NP-MRD: Showing NP-Card for 6-hydroxyphenazine-1-carboxamide (NP0019363)

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Record Information

Version

2.0

Created at

2021-01-06 04:53:55 UTC

Updated at

2021-07-15 17:30:46 UTC

NP-MRD ID

NP0019363

Secondary Accession Numbers

None

Natural Product Identification

Common Name

6-hydroxyphenazine-1-carboxamide

Provided By

NPAtlas

Description

6-hydroxyphenazine-1-carboxamide is found in bacterium and Streptomyces diastaticus. 6-hydroxyphenazine-1-carboxamide was first documented in 2019 (PMID: 30858498). Based on a literature review very few articles have been published on 6-hydroxyphenazine-1-carboxamide.

Structure

MOL 3D MOL SDF 3D SDF PDB SMILES InChI


  Mrv1652306242120163D          

 27 29  0  0  0  0            999 V2000
   -4.0725   -1.5039    0.7301 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6956   -1.2842    0.5603 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9332   -2.2614    0.8168 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1413   -0.0005    0.1106 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9592    1.0731   -0.1727 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4265    2.2750   -0.5947 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0573    2.3708   -0.7244 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2062    1.3087   -0.4473 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1275    1.4132   -0.5772 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8745    0.3354   -0.2875 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2461    0.4130   -0.4116 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8014    1.6120   -0.8343 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0661   -0.6703   -0.1254 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4850   -1.8710    0.2998 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1165   -1.9593    0.4271 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3176   -0.8755    0.1392 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0178   -0.9695    0.2659 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7725    0.1048   -0.0222 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4182   -2.0840    1.5125 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7447   -1.0822    0.0676 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0214    0.9497   -0.0564 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0753    3.1187   -0.8168 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6242    3.3017   -1.0528 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2203    2.4103   -1.0469 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1296   -0.5475   -0.2416 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1385   -2.7068    0.5191 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6427   -2.8704    0.7520 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18  4  1  0  0  0  0
 18  8  1  0  0  0  0
 16 10  1  0  0  0  0
  1 19  1  0  0  0  0
  1 20  1  0  0  0  0
  5 21  1  0  0  0  0
  6 22  1  0  0  0  0
  7 23  1  0  0  0  0
 12 24  1  0  0  0  0
 13 25  1  0  0  0  0
 14 26  1  0  0  0  0
 15 27  1  0  0  0  0
M  END


  Mrv1652306242120163D          

 27 29  0  0  0  0            999 V2000
   -4.0725   -1.5039    0.7301 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6956   -1.2842    0.5603 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9332   -2.2614    0.8168 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1413   -0.0005    0.1106 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9592    1.0731   -0.1727 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4265    2.2750   -0.5947 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0573    2.3708   -0.7244 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2062    1.3087   -0.4473 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1275    1.4132   -0.5772 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8745    0.3354   -0.2875 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2461    0.4130   -0.4116 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8014    1.6120   -0.8343 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0661   -0.6703   -0.1254 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4850   -1.8710    0.2998 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1165   -1.9593    0.4271 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3176   -0.8755    0.1392 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0178   -0.9695    0.2659 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7725    0.1048   -0.0222 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4182   -2.0840    1.5125 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7447   -1.0822    0.0676 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0214    0.9497   -0.0564 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0753    3.1187   -0.8168 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6242    3.3017   -1.0528 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2203    2.4103   -1.0469 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1296   -0.5475   -0.2416 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1385   -2.7068    0.5191 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6427   -2.8704    0.7520 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18  4  1  0  0  0  0
 18  8  1  0  0  0  0
 16 10  1  0  0  0  0
  1 19  1  0  0  0  0
  1 20  1  0  0  0  0
  5 21  1  0  0  0  0
  6 22  1  0  0  0  0
  7 23  1  0  0  0  0
 12 24  1  0  0  0  0
 13 25  1  0  0  0  0
 14 26  1  0  0  0  0
 15 27  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0019363

