NP-MRD: Showing NP-Card for Cycloheximide (NP0007218)

Jump To Section:

Identification Spectra BioTaxonomy ChemoTaxonomy Physical properties Links References XML

Record Information

Version

1.0

Created at

2020-12-09 04:04:11 UTC

Updated at

2021-07-15 16:56:59 UTC

NP-MRD ID

NP0007218

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Cycloheximide

Provided By

NPAtlas

Description

Cycloheximide is found in Sesbania drummondii and Streptomyces griseus. It was first documented in 1948 (PMID: 17736575). Based on a literature review very few articles have been published on 4-[(2R)-2-[(1R,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]-6-hydroxy-2,3,4,5-tetrahydropyridin-2-one.

Structure

MOL 3D MOL SDF 3D SDF PDB SMILES InChI


  Mrv1652306242118383D          

 43 44  0  0  0  0            999 V2000
    2.8761    0.5534   -2.3017 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9275   -0.7197   -1.5130 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.8378   -0.6245   -0.3111 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.3226    0.4876    0.5547 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.7557    0.1681    1.9876 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8465    0.6521    0.4751 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4753    1.7819    0.7251 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0243   -0.4874    0.1253 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4070   -0.2599   -0.1569 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.5262    0.6244   -1.2428 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2578    0.2448    0.9419 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.6829    0.4253    0.5015 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.3739   -0.7792    0.0218 C   0  0  1  0  0  0  0  0  0  0  0  0
   -4.5910   -1.1692    0.7779 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8633   -2.3504    1.0703 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4716   -0.1289    1.1755 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8773    1.1516    1.4042 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5632    2.1867    1.3808 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4041    1.1221    1.6645 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.6071   -1.2254   -1.0606 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.7633    0.5925   -2.9725 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8910    1.4636   -1.6928 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9701    0.5592   -2.9418 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3708   -1.4975   -2.1797 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7818   -1.6000    0.2169 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8817   -0.4516   -0.6385 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8637    1.4093    0.2571 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8642    0.2813    1.9996 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2901    0.8497    2.7080 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5559   -0.8979    2.2014 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0808   -1.2138    0.9922 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8316   -1.2255   -0.5074 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6293    1.5364   -0.8934 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9476    1.2032    1.3802 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2450   -0.4943    1.7952 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6541    1.2228   -0.3007 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7414   -0.6007   -1.0345 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7592   -1.6918   -0.0620 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5039   -0.2825    1.2976 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0527    2.1488    1.7939 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2493    0.5654    2.6009 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7280   -2.3290   -0.8511 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9177   -1.2011   -1.9470 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
  8 20  1  0  0  0  0
 20  2  1  0  0  0  0
 19 12  1  0  0  0  0
  1 21  1  0  0  0  0
  1 22  1  0  0  0  0
  1 23  1  0  0  0  0
  2 24  1  6  0  0  0
  3 25  1  0  0  0  0
  3 26  1  0  0  0  0
  4 27  1  6  0  0  0
  5 28  1  0  0  0  0
  5 29  1  0  0  0  0
  5 30  1  0  0  0  0
  8 31  1  1  0  0  0
  9 32  1  6  0  0  0
 10 33  1  0  0  0  0
 11 34  1  0  0  0  0
 11 35  1  0  0  0  0
 12 36  1  6  0  0  0
 13 37  1  0  0  0  0
 13 38  1  0  0  0  0
 16 39  1  0  0  0  0
 19 40  1  0  0  0  0
 19 41  1  0  0  0  0
 20 42  1  0  0  0  0
 20 43  1  0  0  0  0
M  END

