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Showing NP-Card for Anserine (NP0001411)

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Record Information
Version2.0
Created at2005-11-16 15:48:42 UTC
Updated at2021-08-19 23:59:07 UTC
NP-MRD IDNP0001411
Secondary Accession NumbersNone
Natural Product Identification
Common NameAnserine
DescriptionAnserine (beta-alanyl-N-3-methylhistidine) is a dipeptide containing beta-alanine and 3-methylhistidine. It is a derivative of carnosine, which had been methylated. The methyl group of anserine is added to carnosine by the enzyme S-adenosylmethionine: Carnosine N-methyltransferase (PMID: 29484990 ). The enzyme is closely related to histamine N-methyltransferase and appears to be present in a majority of anserine-producing species (PMID: 23705015 ). Anserine is a generally a more metabolically stable derivative of carnosine. Anserine can be found in the skeletal muscle and brain of certain mammals (rabbits, cattle), migratory fish and birds. This dipeptide is normally absent from human tissues and body fluids, and its appearance there is usually an artifact of diet. Anserine can also arise from serum carnosinase deficiency. (OMIM 212200 ). Anserine was first discovered in goose muscle in 1929, and was named after this extraction (anser is Latin for goose). Anserine, which is water-soluble, is found at high levels in the muscles of different non-human vertebrates, with poultry, rabbit, tuna, plaice, and salmon having generally higher contents than other marine foods, beef, or pork (PMID: 31908682 ). An increase of urinary anserine excretion has been found in humans after the consumption of chicken, rabbit, and tuna and has been associated with intake of chicken, salmon, and, to a lesser extent, beef (PMID: 31908682 ). Anserine can undergo cleavage to give rise to 3-methylhistidine.(3-MH). The dipeptide balenine, common in some whales, cleaves to form 1-methylhistidine (1-MH) (PMID: 31908682 ). There is considerable confusion with regard to the nomenclature of the methylated nitrogen atoms on the imidazole ring of histidine and other histidine-containing peptides such as anserine. In particular, older literature (mostly prior to the year 2000) designated anserine (N-pi methylated) as beta-alanyl-N1-methyl-histidine, whereas according to standard IUPAC nomenclature, anserine is correctly named as beta-alanyl-N3-methyl-histidine. As a result, many papers published prior to the year 2000 incorrectly identified 1MH as a specific marker for dietary consumption of certain foods or various pathophysiological effects when they really were referring to 3MH or vice versa (PMID: 24137022 ). In particular balenine (a whale or snake-specific dipeptide with 1MH) was often confused with anserine (the poultry dipeptide with 3MH). An animal model study of Alzheimer's disease using mice found that treatment with anserine reduced memory loss (PMID: 28974740 ). Anserine reduced glial inflammatory activity (particularly of astrocyte). The study also found that anserine-treated mice had greater pericyte surface area. The greater area of pericytes was commensurate with improved memory. The anserine-treated mice overall performed better on a spatial memory test (Morris Water Maze) (PMID: 28974740 ). A human study on 84 elderly subjects showed that subjects who took anserine and carnosine supplements for one year showed increased blood flow in the prefrontal cortex on MRI (PMID: 29896423 ).
Structure
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MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for NP0001411 (Anserine)


     RDKit          2D

 33 33  0  0  0  0  0  0  0  0999 V2000
    3.8965    0.9972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5612    1.6807    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3294    3.1627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8483    3.4001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1648    2.0649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2235    1.0022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9860   -0.4789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7486   -1.9600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7325   -1.7226    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2674   -0.3212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7087    0.3661    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7485   -0.0838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2296    0.1537    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7107    0.3911    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2297   -2.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3094   -1.3870    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7647   -3.5988    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5800    2.3325    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5904   -0.3176    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2317    0.3137    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3920    4.2213    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3172    1.8330    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4671   -0.7163    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1714   -0.1312    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5112   -3.4411    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6786   -2.8865    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5111    1.3973    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9859   -1.5649    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9922    1.6347    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4670   -1.3274    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2456    1.7924    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6568   -0.7729    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2457   -3.8362    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13 14  1  0
  8 15  1  0
 15 16  2  0
 15 17  1  0
  6  2  1  0
  1 18  1  1
  1 19  1  0
  1 20  1  0
  3 21  1  0
  5 22  1  0
  7 23  1  6
  7 24  1  0
  8 25  1  6
  9 26  1  0
 12 27  1  6
 12 28  1  0
 13 29  1  6
 13 30  1  0
 14 31  1  0
 14 32  1  0
 17 33  1  0
M  END
Download

