NP-MRD: Showing NP-Card for Kapurimycin A3 (NP0010951)

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Record Information

Version

1.0

Created at

2021-01-05 20:44:41 UTC

Updated at

2021-07-15 17:07:32 UTC

NP-MRD ID

NP0010951

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Kapurimycin A3

Provided By

NPAtlas

Description

2-[8-(Acetyloxy)-12-hydroxy-2-[2-methyl-3-(prop-1-en-1-yl)oxiran-2-yl]-4,11-dioxo-8,9,10,11-tetrahydro-4H-1-oxatetraphen-5-yl]acetic acid belongs to the class of organic compounds known as naphthopyranones. Naphthopyranones are compounds containing a naphthopyran skeleton where a ring carbon bears a carboxylic acid group. Naphthtopyran is made up of the pyran ring fused to a naphthalene ring system. Kapurimycin A3 is found in Streptomyces sp. It was first documented in 1990 (PMID: 2276971). Based on a literature review very few articles have been published on 2-[8-(acetyloxy)-12-hydroxy-2-[2-methyl-3-(prop-1-en-1-yl)oxiran-2-yl]-4,11-dioxo-8,9,10,11-tetrahydro-4H-1-oxatetraphen-5-yl]acetic acid.

Structure

MOL 3D MOL SDF 3D SDF PDB SMILES InChI


  Mrv1652306242107423D          

 60 64  0  0  0  0            999 V2000
   -7.1659   -3.3150    0.3213 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9077   -2.5575   -0.0173 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END

     RDKit          3D

 60 64  0  0  0  0  0  0  0  0999 V2000
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M  END


  Mrv1652306242107423D          

 60 64  0  0  0  0            999 V2000
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    1.4155   -3.5697   -0.2049 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1755   -2.3049   -2.2045 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.4288   -1.2844   -1.1248 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.9622   -1.7681    0.0424 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0574   -1.3345    0.7572 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5113   -2.0179    2.0047 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6409   -0.3649    0.3342 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9464   -4.4118    0.2455 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0125   -3.0209   -0.2824 H   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.9462   -3.0191    0.1473 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8146   -0.7763   -0.7074 H   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.6054    0.1692    1.5570 H   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8563    1.4149   -0.7848 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4329   -2.4624   -0.3957 H   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5749   -3.6428   -2.7157 H   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7578   -1.8039   -3.1016 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0607   -0.4868   -1.4983 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.4701   -1.3704    2.8852 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.4766   -2.4578    1.7806 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7949   -2.8833    2.1519 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  1  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
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 23 25  1  0  0  0  0
 25 26  2  0  0  0  0
 26 27  1  0  0  0  0
 22 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
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 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  2  0  0  0  0
  6  4  1  0  0  0  0
 27  8  1  0  0  0  0
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  1 37  1  0  0  0  0
  1 38  1  0  0  0  0
  1 39  1  0  0  0  0
  2 40  1  0  0  0  0
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  4 42  1  6  0  0  0
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  7 45  1  0  0  0  0
  9 46  1  0  0  0  0
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 32 57  1  6  0  0  0
 35 58  1  0  0  0  0
 35 59  1  0  0  0  0
 35 60  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0010951

> <DATABASE_NAME>
NP-MRD

> <SMILES>
[H]OC(=O)C([H])([H])C1=C2C(=O)C([H])=C(OC2=C2C(O[H])=C3C(=O)C([H])([H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])[H])C3=C([H])C2=C1[H])[C@@]1(O[C@@]1([H])C(\[H])=C(/[H])C([H])([H])[H])C([H])([H])[H]

> <INCHI_IDENTIFIER>
InChI=1S/C27H24O9/c1-4-5-19-27(3,36-19)20-11-17(30)22-14(10-21(31)32)8-13-9-15-18(34-12(2)28)7-6-16(29)24(15)25(33)23(13)26(22)35-20/h4-5,8-9,11,18-19,33H,6-7,10H2,1-3H3,(H,31,32)/b5-4+/t18-,19-,27+/m0/s1

