NP-MRD: Showing NP-Card for Monacolin K (NP0022157)

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Record Information

Version

2.0

Created at

2021-01-06 07:22:52 UTC

Updated at

2026-02-18 16:01:26 UTC

NP-MRD ID

NP0022157

Natural Product DOI

https://doi.org/10.57994/7585

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Monacolin K

Provided By

NPAtlas

Description

Epilovastatin is also known as 6 methylcompactin or mevacor. Monacolin K is found in Aspergillus terreus, Aspergillus terreus ATCC20542 , Monascus pilosus, Monascus purpureus and Monascus ruber No. 1005. Monacolin K was first documented in 1980 (PMID: 7380744). Based on a literature review very few articles have been published on Epilovastatin (PMID: 4008338).

Structure

MOL 3D MOL SDF 3D SDF PDB SMILES InChI


  Mrv1652306242105213D          

 65 67  0  0  0  0            999 V2000
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M  END

     RDKit          3D

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M  END


  Mrv1652306242105213D          

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    0.8880   -1.4938   -2.5518 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.5965   -2.7626   -2.2384 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3688   -0.7406   -1.3408 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.3968    0.1559   -0.7392 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.6408   -0.4971   -0.2541 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.5697    0.5522    0.3261 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.9357    1.2872    1.4887 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.0257    2.0247    2.2323 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.6731    1.1136    3.0631 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0123    2.6622    1.2889 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.4970    2.7076   -0.1135 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6013    3.7656   -0.7670 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9113    1.5412   -0.6373 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2893   -1.7006   -0.4356 C   0  0  1  0  0  0  0  0  0  0  0  0
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   -1.5546   -4.1356    1.1163 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8181   -4.6567    0.7984 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7426   -3.6770    2.3571 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3166   -2.9531    0.7556 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9475   -3.6454   -1.1912 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2371   -2.5598   -3.3177 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2747   -1.7439   -4.4617 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5868   -0.8240   -3.0991 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5920   -2.8063   -2.7726 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8089   -2.9718   -1.1984 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0640   -3.6799   -2.6319 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4289   -0.0578   -1.7298 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9626    0.7172    0.1108 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6606    0.9124   -1.5092 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2143   -1.0442   -1.0214 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4434   -1.2194    0.5652 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4625    0.0320    0.7278 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2265    2.0596    1.1135 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4587    0.5664    2.1836 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5829    2.7981    2.9206 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6319    1.0780    2.8165 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2793    3.6789    1.6243 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.9841    2.0888    1.2642 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3521   -2.4068    0.0963 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 18 29  1  0  0  0  0
 29  8  1  0  0  0  0
 29 13  1  0  0  0  0
 28 21  1  0  0  0  0
  1 30  1  0  0  0  0
  1 31  1  0  0  0  0
  1 32  1  0  0  0  0
  2 33  1  0  0  0  0
  2 34  1  0  0  0  0
  3 35  1  6  0  0  0
  4 36  1  0  0  0  0
  4 37  1  0  0  0  0
  4 38  1  0  0  0  0
  8 39  1  1  0  0  0
  9 40  1  0  0  0  0
  9 41  1  0  0  0  0
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 24 62  1  0  0  0  0
 25 63  1  0  0  0  0
 25 64  1  0  0  0  0
 29 65  1  1  0  0  0
M  END
> <DATABASE_ID>
NP0022157

> <DATABASE_NAME>
NP-MRD

> <SMILES>
[H]O[C@@]1([H])C([H])([H])C(=O)O[C@]([H])(C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C([H])=C([H])C3=C([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(OC(=O)[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]23[H])C([H])([H])[H])C1([H])[H]

> <INCHI_IDENTIFIER>
InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15+,16-,18+,19+,20-,21-,23-/m0/s1

> <INCHI_KEY>
PCZOHLXUXFIOCF-YPQFMRJXSA-N

> <FORMULA>
C24H36O5

> <MOLECULAR_WEIGHT>
404.547

> <EXACT_MASS>
404.256274259

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
65

> <JCHEM_AVERAGE_POLARIZABILITY>
45.05147832572042

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2R)-2-methylbutanoate

> <ALOGPS_LOGP>
4.11

> <JCHEM_LOGP>
3.9021869143333325

> <ALOGPS_LOGS>
-4.22

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.914537666911102

> <JCHEM_PKA_STRONGEST_BASIC>
-2.8361812244930835

> <JCHEM_POLAR_SURFACE_AREA>
72.83000000000001

> <JCHEM_REFRACTIVITY>
113.18239999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
7

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.43e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2R)-2-methylbutanoate