3D MOL for NP0001411 (Anserine)

HMDB0000194
     RDKit          3D
Anserine
 33 33  0  0  0  0  0  0  0  0999 V2000
   -4.0174    0.1847   -1.2076 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8596    0.9779   -0.8370 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7313    2.2739   -1.1527 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5565    2.6732   -0.6568 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9451    1.6258   -0.0278 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7717    0.5680   -0.1476 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6271   -0.8012    0.3479 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3359   -1.1138    1.0234 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.8234   -0.9534    0.1812 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9802   -0.3110    0.6463 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9814    0.1299    1.8383 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1769   -0.1546   -0.2481 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2306    0.5722    0.5590 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6497    1.8663    0.9378 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3795   -2.5614    1.4708 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4751   -3.3869    1.1222 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4260   -2.9287    2.2951 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7793   -0.8912   -1.2556 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4614    0.5576   -2.1694 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8003    0.3523   -0.4385 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4304    2.8976   -1.7022 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0095    1.6951    0.4570 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5106   -1.0993    0.9713 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6962   -1.4820   -0.5435 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2239   -0.5106    1.9634 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7970   -1.3248   -0.7953 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8928    0.3895   -1.1588 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5192   -1.1959   -0.4731 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4062   -0.0345    1.4722 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1410    0.7147   -0.0515 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1962    2.3165    0.1151 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4455    2.4509    1.2842 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1726   -3.4970    1.9031 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13 14  1  0
  8 15  1  0
 15 16  2  0
 15 17  1  0
  6  2  1  0
  1 18  1  0
  1 19  1  0
  1 20  1  0
  3 21  1  0
  5 22  1  0
  7 23  1  0
  7 24  1  0
  8 25  1  1
  9 26  1  0
 12 27  1  0
 12 28  1  0
 13 29  1  0
 13 30  1  0
 14 31  1  0
 14 32  1  0
 17 33  1  0
M  END
Download

3D SDF for NP0001411 (Anserine)


     RDKit          2D

 33 33  0  0  0  0  0  0  0  0999 V2000
    3.8965    0.9972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5612    1.6807    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3294    3.1627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8483    3.4001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1648    2.0649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2235    1.0022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9860   -0.4789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7486   -1.9600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7325   -1.7226    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2674   -0.3212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7087    0.3661    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7485   -0.0838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2296    0.1537    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7107    0.3911    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2297   -2.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3094   -1.3870    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7647   -3.5988    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5800    2.3325    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5904   -0.3176    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2317    0.3137    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3920    4.2213    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3172    1.8330    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4671   -0.7163    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1714   -0.1312    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5112   -3.4411    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6786   -2.8865    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5111    1.3973    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9859   -1.5649    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9922    1.6347    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4670   -1.3274    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2456    1.7924    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6568   -0.7729    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2457   -3.8362    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13 14  1  0
  8 15  1  0
 15 16  2  0
 15 17  1  0
  6  2  1  0
  1 18  1  1
  1 19  1  0
  1 20  1  0
  3 21  1  0
  5 22  1  0
  7 23  1  6
  7 24  1  0
  8 25  1  6
  9 26  1  0
 12 27  1  6
 12 28  1  0
 13 29  1  6
 13 30  1  0
 14 31  1  0
 14 32  1  0
 17 33  1  0
M  END
> <DATABASE_ID>
NP0001411

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CN1C=NC=C1C[C@H](NC(=O)CCN)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C10H16N4O3/c1-14-6-12-5-7(14)4-8(10(16)17)13-9(15)2-3-11/h5-6,8H,2-4,11H2,1H3,(H,13,15)(H,16,17)/t8-/m0/s1

> <INCHI_KEY>
MYYIAHXIVFADCU-QMMMGPOBSA-N

> <FORMULA>
C10H16N4O3

> <MOLECULAR_WEIGHT>
240.259

> <EXACT_MASS>
240.122240398

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
33

> <JCHEM_AVERAGE_POLARIZABILITY>
24.30257648493638

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2S)-2-(3-aminopropanamido)-3-(1-methyl-1H-imidazol-5-yl)propanoic acid