     RDKit          3D

 43 44  0  0  0  0  0  0  0  0999 V2000
    2.8761    0.5534   -2.3017 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9275   -0.7197   -1.5130 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.8378   -0.6245   -0.3111 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3226    0.4876    0.5547 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.7557    0.1681    1.9876 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8465    0.6521    0.4751 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4753    1.7819    0.7251 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0243   -0.4874    0.1253 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4070   -0.2599   -0.1569 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.5262    0.6244   -1.2428 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2578    0.2448    0.9419 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6829    0.4253    0.5015 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.3739   -0.7792    0.0218 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5910   -1.1692    0.7779 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8633   -2.3504    1.0703 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4716   -0.1289    1.1755 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8773    1.1516    1.4042 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5632    2.1867    1.3808 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4041    1.1221    1.6645 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6071   -1.2254   -1.0606 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7633    0.5925   -2.9725 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8910    1.4636   -1.6928 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9701    0.5592   -2.9418 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3708   -1.4975   -2.1797 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7818   -1.6000    0.2169 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8817   -0.4516   -0.6385 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8637    1.4093    0.2571 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8642    0.2813    1.9996 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2901    0.8497    2.7080 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5559   -0.8979    2.2014 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0808   -1.2138    0.9922 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8316   -1.2255   -0.5074 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6293    1.5364   -0.8934 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9476    1.2032    1.3802 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2450   -0.4943    1.7952 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6541    1.2228   -0.3007 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7414   -0.6007   -1.0345 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7592   -1.6918   -0.0620 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5039   -0.2825    1.2976 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0527    2.1488    1.7939 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2493    0.5654    2.6009 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7280   -2.3290   -0.8511 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9177   -1.2011   -1.9470 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  4  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  1  0
  9 10  1  0
  9 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 18  2  0
 17 19  1  0
  8 20  1  0
 20  2  1  0
 19 12  1  0
  1 21  1  0
  1 22  1  0
  1 23  1  0
  2 24  1  6
  3 25  1  0
  3 26  1  0
  4 27  1  6
  5 28  1  0
  5 29  1  0
  5 30  1  0
  8 31  1  1
  9 32  1  6
 10 33  1  0
 11 34  1  0
 11 35  1  0
 12 36  1  6
 13 37  1  0
 13 38  1  0
 16 39  1  0
 19 40  1  0
 19 41  1  0
 20 42  1  0
 20 43  1  0
M  END


  Mrv1652306242118383D          

 43 44  0  0  0  0            999 V2000
    2.8761    0.5534   -2.3017 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9275   -0.7197   -1.5130 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.8378   -0.6245   -0.3111 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.3226    0.4876    0.5547 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.7557    0.1681    1.9876 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8465    0.6521    0.4751 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4753    1.7819    0.7251 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0243   -0.4874    0.1253 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4070   -0.2599   -0.1569 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.5262    0.6244   -1.2428 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2578    0.2448    0.9419 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.6829    0.4253    0.5015 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.3739   -0.7792    0.0218 C   0  0  1  0  0  0  0  0  0  0  0  0
   -4.5910   -1.1692    0.7779 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8633   -2.3504    1.0703 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4716   -0.1289    1.1755 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8773    1.1516    1.4042 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5632    2.1867    1.3808 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4041    1.1221    1.6645 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.6071   -1.2254   -1.0606 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.7633    0.5925   -2.9725 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8910    1.4636   -1.6928 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9701    0.5592   -2.9418 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3708   -1.4975   -2.1797 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7818   -1.6000    0.2169 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8817   -0.4516   -0.6385 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8637    1.4093    0.2571 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8642    0.2813    1.9996 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2901    0.8497    2.7080 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5559   -0.8979    2.2014 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0808   -1.2138    0.9922 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8316   -1.2255   -0.5074 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6293    1.5364   -0.8934 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9476    1.2032    1.3802 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2450   -0.4943    1.7952 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6541    1.2228   -0.3007 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7414   -0.6007   -1.0345 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7592   -1.6918   -0.0620 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5039   -0.2825    1.2976 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0527    2.1488    1.7939 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2493    0.5654    2.6009 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7280   -2.3290   -0.8511 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9177   -1.2011   -1.9470 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
  8 20  1  0  0  0  0
 20  2  1  0  0  0  0
 19 12  1  0  0  0  0
  1 21  1  0  0  0  0
  1 22  1  0  0  0  0
  1 23  1  0  0  0  0
  2 24  1  6  0  0  0
  3 25  1  0  0  0  0
  3 26  1  0  0  0  0
  4 27  1  6  0  0  0
  5 28  1  0  0  0  0
  5 29  1  0  0  0  0
  5 30  1  0  0  0  0
  8 31  1  1  0  0  0
  9 32  1  6  0  0  0
 10 33  1  0  0  0  0
 11 34  1  0  0  0  0
 11 35  1  0  0  0  0
 12 36  1  6  0  0  0
 13 37  1  0  0  0  0
 13 38  1  0  0  0  0
 16 39  1  0  0  0  0
 19 40  1  0  0  0  0
 19 41  1  0  0  0  0
 20 42  1  0  0  0  0
 20 43  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0007218