> <JCHEM_VEBER_RULE>
0

$$$$

     RDKit          3D

 65 67  0  0  0  0  0  0  0  0999 V2000
   -3.1560    3.5425    1.8613 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1277    3.4259    0.3590 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7107   -2.0603    1.5778 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.6152   -3.6508    1.2639 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1918   -3.1263   -0.6230 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3262   -2.4098   -1.2805 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3514   -2.2899   -2.7284 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2932   -1.8473   -3.3848 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8880   -1.4938   -2.5518 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.5965   -2.7626   -2.2384 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3688   -0.7406   -1.3408 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.3968    0.1559   -0.7392 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6408   -0.4971   -0.2541 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5697    0.5522    0.3261 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.9357    1.2872    1.4887 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0257    2.0247    2.2323 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.6731    1.1136    3.0631 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0123    2.6622    1.2889 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4970    2.7076   -0.1135 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6013    3.7656   -0.7670 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9113    1.5412   -0.6373 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.9044    2.7913   -2.0185 H   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.4465   -0.4101    1.2549 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5804   -1.5921    2.0833 H   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5546   -4.1356    1.1163 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8181   -4.6567    0.7984 H   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.3166   -2.9531    0.7556 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9475   -3.6454   -1.1912 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2371   -2.5598   -3.3177 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2747   -1.7439   -4.4617 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5868   -0.8240   -3.0991 H   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8089   -2.9718   -1.1984 H   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.4289   -0.0578   -1.7298 H   0  0  0  0  0  0  0  0  0  0  0  0
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    3.2143   -1.0442   -1.0214 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4434   -1.2194    0.5652 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4625    0.0320    0.7278 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2265    2.0596    1.1135 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4587    0.5664    2.1836 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5829    2.7981    2.9206 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6319    1.0780    2.8165 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2793    3.6789    1.6243 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.9841    2.0888    1.2642 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3521   -2.4068    0.0963 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
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 12 13  2  0
 13 14  1  0
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 23 24  1  0
 23 25  1  0
 25 26  1  0
 26 27  2  0
 26 28  1  0
 18 29  1  0
 29  8  1  0
 29 13  1  0
 28 21  1  0
  1 30  1  0
  1 31  1  0
  1 32  1  0
  2 33  1  0
  2 34  1  0
  3 35  1  6
  4 36  1  0
  4 37  1  0
  4 38  1  0
  8 39  1  1
  9 40  1  0
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 23 61  1  1
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 25 64  1  0
 29 65  1  1
M  END

