NP-MRD: Showing NP-Card for Lactone II (NP0001802)

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Record Information

Version

1.0

Created at

2020-10-21 16:38:18 UTC

Updated at

2021-07-15 16:45:18 UTC

NP-MRD ID

NP0001802

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Lactone II

Provided By

NPAtlas

Description

Lactone II is found in Streptomyces sp. It was first documented in 1999 (PMID: 10513843). Based on a literature review very few articles have been published on [(3S,4S)-4-hydroxy-5-oxooxolan-3-yl]methyl (2E)-3-[(2R,3S)-3-methyloxiran-2-yl]prop-2-enoate (PMID: 30825578) (PMID: 30166552) (PMID: 22572126) (PMID: 15455149) (PMID: 12240331).

Structure

MOL 3D MOL SDF 3D SDF PDB SMILES InChI


  Mrv1652306242117443D          

 31 32  0  0  0  0            999 V2000
    4.2271    0.7287   -1.2187 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8517   -0.1257   -0.1526 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.4633   -1.5215   -0.2826 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0961   -0.8282    0.8660 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.6501   -0.6425    1.0653 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7131   -1.0924    0.2731 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3075   -0.8427    0.5789 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0085   -0.1925    1.6074 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7219   -1.2897   -0.2149 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0806   -1.0909    0.0117 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.4924    0.3513    0.0599 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.2104    1.1072   -1.1971 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.1821    2.1460   -1.1666 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2959    1.7178   -0.4607 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3458    2.3852   -0.3285 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0284    0.3691    0.0923 C   0  0  1  0  0  0  0  0  0  0  0  0
   -4.4830   -0.6436   -0.7538 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4311    1.7996   -0.9680 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1664    0.4902   -1.2900 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7875    0.5281   -2.1728 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.9563   -0.0705   -0.0351 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6403   -1.0718    1.8218 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3347   -0.0785    1.9545 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9981   -1.6447   -0.5993 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6320   -1.5534   -0.8512 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4725   -1.5850    0.9187 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1759    0.8684    0.9794 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2108    1.5544   -1.2404 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4473    0.4526   -2.0539 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3980    0.2569    1.1218 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4379   -0.4817   -0.9269 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
  4  2  1  0  0  0  0
 16 11  1  0  0  0  0
  1 18  1  0  0  0  0
  1 19  1  0  0  0  0
  1 20  1  0  0  0  0
  2 21  1  1  0  0  0
  4 22  1  1  0  0  0
  5 23  1  0  0  0  0
  6 24  1  0  0  0  0
 10 25  1  0  0  0  0
 10 26  1  0  0  0  0
 11 27  1  1  0  0  0
 12 28  1  0  0  0  0
 12 29  1  0  0  0  0
 16 30  1  1  0  0  0
 17 31  1  0  0  0  0
M  END

     RDKit          3D

 31 32  0  0  0  0  0  0  0  0999 V2000
    4.2271    0.7287   -1.2187 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8517   -0.1257   -0.1526 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.4633   -1.5215   -0.2826 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0961   -0.8282    0.8660 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.6501   -0.6425    1.0653 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7131   -1.0924    0.2731 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3075   -0.8427    0.5789 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0085   -0.1925    1.6074 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7219   -1.2897   -0.2149 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0806   -1.0909    0.0117 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4924    0.3513    0.0599 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.2104    1.1072   -1.1971 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1821    2.1460   -1.1666 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2959    1.7178   -0.4607 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3458    2.3852   -0.3285 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0284    0.3691    0.0923 C   0  0  1  0  0  0  0  0  0  0  0  0
   -4.4830   -0.6436   -0.7538 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4311    1.7996   -0.9680 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1664    0.4902   -1.2900 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7875    0.5281   -2.1728 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.9563   -0.0705   -0.0351 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6403   -1.0718    1.8218 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3347   -0.0785    1.9545 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9981   -1.6447   -0.5993 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6320   -1.5534   -0.8512 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4725   -1.5850    0.9187 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1759    0.8684    0.9794 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2108    1.5544   -1.2404 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4473    0.4526   -2.0539 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3980    0.2569    1.1218 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4379   -0.4817   -0.9269 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
  4  2  1  0
 16 11  1  0
  1 18  1  0
  1 19  1  0
  1 20  1  0
  2 21  1  1
  4 22  1  1
  5 23  1  0
  6 24  1  0
 10 25  1  0
 10 26  1  0
 11 27  1  1
 12 28  1  0
 12 29  1  0
 16 30  1  1
 17 31  1  0
M  END