> <ALOGPS_LOGP>
-2.95

> <JCHEM_LOGP>
-4.26466129830276

> <ALOGPS_LOGS>
-1.78

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.7461992021571

> <JCHEM_PKA_STRONGEST_ACIDIC>
3.4429691588256897

> <JCHEM_PKA_STRONGEST_BASIC>
9.125526276418753

> <JCHEM_POLAR_SURFACE_AREA>
110.24

> <JCHEM_REFRACTIVITY>
60.458600000000004

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
4.01e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
anserine

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for NP0001411 (Anserine)

HMDB0000194
     RDKit          3D
Anserine
 33 33  0  0  0  0  0  0  0  0999 V2000
   -4.0174    0.1847   -1.2076 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8596    0.9779   -0.8370 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7313    2.2739   -1.1527 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5565    2.6732   -0.6568 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9451    1.6258   -0.0278 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7717    0.5680   -0.1476 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6271   -0.8012    0.3479 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3359   -1.1138    1.0234 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.8234   -0.9534    0.1812 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9802   -0.3110    0.6463 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9814    0.1299    1.8383 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1769   -0.1546   -0.2481 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2306    0.5722    0.5590 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6497    1.8663    0.9378 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3795   -2.5614    1.4708 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4751   -3.3869    1.1222 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4260   -2.9287    2.2951 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7793   -0.8912   -1.2556 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4614    0.5576   -2.1694 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8003    0.3523   -0.4385 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4304    2.8976   -1.7022 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0095    1.6951    0.4570 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5106   -1.0993    0.9713 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6962   -1.4820   -0.5435 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2239   -0.5106    1.9634 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7970   -1.3248   -0.7953 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8928    0.3895   -1.1588 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5192   -1.1959   -0.4731 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4062   -0.0345    1.4722 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1410    0.7147   -0.0515 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1962    2.3165    0.1151 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4455    2.4509    1.2842 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1726   -3.4970    1.9031 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13 14  1  0
  8 15  1  0
 15 16  2  0
 15 17  1  0
  6  2  1  0
  1 18  1  0
  1 19  1  0
  1 20  1  0
  3 21  1  0
  5 22  1  0
  7 23  1  0
  7 24  1  0
  8 25  1  1
  9 26  1  0
 12 27  1  0
 12 28  1  0
 13 29  1  0
 13 30  1  0
 14 31  1  0
 14 32  1  0
 17 33  1  0
M  END
Download

PDB for NP0001411 (Anserine)

HEADER    PROTEIN                                 27-MAY-19   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   27-MAY-19         0                                  
HETATM    1  C   UNK     0       4.330  -2.768   0.000  0.00  0.00           C+0
HETATM    2  N   UNK     0       3.185  -1.738   0.000  0.00  0.00           N+0
HETATM    3  C   UNK     0       1.679  -2.058   0.000  0.00  0.00           C+0
HETATM    4  N   UNK     0       0.909  -0.724   0.000  0.00  0.00           N+0
HETATM    5  C   UNK     0       1.939   0.420   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       3.346  -0.206   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       4.680   0.564   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       4.680   2.104   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       3.346   2.874   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       3.346   4.414   0.000  0.00  0.00           O+0
HETATM   11  O   UNK     0       2.012   2.104   0.000  0.00  0.00           O+0
HETATM   12  N   UNK     0       6.013   2.874   0.000  0.00  0.00           N+0
HETATM   13  C   UNK     0       7.347   2.104   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0       7.347   0.564   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0       8.681   2.874   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      10.014   2.104   0.000  0.00  0.00           C+0
HETATM   17  N   UNK     0      11.348   2.874   0.000  0.00  0.00           N+0
CONECT    1    2                                                            
CONECT    2    1    3    6                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    2    7                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9   12                                                  
CONECT    9    8   10   11                                                  
CONECT   10    9                                                            
CONECT   11    9                                                            
CONECT   12    8   13                                                       
CONECT   13   12   14   15                                                  
CONECT   14   13                                                            
CONECT   15   13   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16                                                            
MASTER        0    0    0    0    0    0    0    0   17    0   34    0
END
Download

3D PDB for NP0001411 (Anserine)