> <DATABASE_NAME>
NP-MRD

> <SMILES>
[H]O[C@]([H])(C([H])([H])C1([H])C([H])([H])C(=O)N([H])C(=O)C1([H])[H])[C@]1([H])C(=O)[C@@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])[H]

> <INCHI_IDENTIFIER>
InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11+,12+/m0/s1

> <INCHI_KEY>
YPHMISFOHDHNIV-GAIPPQHRSA-N

> <FORMULA>
C15H23NO4

> <MOLECULAR_WEIGHT>
281.352

> <EXACT_MASS>
281.162708225

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
43

> <JCHEM_AVERAGE_POLARIZABILITY>
30.182438279151413

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
4-[(2R)-2-[(1R,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione

> <ALOGPS_LOGP>
0.99

> <JCHEM_LOGP>
0.9047651483333341

> <ALOGPS_LOGS>
-2.06

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.768465139594884

> <JCHEM_PKA_STRONGEST_ACIDIC>
11.799868459252808

> <JCHEM_PKA_STRONGEST_BASIC>
-2.9007930767025343

> <JCHEM_POLAR_SURFACE_AREA>
83.47

> <JCHEM_REFRACTIVITY>
73.08930000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.48e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
4-[(2R)-2-[(1R,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione

> <JCHEM_VEBER_RULE>
0

$$$$

     RDKit          3D

 43 44  0  0  0  0  0  0  0  0999 V2000
    2.8761    0.5534   -2.3017 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9275   -0.7197   -1.5130 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.8378   -0.6245   -0.3111 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3226    0.4876    0.5547 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.7557    0.1681    1.9876 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8465    0.6521    0.4751 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4753    1.7819    0.7251 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0243   -0.4874    0.1253 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4070   -0.2599   -0.1569 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.5262    0.6244   -1.2428 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2578    0.2448    0.9419 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6829    0.4253    0.5015 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.3739   -0.7792    0.0218 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5910   -1.1692    0.7779 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8633   -2.3504    1.0703 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4716   -0.1289    1.1755 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8773    1.1516    1.4042 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5632    2.1867    1.3808 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4041    1.1221    1.6645 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6071   -1.2254   -1.0606 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7633    0.5925   -2.9725 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8910    1.4636   -1.6928 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9701    0.5592   -2.9418 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3708   -1.4975   -2.1797 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7818   -1.6000    0.2169 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8817   -0.4516   -0.6385 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8637    1.4093    0.2571 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8642    0.2813    1.9996 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2901    0.8497    2.7080 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5559   -0.8979    2.2014 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0808   -1.2138    0.9922 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8316   -1.2255   -0.5074 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6293    1.5364   -0.8934 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9476    1.2032    1.3802 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2450   -0.4943    1.7952 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6541    1.2228   -0.3007 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7414   -0.6007   -1.0345 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7592   -1.6918   -0.0620 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5039   -0.2825    1.2976 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0527    2.1488    1.7939 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2493    0.5654    2.6009 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7280   -2.3290   -0.8511 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9177   -1.2011   -1.9470 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  4  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  1  0
  9 10  1  0
  9 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 18  2  0
 17 19  1  0
  8 20  1  0
 20  2  1  0
 19 12  1  0
  1 21  1  0
  1 22  1  0
  1 23  1  0
  2 24  1  6
  3 25  1  0
  3 26  1  0
  4 27  1  6
  5 28  1  0
  5 29  1  0
  5 30  1  0
  8 31  1  1
  9 32  1  6
 10 33  1  0
 11 34  1  0
 11 35  1  0
 12 36  1  6
 13 37  1  0
 13 38  1  0
 16 39  1  0
 19 40  1  0
 19 41  1  0
 20 42  1  0
 20 43  1  0
M  END

