NP-MRD: Showing NP-Card for Biopterin (NP0001044)

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Record Information

Version

2.0

Created at

2005-11-16 15:48:42 UTC

Updated at

2025-02-11 15:42:31 UTC

NP-MRD ID

NP0001044

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Biopterin

Description

Biopterin, also known as tetrahydrobiopterin or BH4, belongs to the class of organic compounds known as biopterins and derivatives. These are coenzymes containing a 2-amino-pteridine-4-one derivative. Biopterin or tetrahydrobiopterin is also classified as a pterin derivative that consists of pterin group bearing an amino, an oxo and a 1,2-dihydroxypropyl substituent at positions 2, 4 and 6, respectively. Biopterin compounds found within the animals include BH4 (tetrahydrobiopterin), the free radical BH3, and BH2 (also a free radical, called Dihydrobiopterin). BH2 is produced in the synthesis of L-DOPA, dopamine, norepinephrine and epinephrine. It is restored to the required cofactor tetrahydrobiopterin by the enzyme dihydrobiopterin reductase. Tetrahydrobiopterin (BH4) is a cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine, 5-HT), melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline). It is also a cofactor for the production of nitric oxide (NO) by the nitric oxide syntheses. Tetrahydrobiopterin is biosynthesized from guanosine triphosphate (GTP) by three chemical reactions mediated by the enzymes GTP cyclohydrolase I (GTPCH), 6-pyruvoyltetrahydropterin synthase (PTPS), and sepiapterin reductase (SR). Biopterin synthesis disorders are a cause of hyperphenylalaninemia. There are 3 distinct forms of phenylketonuria or hyperphenylalaninemia, each caused by lack of aromatic amino acid hydroxylase enzymes. The variant forms of hyperphenylalaninemia that are caused by the lack of dihydropteridine reductase or tetrahydrobiopterin are characterized by severe neurological deterioration, impaired functioning of tyrosine and tryptophan hydroxylases, and the resultant deficiency of tyrosine- and tryptophan-derived monoamine neurotransmitters in brain. (PMID 3930837 ).

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

  Mrv1652305271900042D          

 17 18  0  0  0  0            999 V2000
 9997.370910000.0266    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10000.2228 9999.1997    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
10000.9364 9998.7851    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
10001.6519 9999.1997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10000.9364 9997.9610    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10000.222810000.0246    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9995.9441 9997.5435    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9998.7953 9999.1952    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9998.7953 9997.5453    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9999.5097 9997.9577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9999.5097 9998.7827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.0845 9998.7828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.3702 9999.1952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9996.6557 9998.7827    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9996.6557 9997.9578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.3701 9997.5454    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9998.0845 9997.9578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  3  1  0  0  0  0
  2  6  1  1  0  0  0
  3  4  1  0  0  0  0
  3  5  1  6  0  0  0
 10 11  2  0  0  0  0
 11  8  1  0  0  0  0
  9 10  1  0  0  0  0
 11  2  1  0  0  0  0
 12 13  1  0  0  0  0
 17 12  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
  1 13  2  0  0  0  0
 15  7  1  0  0  0  0
  8 12  2  0  0  0  0
 17  9  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0001044

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[C@H](O)[C@H](O)C1=CNC2=NC(N)=NC(=O)C2=N1

> <INCHI_IDENTIFIER>
InChI=1S/C9H11N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h2-3,6,15-16H,1H3,(H3,10,11,13,14,17)/t3-,6-/m0/s1