COMPND    HMDB0000194
HETATM    1  C1  UNL     1      -4.017   0.185  -1.208  1.00  0.00           C  
HETATM    2  N1  UNL     1      -2.860   0.978  -0.837  1.00  0.00           N  
HETATM    3  C2  UNL     1      -2.731   2.274  -1.153  1.00  0.00           C  
HETATM    4  N2  UNL     1      -1.556   2.673  -0.657  1.00  0.00           N  
HETATM    5  C3  UNL     1      -0.945   1.626  -0.028  1.00  0.00           C  
HETATM    6  C4  UNL     1      -1.772   0.568  -0.148  1.00  0.00           C  
HETATM    7  C5  UNL     1      -1.627  -0.801   0.348  1.00  0.00           C  
HETATM    8  C6  UNL     1      -0.336  -1.114   1.023  1.00  0.00           C  
HETATM    9  N3  UNL     1       0.823  -0.953   0.181  1.00  0.00           N  
HETATM   10  C7  UNL     1       1.980  -0.311   0.646  1.00  0.00           C  
HETATM   11  O1  UNL     1       1.981   0.130   1.838  1.00  0.00           O  
HETATM   12  C8  UNL     1       3.177  -0.155  -0.248  1.00  0.00           C  
HETATM   13  C9  UNL     1       4.231   0.572   0.559  1.00  0.00           C  
HETATM   14  N4  UNL     1       3.650   1.866   0.938  1.00  0.00           N  
HETATM   15  C10 UNL     1      -0.379  -2.561   1.471  1.00  0.00           C  
HETATM   16  O2  UNL     1       0.475  -3.387   1.122  1.00  0.00           O  
HETATM   17  O3  UNL     1      -1.426  -2.929   2.295  1.00  0.00           O  
HETATM   18  H1  UNL     1      -3.779  -0.891  -1.256  1.00  0.00           H  
HETATM   19  H2  UNL     1      -4.461   0.558  -2.169  1.00  0.00           H  
HETATM   20  H3  UNL     1      -4.800   0.352  -0.439  1.00  0.00           H  
HETATM   21  H4  UNL     1      -3.430   2.898  -1.702  1.00  0.00           H  
HETATM   22  H5  UNL     1       0.009   1.695   0.457  1.00  0.00           H  
HETATM   23  H6  UNL     1      -2.511  -1.099   0.971  1.00  0.00           H  
HETATM   24  H7  UNL     1      -1.696  -1.482  -0.544  1.00  0.00           H  
HETATM   25  H8  UNL     1      -0.224  -0.511   1.963  1.00  0.00           H  
HETATM   26  H9  UNL     1       0.797  -1.325  -0.795  1.00  0.00           H  
HETATM   27  H10 UNL     1       2.893   0.390  -1.159  1.00  0.00           H  
HETATM   28  H11 UNL     1       3.519  -1.196  -0.473  1.00  0.00           H  
HETATM   29  H12 UNL     1       4.406  -0.035   1.472  1.00  0.00           H  
HETATM   30  H13 UNL     1       5.141   0.715  -0.051  1.00  0.00           H  
HETATM   31  H14 UNL     1       3.196   2.317   0.115  1.00  0.00           H  
HETATM   32  H15 UNL     1       4.445   2.451   1.284  1.00  0.00           H  
HETATM   33  H16 UNL     1      -2.173  -3.497   1.903  1.00  0.00           H  
CONECT    1    2   18   19   20
CONECT    2    3    6
CONECT    3    4    4   21
CONECT    4    5
CONECT    5    6    6   22
CONECT    6    7
CONECT    7    8   23   24
CONECT    8    9   15   25
CONECT    9   10   26
CONECT   10   11   11   12
CONECT   12   13   27   28
CONECT   13   14   29   30
CONECT   14   31   32
CONECT   15   16   16   17
CONECT   17   33
END
Download

SMILES for NP0001411 (Anserine)

CN1C=NC=C1C[C@H](NC(=O)CCN)C(O)=O
Download

INCHI for NP0001411 (Anserine)