HEADER    PROTEIN                                 24-JUN-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-JUN-21         0                                  
HETATM    1  C   UNK     0      -3.156   3.543   1.861  0.00  0.00           C+0
HETATM    2  C   UNK     0      -3.128   3.426   0.359  0.00  0.00           C+0
HETATM    3  C   UNK     0      -3.286   2.018  -0.118  0.00  0.00           C+0
HETATM    4  C   UNK     0      -3.244   2.011  -1.619  0.00  0.00           C+0
HETATM    5  C   UNK     0      -2.205   1.123   0.426  0.00  0.00           C+0
HETATM    6  O   UNK     0      -1.356   1.669   1.175  0.00  0.00           O+0
HETATM    7  O   UNK     0      -2.155  -0.219   0.116  0.00  0.00           O+0
HETATM    8  C   UNK     0      -1.131  -1.017   0.640  0.00  0.00           C+0
HETATM    9  C   UNK     0      -1.711  -2.060   1.578  0.00  0.00           C+0
HETATM   10  C   UNK     0      -2.208  -3.279   0.851  0.00  0.00           C+0
HETATM   11  C   UNK     0      -3.615  -3.651   1.264  0.00  0.00           C+0
HETATM   12  C   UNK     0      -2.192  -3.126  -0.623  0.00  0.00           C+0
HETATM   13  C   UNK     0      -1.326  -2.410  -1.281  0.00  0.00           C+0
HETATM   14  C   UNK     0      -1.351  -2.290  -2.728  0.00  0.00           C+0
HETATM   15  C   UNK     0      -0.293  -1.847  -3.385  0.00  0.00           C+0
HETATM   16  C   UNK     0       0.888  -1.494  -2.552  0.00  0.00           C+0
HETATM   17  C   UNK     0       1.597  -2.763  -2.238  0.00  0.00           C+0
HETATM   18  C   UNK     0       0.369  -0.741  -1.341  0.00  0.00           C+0
HETATM   19  C   UNK     0       1.397   0.156  -0.739  0.00  0.00           C+0
HETATM   20  C   UNK     0       2.641  -0.497  -0.254  0.00  0.00           C+0
HETATM   21  C   UNK     0       3.570   0.552   0.326  0.00  0.00           C+0
HETATM   22  C   UNK     0       2.936   1.287   1.489  0.00  0.00           C+0
HETATM   23  C   UNK     0       4.026   2.025   2.232  0.00  0.00           C+0
HETATM   24  O   UNK     0       4.673   1.114   3.063  0.00  0.00           O+0
HETATM   25  C   UNK     0       5.012   2.662   1.289  0.00  0.00           C+0
HETATM   26  C   UNK     0       4.497   2.708  -0.114  0.00  0.00           C+0
HETATM   27  O   UNK     0       4.601   3.766  -0.767  0.00  0.00           O+0
HETATM   28  O   UNK     0       3.911   1.541  -0.637  0.00  0.00           O+0
HETATM   29  C   UNK     0      -0.289  -1.701  -0.436  0.00  0.00           C+0
HETATM   30  H   UNK     0      -3.307   2.544   2.344  0.00  0.00           H+0
HETATM   31  H   UNK     0      -2.196   4.002   2.215  0.00  0.00           H+0
HETATM   32  H   UNK     0      -3.961   4.213   2.203  0.00  0.00           H+0
HETATM   33  H   UNK     0      -2.161   3.849  -0.035  0.00  0.00           H+0
HETATM   34  H   UNK     0      -3.966   4.025  -0.044  0.00  0.00           H+0
HETATM   35  H   UNK     0      -4.283   1.642   0.194  0.00  0.00           H+0
HETATM   36  H   UNK     0      -3.503   0.996  -1.983  0.00  0.00           H+0
HETATM   37  H   UNK     0      -3.904   2.791  -2.018  0.00  0.00           H+0
HETATM   38  H   UNK     0      -2.185   2.208  -1.920  0.00  0.00           H+0
HETATM   39  H   UNK     0      -0.447  -0.410   1.255  0.00  0.00           H+0
HETATM   40  H   UNK     0      -2.580  -1.592   2.083  0.00  0.00           H+0
HETATM   41  H   UNK     0      -0.969  -2.324   2.352  0.00  0.00           H+0
HETATM   42  H   UNK     0      -1.555  -4.136   1.116  0.00  0.00           H+0
HETATM   43  H   UNK     0      -3.818  -4.657   0.798  0.00  0.00           H+0
HETATM   44  H   UNK     0      -3.743  -3.677   2.357  0.00  0.00           H+0
HETATM   45  H   UNK     0      -4.317  -2.953   0.756  0.00  0.00           H+0
HETATM   46  H   UNK     0      -2.947  -3.645  -1.191  0.00  0.00           H+0
HETATM   47  H   UNK     0      -2.237  -2.560  -3.318  0.00  0.00           H+0
HETATM   48  H   UNK     0      -0.275  -1.744  -4.462  0.00  0.00           H+0
HETATM   49  H   UNK     0       1.587  -0.824  -3.099  0.00  0.00           H+0
HETATM   50  H   UNK     0       2.592  -2.806  -2.773  0.00  0.00           H+0
HETATM   51  H   UNK     0       1.809  -2.972  -1.198  0.00  0.00           H+0
HETATM   52  H   UNK     0       1.064  -3.680  -2.632  0.00  0.00           H+0
HETATM   53  H   UNK     0      -0.429  -0.058  -1.730  0.00  0.00           H+0
HETATM   54  H   UNK     0       0.963   0.717   0.111  0.00  0.00           H+0
HETATM   55  H   UNK     0       1.661   0.912  -1.509  0.00  0.00           H+0
HETATM   56  H   UNK     0       3.214  -1.044  -1.021  0.00  0.00           H+0
HETATM   57  H   UNK     0       2.443  -1.219   0.565  0.00  0.00           H+0
HETATM   58  H   UNK     0       4.463   0.032   0.728  0.00  0.00           H+0
HETATM   59  H   UNK     0       2.227   2.060   1.113  0.00  0.00           H+0
HETATM   60  H   UNK     0       2.459   0.566   2.184  0.00  0.00           H+0
HETATM   61  H   UNK     0       3.583   2.798   2.921  0.00  0.00           H+0
HETATM   62  H   UNK     0       5.632   1.078   2.817  0.00  0.00           H+0
HETATM   63  H   UNK     0       5.279   3.679   1.624  0.00  0.00           H+0
HETATM   64  H   UNK     0       5.984   2.089   1.264  0.00  0.00           H+0
HETATM   65  H   UNK     0       0.352  -2.407   0.096  0.00  0.00           H+0
CONECT    1    2   30   31   32                                             
CONECT    2    1    3   33   34                                             
CONECT    3    2    4    5   35                                             
CONECT    4    3   36   37   38                                             
CONECT    5    3    6    7                                                  
CONECT    6    5                                                            
CONECT    7    5    8                                                       
CONECT    8    7    9   29   39                                             
CONECT    9    8   10   40   41                                             
CONECT   10    9   11   12   42                                             
CONECT   11   10   43   44   45                                             
CONECT   12   10   13   46                                                  
CONECT   13   12   14   29                                                  
CONECT   14   13   15   47                                                  
CONECT   15   14   16   48                                                  
CONECT   16   15   17   18   49                                             
CONECT   17   16   50   51   52                                             
CONECT   18   16   19   29   53                                             
CONECT   19   18   20   54   55                                             
CONECT   20   19   21   56   57                                             
CONECT   21   20   22   28   58                                             
CONECT   22   21   23   59   60                                             
CONECT   23   22   24   25   61                                             
CONECT   24   23   62                                                       
CONECT   25   23   26   63   64                                             
CONECT   26   25   27   28                                                  
CONECT   27   26                                                            
CONECT   28   26   21                                                       
CONECT   29   18    8   13   65                                             
CONECT   30    1                                                            
CONECT   31    1                                                            
CONECT   32    1                                                            
CONECT   33    2                                                            
CONECT   34    2                                                            
CONECT   35    3                                                            
CONECT   36    4                                                            
CONECT   37    4                                                            
CONECT   38    4                                                            
CONECT   39    8                                                            
CONECT   40    9                                                            
CONECT   41    9                                                            
CONECT   42   10                                                            
CONECT   43   11                                                            
CONECT   44   11                                                            
CONECT   45   11                                                            
CONECT   46   12                                                            
CONECT   47   14                                                            
CONECT   48   15                                                            
CONECT   49   16                                                            
CONECT   50   17                                                            
CONECT   51   17                                                            
CONECT   52   17                                                            
CONECT   53   18                                                            
CONECT   54   19                                                            
CONECT   55   19                                                            
CONECT   56   20                                                            
CONECT   57   20                                                            
CONECT   58   21                                                            
CONECT   59   22                                                            
CONECT   60   22                                                            
CONECT   61   23                                                            
CONECT   62   24                                                            
CONECT   63   25                                                            
CONECT   64   25                                                            
CONECT   65   29                                                            
MASTER        0    0    0    0    0    0    0    0   65    0  134    0
END