> <INCHI_KEY>
LHQIJBMDNUYRAM-DZSWIPIPSA-N

> <FORMULA>
C9H11N5O3

> <MOLECULAR_WEIGHT>
237.2153

> <EXACT_MASS>
237.086189243

> <JCHEM_ACCEPTOR_COUNT>
8

> <JCHEM_ATOM_COUNT>
28

> <JCHEM_AVERAGE_POLARIZABILITY>
22.465204903692857

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-4,8-dihydropteridin-4-one

> <ALOGPS_LOGP>
-1.41

> <JCHEM_LOGP>
-2.202784988

> <ALOGPS_LOGS>
-2.48

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.202343462619009

> <JCHEM_PKA_STRONGEST_ACIDIC>
8.182676489158556

> <JCHEM_PKA_STRONGEST_BASIC>
-1.4063089544608536

> <JCHEM_POLAR_SURFACE_AREA>
132.66

> <JCHEM_REFRACTIVITY>
57.81110000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
7.87e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-8H-pteridin-4-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 27-MAY-19   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   27-MAY-19         0                                  
HETATM    1  O   UNK     0    8661.7598666.716   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0    8667.0838665.173   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0    8668.4158664.399   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0    8669.7508665.173   0.000  0.00  0.00           C+0
HETATM    5  O   UNK     0    8668.4158662.861   0.000  0.00  0.00           O+0
HETATM    6  O   UNK     0    8667.0838666.713   0.000  0.00  0.00           O+0
HETATM    7  N   UNK     0    8659.0968662.081   0.000  0.00  0.00           N+0
HETATM    8  N   UNK     0    8664.4188665.164   0.000  0.00  0.00           N+0
HETATM    9  N   UNK     0    8664.4188662.085   0.000  0.00  0.00           N+0
HETATM   10  C   UNK     0    8665.7518662.854   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0    8665.7518664.394   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0    8663.0918664.395   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0    8661.7588665.164   0.000  0.00  0.00           C+0
HETATM   14  N   UNK     0    8660.4248664.394   0.000  0.00  0.00           N+0
HETATM   15  C   UNK     0    8660.4248662.855   0.000  0.00  0.00           C+0
HETATM   16  N   UNK     0    8661.7588662.085   0.000  0.00  0.00           N+0
HETATM   17  C   UNK     0    8663.0918662.855   0.000  0.00  0.00           C+0
CONECT    1   13                                                            
CONECT    2    3    6   11                                                  
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3                                                            
CONECT    6    2                                                            
CONECT    7   15                                                            
CONECT    8   11   12                                                       
CONECT    9   10   17                                                       
CONECT   10   11    9                                                       
CONECT   11   10    8    2                                                  
CONECT   12   13   17    8                                                  
CONECT   13   12   14    1                                                  
CONECT   14   13   15                                                       
CONECT   15   14   16    7                                                  
CONECT   16   15   17                                                       
CONECT   17   12   16    9                                                  
MASTER        0    0    0    0    0    0    0    0   17    0   36    0
END

COMPND    HMDB0000468
HETATM    1  C1  UNL     1      -4.370   0.451  -0.323  1.00  0.00           C  
HETATM    2  C2  UNL     1      -2.956   0.346   0.237  1.00  0.00           C  
HETATM    3  O1  UNL     1      -2.454   1.635   0.304  1.00  0.00           O  
HETATM    4  C3  UNL     1      -2.152  -0.461  -0.754  1.00  0.00           C  
HETATM    5  O2  UNL     1      -2.639  -1.761  -0.839  1.00  0.00           O  
HETATM    6  C4  UNL     1      -0.699  -0.434  -0.438  1.00  0.00           C  
HETATM    7  C5  UNL     1      -0.191  -1.251   0.550  1.00  0.00           C  
HETATM    8  N1  UNL     1       1.119  -1.263   0.873  1.00  0.00           N  
HETATM    9  C6  UNL     1       2.001  -0.464   0.235  1.00  0.00           C  
HETATM   10  N2  UNL     1       3.302  -0.437   0.515  1.00  0.00           N  
HETATM   11  C7  UNL     1       4.174   0.372  -0.137  1.00  0.00           C  
HETATM   12  N3  UNL     1       5.565   0.379   0.186  1.00  0.00           N  
HETATM   13  N4  UNL     1       3.660   1.162  -1.096  1.00  0.00           N  
HETATM   14  C8  UNL     1       2.388   1.219  -1.458  1.00  0.00           C  
HETATM   15  O3  UNL     1       1.951   1.980  -2.369  1.00  0.00           O  
HETATM   16  C9  UNL     1       1.477   0.405  -0.811  1.00  0.00           C  
HETATM   17  N5  UNL     1       0.175   0.372  -1.085  1.00  0.00           N  
HETATM   18  H1  UNL     1      -5.124   0.443   0.495  1.00  0.00           H  
HETATM   19  H2  UNL     1      -4.472   1.388  -0.930  1.00  0.00           H  
HETATM   20  H3  UNL     1      -4.595  -0.382  -1.022  1.00  0.00           H  
HETATM   21  H4  UNL     1      -2.984  -0.103   1.235  1.00  0.00           H  
HETATM   22  H5  UNL     1      -1.822   1.839  -0.433  1.00  0.00           H  
HETATM   23  H6  UNL     1      -2.337   0.002  -1.760  1.00  0.00           H  
HETATM   24  H7  UNL     1      -1.850  -2.346  -0.976  1.00  0.00           H  
HETATM   25  H8  UNL     1      -0.845  -1.921   1.105  1.00  0.00           H  
HETATM   26  H9  UNL     1       1.511  -1.883   1.624  1.00  0.00           H  
HETATM   27  H10 UNL     1       6.001  -0.514   0.465  1.00  0.00           H  
HETATM   28  H11 UNL     1       6.168   1.227   0.159  1.00  0.00           H  
CONECT    1    2   18   19   20
CONECT    2    3    4   21
CONECT    3   22
CONECT    4    5    6   23
CONECT    5   24
CONECT    6    7    7   17
CONECT    7    8   25
CONECT    8    9   26
CONECT    9   10   10   16
CONECT   10   11
CONECT   11   12   13   13
CONECT   12   27   28
CONECT   13   14
CONECT   14   15   15   16
CONECT   16   17   17
END