> <INCHI_KEY>
GMKMVBAGONGKOV-UHFFFAOYSA-N

> <FORMULA>
C27H24O9

> <MOLECULAR_WEIGHT>
492.48

> <EXACT_MASS>
492.142032353

> <JCHEM_ACCEPTOR_COUNT>
8

> <JCHEM_ATOM_COUNT>
60

> <JCHEM_AVERAGE_POLARIZABILITY>
51.044305689442524

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
2-[(8S)-8-(acetyloxy)-12-hydroxy-2-[(2R,3S)-2-methyl-3-[(1E)-prop-1-en-1-yl]oxiran-2-yl]-4,11-dioxo-8,9,10,11-tetrahydro-4H-1-oxatetraphen-5-yl]acetic acid

> <ALOGPS_LOGP>
3.26

> <JCHEM_LOGP>
3.3060934093333323

> <ALOGPS_LOGS>
-4.66

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
7.292973794862078

> <JCHEM_PKA_STRONGEST_ACIDIC>
3.5021439260406644

> <JCHEM_PKA_STRONGEST_BASIC>
-4.270354148947288

> <JCHEM_POLAR_SURFACE_AREA>
139.73000000000002

> <JCHEM_REFRACTIVITY>
128.92229999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.08e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
[(8S)-8-(acetyloxy)-12-hydroxy-2-[(2R,3S)-2-methyl-3-[(1E)-prop-1-en-1-yl]oxiran-2-yl]-4,11-dioxo-9,10-dihydro-8H-1-oxatetraphen-5-yl]acetic acid

> <JCHEM_VEBER_RULE>
0

$$$$

     RDKit          3D

 60 64  0  0  0  0  0  0  0  0999 V2000
   -7.1659   -3.3150    0.3213 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9077   -2.5575   -0.0173 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.5199   -1.3493   -0.2422 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.5572   -0.0976    1.6430 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7762    0.9233    0.1431 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9370    2.2787    0.2321 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8640    3.1662    0.1354 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0529    4.3672    0.2190 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6269    2.6329   -0.0537 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4780    3.4275   -0.1610 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5297    4.8980    0.0102 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6885    5.3470    1.3897 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6999    2.7420   -0.3731 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7987    1.3801   -0.4637 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0357    0.7425   -0.7044 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1084   -0.6099   -0.8190 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9774   -1.3818   -0.7009 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7655   -0.7807   -0.4663 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3854   -1.5039   -0.3438 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6833    0.6147   -0.3489 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5325    1.2366   -0.1419 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5618    0.4501   -0.0449 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1432   -2.8012   -0.8629 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4155   -3.5697   -0.2049 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1417   -3.3304   -1.7840 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1755   -2.3049   -2.2045 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4288   -1.2844   -1.1248 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.9622   -1.7681    0.0424 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0574   -1.3345    0.7572 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5113   -2.0179    2.0047 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6409   -0.3649    0.3342 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9464   -4.4118    0.2455 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0125   -3.0209   -0.2824 H   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.9462   -3.0191    0.1473 H   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.3951   -0.4605   -1.9059 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6054    0.1692    1.5570 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0116    0.5593    2.3644 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4078   -1.1318    2.0396 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9412    2.7067    0.3877 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2572    5.4447   -0.5689 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4522    5.2389   -0.5475 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9842    6.2561    2.7456 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6022    3.3682   -0.4703 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8563    1.4149   -0.7848 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4329   -2.4624   -0.3957 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5267   -4.2537   -1.3638 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5749   -3.6428   -2.7157 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0648   -2.8329   -2.5402 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7578   -1.8039   -3.1016 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0607   -0.4868   -1.4983 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.4701   -1.3704    2.8852 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.4766   -2.4578    1.7806 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7949   -2.8833    2.1519 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  1
  6  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 15 17  1  0
 13 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 23 25  1  0
 25 26  2  0
 26 27  1  0
 22 28  1  0
 28 29  2  0
 28 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 34 35  1  0
 34 36  2  0
  6  4  1  0
 27  8  1  0
 26 12  1  0
 25 19  1  0
 32 21  1  0
  1 37  1  0
  1 38  1  0
  1 39  1  0
  2 40  1  0
  3 41  1  0
  4 42  1  6
  7 43  1  0
  7 44  1  0
  7 45  1  0
  9 46  1  0
 14 47  1  0
 14 48  1  0
 17 49  1  0
 18 50  1  0
 20 51  1  0
 24 52  1  0
 30 53  1  0
 30 54  1  0
 31 55  1  0
 31 56  1  0
 32 57  1  6
 35 58  1  0
 35 59  1  0
 35 60  1  0
M  END

