NP-MRD: Showing NP-Card for Gilvocarcin V (NP0022146)

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Record Information

Version

1.0

Created at

2021-01-06 07:22:05 UTC

Updated at

2021-07-15 17:38:15 UTC

NP-MRD ID

NP0022146

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Gilvocarcin V

Provided By

NPAtlas

Description

Gilvocarcin V is found in Streptomyces anandii and Streptomyces anandii C-22437. It was first documented in 1981 (PMID: 7344705). Based on a literature review very few articles have been published on 12-[(2R,3R,4R,5S)-3,4-dihydroxy-5-[(1R)-1-hydroxyethyl]oxolan-2-yl]-5-ethenyl-15-hydroxy-3,17-dimethoxy-9-oxatetracyclo[8.8.0.0²,⁷.0¹¹,¹⁶]Octadeca-1(10),2(7),3,5,11,13,15,17-octaen-8-one.

Structure

MOL 3D MOL SDF 3D SDF PDB SMILES InChI


  Mrv1652306242105213D          

 62 66  0  0  0  0            999 V2000
   -3.2452    3.6657   -5.3275 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END

     RDKit          3D

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M  END


  Mrv1652306242105213D          

 62 66  0  0  0  0            999 V2000
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    2.6451    3.1962    2.3459 C   0  0  1  0  0  0  0  0  0  0  0  0
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   -3.6188    1.2446   -4.3375 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0950   -0.9594   -4.8786 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9516   -1.9253   -3.6363 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1307   -0.1616   -3.6064 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3958    3.4284   -2.6111 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7145   -2.0318   -1.7196 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8597   -5.0503   -1.0498 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3896   -5.9719   -0.6239 H   0  0  0  0  0  0  0  0  0  0  0  0
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    2.4045   -2.4258    3.0631 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5884   -0.0254    0.6887 H   0  0  0  0  0  0  0  0  0  0  0  0
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    1.9157    3.7361    1.6781 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5076    4.2551    3.8572 H   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  3  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
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 16 17  2  0  0  0  0
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 21 23  1  0  0  0  0
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 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
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 10  3  1  0  0  0  0
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 15  8  1  0  0  0  0
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  2 39  1  0  0  0  0
  4 40  1  0  0  0  0
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 32 59  1  1  0  0  0
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 34 61  1  6  0  0  0
 35 62  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0022146

> <DATABASE_NAME>
NP-MRD

> <SMILES>
[H]OC1=C2C(OC([H])([H])[H])=C([H])C3=C(OC(=O)C4=C([H])C(C([H])=C([H])[H])=C([H])C(OC([H])([H])[H])=C34)C2=C(C([H])=C1[H])[C@@]1([H])O[C@@]([H])([C@]([H])(O[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]1([H])O[H]

> <INCHI_IDENTIFIER>
InChI=1S/C27H26O9/c1-5-12-8-15-19(17(9-12)33-3)14-10-18(34-4)21-16(29)7-6-13(20(21)25(14)36-27(15)32)26-23(31)22(30)24(35-26)11(2)28/h5-11,22-24,26,28-31H,1H2,2-4H3/t11-,22-,23-,24+,26-/m1/s1

> <INCHI_KEY>
XCWHINLKQMCRON-UCDARZNSSA-N

> <FORMULA>
C27H26O9

> <MOLECULAR_WEIGHT>
494.496

> <EXACT_MASS>
494.157682417

> <JCHEM_ACCEPTOR_COUNT>
8

> <JCHEM_ATOM_COUNT>
62

> <JCHEM_AVERAGE_POLARIZABILITY>
52.746670825298395

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
12-[(2R,3R,4R,5S)-3,4-dihydroxy-5-[(1R)-1-hydroxyethyl]oxolan-2-yl]-5-ethenyl-15-hydroxy-3,17-dimethoxy-9-oxatetracyclo[8.8.0.0^{2,7}.0^{11,16}]octadeca-1(10),2,4,6,11,13,15,17-octaen-8-one

> <ALOGPS_LOGP>
2.78

> <JCHEM_LOGP>
2.322187474666667

> <ALOGPS_LOGS>
-3.50

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
12.737215166500938

> <JCHEM_PKA_STRONGEST_ACIDIC>
8.521064109152707

> <JCHEM_PKA_STRONGEST_BASIC>
-3.0537466829921094

> <JCHEM_POLAR_SURFACE_AREA>
134.91000000000003

> <JCHEM_REFRACTIVITY>
129.5575

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.57e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
12-[(2R,3R,4R,5S)-3,4-dihydroxy-5-[(1R)-1-hydroxyethyl]oxolan-2-yl]-5-ethenyl-15-hydroxy-3,17-dimethoxy-9-oxatetracyclo[8.8.0.0^{2,7}.0^{11,16}]octadeca-1(10),2,4,6,11,13,15,17-octaen-8-one

