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Showing NP-Card for Iodotyrosine (NP0001348)

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Record Information
Version1.0
Created at2005-11-16 15:48:42 UTC
Updated at2020-11-24 22:22:43 UTC
NP-MRD IDNP0001348
Secondary Accession NumbersNone
Natural Product Identification
Common NameIodotyrosine
DescriptionIodotyrosine is an iodated derivative of L-tyrosine. This is an early precursor to L-thyroxine, one of the primary thyroid hormones. In the thyroid gland, iodide is trapped, transported, and concentrated in the follicular lumen for thyroid hormone synthesis. Before trapped iodide can react with tyrosine residues, it must be oxidized by thyroid peroxidase. Iodotyrosine is made from tyrosine via thyroid peroxidase and then further iodinated by this enzyme to make the di-iodo and tri-iodo variants. Two molecules of di-iodotyrosine combine to form T4, and one molecule of mono-iodotyrosine combines with one molecule of di-iodotyrosine to form T3.
Structure
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MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for NP0001348 (Iodotyrosine)


  Mrv1652303182019222D          

 14 14  0  0  1  0            999 V2000
    2.8579    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
  4 11  1  0  0  0  0
  2 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
M  END
Download

3D MOL for NP0001348 (Iodotyrosine)

HMDB0000021
     RDKit          3D
Iodotyrosine
 24 24  0  0  0  0  0  0  0  0999 V2000
   -3.2891   -0.8573    0.1574 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9394   -0.4810    0.5286 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.0624   -0.6991   -0.6676 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3609   -0.3550   -0.4496 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2462   -1.2876    0.0390 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5850   -0.9718    0.2401 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0613    0.2823   -0.0440 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3973    0.6221    0.1491 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1922    1.2248   -0.5321 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9282    3.1559   -0.9691 I   0  0  0  0  0  0  0  0  0  0  0  0
    0.8625    0.8991   -0.7282 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9607    0.9385    0.9479 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8960    1.4734    1.3570 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1361    1.6864    0.8964 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5703   -1.7876    0.5088 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5137   -0.6671   -0.8205 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6456   -1.1391    1.3734 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5015   -0.0984   -1.5047 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1897   -1.7635   -0.9772 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8832   -2.2764    0.2658 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2738   -1.7117    0.6247 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0527   -0.0629    0.5091 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2349    1.6872   -1.1184 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3740    2.1887    0.0527 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  7  9  1  0
  9 10  1  0
  9 11  2  0
  2 12  1  0
 12 13  2  0
 12 14  1  0
 11  4  1  0
  1 15  1  0
  1 16  1  0
  2 17  1  1
  3 18  1  0
  3 19  1  0
  5 20  1  0
  6 21  1  0
  8 22  1  0
 11 23  1  0
 14 24  1  0
M  END
Download

3D SDF for NP0001348 (Iodotyrosine)


  Mrv1652303182019222D          

 14 14  0  0  1  0            999 V2000
    2.8579    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
  4 11  1  0  0  0  0
  2 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0001348

> <DATABASE_NAME>
NP-MRD

> <SMILES>
N[C@@H](CC1=CC=C(O)C(I)=C1)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1

> <INCHI_KEY>
UQTZMGFTRHFAAM-ZETCQYMHSA-N

> <FORMULA>
C9H10INO3

> <MOLECULAR_WEIGHT>
307.0851

> <EXACT_MASS>
306.970536611

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
24

> <JCHEM_AVERAGE_POLARIZABILITY>
23.544080579143227

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid

> <ALOGPS_LOGP>
-1.51

> <JCHEM_LOGP>
-0.559798647037047

> <ALOGPS_LOGS>
-2.52

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
8.335155330087229

> <JCHEM_PKA_STRONGEST_ACIDIC>
0.9928460641360015

> <JCHEM_PKA_STRONGEST_BASIC>
9.49549159056975

> <JCHEM_POLAR_SURFACE_AREA>
83.55000000000001

> <JCHEM_REFRACTIVITY>
60.4597

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
9.37e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
iodotyrosine

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for NP0001348 (Iodotyrosine)

HMDB0000021
     RDKit          3D
Iodotyrosine
 24 24  0  0  0  0  0  0  0  0999 V2000
   -3.2891   -0.8573    0.1574 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9394   -0.4810    0.5286 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.0624   -0.6991   -0.6676 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3609   -0.3550   -0.4496 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2462   -1.2876    0.0390 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5850   -0.9718    0.2401 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0613    0.2823   -0.0440 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3973    0.6221    0.1491 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1922    1.2248   -0.5321 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9282    3.1559   -0.9691 I   0  0  0  0  0  0  0  0  0  0  0  0
    0.8625    0.8991   -0.7282 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9607    0.9385    0.9479 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8960    1.4734    1.3570 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1361    1.6864    0.8964 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5703   -1.7876    0.5088 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5137   -0.6671   -0.8205 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6456   -1.1391    1.3734 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5015   -0.0984   -1.5047 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1897   -1.7635   -0.9772 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8832   -2.2764    0.2658 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2738   -1.7117    0.6247 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0527   -0.0629    0.5091 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2349    1.6872   -1.1184 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3740    2.1887    0.0527 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  7  9  1  0
  9 10  1  0
  9 11  2  0
  2 12  1  0
 12 13  2  0
 12 14  1  0
 11  4  1  0
  1 15  1  0
  1 16  1  0
  2 17  1  1
  3 18  1  0
  3 19  1  0
  5 20  1  0
  6 21  1  0
  8 22  1  0
 11 23  1  0
 14 24  1  0
M  END
Download

