Np mrd loader

Showing NP-Card for 3-Chlorotyrosine (NP0001341)

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Record Information
Version2.0
Created at2006-02-28 10:36:16 UTC
Updated at2020-11-24 22:22:40 UTC
NP-MRD IDNP0001341
Secondary Accession NumbersNone
Natural Product Identification
Common Name3-Chlorotyrosine
Description3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima. (PMID 9151778 ). In particular, myeloperoxidase halogenates tyrosine residues in plasma proteins and and generates 3-chlorotyrosine (CY). The detection of free chlorotyrosine in blood or urine arises from the degradation of these chlorinated proteins. CY concentrations may be useful for monitoring the activation of neutrophils in asthmatic patients (PMID 15196282 ).
Structure
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MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for NP0001341 (3-Chlorotyrosine)

Untitled Document-1
  Mrv1652305261923562D          

 14 14  0  0  0  0            999 V2000
   -2.4750   -1.0717    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0625   -0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4750    0.3572    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375   -0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250    0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -1.0717    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375   -0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500    0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375    1.0717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    1.0717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4750    0.3572    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -1.0717    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12  7  1  0  0  0  0
 10 13  1  0  0  0  0
  9 14  1  0  0  0  0
M  END
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3D MOL for NP0001341 (3-Chlorotyrosine)

HMDB0001885
     RDKit          3D
3-Chlorotyrosine
 24 24  0  0  0  0  0  0  0  0999 V2000
   -1.5393   -1.1436    1.2708 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9230    0.0045    0.4734 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0968   -0.0270   -0.7879 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3566    0.0394   -0.4824 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0685   -1.1249   -0.2841 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4251   -1.1114    0.0031 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0658    0.0868    0.0903 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4391    0.1495    0.3790 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3809    1.2654   -0.1029 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2315    2.8141    0.0146 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.0469    1.2194   -0.3839 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3507   -0.1707    0.1044 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0203   -1.1710    0.4676 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0148    0.7787   -0.6694 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7261   -2.0000    0.7026 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5557   -1.1009    1.5698 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8455    0.9548    1.0190 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3471    0.7920   -1.4926 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3487   -0.9813   -1.3054 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5831   -2.0994   -0.3474 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9753   -2.0374    0.1574 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9137    1.0174    0.4444 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4860    2.1283   -0.5398 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2045    1.7172   -0.3005 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  7  9  1  0
  9 10  1  0
  9 11  2  0
  2 12  1  0
 12 13  2  0
 12 14  1  0
 11  4  1  0
  1 15  1  0
  1 16  1  0
  2 17  1  0
  3 18  1  0
  3 19  1  0
  5 20  1  0
  6 21  1  0
  8 22  1  0
 11 23  1  0
 14 24  1  0
M  END
Download

3D SDF for NP0001341 (3-Chlorotyrosine)

Untitled Document-1
  Mrv1652305261923562D          

 14 14  0  0  0  0            999 V2000
   -2.4750   -1.0717    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0625   -0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4750    0.3572    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375   -0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250    0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -1.0717    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375   -0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500    0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375    1.0717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    1.0717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4750    0.3572    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -1.0717    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12  7  1  0  0  0  0
 10 13  1  0  0  0  0
  9 14  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0001341

> <DATABASE_NAME>
NP-MRD

> <SMILES>
NC(CC1=CC(Cl)=C(O)C=C1)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C9H10ClNO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)

> <INCHI_KEY>
ACWBBAGYTKWBCD-UHFFFAOYSA-N

> <FORMULA>
C9H10ClNO3

> <MOLECULAR_WEIGHT>
215.634

> <EXACT_MASS>
215.034920898

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
24

> <JCHEM_AVERAGE_POLARIZABILITY>
20.351929982702742

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
2-amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid

> <ALOGPS_LOGP>
-1.65

> <JCHEM_LOGP>
-0.8850358142060988

> <ALOGPS_LOGS>
-2.33

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
7.922885095364729

> <JCHEM_PKA_STRONGEST_ACIDIC>
1.5613557553897812

> <JCHEM_PKA_STRONGEST_BASIC>
9.470030440170163

> <JCHEM_POLAR_SURFACE_AREA>
83.55

> <JCHEM_REFRACTIVITY>
51.90200000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.01e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
monochlorotyrosine