> <JCHEM_VEBER_RULE>
0

$$$$

     RDKit          3D

 62 66  0  0  0  0  0  0  0  0999 V2000
   -3.2452    3.6657   -5.3275 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7232    1.4971   -1.8453 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0032    2.5463   -2.6759 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3214    1.5554   -0.9299 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1001   -0.5199   -0.1749 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1822   -0.6939   -1.0605 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.2632   -3.9838   -0.2451 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8520   -3.6537    2.3590 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5584   -2.5131    2.3784 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6269    1.0496    1.9426 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.1369    3.3228    3.7411 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8610    3.8563    2.1694 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.9591    1.0091    1.3917 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3385   -0.3310    2.5756 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.0786   -0.5210    3.9076 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2496   -1.5297    0.6939 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3730    4.5617   -5.9347 H   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.3958    3.4284   -2.6111 H   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3896   -5.9719   -0.6239 H   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5884   -0.0254    0.6887 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9501    1.9220    0.7076 H   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5415    2.4932    4.1122 H   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2641    3.4948    1.3356 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3656    1.4096    3.2921 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.8397    1.2901    1.8030 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0839   -1.0605    2.2658 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7602   -0.9869    4.4084 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  3
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  5  8  2  0
  8  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  2  0
 11 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
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 18 19  1  0
 17 20  1  0
 20 21  2  0
 21 22  1  0
 21 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 29 31  1  0
 28 32  1  0
 32 33  1  0
 32 34  1  0
 34 35  1  0
 25 36  2  0
 10  3  1  0
 36 14  1  0
 15  8  1  0
 36 20  1  0
 34 26  1  0
  1 37  1  0
  1 38  1  0
  2 39  1  0
  4 40  1  0
  7 41  1  0
  7 42  1  0
  7 43  1  0
 10 44  1  0
 16 45  1  0
 19 46  1  0
 19 47  1  0
 19 48  1  0
 22 49  1  0
 23 50  1  0
 24 51  1  0
 26 52  1  6
 28 53  1  6
 29 54  1  6
 30 55  1  0
 30 56  1  0
 30 57  1  0
 31 58  1  0
 32 59  1  1
 33 60  1  0
 34 61  1  6
 35 62  1  0
M  END