PDB for NP0001348 (Iodotyrosine)

HEADER    PROTEIN                                 18-MAR-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   18-MAR-20         0                                  
HETATM    1  N   UNK     0       5.335   1.540   0.000  0.00  0.00           N+0
HETATM    2  C   UNK     0       5.335   0.000   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       4.001  -0.770   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       2.667   0.000   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       0.000   1.540   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0      -1.334   2.310   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0       1.334   2.310   0.000  0.00  0.00           C+0
HETATM   10  I   UNK     0       1.334   3.850   0.000  0.00  0.00           I+0
HETATM   11  C   UNK     0       2.667   1.540   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       6.668  -0.770   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0       8.002   0.000   0.000  0.00  0.00           O+0
HETATM   14  O   UNK     0       6.668  -2.310   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3   12                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5   11                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8    9                                                  
CONECT    8    7                                                            
CONECT    9    7   10   11                                                  
CONECT   10    9                                                            
CONECT   11    9    4                                                       
CONECT   12    2   13   14                                                  
CONECT   13   12                                                            
CONECT   14   12                                                            
MASTER        0    0    0    0    0    0    0    0   14    0   28    0
END
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3D PDB for NP0001348 (Iodotyrosine)

COMPND    HMDB0000021
HETATM    1  N1  UNL     1      -3.289  -0.857   0.157  1.00  0.00           N  
HETATM    2  C1  UNL     1      -1.939  -0.481   0.529  1.00  0.00           C  
HETATM    3  C2  UNL     1      -1.062  -0.699  -0.668  1.00  0.00           C  
HETATM    4  C3  UNL     1       0.361  -0.355  -0.450  1.00  0.00           C  
HETATM    5  C4  UNL     1       1.246  -1.288   0.039  1.00  0.00           C  
HETATM    6  C5  UNL     1       2.585  -0.972   0.240  1.00  0.00           C  
HETATM    7  C6  UNL     1       3.061   0.282  -0.044  1.00  0.00           C  
HETATM    8  O1  UNL     1       4.397   0.622   0.149  1.00  0.00           O  
HETATM    9  C7  UNL     1       2.192   1.225  -0.532  1.00  0.00           C  
HETATM   10  I1  UNL     1       2.928   3.156  -0.969  1.00  0.00           I  
HETATM   11  C8  UNL     1       0.863   0.899  -0.728  1.00  0.00           C  
HETATM   12  C9  UNL     1      -1.961   0.939   0.948  1.00  0.00           C  
HETATM   13  O2  UNL     1      -0.896   1.473   1.357  1.00  0.00           O  
HETATM   14  O3  UNL     1      -3.136   1.686   0.896  1.00  0.00           O  
HETATM   15  H1  UNL     1      -3.570  -1.788   0.509  1.00  0.00           H  
HETATM   16  H2  UNL     1      -3.514  -0.667  -0.820  1.00  0.00           H  
HETATM   17  H3  UNL     1      -1.646  -1.139   1.373  1.00  0.00           H  
HETATM   18  H4  UNL     1      -1.502  -0.098  -1.505  1.00  0.00           H  
HETATM   19  H5  UNL     1      -1.190  -1.763  -0.977  1.00  0.00           H  
HETATM   20  H6  UNL     1       0.883  -2.276   0.266  1.00  0.00           H  
HETATM   21  H7  UNL     1       3.274  -1.712   0.625  1.00  0.00           H  
HETATM   22  H8  UNL     1       5.053  -0.063   0.509  1.00  0.00           H  
HETATM   23  H9  UNL     1       0.235   1.687  -1.118  1.00  0.00           H  
HETATM   24  H10 UNL     1      -3.374   2.189   0.053  1.00  0.00           H  
CONECT    1    2   15   16
CONECT    2    3   12   17
CONECT    3    4   18   19
CONECT    4    5    5   11
CONECT    5    6   20
CONECT    6    7    7   21
CONECT    7    8    9
CONECT    8   22
CONECT    9   10   11   11
CONECT   11   23
CONECT   12   13   13   14
CONECT   14   24
END
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SMILES for NP0001348 (Iodotyrosine)

N[C@@H](CC1=CC=C(O)C(I)=C1)C(O)=O
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INCHI for NP0001348 (Iodotyrosine)