  Mrv1652306242117443D          

 31 32  0  0  0  0            999 V2000
    4.2271    0.7287   -1.2187 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8517   -0.1257   -0.1526 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.4633   -1.5215   -0.2826 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0961   -0.8282    0.8660 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.6501   -0.6425    1.0653 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7131   -1.0924    0.2731 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3075   -0.8427    0.5789 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0085   -0.1925    1.6074 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7219   -1.2897   -0.2149 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0806   -1.0909    0.0117 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.4924    0.3513    0.0599 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.2104    1.1072   -1.1971 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.1821    2.1460   -1.1666 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2959    1.7178   -0.4607 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3458    2.3852   -0.3285 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0284    0.3691    0.0923 C   0  0  1  0  0  0  0  0  0  0  0  0
   -4.4830   -0.6436   -0.7538 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4311    1.7996   -0.9680 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1664    0.4902   -1.2900 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7875    0.5281   -2.1728 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.9563   -0.0705   -0.0351 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6403   -1.0718    1.8218 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3347   -0.0785    1.9545 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9981   -1.6447   -0.5993 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6320   -1.5534   -0.8512 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4725   -1.5850    0.9187 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1759    0.8684    0.9794 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2108    1.5544   -1.2404 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4473    0.4526   -2.0539 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3980    0.2569    1.1218 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4379   -0.4817   -0.9269 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
  4  2  1  0  0  0  0
 16 11  1  0  0  0  0
  1 18  1  0  0  0  0
  1 19  1  0  0  0  0
  1 20  1  0  0  0  0
  2 21  1  1  0  0  0
  4 22  1  1  0  0  0
  5 23  1  0  0  0  0
  6 24  1  0  0  0  0
 10 25  1  0  0  0  0
 10 26  1  0  0  0  0
 11 27  1  1  0  0  0
 12 28  1  0  0  0  0
 12 29  1  0  0  0  0
 16 30  1  1  0  0  0
 17 31  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0001802

> <DATABASE_NAME>
NP-MRD

> <SMILES>
[H]O[C@]1([H])C(=O)OC([H])([H])[C@]1([H])C([H])([H])OC(=O)C(\[H])=C(/[H])[C@@]1([H])O[C@@]1([H])C([H])([H])[H]

> <INCHI_IDENTIFIER>
InChI=1S/C11H14O6/c1-6-8(17-6)2-3-9(12)15-4-7-5-16-11(14)10(7)13/h2-3,6-8,10,13H,4-5H2,1H3/b3-2+/t6-,7-,8+,10-/m0/s1

> <INCHI_KEY>
MDZROSJVVHMKCB-VHSKBXSJSA-N

> <FORMULA>
C11H14O6

> <MOLECULAR_WEIGHT>
242.227

> <EXACT_MASS>
242.079038171

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
31

> <JCHEM_AVERAGE_POLARIZABILITY>
23.315469032431245

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
[(3S,4S)-4-hydroxy-5-oxooxolan-3-yl]methyl (2E)-3-[(2R,3S)-3-methyloxiran-2-yl]prop-2-enoate

> <ALOGPS_LOGP>
-0.25

> <JCHEM_LOGP>
-0.006025283666666839

> <ALOGPS_LOGS>
-1.01

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.32537115626187

> <JCHEM_PKA_STRONGEST_BASIC>
-3.9686826562510573

> <JCHEM_POLAR_SURFACE_AREA>
85.36

> <JCHEM_REFRACTIVITY>
55.85960000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.37e+01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
[(3S,4S)-4-hydroxy-5-oxooxolan-3-yl]methyl (2E)-3-[(2R,3S)-3-methyloxiran-2-yl]prop-2-enoate