HEADER    PROTEIN                                 24-JUN-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-JUN-21         0                                  
HETATM    1  C   UNK     0      -7.166  -3.315   0.321  0.00  0.00           C+0
HETATM    2  C   UNK     0      -5.908  -2.558  -0.017  0.00  0.00           C+0
HETATM    3  C   UNK     0      -5.921  -1.321  -0.521  0.00  0.00           C+0
HETATM    4  C   UNK     0      -4.599  -0.663  -0.820  0.00  0.00           C+0
HETATM    5  O   UNK     0      -3.520  -1.349  -0.242  0.00  0.00           O+0
HETATM    6  C   UNK     0      -3.924   0.009   0.263  0.00  0.00           C+0
HETATM    7  C   UNK     0      -4.557  -0.098   1.643  0.00  0.00           C+0
HETATM    8  C   UNK     0      -2.776   0.923   0.143  0.00  0.00           C+0
HETATM    9  C   UNK     0      -2.937   2.279   0.232  0.00  0.00           C+0
HETATM   10  C   UNK     0      -1.864   3.166   0.135  0.00  0.00           C+0
HETATM   11  O   UNK     0      -2.053   4.367   0.219  0.00  0.00           O+0
HETATM   12  C   UNK     0      -0.627   2.633  -0.054  0.00  0.00           C+0
HETATM   13  C   UNK     0       0.478   3.428  -0.161  0.00  0.00           C+0
HETATM   14  C   UNK     0       0.530   4.898   0.010  0.00  0.00           C+0
HETATM   15  C   UNK     0       0.689   5.347   1.390  0.00  0.00           C+0
HETATM   16  O   UNK     0      -0.261   5.349   2.211  0.00  0.00           O+0
HETATM   17  O   UNK     0       1.921   5.788   1.861  0.00  0.00           O+0
HETATM   18  C   UNK     0       1.700   2.742  -0.373  0.00  0.00           C+0
HETATM   19  C   UNK     0       1.799   1.380  -0.464  0.00  0.00           C+0
HETATM   20  C   UNK     0       3.036   0.743  -0.704  0.00  0.00           C+0
HETATM   21  C   UNK     0       3.108  -0.610  -0.819  0.00  0.00           C+0
HETATM   22  C   UNK     0       1.977  -1.382  -0.701  0.00  0.00           C+0
HETATM   23  C   UNK     0       0.766  -0.781  -0.466  0.00  0.00           C+0
HETATM   24  O   UNK     0      -0.385  -1.504  -0.344  0.00  0.00           O+0
HETATM   25  C   UNK     0       0.683   0.615  -0.349  0.00  0.00           C+0
HETATM   26  C   UNK     0      -0.533   1.237  -0.142  0.00  0.00           C+0
HETATM   27  O   UNK     0      -1.562   0.450  -0.045  0.00  0.00           O+0
HETATM   28  C   UNK     0       2.143  -2.801  -0.863  0.00  0.00           C+0
HETATM   29  O   UNK     0       1.416  -3.570  -0.205  0.00  0.00           O+0
HETATM   30  C   UNK     0       3.142  -3.330  -1.784  0.00  0.00           C+0
HETATM   31  C   UNK     0       4.176  -2.305  -2.204  0.00  0.00           C+0
HETATM   32  C   UNK     0       4.429  -1.284  -1.125  0.00  0.00           C+0
HETATM   33  O   UNK     0       4.962  -1.768   0.042  0.00  0.00           O+0
HETATM   34  C   UNK     0       6.057  -1.335   0.757  0.00  0.00           C+0
HETATM   35  C   UNK     0       6.511  -2.018   2.005  0.00  0.00           C+0
HETATM   36  O   UNK     0       6.641  -0.365   0.334  0.00  0.00           O+0
HETATM   37  H   UNK     0      -6.946  -4.412   0.246  0.00  0.00           H+0
HETATM   38  H   UNK     0      -8.012  -3.021  -0.282  0.00  0.00           H+0
HETATM   39  H   UNK     0      -7.421  -3.139   1.415  0.00  0.00           H+0
HETATM   40  H   UNK     0      -4.946  -3.019   0.147  0.00  0.00           H+0
HETATM   41  H   UNK     0      -6.815  -0.776  -0.707  0.00  0.00           H+0
HETATM   42  H   UNK     0      -4.395  -0.461  -1.906  0.00  0.00           H+0
HETATM   43  H   UNK     0      -5.605   0.169   1.557  0.00  0.00           H+0
HETATM   44  H   UNK     0      -4.012   0.559   2.364  0.00  0.00           H+0
HETATM   45  H   UNK     0      -4.408  -1.132   2.040  0.00  0.00           H+0
HETATM   46  H   UNK     0      -3.941   2.707   0.388  0.00  0.00           H+0
HETATM   47  H   UNK     0      -0.257   5.445  -0.569  0.00  0.00           H+0
HETATM   48  H   UNK     0       1.452   5.239  -0.548  0.00  0.00           H+0
HETATM   49  H   UNK     0       1.984   6.256   2.746  0.00  0.00           H+0
HETATM   50  H   UNK     0       2.602   3.368  -0.470  0.00  0.00           H+0
HETATM   51  H   UNK     0       3.856   1.415  -0.785  0.00  0.00           H+0
HETATM   52  H   UNK     0      -0.433  -2.462  -0.396  0.00  0.00           H+0
HETATM   53  H   UNK     0       3.527  -4.254  -1.364  0.00  0.00           H+0
HETATM   54  H   UNK     0       2.575  -3.643  -2.716  0.00  0.00           H+0
HETATM   55  H   UNK     0       5.065  -2.833  -2.540  0.00  0.00           H+0
HETATM   56  H   UNK     0       3.758  -1.804  -3.102  0.00  0.00           H+0
HETATM   57  H   UNK     0       5.061  -0.487  -1.498  0.00  0.00           H+0