HEADER    PROTEIN                                 24-JUN-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-JUN-21         0                                  
HETATM    1  C   UNK     0      -3.245   3.666  -5.327  0.00  0.00           C+0
HETATM    2  C   UNK     0      -2.294   3.633  -4.442  0.00  0.00           C+0
HETATM    3  C   UNK     0      -2.049   2.483  -3.591  0.00  0.00           C+0
HETATM    4  C   UNK     0      -2.798   1.330  -3.638  0.00  0.00           C+0
HETATM    5  C   UNK     0      -2.528   0.236  -2.792  0.00  0.00           C+0
HETATM    6  O   UNK     0      -3.338  -0.861  -2.926  0.00  0.00           O+0
HETATM    7  C   UNK     0      -4.394  -0.986  -3.818  0.00  0.00           C+0
HETATM    8  C   UNK     0      -1.490   0.355  -1.915  0.00  0.00           C+0
HETATM    9  C   UNK     0      -0.723   1.497  -1.845  0.00  0.00           C+0
HETATM   10  C   UNK     0      -1.003   2.546  -2.676  0.00  0.00           C+0
HETATM   11  C   UNK     0       0.321   1.555  -0.930  0.00  0.00           C+0
HETATM   12  O   UNK     0       0.973   2.626  -0.926  0.00  0.00           O+0
HETATM   13  O   UNK     0       0.589   0.558  -0.142  0.00  0.00           O+0
HETATM   14  C   UNK     0      -0.100  -0.520  -0.175  0.00  0.00           C+0
HETATM   15  C   UNK     0      -1.182  -0.694  -1.061  0.00  0.00           C+0
HETATM   16  C   UNK     0      -1.894  -1.825  -1.088  0.00  0.00           C+0
HETATM   17  C   UNK     0      -1.571  -2.892  -0.214  0.00  0.00           C+0
HETATM   18  O   UNK     0      -2.263  -3.984  -0.245  0.00  0.00           O+0
HETATM   19  C   UNK     0      -2.979  -5.031  -0.323  0.00  0.00           C+0
HETATM   20  C   UNK     0      -0.485  -2.694   0.663  0.00  0.00           C+0
HETATM   21  C   UNK     0      -0.198  -3.767   1.489  0.00  0.00           C+0
HETATM   22  O   UNK     0      -0.938  -4.951   1.464  0.00  0.00           O+0
HETATM   23  C   UNK     0       0.852  -3.654   2.359  0.00  0.00           C+0
HETATM   24  C   UNK     0       1.558  -2.513   2.378  0.00  0.00           C+0
HETATM   25  C   UNK     0       1.318  -1.375   1.561  0.00  0.00           C+0
HETATM   26  C   UNK     0       2.125  -0.206   1.675  0.00  0.00           C+0
HETATM   27  O   UNK     0       1.627   1.050   1.943  0.00  0.00           O+0
HETATM   28  C   UNK     0       2.796   1.817   1.824  0.00  0.00           C+0
HETATM   29  C   UNK     0       2.645   3.196   2.346  0.00  0.00           C+0
HETATM   30  C   UNK     0       2.137   3.323   3.741  0.00  0.00           C+0
HETATM   31  O   UNK     0       3.861   3.856   2.169  0.00  0.00           O+0
HETATM   32  C   UNK     0       3.959   1.054   2.325  0.00  0.00           C+0
HETATM   33  O   UNK     0       4.959   1.009   1.392  0.00  0.00           O+0
HETATM   34  C   UNK     0       3.338  -0.331   2.576  0.00  0.00           C+0
HETATM   35  O   UNK     0       3.079  -0.521   3.908  0.00  0.00           O+0
HETATM   36  C   UNK     0       0.250  -1.530   0.694  0.00  0.00           C+0
HETATM   37  H   UNK     0      -3.373   4.562  -5.935  0.00  0.00           H+0
HETATM   38  H   UNK     0      -3.922   2.849  -5.500  0.00  0.00           H+0
HETATM   39  H   UNK     0      -1.643   4.503  -4.325  0.00  0.00           H+0
HETATM   40  H   UNK     0      -3.619   1.245  -4.338  0.00  0.00           H+0
HETATM   41  H   UNK     0      -4.095  -0.959  -4.879  0.00  0.00           H+0
HETATM   42  H   UNK     0      -4.952  -1.925  -3.636  0.00  0.00           H+0
HETATM   43  H   UNK     0      -5.131  -0.162  -3.606  0.00  0.00           H+0
HETATM   44  H   UNK     0      -0.396   3.428  -2.611  0.00  0.00           H+0
HETATM   45  H   UNK     0      -2.715  -2.032  -1.720  0.00  0.00           H+0
HETATM   46  H   UNK     0      -3.860  -5.050  -1.050  0.00  0.00           H+0
HETATM   47  H   UNK     0      -2.390  -5.972  -0.624  0.00  0.00           H+0
HETATM   48  H   UNK     0      -3.500  -5.384   0.638  0.00  0.00           H+0
HETATM   49  H   UNK     0      -0.683  -5.700   2.087  0.00  0.00           H+0
HETATM   50  H   UNK     0       1.138  -4.464   3.042  0.00  0.00           H+0
HETATM   51  H   UNK     0       2.405  -2.426   3.063  0.00  0.00           H+0
HETATM   52  H   UNK     0       2.588  -0.025   0.689  0.00  0.00           H+0
HETATM   53  H   UNK     0       2.950   1.922   0.708  0.00  0.00           H+0
HETATM   54  H   UNK     0       1.916   3.736   1.678  0.00  0.00           H+0
HETATM   55  H   UNK     0       1.508   4.255   3.857  0.00  0.00           H+0
HETATM   56  H   UNK     0       1.542   2.493   4.112  0.00  0.00           H+0
HETATM   57  H   UNK     0       3.004   3.500   4.431  0.00  0.00           H+0
HETATM   58  H   UNK     0       4.264   3.495   1.336  0.00  0.00           H+0
HETATM   59  H   UNK     0       4.366   1.410   3.292  0.00  0.00           H+0
HETATM   60  H   UNK     0       5.840   1.290   1.803  0.00  0.00           H+0
HETATM   61  H   UNK     0       4.084  -1.061   2.266  0.00  0.00           H+0
HETATM   62  H   UNK     0       3.760  -0.987   4.408  0.00  0.00           H+0
CONECT    1    2   37   38                                                  
CONECT    2    1    3   39                                                  
CONECT    3    2    4   10                                                  
CONECT    4    3    5   40                                                  
CONECT    5    4    6    8                                                  
CONECT    6    5    7                                                       
CONECT    7    6   41   42   43                                             
CONECT    8    5    9   15                                                  
CONECT    9    8   10   11                                                  
CONECT   10    9    3   44                                                  
CONECT   11    9   12   13                                                  
CONECT   12   11                                                            
CONECT   13   11   14                                                       
CONECT   14   13   15   36                                                  
CONECT   15   14   16    8                                                  
CONECT   16   15   17   45                                                  
CONECT   17   16   18   20                                                  
CONECT   18   17   19                                                       
CONECT   19   18   46   47   48                                             
CONECT   20   17   21   36                                                  
CONECT   21   20   22   23                                                  
CONECT   22   21   49                                                       
CONECT   23   21   24   50                                                  
CONECT   24   23   25   51                                                  
CONECT   25   24   26   36                                                  
CONECT   26   25   27   34   52                                             
CONECT   27   26   28                                                       
CONECT   28   27   29   32   53                                             
CONECT   29   28   30   31   54                                             
CONECT   30   29   55   56   57                                             
CONECT   31   29   58                                                       
CONECT   32   28   33   34   59                                             
CONECT   33   32   60                                                       
CONECT   34   32   35   26   61                                             
CONECT   35   34   62                                                       
CONECT   36   25   14   20                                                  
CONECT   37    1                                                            
CONECT   38    1                                                            
CONECT   39    2                                                            
CONECT   40    4                                                            
CONECT   41    7                                                            
CONECT   42    7                                                            
CONECT   43    7                                                            
CONECT   44   10                                                            
CONECT   45   16                                                            
CONECT   46   19                                                            
CONECT   47   19                                                            
CONECT   48   19                                                            
CONECT   49   22                                                            
CONECT   50   23                                                            
CONECT   51   24                                                            
CONECT   52   26                                                            
CONECT   53   28                                                            
CONECT   54   29                                                            
CONECT   55   30                                                            
CONECT   56   30                                                            
CONECT   57   30                                                            
CONECT   58   31                                                            
CONECT   59   32                                                            
CONECT   60   33                                                            
CONECT   61   34                                                            
CONECT   62   35                                                            
MASTER        0    0    0    0    0    0    0    0   62    0  132    0
END