HEADER    PROTEIN                                 24-JUN-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-JUN-21         0                                  
HETATM    1  C   UNK     0       2.876   0.553  -2.302  0.00  0.00           C+0
HETATM    2  C   UNK     0       2.928  -0.720  -1.513  0.00  0.00           C+0
HETATM    3  C   UNK     0       3.838  -0.625  -0.311  0.00  0.00           C+0
HETATM    4  C   UNK     0       3.323   0.488   0.555  0.00  0.00           C+0
HETATM    5  C   UNK     0       3.756   0.168   1.988  0.00  0.00           C+0
HETATM    6  C   UNK     0       1.847   0.652   0.475  0.00  0.00           C+0
HETATM    7  O   UNK     0       1.475   1.782   0.725  0.00  0.00           O+0
HETATM    8  C   UNK     0       1.024  -0.487   0.125  0.00  0.00           C+0
HETATM    9  C   UNK     0      -0.407  -0.260  -0.157  0.00  0.00           C+0
HETATM   10  O   UNK     0      -0.526   0.624  -1.243  0.00  0.00           O+0
HETATM   11  C   UNK     0      -1.258   0.245   0.942  0.00  0.00           C+0
HETATM   12  C   UNK     0      -2.683   0.425   0.501  0.00  0.00           C+0
HETATM   13  C   UNK     0      -3.374  -0.779   0.022  0.00  0.00           C+0
HETATM   14  C   UNK     0      -4.591  -1.169   0.778  0.00  0.00           C+0
HETATM   15  O   UNK     0      -4.863  -2.350   1.070  0.00  0.00           O+0
HETATM   16  N   UNK     0      -5.472  -0.129   1.176  0.00  0.00           N+0
HETATM   17  C   UNK     0      -4.877   1.152   1.404  0.00  0.00           C+0
HETATM   18  O   UNK     0      -5.563   2.187   1.381  0.00  0.00           O+0
HETATM   19  C   UNK     0      -3.404   1.122   1.665  0.00  0.00           C+0
HETATM   20  C   UNK     0       1.607  -1.225  -1.061  0.00  0.00           C+0
HETATM   21  H   UNK     0       3.763   0.593  -2.973  0.00  0.00           H+0
HETATM   22  H   UNK     0       2.891   1.464  -1.693  0.00  0.00           H+0
HETATM   23  H   UNK     0       1.970   0.559  -2.942  0.00  0.00           H+0
HETATM   24  H   UNK     0       3.371  -1.498  -2.180  0.00  0.00           H+0
HETATM   25  H   UNK     0       3.782  -1.600   0.217  0.00  0.00           H+0
HETATM   26  H   UNK     0       4.882  -0.452  -0.639  0.00  0.00           H+0
HETATM   27  H   UNK     0       3.864   1.409   0.257  0.00  0.00           H+0
HETATM   28  H   UNK     0       4.864   0.281   2.000  0.00  0.00           H+0
HETATM   29  H   UNK     0       3.290   0.850   2.708  0.00  0.00           H+0
HETATM   30  H   UNK     0       3.556  -0.898   2.201  0.00  0.00           H+0
HETATM   31  H   UNK     0       1.081  -1.214   0.992  0.00  0.00           H+0
HETATM   32  H   UNK     0      -0.832  -1.226  -0.507  0.00  0.00           H+0
HETATM   33  H   UNK     0      -0.629   1.536  -0.893  0.00  0.00           H+0
HETATM   34  H   UNK     0      -0.948   1.203   1.380  0.00  0.00           H+0
HETATM   35  H   UNK     0      -1.245  -0.494   1.795  0.00  0.00           H+0
HETATM   36  H   UNK     0      -2.654   1.223  -0.301  0.00  0.00           H+0
HETATM   37  H   UNK     0      -3.741  -0.601  -1.034  0.00  0.00           H+0
HETATM   38  H   UNK     0      -2.759  -1.692  -0.062  0.00  0.00           H+0
HETATM   39  H   UNK     0      -6.504  -0.283   1.298  0.00  0.00           H+0
HETATM   40  H   UNK     0      -3.053   2.149   1.794  0.00  0.00           H+0
HETATM   41  H   UNK     0      -3.249   0.565   2.601  0.00  0.00           H+0
