Record Information |
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Version | 1.0 |
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Created at | 2020-11-23 19:39:23 UTC |
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Updated at | 2024-05-04 00:30:58 UTC |
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NP-MRD ID | NP0002746 |
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Secondary Accession Numbers | None |
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Natural Product Identification |
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Common Name | Maleamic acid |
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Provided By | BMRB |
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Description | Maleamate, also known as maleamic acid or maleic monoamide, belongs to the class of organic compounds known as straight chain fatty acids. These are fatty acids with a straight aliphatic chain. Maleamic acid is found in Pogostemon cablin and Trypanosoma brucei. It was first documented in 2000 (PMID: 10742217). Based on a literature review a significant number of articles have been published on Maleamate (PMID: 17984079) (PMID: 22530095) (PMID: 31433182) (PMID: 30646534). |
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Structure | [H]\C(=C(/[H])C(O)=O)C(O)=N InChI=1S/C4H5NO3/c5-3(6)1-2-4(7)8/h1-2H,(H2,5,6)(H,7,8)/b2-1- |
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Synonyms | Value | Source |
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(Z)-3-Carbamoyl acrylic acid | ChEBI | (Z)-4-Amino-4-oxo-2-butenoic acid | ChEBI | Maleic monoamide | ChEBI | Maleamic acid | Kegg | (Z)-3-Carbamoyl acrylate | Generator | (Z)-4-Amino-4-oxo-2-butenoate | Generator | Maleamate | Generator | Maleic acid monoamide | MeSH |
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Chemical Formula | C4H5NO3 |
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Average Mass | 115.0874 Da |
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Monoisotopic Mass | 115.02694 Da |
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IUPAC Name | (2Z)-3-(C-hydroxycarbonimidoyl)prop-2-enoic acid |
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Traditional Name | maleic monoamide |
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CAS Registry Number | Not Available |
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SMILES | [H]\C(=C(/[H])C(O)=O)C(O)=N |
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InChI Identifier | InChI=1S/C4H5NO3/c5-3(6)1-2-4(7)8/h1-2H,(H2,5,6)(H,7,8)/b2-1- |
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InChI Key | FSQQTNAZHBEJLS-UPHRSURJSA-N |
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Experimental Spectra |
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| Spectrum Type | Description | Depositor Email | Depositor Organization | Depositor | Deposition Date | View |
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HSQC NMR | [1H, 13C] NMR Spectrum (2D, 600 MHz, CD3OD, experimental) | bgnzk@missouri.edu | MU Metabolomics Center, University of Missouri, Columbia. MO, USA | Dr. Bharat Goel | 2024-05-02 | View Spectrum | HMBC NMR | [1H, 13C] NMR Spectrum (2D, 600 MHz, CD3OD, experimental) | bgnzk@missouri.edu | MU Metabolomics Center, University of Missouri, Columbia. MO, USA | Dr. Bharat Goel | 2024-05-02 | View Spectrum | COSY NMR | [1H, 1H] NMR Spectrum (2D, 600 MHz, CD3OD, experimental) | bgnzk@missouri.edu | MU Metabolomics Center, University of Missouri, Columbia. MO, USA | Dr. Bharat Goel | 2024-05-02 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 201 MHz, CD3OD, experimental) | bgnzk@missouri.edu | MU Metabolomics Center, University of Missouri, Columbia. MO, USA | Dr. Bharat Goel | 2024-05-02 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 600 MHz, CD3OD, experimental) | bgnzk@missouri.edu | MU Metabolomics Center, University of Missouri, Columbia. MO, USA | Dr. Bharat Goel | 2024-05-02 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 500 MHz, D2O, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 500 MHz, D2O, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 500 MHz, D2O, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 500 MHz, D2O, experimental) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum |
| Predicted Spectra |
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| Not Available | Chemical Shift Submissions |
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| Spectrum Type | Description | Depositor Email | Depositor Organization | Depositor | Deposition Date | View |
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1D NMR | 1H NMR Spectrum (1D, 600.133705802, CD3OD, simulated) | bgnzk@missouri.edu | Sumner Lab, MU Metabolomics Center, University of Missouri, Columbia. MO, USA | Dr. Bharat Goel | 2024-05-02 | View Spectrum |
| Species |
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Species of Origin | |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as straight chain fatty acids. These are fatty acids with a straight aliphatic chain. |
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Kingdom | Organic compounds |
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Super Class | Lipids and lipid-like molecules |
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Class | Fatty Acyls |
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Sub Class | Fatty acids and conjugates |
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Direct Parent | Straight chain fatty acids |
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Alternative Parents | Not Available |
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Substituents | Not Available |
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Molecular Framework | Aliphatic acyclic compounds |
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External Descriptors | Not Available |
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Physical Properties |
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State | Not Available |
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Experimental Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Predicted Properties | |
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General References | - Ulrich EL, Akutsu H, Doreleijers JF, Harano Y, Ioannidis YE, Lin J, Livny M, Mading S, Maziuk D, Miller Z, Nakatani E, Schulte CF, Tolmie DE, Kent Wenger R, Yao H, Markley JL: BioMagResBank. Nucleic Acids Res. 2008 Jan;36(Database issue):D402-8. doi: 10.1093/nar/gkm957. Epub 2007 Nov 4. [PubMed:17984079 ]
- McLaggan D, Rufino H, Jaspars M, Booth IR: Glutathione-dependent conversion of N-ethylmaleimide to the maleamic acid by Escherichia coli: an intracellular detoxification process. Appl Environ Microbiol. 2000 Apr;66(4):1393-9. doi: 10.1128/AEM.66.4.1393-1399.2000. [PubMed:10742217 ]
- Tang H, Yao Y, Wang L, Yu H, Ren Y, Wu G, Xu P: Genomic analysis of Pseudomonas putida: genes in a genome island are crucial for nicotine degradation. Sci Rep. 2012;2:377. doi: 10.1038/srep00377. Epub 2012 Apr 23. [PubMed:22530095 ]
- Ion BF, Meister PJ, Gauld JW: Multiscale Computational Study on the Catalytic Mechanism of the Nonmetallo Amidase Maleamate Amidohydrolase (NicF). J Phys Chem A. 2019 Sep 12;123(36):7710-7719. doi: 10.1021/acs.jpca.9b05914. Epub 2019 Sep 3. [PubMed:31433182 ]
- Diaz-Garcia D, Ardiles PR, Prashar S, Rodriguez-Dieguez A, Paez PL, Gomez-Ruiz S: Preparation and Study of the Antibacterial Applications and Oxidative Stress Induction of Copper Maleamate-Functionalized Mesoporous Silica Nanoparticles. Pharmaceutics. 2019 Jan 14;11(1). pii: pharmaceutics11010030. doi: 10.3390/pharmaceutics11010030. [PubMed:30646534 ]
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