InChI=1S/C10H16N4O3/c1-14-6-12-5-7(14)4-8(10(16)17)13-9(15)2-3-11/h5-6,8H,2-4,11H2,1H3,(H,13,15)(H,16,17)/t8-/m0/s1
Download
View in JSmol
Synonyms
ValueSource
beta-Alanyl-3-methyl-L-histidineChEBI
beta-Alanyl-N(pai)-methyl-L-histidineChEBI
b-Alanyl-3-methyl-L-histidineGenerator
Β-alanyl-3-methyl-L-histidineGenerator
b-Alanyl-N(pai)-methyl-L-histidineGenerator
Β-alanyl-N(pai)-methyl-L-histidineGenerator
L-AnserineHMDB
L-N-b-Alanyl-3-methyl-histidineHMDB
L-N-beta-Alanyl-3-methyl-histidineHMDB
N-b-Alanyl-3-methyl-L-histidineHMDB
N-beta-Alanyl-3-methyl-L-histidineHMDB
BalanineHMDB
Beta Alanyl 3 methylhistidineHMDB
Beta-Alanyl-3-methylhistidineHMDB
OphidineHMDB
Chemical FormulaC10H16N4O3
Average Mass240.2590 Da
Monoisotopic Mass240.12224 Da
IUPAC Name(2S)-2-(3-aminopropanamido)-3-(1-methyl-1H-imidazol-5-yl)propanoic acid
Traditional Nameanserine
CAS Registry Number584-85-0
SMILES
CN1C=NC=C1C[C@H](NC(=O)CCN)C(O)=O
InChI Identifier
InChI=1S/C10H16N4O3/c1-14-6-12-5-7(14)4-8(10(16)17)13-9(15)2-3-11/h5-6,8H,2-4,11H2,1H3,(H,13,15)(H,16,17)/t8-/m0/s1
InChI KeyMYYIAHXIVFADCU-QMMMGPOBSA-N
Experimental Spectra
Spectrum TypeDescriptionDepositor EmailDepositor OrganizationDepositorDeposition DateView
1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, experimental)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
Predicted Spectra
Not Available
Chemical Shift Submissions
Not Available
Species
Species of Origin
Species NameSourceReference
Anas platyrhynchosFooDB
AnatidaeFooDB
Anser anserFooDB
Bison bisonFooDB
Bos taurusFooDB
Bos taurus X Bison bisonFooDB
Bubalus bubalisFooDB
Capra aegagrus hircusFooDB
CervidaeFooDB
Cervus canadensisFooDB
ColumbaFooDB
ColumbidaeFooDB
Dromaius novaehollandiaeFooDB
Equus caballusFooDB
Gallus gallusFooDB
Lagopus mutaFooDB
LeporidaeFooDB
Lepus timidusFooDB
Melanitta fuscaFooDB
Meleagris gallopavoFooDB
Mus musculusLOTUS Database
Numida meleagrisFooDB
OdocoileusFooDB
OryctolagusFooDB
Ovis ariesFooDB
PhasianidaeFooDB
Phasianus colchicusFooDB
Struthio camelusFooDB
Sus scrofaFooDB
Sus scrofa domesticaFooDB
Species Where Detected
Species NameSourceReference
Homo sapiens (Urine)KNApSAcK Database
Chemical Taxonomy
Description Belongs to the class of organic compounds known as hybrid peptides. Hybrid peptides are compounds containing at least two different types of amino acids (alpha, beta, gamma, delta) linked to each other through a peptide bond.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassPeptidomimetics
Sub ClassHybrid peptides
Direct ParentHybrid peptides
Alternative Parents
Substituents
  • Hybrid peptide
  • Histidine or derivatives
  • N-acyl-alpha-amino acid
  • N-acyl-alpha amino acid or derivatives
  • Alpha-amino acid or derivatives
  • Imidazolyl carboxylic acid derivative
  • N-substituted imidazole
  • Azole
  • Imidazole
  • Heteroaromatic compound
  • Amino acid or derivatives
  • Amino acid
  • Carboximidic acid
  • Carboximidic acid derivative
  • Carboxylic acid derivative
  • Carboxylic acid
  • Azacycle
  • Monocarboxylic acid or derivatives
  • Organoheterocyclic compound
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Hydrocarbon derivative
  • Organic oxide
  • Organopnictogen compound
  • Primary aliphatic amine
  • Carbonyl group
  • Organic nitrogen compound
  • Amine
  • Organic oxygen compound
  • Organonitrogen compound
  • Organooxygen compound
  • Primary amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point226 - 228 °CNot Available