> <DATABASE_NAME>
NP-MRD

> <SMILES>
[H]OC1=C2N=C3C([H])=C([H])C([H])=C(C(=O)N([H])[H])C3=NC2=C([H])C([H])=C1[H]

> <INCHI_IDENTIFIER>
InChI=1S/C13H9N3O2/c14-13(18)7-3-1-4-8-11(7)15-9-5-2-6-10(17)12(9)16-8/h1-6,17H,(H2,14,18)

> <INCHI_KEY>
CICBWSRPGNLNJE-UHFFFAOYSA-N

> <FORMULA>
C13H9N3O2

> <MOLECULAR_WEIGHT>
239.234

> <EXACT_MASS>
239.069476542

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
27

> <JCHEM_AVERAGE_POLARIZABILITY>
24.07067746584338

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
6-hydroxyphenazine-1-carboxamide

> <ALOGPS_LOGP>
1.63

> <JCHEM_LOGP>
1.6073307506666668

> <ALOGPS_LOGS>
-2.61

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.589697983543157

> <JCHEM_PKA_STRONGEST_ACIDIC>
7.790173999702195

> <JCHEM_PKA_STRONGEST_BASIC>
0.11039431016206536

> <JCHEM_POLAR_SURFACE_AREA>
89.10000000000001

> <JCHEM_REFRACTIVITY>
64.2159

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
5.93e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
6-hydroxyphenazine-1-carboxamide

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 24-JUN-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-JUN-21         0                                  
HETATM    1  N   UNK     0      -4.072  -1.504   0.730  0.00  0.00           N+0
HETATM    2  C   UNK     0      -2.696  -1.284   0.560  0.00  0.00           C+0
HETATM    3  O   UNK     0      -1.933  -2.261   0.817  0.00  0.00           O+0
HETATM    4  C   UNK     0      -2.141  -0.001   0.111  0.00  0.00           C+0
HETATM    5  C   UNK     0      -2.959   1.073  -0.173  0.00  0.00           C+0
HETATM    6  C   UNK     0      -2.426   2.275  -0.595  0.00  0.00           C+0
HETATM    7  C   UNK     0      -1.057   2.371  -0.724  0.00  0.00           C+0
HETATM    8  C   UNK     0      -0.206   1.309  -0.447  0.00  0.00           C+0
HETATM    9  N   UNK     0       1.127   1.413  -0.577  0.00  0.00           N+0
HETATM   10  C   UNK     0       1.875   0.335  -0.288  0.00  0.00           C+0
HETATM   11  C   UNK     0       3.246   0.413  -0.412  0.00  0.00           C+0
HETATM   12  O   UNK     0       3.801   1.612  -0.834  0.00  0.00           O+0
HETATM   13  C   UNK     0       4.066  -0.670  -0.125  0.00  0.00           C+0
HETATM   14  C   UNK     0       3.485  -1.871   0.300  0.00  0.00           C+0
HETATM   15  C   UNK     0       2.116  -1.959   0.427  0.00  0.00           C+0
HETATM   16  C   UNK     0       1.318  -0.876   0.139  0.00  0.00           C+0
HETATM   17  N   UNK     0      -0.018  -0.970   0.266  0.00  0.00           N+0
HETATM   18  C   UNK     0      -0.773   0.105  -0.022  0.00  0.00           C+0
HETATM   19  H   UNK     0      -4.418  -2.084   1.513  0.00  0.00           H+0
HETATM   20  H   UNK     0      -4.745  -1.082   0.068  0.00  0.00           H+0
HETATM   21  H   UNK     0      -4.021   0.950  -0.056  0.00  0.00           H+0
HETATM   22  H   UNK     0      -3.075   3.119  -0.817  0.00  0.00           H+0
HETATM   23  H   UNK     0      -0.624   3.302  -1.053  0.00  0.00           H+0
HETATM   24  H   UNK     0       3.220   2.410  -1.047  0.00  0.00           H+0
HETATM   25  H   UNK     0       5.130  -0.548  -0.242  0.00  0.00           H+0
HETATM   26  H   UNK     0       4.138  -2.707   0.519  0.00  0.00           H+0
HETATM   27  H   UNK     0       1.643  -2.870   0.752  0.00  0.00           H+0
CONECT    1    2   19   20                                                  
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5   18                                                  
CONECT    5    4    6   21                                                  
CONECT    6    5    7   22                                                  
CONECT    7    6    8   23                                                  
CONECT    8    7    9   18                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11   16                                                  
CONECT   11   10   12   13                                                  
CONECT   12   11   24                                                       
CONECT   13   11   14   25                                                  
CONECT   14   13   15   26                                                  
CONECT   15   14   16   27                                                  
CONECT   16   15   17   10                                                  
CONECT   17   16   18                                                       
CONECT   18   17    4    8                                                  
CONECT   19    1                                                            
CONECT   20    1                                                            
CONECT   21    5                                                            
CONECT   22    6                                                            
CONECT   23    7                                                            
CONECT   24   12                                                            
CONECT   25   13                                                            
CONECT   26   14                                                            
CONECT   27   15                                                            
MASTER        0    0    0    0    0    0    0    0   27    0   58    0
END