RDKit          3D

65 67  0  0  0  0  0  0  0  0999 V2000
   -3.1560    3.5425    1.8613 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1277    3.4259    0.3590 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2861    2.0180   -0.1181 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.2444    2.0112   -1.6193 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2049    1.1229    0.4257 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3558    1.6692    1.1749 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1548   -0.2194    0.1155 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1308   -1.0173    0.6402 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.7107   -2.0603    1.5778 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2079   -3.2788    0.8507 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.6152   -3.6508    1.2639 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1918   -3.1263   -0.6230 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3262   -2.4098   -1.2805 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3514   -2.2899   -2.7284 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2932   -1.8473   -3.3848 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8880   -1.4938   -2.5518 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.5965   -2.7626   -2.2384 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3688   -0.7406   -1.3408 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.3968    0.1559   -0.7392 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6408   -0.4971   -0.2541 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5697    0.5522    0.3261 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.9357    1.2872    1.4887 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0257    2.0247    2.2323 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.6731    1.1136    3.0631 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0123    2.6622    1.2889 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4970    2.7076   -0.1135 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6013    3.7656   -0.7670 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9113    1.5412   -0.6373 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2893   -1.7006   -0.4356 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.3066    2.5440    2.3443 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1955    4.0016    2.2146 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9613    4.2131    2.2030 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1608    3.8493   -0.0352 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9664    4.0250   -0.0435 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2829    1.6416    0.1944 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5026    0.9964   -1.9831 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9044    2.7913   -2.0185 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1853    2.2082   -1.9196 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4465   -0.4101    1.2549 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5804   -1.5921    2.0833 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9685   -2.3236    2.3519 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5546   -4.1356    1.1163 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8181   -4.6567    0.7984 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7426   -3.6770    2.3571 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3166   -2.9531    0.7556 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9475   -3.6454   -1.1912 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2371   -2.5598   -3.3177 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2747   -1.7439   -4.4617 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5868   -0.8240   -3.0991 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5920   -2.8063   -2.7726 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8089   -2.9718   -1.1984 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0640   -3.6799   -2.6319 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4289   -0.0578   -1.7298 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9626    0.7172    0.1108 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6606    0.9124   -1.5092 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2143   -1.0442   -1.0214 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4434   -1.2194    0.5652 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4625    0.0320    0.7278 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2265    2.0596    1.1135 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4587    0.5664    2.1836 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5829    2.7981    2.9206 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6319    1.0780    2.8165 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2793    3.6789    1.6243 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.9841    2.0888    1.2642 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3521   -2.4068    0.0963 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 10 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 16 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 23 25  1  0
 25 26  1  0
 26 27  2  0
 26 28  1  0
 18 29  1  0
 29  8  1  0
 29 13  1  0
 28 21  1  0
  1 30  1  0
  1 31  1  0
  1 32  1  0
  2 33  1  0
  2 34  1  0
  3 35  1  6
  4 36  1  0
  4 37  1  0
  4 38  1  0
  8 39  1  1
  9 40  1  0
  9 41  1  0
 10 42  1  6
 11 43  1  0
 11 44  1  0
 11 45  1  0
 12 46  1  0
 14 47  1  0
 15 48  1  0
 16 49  1  6
 17 50  1  0
 17 51  1  0
 17 52  1  0
 18 53  1  6
 19 54  1  0
 19 55  1  0
 20 56  1  0
 20 57  1  0
 21 58  1  1
 22 59  1  0
 22 60  1  0
 23 61  1  1
 24 62  1  0
 25 63  1  0
 25 64  1  0
 29 65  1  1
M  END