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for NP0001341 (3-Chlorotyrosine)

HMDB0001885
     RDKit          3D
3-Chlorotyrosine
 24 24  0  0  0  0  0  0  0  0999 V2000
   -1.5393   -1.1436    1.2708 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9230    0.0045    0.4734 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0968   -0.0270   -0.7879 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3566    0.0394   -0.4824 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0685   -1.1249   -0.2841 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4251   -1.1114    0.0031 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0658    0.0868    0.0903 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4391    0.1495    0.3790 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3809    1.2654   -0.1029 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2315    2.8141    0.0146 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.0469    1.2194   -0.3839 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3507   -0.1707    0.1044 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0203   -1.1710    0.4676 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0148    0.7787   -0.6694 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7261   -2.0000    0.7026 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5557   -1.1009    1.5698 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8455    0.9548    1.0190 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3471    0.7920   -1.4926 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3487   -0.9813   -1.3054 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5831   -2.0994   -0.3474 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9753   -2.0374    0.1574 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9137    1.0174    0.4444 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4860    2.1283   -0.5398 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2045    1.7172   -0.3005 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  7  9  1  0
  9 10  1  0
  9 11  2  0
  2 12  1  0
 12 13  2  0
 12 14  1  0
 11  4  1  0
  1 15  1  0
  1 16  1  0
  2 17  1  0
  3 18  1  0
  3 19  1  0
  5 20  1  0
  6 21  1  0
  8 22  1  0
 11 23  1  0
 14 24  1  0
M  END
Download

PDB for NP0001341 (3-Chlorotyrosine)

HEADER    PROTEIN                                 26-MAY-19   NONE
TITLE     NULL                                                        
COMPND    MOLECULE: Untitled Document-1                               
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   26-MAY-19         0                                  
HETATM    1  O   UNK     0      -4.620  -2.001   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0      -3.850  -0.667   0.000  0.00  0.00           C+0
HETATM    3  O   UNK     0      -4.620   0.667   0.000  0.00  0.00           O+0
HETATM    4  C   UNK     0      -2.310  -0.667   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -1.540   0.667   0.000  0.00  0.00           C+0
HETATM    6  N   UNK     0      -1.540  -2.001   0.000  0.00  0.00           N+0
HETATM    7  C   UNK     0       0.000   0.667   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       0.770  -0.667   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       2.310  -0.667   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       3.080   0.667   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       2.310   2.001   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       0.770   2.001   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0       4.620   0.667   0.000  0.00  0.00           O+0
HETATM   14 Cl   UNK     0       3.080  -2.001   0.000  0.00  0.00          Cl+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5    6                                                  
CONECT    5    4    7                                                       
CONECT    6    4                                                            
CONECT    7    5    8   12                                                  
CONECT    8    7    9                                                       
CONECT    9    8   10   14                                                  
CONECT   10    9   11   13                                                  
CONECT   11   10   12                                                       
CONECT   12   11    7                                                       
CONECT   13   10                                                            
CONECT   14    9                                                            
MASTER        0    0    0    0    0    0    0    0   14    0   28    0
END
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3D PDB for NP0001341 (3-Chlorotyrosine)

