Record Information |
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Version | 1.0 |
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Created at | 2020-11-23 19:39:36 UTC |
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Updated at | 2021-08-12 19:52:03 UTC |
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NP-MRD ID | NP0002755 |
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Secondary Accession Numbers | None |
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Natural Product Identification |
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Common Name | R-(+)-2-Pyrrolidinone-5-carboxylate |
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Provided By | BMRB |
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Description | 5-Oxo-D-proline is also known as D-pyroglutamate. R-(+)-2-Pyrrolidinone-5-carboxylate is found in Rehmannia glutinosa. It was first documented in 2008 (PMID: 17984079). Based on a literature review very few articles have been published on 5-oxo-D-proline (PMID: 22770225) (PMID: 30611573) (PMID: 27477667) (PMID: 20932022). |
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Structure | InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m1/s1 |
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Synonyms | Value | Source |
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D-5-Pyrrolidone-2-carboxylic acid | ChEBI | D-Pyroglutamic acid | ChEBI | D-5-Pyrrolidone-2-carboxylate | Generator | D-Pyroglutamate | Generator | Pyrrolidonecarboxylate | Generator | 5-Ketoproline | MeSH | 5-Oxoproline | MeSH | Pidolate, magnesium | MeSH | Pidolic acid | MeSH | 5-Oxopyrrolidine-2-carboxylic acid | MeSH | Magnesium pidolate | MeSH | Pyroglutamic acid | MeSH | Pyroglutamate | MeSH |
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Chemical Formula | C5H7NO3 |
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Average Mass | 129.1140 Da |
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Monoisotopic Mass | 129.04259 Da |
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IUPAC Name | (2R)-5-oxopyrrolidine-2-carboxylic acid |
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Traditional Name | 5-oxo-D-proline |
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CAS Registry Number | Not Available |
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SMILES | OC(=O)[C@H]1CCC(=O)N1 |
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InChI Identifier | InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m1/s1 |
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InChI Key | ODHCTXKNWHHXJC-GSVOUGTGSA-N |
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Experimental Spectra |
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| Spectrum Type | Description | Depositor Email | Depositor Organization | Depositor | Deposition Date | View |
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1D NMR | 13C NMR Spectrum (1D, 500 MHz, D2O, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 500 MHz, D2O, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 500 MHz, D2O, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 500 MHz, D2O, experimental) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum |
| Predicted Spectra |
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| Not Available | Chemical Shift Submissions |
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| Not Available | Species |
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Species of Origin | |
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Chemical Taxonomy |
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Description | This compound belongs to the class of organic compounds known as proline and derivatives. These are compounds containing proline or a derivative thereof resulting from reaction of proline at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. |
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Kingdom | Organic compounds |
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Super Class | Organic acids and derivatives |
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Class | Carboxylic acids and derivatives |
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Sub Class | Amino acids, peptides, and analogues |
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Direct Parent | Proline and derivatives |
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Alternative Parents | |
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Substituents | - Proline or derivatives
- Oxoproline
- Pyrrolidine carboxylic acid
- Pyrrolidine carboxylic acid or derivatives
- Pyrrolidone
- 2-pyrrolidone
- Pyrrolidine
- Carboxamide group
- Lactam
- Secondary carboxylic acid amide
- Carboxylic acid
- Monocarboxylic acid or derivatives
- Azacycle
- Organoheterocyclic compound
- Organopnictogen compound
- Organooxygen compound
- Organonitrogen compound
- Carbonyl group
- Organic oxygen compound
- Organic oxide
- Hydrocarbon derivative
- Organic nitrogen compound
- Aliphatic heteromonocyclic compound
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Molecular Framework | Aliphatic heteromonocyclic compounds |
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External Descriptors | |
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Physical Properties |
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State | Not Available |
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Experimental Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Predicted Properties | |
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General References | - Roux A, Xu Y, Heilier JF, Olivier MF, Ezan E, Tabet JC, Junot C: Annotation of the human adult urinary metabolome and metabolite identification using ultra high performance liquid chromatography coupled to a linear quadrupole ion trap-Orbitrap mass spectrometer. Anal Chem. 2012 Aug 7;84(15):6429-37. doi: 10.1021/ac300829f. Epub 2012 Jul 17. [PubMed:22770225 ]
- Ulrich EL, Akutsu H, Doreleijers JF, Harano Y, Ioannidis YE, Lin J, Livny M, Mading S, Maziuk D, Miller Z, Nakatani E, Schulte CF, Tolmie DE, Kent Wenger R, Yao H, Markley JL: BioMagResBank. Nucleic Acids Res. 2008 Jan;36(Database issue):D402-8. doi: 10.1093/nar/gkm957. Epub 2007 Nov 4. [PubMed:17984079 ]
- Shim K, Gulhar R, Jialal I: Exploratory metabolomics of nascent metabolic syndrome. J Diabetes Complications. 2019 Mar;33(3):212-216. doi: 10.1016/j.jdiacomp.2018.12.002. Epub 2018 Dec 10. [PubMed:30611573 ]
- Amino Y: Concise Synthesis of (2R,4R)-Monatin. Chem Pharm Bull (Tokyo). 2016;64(8):1242-7. doi: 10.1248/cpb.c16-00358. [PubMed:27477667 ]
- Nilson MG, Funk RL: Total synthesis of (-)-nakadomarin A. Org Lett. 2010 Nov 5;12(21):4912-5. doi: 10.1021/ol102079z. [PubMed:20932022 ]
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