RDKit          3D

62 66  0  0  0  0  0  0  0  0999 V2000
   -3.2452    3.6657   -5.3275 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2936    3.6327   -4.4425 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0488    2.4833   -3.5909 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7983    1.3297   -3.6381 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5280    0.2357   -2.7919 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3384   -0.8605   -2.9256 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3944   -0.9855   -3.8178 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4898    0.3551   -1.9145 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7232    1.4971   -1.8453 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0032    2.5463   -2.6759 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3214    1.5554   -0.9299 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9726    2.6263   -0.9260 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5887    0.5583   -0.1417 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1001   -0.5199   -0.1749 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1822   -0.6939   -1.0605 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8937   -1.8247   -1.0881 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5713   -2.8919   -0.2138 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2632   -3.9838   -0.2451 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9794   -5.0311   -0.3228 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4849   -2.6936    0.6626 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1979   -3.7672    1.4890 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9380   -4.9513    1.4635 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8520   -3.6537    2.3590 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5584   -2.5131    2.3784 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3179   -1.3747    1.5606 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1248   -0.2057    1.6751 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.6269    1.0496    1.9426 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7958    1.8175    1.8242 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.6451    3.1962    2.3459 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.1369    3.3228    3.7411 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8610    3.8563    2.1694 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9592    1.0536    2.3250 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.9591    1.0091    1.3917 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3385   -0.3310    2.5756 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.0786   -0.5210    3.9076 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2496   -1.5297    0.6939 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3730    4.5617   -5.9347 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9220    2.8492   -5.4997 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6433    4.5028   -4.3252 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6188    1.2446   -4.3375 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0950   -0.9594   -4.8786 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9516   -1.9253   -3.6363 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1307   -0.1616   -3.6064 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3958    3.4284   -2.6111 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7145   -2.0318   -1.7196 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8597   -5.0503   -1.0498 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3896   -5.9719   -0.6239 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4999   -5.3841    0.6379 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6828   -5.6996    2.0871 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1381   -4.4641    3.0419 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4045   -2.4258    3.0631 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5884   -0.0254    0.6887 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9501    1.9220    0.7076 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9157    3.7361    1.6781 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5076    4.2551    3.8572 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5415    2.4932    4.1122 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0041    3.5004    4.4305 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2641    3.4948    1.3356 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3656    1.4096    3.2921 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.8397    1.2901    1.8030 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0839   -1.0605    2.2658 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7602   -0.9869    4.4084 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  3
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  5  8  2  0
  8  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  2  0
 11 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  1  0
 17 20  1  0
 20 21  2  0
 21 22  1  0
 21 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 29 31  1  0
 28 32  1  0
 32 33  1  0
 32 34  1  0
 34 35  1  0
 25 36  2  0
 10  3  1  0
 36 14  1  0
 15  8  1  0
 36 20  1  0
 34 26  1  0
  1 37  1  0
  1 38  1  0
  2 39  1  0
  4 40  1  0
  7 41  1  0
  7 42  1  0
  7 43  1  0
 10 44  1  0
 16 45  1  0
 19 46  1  0
 19 47  1  0
 19 48  1  0
 22 49  1  0
 23 50  1  0
 24 51  1  0
 26 52  1  6
 28 53  1  6
 29 54  1  6
 30 55  1  0
 30 56  1  0
 30 57  1  0
 31 58  1  0
 32 59  1  1
 33 60  1  0
 34 61  1  6
 35 62  1  0
M  END