COMPND    HMDB0001885
HETATM    1  N1  UNL     1      -1.539  -1.144   1.271  1.00  0.00           N  
HETATM    2  C1  UNL     1      -1.923   0.004   0.473  1.00  0.00           C  
HETATM    3  C2  UNL     1      -1.097  -0.027  -0.788  1.00  0.00           C  
HETATM    4  C3  UNL     1       0.357   0.039  -0.482  1.00  0.00           C  
HETATM    5  C4  UNL     1       1.068  -1.125  -0.284  1.00  0.00           C  
HETATM    6  C5  UNL     1       2.425  -1.111   0.003  1.00  0.00           C  
HETATM    7  C6  UNL     1       3.066   0.087   0.090  1.00  0.00           C  
HETATM    8  O1  UNL     1       4.439   0.149   0.379  1.00  0.00           O  
HETATM    9  C7  UNL     1       2.381   1.265  -0.103  1.00  0.00           C  
HETATM   10 CL1  UNL     1       3.232   2.814   0.015  1.00  0.00          CL  
HETATM   11  C8  UNL     1       1.047   1.219  -0.384  1.00  0.00           C  
HETATM   12  C9  UNL     1      -3.351  -0.171   0.104  1.00  0.00           C  
HETATM   13  O2  UNL     1      -4.020  -1.171   0.468  1.00  0.00           O  
HETATM   14  O3  UNL     1      -4.015   0.779  -0.669  1.00  0.00           O  
HETATM   15  H1  UNL     1      -1.726  -2.000   0.703  1.00  0.00           H  
HETATM   16  H2  UNL     1      -0.556  -1.101   1.570  1.00  0.00           H  
HETATM   17  H3  UNL     1      -1.845   0.955   1.019  1.00  0.00           H  
HETATM   18  H4  UNL     1      -1.347   0.792  -1.493  1.00  0.00           H  
HETATM   19  H5  UNL     1      -1.349  -0.981  -1.305  1.00  0.00           H  
HETATM   20  H6  UNL     1       0.583  -2.099  -0.347  1.00  0.00           H  
HETATM   21  H7  UNL     1       2.975  -2.037   0.157  1.00  0.00           H  
HETATM   22  H8  UNL     1       4.914   1.017   0.444  1.00  0.00           H  
HETATM   23  H9  UNL     1       0.486   2.128  -0.540  1.00  0.00           H  
HETATM   24  H10 UNL     1      -4.205   1.717  -0.301  1.00  0.00           H  
CONECT    1    2   15   16
CONECT    2    3   12   17
CONECT    3    4   18   19
CONECT    4    5    5   11
CONECT    5    6   20
CONECT    6    7    7   21
CONECT    7    8    9
CONECT    8   22
CONECT    9   10   11   11
CONECT   11   23
CONECT   12   13   13   14
CONECT   14   24
END
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SMILES for NP0001341 (3-Chlorotyrosine)

NC(CC1=CC(Cl)=C(O)C=C1)C(O)=O
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INCHI for NP0001341 (3-Chlorotyrosine)