HETATM   58  H   UNK     0       6.470  -1.370   2.885  0.00  0.00           H+0
HETATM   59  H   UNK     0       7.477  -2.458   1.781  0.00  0.00           H+0
HETATM   60  H   UNK     0       5.795  -2.883   2.152  0.00  0.00           H+0
CONECT    1    2   37   38   39                                             
CONECT    2    1    3   40                                                  
CONECT    3    2    4   41                                                  
CONECT    4    3    5    6   42                                             
CONECT    5    4    6                                                       
CONECT    6    5    7    8    4                                             
CONECT    7    6   43   44   45                                             
CONECT    8    6    9   27                                                  
CONECT    9    8   10   46                                                  
CONECT   10    9   11   12                                                  
CONECT   11   10                                                            
CONECT   12   10   13   26                                                  
CONECT   13   12   14   18                                                  
CONECT   14   13   15   47   48                                             
CONECT   15   14   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15   49                                                       
CONECT   18   13   19   50                                                  
CONECT   19   18   20   25                                                  
CONECT   20   19   21   51                                                  
CONECT   21   20   22   32                                                  
CONECT   22   21   23   28                                                  
CONECT   23   22   24   25                                                  
CONECT   24   23   52                                                       
CONECT   25   23   26   19                                                  
CONECT   26   25   27   12                                                  
CONECT   27   26    8                                                       
CONECT   28   22   29   30                                                  
CONECT   29   28                                                            
CONECT   30   28   31   53   54                                             
CONECT   31   30   32   55   56                                             
CONECT   32   31   33   21   57                                             
CONECT   33   32   34                                                       
CONECT   34   33   35   36                                                  
CONECT   35   34   58   59   60                                             
CONECT   36   34                                                            
CONECT   37    1                                                            
CONECT   38    1                                                            
CONECT   39    1                                                            
CONECT   40    2                                                            
CONECT   41    3                                                            
CONECT   42    4                                                            
CONECT   43    7                                                            
CONECT   44    7                                                            
CONECT   45    7                                                            
CONECT   46    9                                                            
CONECT   47   14                                                            
CONECT   48   14                                                            
CONECT   49   17                                                            
CONECT   50   18                                                            
CONECT   51   20                                                            
CONECT   52   24                                                            
CONECT   53   30                                                            
CONECT   54   30                                                            
CONECT   55   31                                                            
CONECT   56   31                                                            
CONECT   57   32                                                            
CONECT   58   35                                                            
CONECT   59   35                                                            
CONECT   60   35                                                            
MASTER        0    0    0    0    0    0    0    0   60    0  128    0
END