View in JSmol View NMR Assignments

Synonyms

Value	Source
4-Fucofuranose-1-hydroxy-10,12-dimethoxy-8-vinyl-6H-benz(D)naphtho(1,2b)pyran-6-one	MeSH

Chemical Formula

C₂₇H₂₆O₉

Average Mass

494.4960 Da

Monoisotopic Mass

494.15768 Da

IUPAC Name

12-[(2R,3R,4R,5S)-3,4-dihydroxy-5-[(1R)-1-hydroxyethyl]oxolan-2-yl]-5-ethenyl-15-hydroxy-3,17-dimethoxy-9-oxatetracyclo[8.8.0.0^{2,7}.0^{11,16}]octadeca-1(10),2,4,6,11,13,15,17-octaen-8-one

Traditional Name

12-[(2R,3R,4R,5S)-3,4-dihydroxy-5-[(1R)-1-hydroxyethyl]oxolan-2-yl]-5-ethenyl-15-hydroxy-3,17-dimethoxy-9-oxatetracyclo[8.8.0.0^{2,7}.0^{11,16}]octadeca-1(10),2,4,6,11,13,15,17-octaen-8-one

CAS Registry Number

Not Available

SMILES

COC1=CC2=C(OC(=O)C3=CC(C=C)=CC(OC)=C23)C2=C(C=CC(O)=C12)[C@H]1O[C@@H]([C@@H](C)O)[C@H](O)[C@H]1O

InChI Identifier

InChI=1S/C27H26O9/c1-5-12-8-15-19(17(9-12)33-3)14-10-18(34-4)21-16(29)7-6-13(20(21)25(14)36-27(15)32)26-23(31)22(30)24(35-26)11(2)28/h5-11,22-24,26,28-31H,1H2,2-4H3/t11-,22-,23-,24+,26-/m1/s1

InChI Key

XCWHINLKQMCRON-UCDARZNSSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Streptomyces anandii	NPAtlas	7344705
Streptomyces anandii C-22437	Bacteria	KNApSAcK

Chemical Taxonomy

Classification

Not classified

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.78	ALOGPS
logP	2.32	ChemAxon
logS	-3.5	ALOGPS
pKa (Strongest Acidic)	8.52	ChemAxon
pKa (Strongest Basic)	-3.1	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	8	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	134.91 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	129.56 m³·mol⁻¹	ChemAxon
Polarizability	52.75 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

NPAtlas ID

NPA009430

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

9202598

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

11027418

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Balitz DM, O'Herron FA, Bush J, Vyas DM, Nettleton DE, Grulich RE, Bradner WT, Doyle TW, Arnold E, Clardy J: Antitumor agents from Streptomyces anandii: gilvocarcins V, M and E. J Antibiot (Tokyo). 1981 Dec;34(12):1544-55. doi: 10.7164/antibiotics.34.1544. [PubMed:7344705 ]

Showing NP-Card for Gilvocarcin V (NP0022146)

MOL for NP0022146 (Gilvocarcin V)

3D MOL for NP0022146 (Gilvocarcin V)

3D SDF for NP0022146 (Gilvocarcin V)

3D-SDF for NP0022146 (Gilvocarcin V)

PDB for NP0022146 (Gilvocarcin V)

3D PDB for NP0022146 (Gilvocarcin V)

SMILES for NP0022146 (Gilvocarcin V)

INCHI for NP0022146 (Gilvocarcin V)

Structure for NP0022146 (Gilvocarcin V)

3D Structure for NP0022146 (Gilvocarcin V)