InChI=1S/C9H10ClNO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)
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Synonyms
ValueSource
3-Chloro-L-tyrosineHMDB
ChlorotyrosineHMDB
L-(8CI)-3-chloro-tyrosineHMDB
MonochlorotyrosineHMDB
3-Chlorotyrosine, (L)-isomerHMDB
3-Chlorotyrosine hydrochloride, (L)-isomerHMDB
2-Amino-3-(3-chloro-4-hydroxyphenyl)propanoateHMDB
Chemical FormulaC9H10ClNO3
Average Mass215.6340 Da
Monoisotopic Mass215.03492 Da
IUPAC Name2-amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid
Traditional Namemonochlorotyrosine
CAS Registry Number7423-93-0
SMILES
NC(CC1=CC(Cl)=C(O)C=C1)C(O)=O
InChI Identifier
InChI=1S/C9H10ClNO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)
InChI KeyACWBBAGYTKWBCD-UHFFFAOYSA-N
Experimental Spectra
Spectrum TypeDescriptionDepositor EmailDepositor OrganizationDepositorDeposition DateView
1D NMR1H NMR Spectrum (1D, 500 MHz, CDCl3, experimental)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
Predicted Spectra
Not Available
Chemical Shift Submissions
Not Available
Species
Species of Origin
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Anas platyrhynchosFooDB
AnatidaeFooDB
Anser anserFooDB
Bison bisonFooDB
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Bubalus bubalisFooDB
Capra aegagrus hircusFooDB
CervidaeFooDB
Cervus canadensisFooDB
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Chemical Taxonomy
Description Belongs to the class of organic compounds known as tyrosine and derivatives. Tyrosine and derivatives are compounds containing tyrosine or a derivative thereof resulting from reaction of tyrosine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentTyrosine and derivatives
Alternative Parents
Substituents
  • Tyrosine or derivatives
  • Phenylalanine or derivatives
  • 3-phenylpropanoic-acid
  • Alpha-amino acid
  • Amphetamine or derivatives
  • 2-chlorophenol
  • 2-halophenol
  • 1-hydroxy-2-unsubstituted benzenoid
  • Halobenzene
  • Chlorobenzene
  • Phenol
  • Aralkylamine
  • Aryl halide
  • Benzenoid
  • Aryl chloride
  • Monocyclic benzene moiety
  • Amino acid
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Organic nitrogen compound
  • Organohalogen compound
  • Primary aliphatic amine
  • Organochloride
  • Organonitrogen compound
  • Organooxygen compound
  • Primary amine
  • Carbonyl group
  • Hydrocarbon derivative
  • Organic oxide
  • Organopnictogen compound
  • Organic oxygen compound
  • Amine
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
Water Solubility1.01 g/LALOGPS
logP-1.6ALOGPS
logP-0.89ChemAxon
logS-2.3ALOGPS
pKa (Strongest Acidic)1.56ChemAxon
pKa (Strongest Basic)9.47ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area83.55 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity51.9 m³·mol⁻¹ChemAxon
Polarizability20.35 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
HMDB IDHMDB0001885
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDFDB022723
KNApSAcK IDNot Available
Chemspider ID106510
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN ID6369
PubChem Compound119226
PDB IDNot Available
ChEBI IDNot Available
Good Scents IDNot Available
References
General References
  1. Gaut JP, Byun J, Tran HD, Heinecke JW: Artifact-free quantification of free 3-chlorotyrosine, 3-bromotyrosine, and 3-nitrotyrosine in human plasma by electron capture-negative chemical ionization gas chromatography mass spectrometry and liquid chromatography-electrospray ionization tandem mass spectrometry. Anal Biochem. 2002 Jan 15;300(2):252-9. [PubMed:11779118 ]
  2. Jasin HE: Oxidative modification of inflammatory synovial fluid immunoglobulin G. Inflammation. 1993 Apr;17(2):167-81. [PubMed:8387962 ]
  3. Lamb NJ, Quinlan GJ, Westerman ST, Gutteridge JM, Evans TW: Nitration of proteins in bronchoalveolar lavage fluid from patients with acute respiratory distress syndrome receiving inhaled nitric oxide. Am J Respir Crit Care Med. 1999 Sep;160(3):1031-4. [PubMed:10471637 ]
  4. Rosen H, Crowley JR, Heinecke JW: Human neutrophils use the myeloperoxidase-hydrogen peroxide-chloride system to chlorinate but not nitrate bacterial proteins during phagocytosis. J Biol Chem. 2002 Aug 23;277(34):30463-8. Epub 2002 Jun 11. [PubMed:12060654 ]
  5. Kettle AJ: Detection of 3-chlorotyrosine in proteins exposed to neutrophil oxidants. Methods Enzymol. 1999;300:111-20. [PubMed:9919515 ]
  6. Buss IH, Senthilmohan R, Darlow BA, Mogridge N, Kettle AJ, Winterbourn CC: 3-Chlorotyrosine as a marker of protein damage by myeloperoxidase in tracheal aspirates from preterm infants: association with adverse respiratory outcome. Pediatr Res. 2003 Mar;53(3):455-62. [PubMed:12595594 ]
  7. Khan J, Brennand DM, Bradley N, Gao B, Bruckdorfer R, Jacobs M: 3-Nitrotyrosine in the proteins of human plasma determined by an ELISA method. Biochem J. 1998 Mar 1;330 ( Pt 2):795-801. [PubMed:9480893 ]
  8. Mita H, Higashi N, Taniguchi M, Higashi A, Kawagishi Y, Akiyama K: Urinary 3-bromotyrosine and 3-chlorotyrosine concentrations in asthmatic patients: lack of increase in 3-bromotyrosine concentration in urine and plasma proteins in aspirin-induced asthma after intravenous aspirin challenge. Clin Exp Allergy. 2004 Jun;34(6):931-8. [PubMed:15196282 ]
  9. Hazen SL, Heinecke JW: 3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima. J Clin Invest. 1997 May 1;99(9):2075-81. [PubMed:9151778 ]