> <JCHEM_VEBER_RULE>
0

$$$$

     RDKit          3D

 31 32  0  0  0  0  0  0  0  0999 V2000
    4.2271    0.7287   -1.2187 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8517   -0.1257   -0.1526 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.4633   -1.5215   -0.2826 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0961   -0.8282    0.8660 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.6501   -0.6425    1.0653 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7131   -1.0924    0.2731 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3075   -0.8427    0.5789 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0085   -0.1925    1.6074 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7219   -1.2897   -0.2149 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0806   -1.0909    0.0117 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4924    0.3513    0.0599 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.2104    1.1072   -1.1971 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1821    2.1460   -1.1666 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2959    1.7178   -0.4607 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3458    2.3852   -0.3285 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0284    0.3691    0.0923 C   0  0  1  0  0  0  0  0  0  0  0  0
   -4.4830   -0.6436   -0.7538 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4311    1.7996   -0.9680 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1664    0.4902   -1.2900 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7875    0.5281   -2.1728 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.9563   -0.0705   -0.0351 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6403   -1.0718    1.8218 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3347   -0.0785    1.9545 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9981   -1.6447   -0.5993 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6320   -1.5534   -0.8512 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4725   -1.5850    0.9187 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1759    0.8684    0.9794 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2108    1.5544   -1.2404 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4473    0.4526   -2.0539 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3980    0.2569    1.1218 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4379   -0.4817   -0.9269 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
  4  2  1  0
 16 11  1  0
  1 18  1  0
  1 19  1  0
  1 20  1  0
  2 21  1  1
  4 22  1  1
  5 23  1  0
  6 24  1  0
 10 25  1  0
 10 26  1  0
 11 27  1  1
 12 28  1  0
 12 29  1  0
 16 30  1  1
 17 31  1  0
M  END

HEADER    PROTEIN                                 24-JUN-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-JUN-21         0                                  
HETATM    1  C   UNK     0       4.227   0.729  -1.219  0.00  0.00           C+0
HETATM    2  C   UNK     0       4.852  -0.126  -0.153  0.00  0.00           C+0
HETATM    3  O   UNK     0       4.463  -1.522  -0.283  0.00  0.00           O+0
HETATM    4  C   UNK     0       4.096  -0.828   0.866  0.00  0.00           C+0
HETATM    5  C   UNK     0       2.650  -0.643   1.065  0.00  0.00           C+0
HETATM    6  C   UNK     0       1.713  -1.092   0.273  0.00  0.00           C+0
HETATM    7  C   UNK     0       0.308  -0.843   0.579  0.00  0.00           C+0
HETATM    8  O   UNK     0      -0.009  -0.193   1.607  0.00  0.00           O+0
HETATM    9  O   UNK     0      -0.722  -1.290  -0.215  0.00  0.00           O+0
HETATM   10  C   UNK     0      -2.081  -1.091   0.012  0.00  0.00           C+0
HETATM   11  C   UNK     0      -2.492   0.351   0.060  0.00  0.00           C+0
HETATM   12  C   UNK     0      -2.210   1.107  -1.197  0.00  0.00           C+0
HETATM   13  O   UNK     0      -3.182   2.146  -1.167  0.00  0.00           O+0
HETATM   14  C   UNK     0      -4.296   1.718  -0.461  0.00  0.00           C+0
HETATM   15  O   UNK     0      -5.346   2.385  -0.329  0.00  0.00           O+0
HETATM   16  C   UNK     0      -4.028   0.369   0.092  0.00  0.00           C+0
HETATM   17  O   UNK     0      -4.483  -0.644  -0.754  0.00  0.00           O+0
HETATM   18  H   UNK     0       4.431   1.800  -0.968  0.00  0.00           H+0
HETATM   19  H   UNK     0       3.166   0.490  -1.290  0.00  0.00           H+0
HETATM   20  H   UNK     0       4.787   0.528  -2.173  0.00  0.00           H+0
HETATM   21  H   UNK     0       5.956  -0.071  -0.035  0.00  0.00           H+0
HETATM   22  H   UNK     0       4.640  -1.072   1.822  0.00  0.00           H+0
HETATM   23  H   UNK     0       2.335  -0.079   1.954  0.00  0.00           H+0
HETATM   24  H   UNK     0       1.998  -1.645  -0.599  0.00  0.00           H+0
HETATM   25  H   UNK     0      -2.632  -1.553  -0.851  0.00  0.00           H+0
HETATM   26  H   UNK     0      -2.473  -1.585   0.919  0.00  0.00           H+0
HETATM   27  H   UNK     0      -2.176   0.868   0.979  0.00  0.00           H+0
HETATM   28  H   UNK     0      -1.211   1.554  -1.240  0.00  0.00           H+0
HETATM   29  H   UNK     0      -2.447   0.453  -2.054  0.00  0.00           H+0
HETATM   30  H   UNK     0      -4.398   0.257   1.122  0.00  0.00           H+0
HETATM   31  H   UNK     0      -5.438  -0.482  -0.927  0.00  0.00           H+0
CONECT    1    2   18   19   20                                             
CONECT    2    1    3    4   21                                             
CONECT    3    2    4                                                       
CONECT    4    3    5    2   22                                             
CONECT    5    4    6   23                                                  
CONECT    6    5    7   24                                                  
CONECT    7    6    8    9                                                  
CONECT    8    7                                                            
CONECT    9    7   10                                                       
CONECT   10    9   11   25   26                                             
CONECT   11   10   12   16   27                                             
CONECT   12   11   13   28   29                                             
CONECT   13   12   14                                                       
CONECT   14   13   15   16                                                  
CONECT   15   14                                                            
CONECT   16   14   17   11   30                                             
CONECT   17   16   31                                                       
CONECT   18    1                                                            
CONECT   19    1                                                            
CONECT   20    1                                                            
CONECT   21    2                                                            
CONECT   22    4                                                            
CONECT   23    5                                                            
CONECT   24    6                                                            
CONECT   25   10                                                            
CONECT   26   10                                                            
CONECT   27   11                                                            
CONECT   28   12                                                            
CONECT   29   12                                                            
CONECT   30   16                                                            
CONECT   31   17                                                            
MASTER        0    0    0    0    0    0    0    0   31    0   64    0
END