HETATM   42  H   UNK     0       1.728  -2.329  -0.851  0.00  0.00           H+0
HETATM   43  H   UNK     0       0.918  -1.201  -1.947  0.00  0.00           H+0
CONECT    1    2   21   22   23                                             
CONECT    2    1    3   20   24                                             
CONECT    3    2    4   25   26                                             
CONECT    4    3    5    6   27                                             
CONECT    5    4   28   29   30                                             
CONECT    6    4    7    8                                                  
CONECT    7    6                                                            
CONECT    8    6    9   20   31                                             
CONECT    9    8   10   11   32                                             
CONECT   10    9   33                                                       
CONECT   11    9   12   34   35                                             
CONECT   12   11   13   19   36                                             
CONECT   13   12   14   37   38                                             
CONECT   14   13   15   16                                                  
CONECT   15   14                                                            
CONECT   16   14   17   39                                                  
CONECT   17   16   18   19                                                  
CONECT   18   17                                                            
CONECT   19   17   12   40   41                                             
CONECT   20    8    2   42   43                                             
CONECT   21    1                                                            
CONECT   22    1                                                            
CONECT   23    1                                                            
CONECT   24    2                                                            
CONECT   25    3                                                            
CONECT   26    3                                                            
CONECT   27    4                                                            
CONECT   28    5                                                            
CONECT   29    5                                                            
CONECT   30    5                                                            
CONECT   31    8                                                            
CONECT   32    9                                                            
CONECT   33   10                                                            
CONECT   34   11                                                            
CONECT   35   11                                                            
CONECT   36   12                                                            
CONECT   37   13                                                            
CONECT   38   13                                                            
CONECT   39   16                                                            
CONECT   40   19                                                            
CONECT   41   19                                                            
CONECT   42   20                                                            
CONECT   43   20                                                            
MASTER        0    0    0    0    0    0    0    0   43    0   88    0
END

