| Record Information |
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| Version | 2.0 |
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| Created at | 2007-04-12 21:16:46 UTC |
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| Updated at | 2025-02-11 15:41:17 UTC |
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| NP-MRD ID | NP0001391 |
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| Secondary Accession Numbers | None |
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| Natural Product Identification |
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| Common Name | o-Tyrosine |
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| Description | O-Tyrosine is a normal human metabolite. Its presence is possible due to the hydroxylation of l-phenylalanine by hydroxyl radical (*OH), and is proposed as an hydroxy radical biomarker of oxidative damage to proteins. O-Tyrosine might also be included in the diet and absorbed. It has been associated with disease such as Kwashiorkor, a severe form of protein-energy malnutrition. However, many publications mention that the results are inconclusive, and o-tyrosine is not selectively altered by antioxidant intervention, exercise training or age. (PMID:14670743 , 10969271 , 9887186 ). |
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| Structure | InChI=1S/C9H11NO3/c10-7(9(12)13)5-6-3-1-2-4-8(6)11/h1-4,7,11H,5,10H2,(H,12,13) |
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| Synonyms | | Value | Source |
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| 2-Amino-3-(2-hydroxyphenyl)propanoic acid | ChEBI | | 2-Amino-3-(2-hydroxyphenyl)propanoate | Generator | | 2-Hydroxy-DL-phenylalanine | HMDB | | 2-Hydroxy-phenylalanine | HMDB | | 2-Hydroxyphenylalanine | HMDB | | 2-Tyrosine | HMDB | | 3-(O-Hydroxyphenyl)DL-alanine | HMDB | | DL- O-Tyrosine | HMDB | | DL-3-(O-Hydroxyphenyl)alanine | HMDB | | DL-O-Tyrosine | HMDB | | Ortho-tyrosine | HMDB | | 2-Tyrosine, (D)-isomer | HMDB | | 2-Tyrosine, (DL)-isomer | HMDB | | 2-Tyrosine, (L)-isomer | HMDB |
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| Chemical Formula | C9H11NO3 |
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| Average Mass | 181.1885 Da |
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| Monoisotopic Mass | 181.07389 Da |
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| IUPAC Name | 2-amino-3-(2-hydroxyphenyl)propanoic acid |
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| Traditional Name | 2-tyrosine |
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| CAS Registry Number | 2370-61-8 |
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| SMILES | NC(CC1=CC=CC=C1O)C(O)=O |
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| InChI Identifier | InChI=1S/C9H11NO3/c10-7(9(12)13)5-6-3-1-2-4-8(6)11/h1-4,7,11H,5,10H2,(H,12,13) |
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| InChI Key | WRFPVMFCRNYQNR-UHFFFAOYSA-N |
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| Experimental Spectra |
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| | Spectrum Type | Description | Depositor Email | Depositor Organization | Depositor | Deposition Date | View |
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| 2D NMR | [1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum |
| | Predicted Spectra |
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| Not Available | | Chemical Shift Submissions |
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| | Spectrum Type | Description | Depositor Email | Depositor Organization | Depositor | Deposition Date | View |
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| 1D NMR | 1H NMR Spectrum (1D, 600 MHz, H2O, simulated) | varshavi.d26@gmail.com | Not Available | Not Available | 2021-08-05 | View Spectrum |
| | Species |
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| Species of Origin | |
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| Chemical Taxonomy |
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| Description | Belongs to the class of organic compounds known as phenylalanine and derivatives. Phenylalanine and derivatives are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. |
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| Kingdom | Organic compounds |
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| Super Class | Organic acids and derivatives |
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| Class | Carboxylic acids and derivatives |
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| Sub Class | Amino acids, peptides, and analogues |
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| Direct Parent | Phenylalanine and derivatives |
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| Alternative Parents | |
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| Substituents | - Phenylalanine or derivatives
- 3-phenylpropanoic-acid
- Amphetamine or derivatives
- Alpha-amino acid
- 1-hydroxy-2-unsubstituted benzenoid
- 1-hydroxy-4-unsubstituted benzenoid
- Aralkylamine
- Phenol
- Monocyclic benzene moiety
- Benzenoid
- Amino acid
- Carboxylic acid
- Monocarboxylic acid or derivatives
- Organic oxygen compound
- Primary amine
- Organooxygen compound
- Organonitrogen compound
- Hydrocarbon derivative
- Primary aliphatic amine
- Organic nitrogen compound
- Carbonyl group
- Organic oxide
- Organopnictogen compound
- Amine
- Aromatic homomonocyclic compound
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| Molecular Framework | Aromatic homomonocyclic compounds |
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| External Descriptors | |
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| Physical Properties |
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| State | Solid |
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| Experimental Properties | | Property | Value | Reference |
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| Melting Point | 262 °C | Not Available | | Boiling Point | Not Available | Not Available | | Water Solubility | 2 mg/mL at 17 °C | Not Available | | LogP | Not Available | Not Available |
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| Predicted Properties | |
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| General References | - Orhan H, Vermeulen NP, Tump C, Zappey H, Meerman JH: Simultaneous determination of tyrosine, phenylalanine and deoxyguanosine oxidation products by liquid chromatography-tandem mass spectrometry as non-invasive biomarkers for oxidative damage. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Jan 25;799(2):245-54. [PubMed:14670743 ]
- Leeuwenburgh C, Hansen PA, Holloszy JO, Heinecke JW: Oxidized amino acids in the urine of aging rats: potential markers for assessing oxidative stress in vivo. Am J Physiol. 1999 Jan;276(1 Pt 2):R128-35. [PubMed:9887186 ]
- Reddy MK, Bhajammanavar V, Baidya M: Annulation Cascade of Sulfamate-Derived Cyclic Imines with Glycine Aldimino Esters: Synthesis of 1,3-Benzoxazepine Scaffolds. Org Lett. 2021 May 21;23(10):3868-3872. doi: 10.1021/acs.orglett.1c01001. Epub 2021 May 6. [PubMed:33956452 ]
- Quan H, Zhang Y, Yin P, Zhao L: Effects of two algicidal substances, ortho-tyrosine and urocanic acid, on the growth and physiology of Heterosoigma akashiwo. Environ Pollut. 2021 Sep 1;284:117004. doi: 10.1016/j.envpol.2021.117004. Epub 2021 Mar 23. [PubMed:33906037 ]
- Pelclova D, Navratil T, Fenclova Z, Vlckova S: Markers of oxidative stress after three days of nanoTiO2 sunscreen use in humans: a pilot study. Cent Eur J Public Health. 2020 Oct;28 Suppl:S17-S21. doi: 10.21101/cejph.a6158. [PubMed:33069176 ]
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