Boiling Point611.30 °C. @ 760.00 mm Hg (est)The Good Scents Company Information System
Water Solubility15750 mg/L @ 25 °C (est)The Good Scents Company Information System
LogP-2.220 (est)The Good Scents Company Information System
Predicted Properties
PropertyValueSource
Water Solubility4.01 g/LALOGPS
logP-3ALOGPS
logP-4.3ChemAxon
logS-1.8ALOGPS
pKa (Strongest Acidic)3.44ChemAxon
pKa (Strongest Basic)9.13ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area110.24 ŲChemAxon
Rotatable Bond Count6ChemAxon
Refractivity60.46 m³·mol⁻¹ChemAxon
Polarizability24.3 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
HMDB IDHMDB0000194
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDFDB021903
KNApSAcK IDC00052191
Chemspider ID100482
KEGG Compound IDC01262
BioCyc IDCPD-401
BiGG IDNot Available
Wikipedia LinkAnserine
METLIN ID5209
PubChem Compound112072
PDB IDNot Available
ChEBI ID18323
Good Scents IDrw1692971
References
General References
  1. Harris RC, Tallon MJ, Dunnett M, Boobis L, Coakley J, Kim HJ, Fallowfield JL, Hill CA, Sale C, Wise JA: The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids. 2006 May;30(3):279-89. Epub 2006 Mar 24. [PubMed:16554972 ]
  2. Pagnano MW, Hanssen AD, Lewallen DG, Stuart MJ: Flexion instability after primary posterior cruciate retaining total knee arthroplasty. Clin Orthop Relat Res. 1998 Nov;(356):39-46. [PubMed:9917666 ]
  3. Abe H, Okuma E, Sekine H, Maeda A, Yoshiue S: Human urinary excretion of L-histidine-related compounds after ingestion of several meats and fish muscle. Int J Biochem. 1993 Sep;25(9):1245-9. [PubMed:8224369 ]
  4. Kang I, Han SW: Anserine bursitis in patients with osteoarthritis of the knee. South Med J. 2000 Feb;93(2):207-9. [PubMed:10701790 ]
  5. Magana Loarte JE, Perez Franco J, Sanchez Sanchez G: [Is therapy with local infiltrations feasible in primary care consultations?]. Aten Primaria. 1999 Jan;23(1):4-7. [PubMed:10079554 ]
  6. Tan KM, Candlish JK: Carnosine and anserine as modulators of neutrophil function. Clin Lab Haematol. 1998 Aug;20(4):239-44. [PubMed:9777271 ]
  7. Boldyrev A, Abe H: Metabolic transformation of neuropeptide carnosine modifies its biological activity. Cell Mol Neurobiol. 1999 Feb;19(1):163-75. [PubMed:10079975 ]
  8. Boldyrev AA, Aldini G, Derave W: Physiology and pathophysiology of carnosine. Physiol Rev. 2013 Oct;93(4):1803-45. doi: 10.1152/physrev.00039.2012. [PubMed:24137022 ]
  9. Kwiatkowski S, Kiersztan A, Drozak J: Biosynthesis of Carnosine and Related Dipeptides in Vertebrates. Curr Protein Pept Sci. 2018;19(8):771-789. doi: 10.2174/1389203719666180226155657. [PubMed:29484990 ]
  10. Drozak J, Chrobok L, Poleszak O, Jagielski AK, Derlacz R: Molecular identification of carnosine N-methyltransferase as chicken histamine N-methyltransferase-like protein (hnmt-like). PLoS One. 2013 May 21;8(5):e64805. doi: 10.1371/journal.pone.0064805. Print 2013. [PubMed:23705015 ]
  11. Kaneko J, Enya A, Enomoto K, Ding Q, Hisatsune T: Anserine (beta-alanyl-3-methyl-L-histidine) improves neurovascular-unit dysfunction and spatial memory in aged AbetaPPswe/PSEN1dE9 Alzheimer's-model mice. Sci Rep. 2017 Oct 3;7(1):12571. doi: 10.1038/s41598-017-12785-7. [PubMed:28974740 ]
  12. Ding Q, Tanigawa K, Kaneko J, Totsuka M, Katakura Y, Imabayashi E, Matsuda H, Hisatsune T: Anserine/Carnosine Supplementation Preserves Blood Flow in the Prefrontal Brain of Elderly People Carrying APOE e4. Aging Dis. 2018 Jun 1;9(3):334-345. doi: 10.14336/AD.2017.0809. eCollection 2018 Jun. [PubMed:29896423 ]