View in JSmol View NMR Assignments

Synonyms

Value	Source
6-Hydroxyphenazine-1-carboximidate	Generator

Chemical Formula

C₁₃H₉N₃O₂

Average Mass

239.2340 Da

Monoisotopic Mass

239.06948 Da

IUPAC Name

6-hydroxyphenazine-1-carboxamide

Traditional Name

6-hydroxyphenazine-1-carboxamide

CAS Registry Number

Not Available

SMILES

NC(=O)C1=C2N=C3C=CC=C(O)C3=NC2=CC=C1

InChI Identifier

InChI=1S/C13H9N3O2/c14-13(18)7-3-1-4-8-11(7)15-9-5-2-6-10(17)12(9)16-8/h1-6,17H,(H2,14,18)

InChI Key

CICBWSRPGNLNJE-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Bacterium; sewage; soil	NPAtlas	30858498
Streptomyces diastaticus	LOTUS Database	35616633

Chemical Taxonomy

Classification

Not classified

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.63	ALOGPS
logP	1.61	ChemAxon
logS	-2.6	ALOGPS
pKa (Strongest Acidic)	7.79	ChemAxon
pKa (Strongest Basic)	0.11	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	89.1 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	64.22 m³·mol⁻¹	ChemAxon
Polarizability	24.07 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

NPAtlas ID

NPA024910

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

137350260

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Hu L, Chen X, Han L, Zhao L, Miao C, Huang X, Chen Y, Li P, Li Y: Two new phenazine metabolites with antimicrobial activities from soil-derived Streptomyces species. J Antibiot (Tokyo). 2019 Jul;72(7):574-577. doi: 10.1038/s41429-019-0163-2. Epub 2019 Mar 11. [PubMed:30858498 ]

Showing NP-Card for 6-hydroxyphenazine-1-carboxamide (NP0019363)

MOL for NP0019363 (6-hydroxyphenazine-1-carboxamide)

3D MOL for NP0019363 (6-hydroxyphenazine-1-carboxamide)

3D SDF for NP0019363 (6-hydroxyphenazine-1-carboxamide)

3D-SDF for NP0019363 (6-hydroxyphenazine-1-carboxamide)

PDB for NP0019363 (6-hydroxyphenazine-1-carboxamide)

3D PDB for NP0019363 (6-hydroxyphenazine-1-carboxamide)

SMILES for NP0019363 (6-hydroxyphenazine-1-carboxamide)

INCHI for NP0019363 (6-hydroxyphenazine-1-carboxamide)

Structure for NP0019363 (6-hydroxyphenazine-1-carboxamide)

3D Structure for NP0019363 (6-hydroxyphenazine-1-carboxamide)