View in JSmol

Synonyms

Value	Source
(-)-Biopterin	ChEBI
(1'r,1's) Biopterin	HMDB
2-Amino-6-(L-erythro-1,2-dihydroxypropyl)-4(3H)-pteridinone	HMDB
6-Biopterin	HMDB
L-Biopterin	HMDB
L-Erythro-biopterin	HMDB
Pterin H b2	HMDB
[S-(R,s)]-2-amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone	HMDB
Orinapterin	HMDB
Dictyopterin	HMDB
2-Amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone	HMDB
Biopterin	MeSH

Chemical Formula

C₉H₁₁N₅O₃

Average Mass

237.2153 Da

Monoisotopic Mass

237.08619 Da

IUPAC Name

2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-4,8-dihydropteridin-4-one

Traditional Name

2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-8H-pteridin-4-one

CAS Registry Number

22150-76-1

SMILES

C[C@H](O)[C@H](O)C1=CNC2=NC(N)=NC(=O)C2=N1

InChI Identifier

InChI=1S/C9H11N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h2-3,6,15-16H,1H3,(H3,10,11,13,14,17)/t3-,6-/m0/s1

InChI Key

LHQIJBMDNUYRAM-DZSWIPIPSA-N

Experimental Spectra

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹H NMR Spectrum (1D, 600 MHz, DMSO, simulated)	V.dorna83			2021-08-22	View Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, 100%_DMSO, experimental)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Predicted Spectra

Not Available

Chemical Shift Submissions

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹H NMR Spectrum (1D, 600 MHz, DMSO, simulated)	v.dorna83@yahoo.com	Not Available	Not Available	2021-08-16	View Spectrum

Species

Species of Origin

Species Name	Source	Reference
Anas platyrhynchos	FooDB	FooDB
Anatidae	FooDB	FooDB
Anser anser	FooDB	FooDB
Bison bison	FooDB	FooDB
Bos taurus	FooDB	FooDB
Bos taurus X Bison bison	FooDB	FooDB
Bubalus bubalis	FooDB	FooDB
Capra aegagrus hircus	FooDB	FooDB
Cervidae	FooDB	FooDB
Cervus canadensis	FooDB	FooDB
Columba	FooDB	FooDB
Columbidae	FooDB	FooDB
Dromaius novaehollandiae	FooDB	FooDB
Equus caballus	FooDB	FooDB
Gallus gallus	FooDB	FooDB
Lagopus muta	FooDB	FooDB
Leporidae	FooDB	FooDB
Lepus timidus	FooDB	FooDB
Melanitta fusca	FooDB	FooDB
Meleagris gallopavo	FooDB	FooDB
Numida meleagris	FooDB	FooDB
Odocoileus	FooDB	FooDB
Oryctolagus	FooDB	FooDB
Ovis aries	FooDB	FooDB
Phasianidae	FooDB	FooDB
Phasianus colchicus	FooDB	FooDB
Struthio camelus	FooDB	FooDB
Sus scrofa	FooDB	FooDB
Sus scrofa domestica	FooDB	FooDB

Species Where Detected

Species Name	Source	Reference
Escherichia coli	KNApSAcK Database	22123792

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as biopterins and derivatives. These are coenzymes containing a 2-amino-pteridine-4-one derivative. They are mainly synthesized in several parts of the body, including the pineal gland.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Pteridines and derivatives

Sub Class

Pterins and derivatives

Direct Parent

Biopterins and derivatives

Alternative Parents

Substituents

Biopterin
Aminopyrimidine
Pyrimidone
Pyrazine
Pyrimidine
Heteroaromatic compound
Vinylogous amide
1,2-diol
Secondary alcohol
Azacycle
Organic oxygen compound
Alcohol
Aromatic alcohol
Hydrocarbon derivative
Primary amine
Organooxygen compound
Organonitrogen compound
Organic nitrogen compound
Organic oxide
Amine
Organopnictogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

biopterin (CHEBI:63931 )

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	0.7 mg/mL	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
Water Solubility	4.06 g/L	ALOGPS
logP	-1.4	ALOGPS
logP	-2.2	ChemAxon
logS	-2.5	ALOGPS
pKa (Strongest Acidic)	8.18	ChemAxon
pKa (Strongest Basic)	-1.4	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	8	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	132.66 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	57.81 m³·mol⁻¹	ChemAxon
Polarizability	22.47 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