RDKit          3D

60 64  0  0  0  0  0  0  0  0999 V2000
   -7.1659   -3.3150    0.3213 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9077   -2.5575   -0.0173 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9210   -1.3214   -0.5210 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5995   -0.6633   -0.8204 C   0  0  2  0  0  0  0  0  0  0  0  0
   -3.5199   -1.3493   -0.2422 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9235    0.0091    0.2630 C   0  0  2  0  0  0  0  0  0  0  0  0
   -4.5572   -0.0976    1.6430 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7762    0.9233    0.1431 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9370    2.2787    0.2321 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8640    3.1662    0.1354 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0529    4.3672    0.2190 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6269    2.6329   -0.0537 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4780    3.4275   -0.1610 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5297    4.8980    0.0102 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6885    5.3470    1.3897 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2606    5.3487    2.2108 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9211    5.7880    1.8605 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6999    2.7420   -0.3731 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7987    1.3801   -0.4637 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0357    0.7425   -0.7044 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1084   -0.6099   -0.8190 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9774   -1.3818   -0.7009 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7655   -0.7807   -0.4663 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3854   -1.5039   -0.3438 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6833    0.6147   -0.3489 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5325    1.2366   -0.1419 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5618    0.4501   -0.0449 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1432   -2.8012   -0.8629 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4155   -3.5697   -0.2049 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1417   -3.3304   -1.7840 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1755   -2.3049   -2.2045 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4288   -1.2844   -1.1248 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.9622   -1.7681    0.0424 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0574   -1.3345    0.7572 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5113   -2.0179    2.0047 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6409   -0.3649    0.3342 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9464   -4.4118    0.2455 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0125   -3.0209   -0.2824 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4209   -3.1395    1.4145 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9462   -3.0191    0.1473 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8146   -0.7763   -0.7074 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3951   -0.4605   -1.9059 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6054    0.1692    1.5570 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0116    0.5593    2.3644 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4078   -1.1318    2.0396 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9412    2.7067    0.3877 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2572    5.4447   -0.5689 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4522    5.2389   -0.5475 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9842    6.2561    2.7456 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6022    3.3682   -0.4703 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8563    1.4149   -0.7848 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4329   -2.4624   -0.3957 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5267   -4.2537   -1.3638 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5749   -3.6428   -2.7157 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0648   -2.8329   -2.5402 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7578   -1.8039   -3.1016 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0607   -0.4868   -1.4983 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.4701   -1.3704    2.8852 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.4766   -2.4578    1.7806 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7949   -2.8833    2.1519 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  1
  6  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 15 17  1  0
 13 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 23 25  1  0
 25 26  2  0
 26 27  1  0
 22 28  1  0
 28 29  2  0
 28 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 34 35  1  0
 34 36  2  0
  6  4  1  0
 27  8  1  0
 26 12  1  0
 25 19  1  0
 32 21  1  0
  1 37  1  0
  1 38  1  0
  1 39  1  0
  2 40  1  0
  3 41  1  0
  4 42  1  6
  7 43  1  0
  7 44  1  0
  7 45  1  0
  9 46  1  0
 14 47  1  0
 14 48  1  0
 17 49  1  0
 18 50  1  0
 20 51  1  0
 24 52  1  0
 30 53  1  0
 30 54  1  0
 31 55  1  0
 31 56  1  0
 32 57  1  6
 35 58  1  0
 35 59  1  0
 35 60  1  0
M  END

