Record Information |
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Version | 1.0 |
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Created at | 2021-06-19 15:47:27 UTC |
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Updated at | 2021-06-19 15:47:27 UTC |
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NP-MRD ID | NP0023989 |
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Secondary Accession Numbers | None |
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Natural Product Identification |
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Common Name | streptonigrin, rufocromomycin |
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Provided By | JEOL Database |
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Description | Streptonigrin, also known as rufocromomycin or brunemycin, belongs to the class of organic compounds known as bipyridines and oligopyridines. These are organic compounds containing two pyridine rings linked to each other. streptonigrin, rufocromomycin is found in Streptomyces flocculus. It was first documented in 1989 (PMID: 2738877). Based on a literature review a significant number of articles have been published on streptonigrin (PMID: 10328288) (PMID: 10465544) (PMID: 1905760) (PMID: 34326026). |
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Structure | [H]OC1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C1C1=C(C(=[N+]([H])C(C2=NC3=C(C([H])=C2[H])C(=O)C(OC([H])([H])[H])=C(N([H])[H])C3=O)=C1N([H])[H])C([O-])=O)C([H])([H])[H] InChI=1S/C25H22N4O8/c1-9-14(10-6-8-13(35-2)23(36-3)20(10)30)15(26)19(29-17(9)25(33)34)12-7-5-11-18(28-12)22(32)16(27)24(37-4)21(11)31/h5-8,30H,26-27H2,1-4H3,(H,33,34) |
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Synonyms | Value | Source |
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5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acid | ChEBI | Rufocromomicina | ChEBI | Rufocromomycin | ChEBI | Rufocromomycine | ChEBI | Rufocromomycinum | ChEBI | Streptonigran | ChEBI | Nigrin | Kegg | 5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinate | Generator | Brunemycin | HMDB | Bruneomycin | HMDB |
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Chemical Formula | C25H22N4O8 |
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Average Mass | 506.4710 Da |
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Monoisotopic Mass | 506.14376 Da |
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IUPAC Name | 5-amino-6-(7-amino-6-methoxy-5,8-dioxo-5,8-dihydroquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpyridin-1-ium-2-carboxylate |
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Traditional Name | 5-amino-6-(7-amino-6-methoxy-5,8-dioxoquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpyridin-1-ium-2-carboxylate |
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CAS Registry Number | Not Available |
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SMILES | [H]OC1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C1C1=C(C(=[N+]([H])C(C2=NC3=C(C([H])=C2[H])C(=O)C(OC([H])([H])[H])=C(N([H])[H])C3=O)=C1N([H])[H])C([O-])=O)C([H])([H])[H] |
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InChI Identifier | InChI=1S/C25H22N4O8/c1-9-14(10-6-8-13(35-2)23(36-3)20(10)30)15(26)19(29-17(9)25(33)34)12-7-5-11-18(28-12)22(32)16(27)24(37-4)21(11)31/h5-8,30H,26-27H2,1-4H3,(H,33,34) |
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InChI Key | PVYJZLYGTZKPJE-UHFFFAOYSA-N |
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Experimental Spectra |
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| Spectrum Type | Description | Depositor Email | Depositor Organization | Depositor | Deposition Date | View |
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1D NMR | 13C NMR Spectrum (1D, 400 MHz, THF-d8, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 400 MHz, THF-d8, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 100 MHz, THF-d8, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 100 MHz, THF-d8, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 200 MHz, THF-d8, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 200 MHz, THF-d8, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 300 MHz, THF-d8, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 300 MHz, THF-d8, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 500 MHz, THF-d8, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 500 MHz, THF-d8, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 600 MHz, THF-d8, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 600 MHz, THF-d8, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 700 MHz, THF-d8, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 700 MHz, THF-d8, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 800 MHz, THF-d8, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 800 MHz, THF-d8, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 900 MHz, THF-d8, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 900 MHz, THF-d8, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 1000 MHz, THF-d8, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 1000 MHz, THF-d8, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum |
| Predicted Spectra |
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| Not Available | Chemical Shift Submissions |
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| Not Available | Species |
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Species of Origin | Species Name | Source | Reference |
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Streptomyces albus | JEOL database | - Anderberg, P. I., et al, Magn. Reson. Chem. 40, 313 (2002)
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Species Where Detected | |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as bipyridines and oligopyridines. These are organic compounds containing two pyridine rings linked to each other. |
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Kingdom | Organic compounds |
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Super Class | Organoheterocyclic compounds |
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Class | Pyridines and derivatives |
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Sub Class | Bipyridines and oligopyridines |
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Direct Parent | Bipyridines and oligopyridines |
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Alternative Parents | Not Available |
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Substituents | Not Available |
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Molecular Framework | Aromatic heteropolycyclic compounds |
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External Descriptors | Not Available |
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Physical Properties |
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State | Not Available |
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Experimental Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Predicted Properties | |
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General References | - Ryu CK, Lee IK, Jung SH, Lee CO: Synthesis and cytotoxic activities of 6-chloro-7-arylamino-5,8-isoquinolinediones. Bioorg Med Chem Lett. 1999 Apr 19;9(8):1075-80. doi: 10.1016/s0960-894x(99)00152-3. [PubMed:10328288 ]
- Fryatt T, Goroski DT, Nilson ZD, Moody CJ, Beall HD: Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1). Bioorg Med Chem Lett. 1999 Aug 2;9(15):2195-8. doi: 10.1016/s0960-894x(99)00369-8. [PubMed:10465544 ]
- Rao KV, Beach JW: Streptonigrin and related compounds. 5. Synthesis and evaluation of some isoquinoline analogues. J Med Chem. 1991 Jun;34(6):1871-9. doi: 10.1021/jm00110a018. [PubMed:1905760 ]
- Moustatih A, Garnier-Suillerot A: Bifunctional antitumor compounds: synthesis and characterization of a Au(III)-streptonigrin complex with thiol-modulating properties. J Med Chem. 1989 Jul;32(7):1426-31. doi: 10.1021/jm00127a004. [PubMed:2738877 ]
- Lin TH, Wu CC, Tseng CY, Fang JH, Lin CT: Effects of gallic acid on capsular polysaccharide biosynthesis in Klebsiella pneumoniae. J Microbiol Immunol Infect. 2021 Jul 22. pii: S1684-1182(21)00141-9. doi: 10.1016/j.jmii.2021.07.002. [PubMed:34326026 ]
- Anderberg, P. I., et al. (2002). Anderberg, P. I., et al, Magn. Reson. Chem. 40, 313 (2002). Mag. Reson. Chem..
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