View in JSmol View NMR Assignments

Synonyms

Value	Source
1 alpha-Isomer lovastatin	MeSH
6 Methylcompactin	MeSH
6-Methylcompactin	MeSH
Lovastatin	MeSH
Lovastatin, (1 alpha(s*))-isomer	MeSH
Lovastatin, 1 alpha isomer	MeSH
Lovastatin, 1 alpha-isomer	MeSH
Mevacor	MeSH
Mevinolin	MeSH
Monacolin K	MeSH
alpha-Isomer lovastatin, 1	MeSH
(1S,3R,7S,8S,8AR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2R)-2-methylbutanoic acid	Generator

Chemical Formula

C₂₄H₃₆O₅

Average Mass

404.5470 Da

Monoisotopic Mass

404.25627 Da

IUPAC Name

(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2R)-2-methylbutanoate

Traditional Name

(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2R)-2-methylbutanoate

CAS Registry Number

Not Available

SMILES

CC[C@@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12

InChI Identifier

InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15+,16-,18+,19+,20-,21-,23-/m0/s1

InChI Key

PCZOHLXUXFIOCF-YPQFMRJXSA-N

Experimental Spectra

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 90.5, Chloroform-d, simulated)	[email protected]	Not Available	Not Available	2026-02-18	View Spectrum

Species

Species of Origin

Species Name	Source	Reference
Aspergillus terreus	NPAtlas	7380744
Aspergillus terreus ATCC20542	Fungi	KNApSAcK
Monascus pilosus	LOTUS Database	35616633
Monascus purpureus	Fungi	KNApSAcK
Monascus ruber No. 1005	Fungi	KNApSAcK

Chemical Taxonomy

Classification

Not classified

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	4.11	ALOGPS
logP	3.9	ChemAxon
logS	-4.2	ALOGPS
pKa (Strongest Acidic)	14.91	ChemAxon
pKa (Strongest Basic)	-2.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	72.83 Å²	ChemAxon
Rotatable Bond Count	7	ChemAxon
Refractivity	113.18 m³·mol⁻¹	ChemAxon
Polarizability	45.05 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

NPAtlas ID

NPA009354

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

29789697

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

40785065

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Endo A: Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase. J Antibiot (Tokyo). 1980 Mar;33(3):334-6. doi: 10.7164/antibiotics.33.334. [PubMed:7380744 ]
Endo A, Negishi Y, Iwashita T, Mizukawa K, Hirama M: Biosynthesis of ML-236B (compactin) and monacolin K. J Antibiot (Tokyo). 1985 Mar;38(3):444-8. doi: 10.7164/antibiotics.38.444. [PubMed:4008338 ]
DOI: 10.7164/antibiotics.38.444
PMID: 4008338

Showing NP-Card for Monacolin K (NP0022157)

MOL for NP0022157 (Monacolin K)

3D MOL for NP0022157 (Monacolin K)

3D SDF for NP0022157 (Monacolin K)

3D-SDF for NP0022157 (Monacolin K)

PDB for NP0022157 (Monacolin K)

3D PDB for NP0022157 (Monacolin K)

SMILES for NP0022157 (Monacolin K)

INCHI for NP0022157 (Monacolin K)

Structure for NP0022157 (Monacolin K)

3D Structure for NP0022157 (Monacolin K)