RDKit          3D

31 32  0  0  0  0  0  0  0  0999 V2000
    4.2271    0.7287   -1.2187 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8517   -0.1257   -0.1526 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.4633   -1.5215   -0.2826 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0961   -0.8282    0.8660 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.6501   -0.6425    1.0653 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7131   -1.0924    0.2731 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3075   -0.8427    0.5789 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0085   -0.1925    1.6074 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7219   -1.2897   -0.2149 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0806   -1.0909    0.0117 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4924    0.3513    0.0599 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.2104    1.1072   -1.1971 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1821    2.1460   -1.1666 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2959    1.7178   -0.4607 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3458    2.3852   -0.3285 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0284    0.3691    0.0923 C   0  0  1  0  0  0  0  0  0  0  0  0
   -4.4830   -0.6436   -0.7538 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4311    1.7996   -0.9680 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1664    0.4902   -1.2900 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7875    0.5281   -2.1728 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.9563   -0.0705   -0.0351 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6403   -1.0718    1.8218 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3347   -0.0785    1.9545 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9981   -1.6447   -0.5993 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6320   -1.5534   -0.8512 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4725   -1.5850    0.9187 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1759    0.8684    0.9794 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2108    1.5544   -1.2404 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4473    0.4526   -2.0539 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3980    0.2569    1.1218 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4379   -0.4817   -0.9269 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
  4  2  1  0
 16 11  1  0
  1 18  1  0
  1 19  1  0
  1 20  1  0
  2 21  1  1
  4 22  1  1
  5 23  1  0
  6 24  1  0
 10 25  1  0
 10 26  1  0
 11 27  1  1
 12 28  1  0
 12 29  1  0
 16 30  1  1
 17 31  1  0
M  END

View in JSmol View NMR Assignments

Synonyms

Value	Source
[(3S,4S)-4-Hydroxy-5-oxooxolan-3-yl]methyl (2E)-3-[(2R,3S)-3-methyloxiran-2-yl]prop-2-enoic acid	Generator

