza uralensisKNApSAcK Database
Gymnocarpium robertianumLOTUS Database
Gyrinops wallaLOTUS Database
Halophila stipulaceaKNApSAcK Database
Isodon enanderianusLOTUS Database
Isodon eriocalyxLOTUS Database
Isodon scopariusLOTUS Database
Isodon umbrosusLOTUS Database
Kaempferia parvifloraLOTUS Database
Klasea flavescensLOTUS Database
Larrea divaricataKNApSAcK Database
Larrea tridentataKNApSAcK Database
Lavandula dentataLOTUS Database
Leonurus japonicusLOTUS Database
Leonurus sibiricusLOTUS Database
Leonurus turkestanicusLOTUS Database
Lycopus europaeusLOTUS Database
Lycopus virginicusLOTUS Database
Medicago polymorphaKNApSAcK Database
Mentha pulegiumLOTUS Database
Mimosa hostilisKNApSAcK Database
Mimosa tenuifloraLOTUS Database
Mirabilis viscosaLOTUS Database
Monticalia vaccinioidesLOTUS Database
Nepeta septemcrenataLOTUS Database
Notholaena greggiiLOTUS Database
Notholaena roseiLOTUS Database
Notholaena sulphureaLOTUS Database
Ocimum americanum L.var.pilosum (Willd.) PatonKNApSAcK Database
Ocimum basilicumPlant
Ocimum basilicum L.KNApSAcK Database
Ocimum kilimandscharicum L.KNApSAcK Database
Ocimum selloiLOTUS Database
Ocimum selloi Benth.KNApSAcK Database
Ocimum x citriodorum Vis.KNApSAcK Database
Origanum akhadarensePlant
Origanum boissieriPlant
Origanum calcaratumPlant
Origanum dictamnusPlant
Origanum floribundumPlant
Origanum hypercifoliumPlant
Origanum intercedensPlant
Origanum majoranaPlant
Origanum micranthumPlant
Origanum microphyllumPlant
Origanum onitesPlant
Origanum syriacumPlant
Origanum vulgarePlant
Origanum vulgare subsp. GlandulosumPlant
Origanum vulgare subsp. HirtumPlant
Oroxylum indicumLOTUS Database
Phlomis herba-ventiLOTUS Database
Pinus morrisonicolaLOTUS Database
Pityrogramma ebeneaLOTUS Database
Plazia daphnoidesLOTUS Database
Plectranthus fruticosusKNApSAcK Database
Populus grandidentataLOTUS Database
Populus laurifoliaLOTUS Database
Populus tremuloidesLOTUS Database
Prunus cerasoidesLOTUS Database
Prunus leveilleanaLOTUS Database
Prunus yedoensisLOTUS Database
Pycnanthus angolensisLOTUS Database
Rosmarinus officinalisKNApSAcK Database
Salvia candelabrumLOTUS Database
Salvia dorriiKNApSAcK Database
Salvia glutinosaKNApSAcK Database
Salvia lavandulaefoliaKNApSAcK Database
Salvia lavandulifoliaKNApSAcK Database
Salvia microsiphonKNApSAcK Database
Salvia moorcroftianaLOTUS Database
Salvia nicolsonianaKNApSAcK Database
Salvia officinalisKNApSAcK Database
Salvia palaestinaKNApSAcK Database
Salvia rosmarinusPlant
Salvia sapinaeKNApSAcK Database
Salvia sapineaLOTUS Database
Salvia stenophyllaKNApSAcK Database
Salvia yosgadensisKNApSAcK Database
Satureja cuneifoliaLOTUS Database
Solanum paludosumLOTUS Database
Streptomyces avermitilisLOTUS Database
Symphyopappus compressusLOTUS Database
Syphopappus polystachyus-
Teucrium ramosissimumKNApSAcK Database
Thymus herba-baronaLOTUS Database
Thymus vulgarisLOTUS Database
Tinospora crispaPlant
Vachellia constrictaLOTUS Database
Vernonanthura nudifloraLOTUS Database
Vernonia fasciculataLOTUS Database
Veronica cupressoidesLOTUS Database
Wikstroemia canescensLOTUS Database
Xanthorrhoea preissiiLOTUS Database
Xerochrysum bracteatumLOTUS Database
Zinnia citreaLOTUS Database
Chemical Taxonomy
Description Belongs to the class of organic compounds known as 7-o-methylated flavonoids. These are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassFlavonoids
Sub ClassO-methylated flavonoids
Direct Parent7-O-methylated flavonoids
Alternative ParentsNot Available
SubstituentsNot Available
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Physical Properties
StateNot Available
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP3.39ALOGPS
logP2.85ChemAxon
logS-3.7ALOGPS
pKa (Strongest Acidic)7.35ChemAxon
pKa (Strongest Basic)-4.7ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area75.99 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity77.4 m³·mol⁻¹ChemAxon
Polarizability29.23 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
HMDB IDHMDB0252684
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDFDB006932
KNApSAcK IDC00001043
Chemspider ID4444936
KEGG Compound IDC10046
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkGenkwanin
METLIN IDNot Available
PubChem Compound5281617
PDB IDNot Available
ChEBI ID75718
Good Scents IDrw1588971
References
General References
  1. Xie H, Liang Y, Ito Y, Wang X, Chen R, He J, Li H, Zhang T: PREPARATIVE ISOLATION AND PURIFICATION OF FOUR FLAVONOIDS FROM DAPHNE GENKWA SIEB. ET ZUCC. BY HIGH-SPEED COUNTERCURRENT CHROMATOGRAPHY. J Liq Chromatogr Relat Technol. 2011;34(19):2360-2372. doi: 10.1080/10826076.2011.589094. [PubMed:22379361 ]
  2. Song Y, Zhang S, Liu H, Jin X: Determination of genkwanin in rat plasma by liquid chromatography-tandem mass spectrometry: application to a bioavailability study. J Pharm Biomed Anal. 2013 Oct;84:129-34. doi: 10.1016/j.jpba.2013.06.006. Epub 2013 Jun 20. [PubMed:23831487 ]
  3. Li S, Chou G, Hseu Y, Yang H, Kwan H, Yu Z: Isolation of anticancer constituents from flos genkwa (Daphne genkwa Sieb.et Zucc.) through bioassay-guided procedures. Chem Cent J. 2013 Sep 23;7(1):159. doi: 10.1186/1752-153X-7-159. [PubMed:24059652 ]
  4. Zeng P, Fang M, Zhao H, Guo J: A network pharmacology approach to uncover the key ingredients in Ginkgo Folium and their anti-Alzheimer's disease mechanisms. Aging (Albany NY). 2021 Jul 27;13(14):18993-19012. doi: 10.18632/aging.203348. Epub 2021 Jul 27. [PubMed:34315132 ]
  5. Kim MK, Park SC, Park G, Choi E, Ji Y, Jang YP: Analytical quality by design methodology for botanical raw material analysis: a case study of flavonoids in Genkwa Flos. Sci Rep. 2021 Jun 7;11(1):11936. doi: 10.1038/s41598-021-91341-w. [PubMed:34099770 ]
  6. Park, Y., et al. (2007). Park, Y., et al, Magn. Reson. Chem. 45, 1072 (2007). Mag. Reson. Chem..