View in JSmol View NMR Assignments

Synonyms

Value	Source
2-[8-(Acetyloxy)-12-hydroxy-2-[2-methyl-3-(prop-1-en-1-yl)oxiran-2-yl]-4,11-dioxo-8,9,10,11-tetrahydro-4H-1-oxatetraphen-5-yl]acetate	Generator

Chemical Formula

C₂₇H₂₄O₉

Average Mass

492.4800 Da

Monoisotopic Mass

492.14203 Da

IUPAC Name

2-[(8S)-8-(acetyloxy)-12-hydroxy-2-[(2R,3S)-2-methyl-3-[(1E)-prop-1-en-1-yl]oxiran-2-yl]-4,11-dioxo-8,9,10,11-tetrahydro-4H-1-oxatetraphen-5-yl]acetic acid

Traditional Name

[(8S)-8-(acetyloxy)-12-hydroxy-2-[(2R,3S)-2-methyl-3-[(1E)-prop-1-en-1-yl]oxiran-2-yl]-4,11-dioxo-9,10-dihydro-8H-1-oxatetraphen-5-yl]acetic acid

CAS Registry Number

Not Available

SMILES

CC=CC1OC1(C)C1=CC(=O)C2=C(O1)C1=C(O)C3=C(C=C1C=C2CC(O)=O)C(CCC3=O)OC(C)=O

InChI Identifier

InChI=1S/C27H24O9/c1-4-5-19-27(3,36-19)20-11-17(30)22-14(10-21(31)32)8-13-9-15-18(34-12(2)28)7-6-16(29)24(15)25(33)23(13)26(22)35-20/h4-5,8-9,11,18-19,33H,6-7,10H2,1-3H3,(H,31,32)

InChI Key

GMKMVBAGONGKOV-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Streptomyces sp.	NPAtlas	2276971

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as naphthopyranones. Naphthopyranones are compounds containing a naphthopyran skeleton where a ring carbon bears a carboxylic acid group. Naphthtopyran is made up of the pyran ring fused to a naphthalene ring system.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Naphthopyrans

Sub Class

Naphthopyranones

Direct Parent

Naphthopyranones

Alternative Parents

Substituents

Naphthopyranone
1-naphthol
Chromone
Naphthalene
Benzopyran
Tetralin
1-benzopyran
Aryl alkyl ketone
Aryl ketone
1-hydroxy-4-unsubstituted benzenoid
Pyranone
Dicarboxylic acid or derivatives
Pyran
Benzenoid
Heteroaromatic compound
Vinylogous acid
Carboxylic acid ester
Ketone
Carboxylic acid derivative
Carboxylic acid
Dialkyl ether
Oxacycle
Oxirane
Ether
Hydrocarbon derivative
Carbonyl group
Organic oxide
Organic oxygen compound
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.26	ALOGPS
logP	3.31	ChemAxon
logS	-4.7	ALOGPS
pKa (Strongest Acidic)	3.5	ChemAxon
pKa (Strongest Basic)	-4.3	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	8	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	139.73 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	128.92 m³·mol⁻¹	ChemAxon
Polarizability	51.04 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

NPAtlas ID

NPA001319

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

78409847

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Yoshida M, Hara M, Saitoh Y, Sano H: The kapurimycins, new antitumor antibiotics produced by Streptomyces. Physico-chemical properties and structure determination. J Antibiot (Tokyo). 1990 Dec;43(12):1519-23. doi: 10.7164/antibiotics.43.1519. [PubMed:2276971 ]

Showing NP-Card for Kapurimycin A3 (NP0010951)

MOL for NP0010951 (Kapurimycin A3)

3D MOL for NP0010951 (Kapurimycin A3)

3D SDF for NP0010951 (Kapurimycin A3)

3D-SDF for NP0010951 (Kapurimycin A3)

PDB for NP0010951 (Kapurimycin A3)

3D PDB for NP0010951 (Kapurimycin A3)

SMILES for NP0010951 (Kapurimycin A3)

INCHI for NP0010951 (Kapurimycin A3)

Structure for NP0010951 (Kapurimycin A3)

3D Structure for NP0010951 (Kapurimycin A3)