Chemical Formula

C₁₁H₁₄O₆

Average Mass

242.2270 Da

Monoisotopic Mass

242.07904 Da

IUPAC Name

[(3S,4S)-4-hydroxy-5-oxooxolan-3-yl]methyl (2E)-3-[(2R,3S)-3-methyloxiran-2-yl]prop-2-enoate

Traditional Name

[(3S,4S)-4-hydroxy-5-oxooxolan-3-yl]methyl (2E)-3-[(2R,3S)-3-methyloxiran-2-yl]prop-2-enoate

CAS Registry Number

Not Available

SMILES

C[C@@H]1O[C@@H]1\C=C\C(=O)OC[C@H]1COC(=O)[C@H]1O

InChI Identifier

InChI=1S/C11H14O6/c1-6-8(17-6)2-3-9(12)15-4-7-5-16-11(14)10(7)13/h2-3,6-8,10,13H,4-5H2,1H3/b3-2+/t6-,7-,8+,10-/m0/s1

InChI Key

MDZROSJVVHMKCB-VHSKBXSJSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Streptomyces sp.	NPAtlas	10513843

Species Where Detected

Species Name	Source	Reference
Ganoderma colossum (FR.) C.F.BAKER	KNApSAcK Database	22123792

Chemical Taxonomy

Classification

Not classified

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-0.25	ALOGPS
logP	-0.006	ChemAxon
logS	-1	ALOGPS
pKa (Strongest Acidic)	12.33	ChemAxon
pKa (Strongest Basic)	-4	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	85.36 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	55.86 m³·mol⁻¹	ChemAxon
Polarizability	23.32 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

NPAtlas ID

NPA008263

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

9405286

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

11230238

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Schiewe HJ, Zeeck A: Cineromycins, gamma-butyrolactones and ansamycins by analysis of the secondary metabolite pattern created by a single strain of Streptomyces. J Antibiot (Tokyo). 1999 Jul;52(7):635-42. doi: 10.7164/antibiotics.52.635. [PubMed:10513843 ]
Jing W, Zhang X, Zhou H, Wang Y, Yang M, Long L, Gao H: Naturally occurring cassane diterpenoids (CAs) of Caesalpinia: A systematic review of its biosynthesis, chemistry and pharmacology. Fitoterapia. 2019 Apr;134:226-249. doi: 10.1016/j.fitote.2019.02.023. Epub 2019 Feb 27. [PubMed:30825578 ]
Awakawa T, Fujioka T, Zhang L, Hoshino S, Hu Z, Hashimoto J, Kozone I, Ikeda H, Shin-Ya K, Liu W, Abe I: Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution. Nat Commun. 2018 Aug 30;9(1):3534. doi: 10.1038/s41467-018-05877-z. [PubMed:30166552 ]
Chen CS, Yu YP, Hsu CH, Zou W, Fang JM, Wu SH: Evaluation of the regioselective delactonization of tri-sialic acid lactone by in-solution molecular dynamics simulation. Carbohydr Res. 2012 Jun 1;354:87-93. doi: 10.1016/j.carres.2012.02.022. Epub 2012 Mar 3. [PubMed:22572126 ]
Ueki T, Kinoshita T: Stereoselective synthesis and structure of butalactin and lactone II isolated from Streptomyces species. Org Biomol Chem. 2004 Oct 7;2(19):2777-85. doi: 10.1039/B407820A. Epub 2004 Aug 23. [PubMed:15455149 ]
Ueki T, Morimoto Y, Kinoshita T: Synthesis and absolute configuration of lactone II isolated from Streptomyces sp. Go 40/10. Chem Commun (Camb). 2001 Sep 21;(18):1820-1. doi: 10.1039/b104920h. [PubMed:12240331 ]

Showing NP-Card for Lactone II (NP0001802)

MOL for NP0001802 (Lactone II)

3D MOL for NP0001802 (Lactone II)

3D SDF for NP0001802 (Lactone II)

3D-SDF for NP0001802 (Lactone II)

PDB for NP0001802 (Lactone II)

3D PDB for NP0001802 (Lactone II)

SMILES for NP0001802 (Lactone II)

INCHI for NP0001802 (Lactone II)

Structure for NP0001802 (Lactone II)

3D Structure for NP0001802 (Lactone II)