RDKit          3D

43 44  0  0  0  0  0  0  0  0999 V2000
    2.8761    0.5534   -2.3017 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9275   -0.7197   -1.5130 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.8378   -0.6245   -0.3111 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3226    0.4876    0.5547 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.7557    0.1681    1.9876 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8465    0.6521    0.4751 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4753    1.7819    0.7251 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0243   -0.4874    0.1253 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4070   -0.2599   -0.1569 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.5262    0.6244   -1.2428 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2578    0.2448    0.9419 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6829    0.4253    0.5015 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.3739   -0.7792    0.0218 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5910   -1.1692    0.7779 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8633   -2.3504    1.0703 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4716   -0.1289    1.1755 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8773    1.1516    1.4042 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5632    2.1867    1.3808 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4041    1.1221    1.6645 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6071   -1.2254   -1.0606 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7633    0.5925   -2.9725 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8910    1.4636   -1.6928 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9701    0.5592   -2.9418 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3708   -1.4975   -2.1797 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7818   -1.6000    0.2169 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8817   -0.4516   -0.6385 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8637    1.4093    0.2571 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8642    0.2813    1.9996 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2901    0.8497    2.7080 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5559   -0.8979    2.2014 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0808   -1.2138    0.9922 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8316   -1.2255   -0.5074 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6293    1.5364   -0.8934 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9476    1.2032    1.3802 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2450   -0.4943    1.7952 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6541    1.2228   -0.3007 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7414   -0.6007   -1.0345 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7592   -1.6918   -0.0620 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5039   -0.2825    1.2976 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0527    2.1488    1.7939 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2493    0.5654    2.6009 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7280   -2.3290   -0.8511 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9177   -1.2011   -1.9470 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  4  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  1  0
  9 10  1  0
  9 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 18  2  0
 17 19  1  0
  8 20  1  0
 20  2  1  0
 19 12  1  0
  1 21  1  0
  1 22  1  0
  1 23  1  0
  2 24  1  6
  3 25  1  0
  3 26  1  0
  4 27  1  6
  5 28  1  0
  5 29  1  0
  5 30  1  0
  8 31  1  1
  9 32  1  6
 10 33  1  0
 11 34  1  0
 11 35  1  0
 12 36  1  6
 13 37  1  0
 13 38  1  0
 16 39  1  0
 19 40  1  0
 19 41  1  0
 20 42  1  0
 20 43  1  0
M  END

View in JSmol View NMR Assignments

Synonyms

Not Available

Chemical Formula

C₁₅H₂₃NO₄

Average Mass

281.3520 Da

Monoisotopic Mass

281.16271 Da

IUPAC Name

4-[(2R)-2-[(1R,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione

Traditional Name

4-[(2R)-2-[(1R,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione

CAS Registry Number

Not Available

SMILES

C[C@H]1C[C@H](C)C(=O)[C@H](C1)[C@H](O)CC1CC(=O)NC(=O)C1

InChI Identifier

InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11+,12+/m0/s1

InChI Key

YPHMISFOHDHNIV-GAIPPQHRSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Sesbania drummondii	Plant	KNApSAcK
Streptomyces griseus	NPAtlas	17736575

Species Where Detected

Species Name	Source	Reference
Streptomyces sp. H7667	KNApSAcK Database	22123792

Chemical Taxonomy

Classification

Not classified

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	0.99	ALOGPS
logP	0.9	ChemAxon
logS	-2.1	ALOGPS
pKa (Strongest Acidic)	11.8	ChemAxon
pKa (Strongest Basic)	-2.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	83.47 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	73.09 m³·mol⁻¹	ChemAxon
Polarizability	30.18 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

NPAtlas ID

NPA012393

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

107799

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

120760

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Kornfeld EC, Jones RG: The Structure of Actidione, An Antibiotic From Streptomyces griseus. Science. 1948 Oct 22;108(2808):437-8. doi: 10.1126/science.108.2808.437-a. [PubMed:17736575 ]

Showing NP-Card for Cycloheximide (NP0007218)

MOL for NP0007218 (Cycloheximide)

3D MOL for NP0007218 (Cycloheximide)

3D SDF for NP0007218 (Cycloheximide)

3D-SDF for NP0007218 (Cycloheximide)

PDB for NP0007218 (Cycloheximide)

3D PDB for NP0007218 (Cycloheximide)

SMILES for NP0007218 (Cycloheximide)

INCHI for NP0007218 (Cycloheximide)

Structure for NP0007218 (Cycloheximide)

3D Structure for NP0007218 (Cycloheximide)