InChI=1S/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
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View in JSmol
Synonyms
ValueSource
(2S)-2-Amino-3-(4-hydroxy-3-iodophenyl)propanoic acidChEBI
3-IODO-tyrosineChEBI
MITChEBI
(2S)-2-Amino-3-(4-hydroxy-3-iodophenyl)propanoateGenerator
3-Iodo-4-hydroxyphenylalanineHMDB
3-Iodo-L-tyrosineHMDB
3-IodotyrosineHMDB
3-Monoiodo-L-tyrosineHMDB
4-Hydroxy-3-iodophenylalanineHMDB
IYRHMDB
L-Tyrosine-3-iodoHMDB
MonoiodotyrosineHMDB
Chemical FormulaC9H10INO3
Average Mass307.0851 Da
Monoisotopic Mass306.97054 Da
IUPAC Name(2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid
Traditional Nameiodotyrosine
CAS Registry Number70-78-0
SMILES
N[C@@H](CC1=CC=C(O)C(I)=C1)C(O)=O
InChI Identifier
InChI=1S/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
InChI KeyUQTZMGFTRHFAAM-ZETCQYMHSA-N
Experimental Spectra
Spectrum TypeDescriptionDepositor EmailDepositor OrganizationDepositorDeposition DateView
1D NMR1H NMR Spectrum (1D, 600 MHz, H2O, experimental)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
Predicted Spectra
Not Available
Chemical Shift Submissions
Not Available
Species
Species of Origin
Species NameSourceReference
Anas platyrhynchosFooDB
AnatidaeFooDB
Anser anserFooDB
Bison bisonFooDB
Bos taurusFooDB
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Chemical Taxonomy
Description Belongs to the class of organic compounds known as tyrosine and derivatives. Tyrosine and derivatives are compounds containing tyrosine or a derivative thereof resulting from reaction of tyrosine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentTyrosine and derivatives
Alternative Parents
Substituents
  • Tyrosine or derivatives
  • Phenylalanine or derivatives
  • 3-phenylpropanoic-acid
  • Alpha-amino acid
  • Amphetamine or derivatives
  • L-alpha-amino acid
  • 2-iodophenol
  • 2-halophenol
  • 1-hydroxy-2-unsubstituted benzenoid
  • Iodobenzene
  • Halobenzene
  • Phenol
  • Aralkylamine
  • Aryl iodide
  • Aryl halide
  • Benzenoid
  • Monocyclic benzene moiety
  • Amino acid
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Organic nitrogen compound
  • Organohalogen compound
  • Primary aliphatic amine
  • Organoiodide
  • Organonitrogen compound
  • Organooxygen compound
  • Primary amine
  • Carbonyl group
  • Hydrocarbon derivative
  • Organic oxide
  • Organopnictogen compound
  • Organic oxygen compound
  • Amine
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point205 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility3 mg/mLNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.94 g/LALOGPS
logP-1.5ALOGPS
logP-0.56ChemAxon
logS-2.5ALOGPS
pKa (Strongest Acidic)0.99ChemAxon
pKa (Strongest Basic)9.5ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area83.55 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity60.46 m³·mol⁻¹ChemAxon
Polarizability23.54 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
HMDB IDHMDB0000021
DrugBank IDDB01758
Phenol Explorer Compound IDNot Available
FoodDB IDFDB021875
KNApSAcK IDNot Available
Chemspider ID388804
KEGG Compound IDC02515
BioCyc IDCPD-12288
BiGG ID39998
Wikipedia Link3-Iodotyrosine
METLIN IDNot Available
PubChem Compound439744
PDB IDNot Available
ChEBI ID27847
Good Scents IDNot Available
References
General References
  1. Sakamoto K, Hayashi A, Sakamoto A, Kiga D, Nakayama H, Soma A, Kobayashi T, Kitabatake M, Takio K, Saito K, Shirouzu M, Hirao I, Yokoyama S: Site-specific incorporation of an unnatural amino acid into proteins in mammalian cells. Nucleic Acids Res. 2002 Nov 1;30(21):4692-9. [PubMed:12409460 ]
  2. Painter K, Vader CR: Interference of iodine-125 ligands in radioimmunoassay: evidence implicating thyroxine-binding globulin. Clin Chem. 1979 May;25(5):797-9. [PubMed:108034 ]
  3. Ismail-Beigi F, Rahimifar M: A variant of iodotyrosine-dehalogenase deficiency. J Clin Endocrinol Metab. 1977 Mar;44(3):499-506. [PubMed:838849 ]
  4. Smythe GA, Compton PJ, Lazarus L: The stimulation of human prolactin secretion by 3-Iodo-L-tyrosine. J Clin Endocrinol Metab. 1975 Apr;40(4):714-6. [PubMed:1127080 ]
  5. Muller EE, Locatelli V, Cella S, Penalva A, Novelli A, Cocchi D: Prolactin-lowering and -releasing drugs. Mechanisms of action and therapeutic applications. Drugs. 1983 Apr;25(4):399-432. [PubMed:6133737 ]
  6. Kucerova Z, Ticha M: Aromatic amino acids and their derivatives as ligands for the isolation of aspartic proteinases. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Apr 25;770(1-2):121-8. [PubMed:12013218 ]