HMDB0000468

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Not Available

Wikipedia Link

Biopterin

METLIN ID

247

PubChem Compound

445040

PDB ID

Not Available

ChEBI ID

63931

Good Scents ID

rw1223491

References

General References

Thony B, Leimbacher W, Blau N, Harvie A, Heizmann CW: Hyperphenylalaninemia due to defects in tetrahydrobiopterin metabolism: molecular characterization of mutations in 6-pyruvoyl-tetrahydropterin synthase. Am J Hum Genet. 1994 May;54(5):782-92. [PubMed:8178819 ]
Bonafe L, Thony B, Penzien JM, Czarnecki B, Blau N: Mutations in the sepiapterin reductase gene cause a novel tetrahydrobiopterin-dependent monoamine-neurotransmitter deficiency without hyperphenylalaninemia. Am J Hum Genet. 2001 Aug;69(2):269-77. Epub 2001 Jul 6. [PubMed:11443547 ]
Fiege B, Ballhausen D, Kierat L, Leimbacher W, Goriounov D, Schircks B, Thony B, Blau N: Plasma tetrahydrobiopterin and its pharmacokinetic following oral administration. Mol Genet Metab. 2004 Jan;81(1):45-51. [PubMed:14728990 ]
Friedland RP, Koss E, Haxby JV, Grady CL, Luxenberg J, Schapiro MB, Kaye J: NIH conference. Alzheimer disease: clinical and biological heterogeneity. Ann Intern Med. 1988 Aug 15;109(4):298-311. [PubMed:2969203 ]
Snyderman SE, Sansaricq C, Pulmones MT: Successful long term therapy of biopterin deficiency. J Inherit Metab Dis. 1987;10(3):260-6. [PubMed:3123784 ]
Nagatsu T, Yamaguchi T, Kato T, Sugimoto T, Matsuura S, Akino M, Nagatsu I, Iizuka R, Narabayashi H: Biopterin in human brain and urine from controls and parkinsonian patients: application of a new radioimmunoassay. Clin Chim Acta. 1981 Feb 5;109(3):305-11. [PubMed:6112078 ]
Katoh S, Sueoka T, Matsuura S, Sugimoto T: Biopterin and neopterin in human saliva. Life Sci. 1989;45(26):2561-8. [PubMed:2615555 ]
Ichinose H, Ohye T, Shinotoh H, Arai K, Yamazaki S, Mizuta E, Kuno S, Nagatsu T: Biopterin metabolism in patients with malignant syndrome. Parkinsonism Relat Disord. 2003 Apr;9 Suppl 1:S11-4. [PubMed:12735910 ]
Zurfluh MR, Giovannini M, Fiori L, Fiege B, Gokdemir Y, Baykal T, Kierat L, Gartner KH, Thony B, Blau N: Screening for tetrahydrobiopterin deficiencies using dried blood spots on filter paper. Mol Genet Metab. 2005 Dec;86 Suppl 1:S96-103. Epub 2005 Nov 7. [PubMed:16275037 ]
Ogiwara S, Kiuchi K, Nagatsu T, Teradaira R, Nagatsu I, Fujita K, Sugimoto T: Highly sensitive, specific enzyme-linked immunosorbent assay of neopterin and biopterin in biological samples. Clin Chem. 1992 Oct;38(10):1954-8. [PubMed:1394977 ]
Hirata Y, Sawada M, Minami M, Arai H, Iizuka R, Nagatsu T: Tyrosine hydroxylase, tryptophan hydroxylase, biopterin, and neopterin in the brain of anorexia nervosa. J Neural Transm Gen Sect. 1990;80(2):145-50. [PubMed:1969283 ]
Dhondt JL, Tilmont P, Ringel J, Farriaux JP: Pterins analysis in amniotic fluid for the prenatal diagnosis of GTP cyclohydrolase deficiency. J Inherit Metab Dis. 1990;13(6):879-82. [PubMed:2079836 ]
Furukawa Y, Kapatos G, Haycock JW, Worsley J, Wong H, Kish SJ, Nygaard TG: Brain biopterin and tyrosine hydroxylase in asymptomatic dopa-responsive dystonia. Ann Neurol. 2002 May;51(5):637-41. [PubMed:12112113 ]
Bonafe L, Thony B, Leimbacher W, Kierat L, Blau N: Diagnosis of dopa-responsive dystonia and other tetrahydrobiopterin disorders by the study of biopterin metabolism in fibroblasts. Clin Chem. 2001 Mar;47(3):477-85. [PubMed:11238300 ]
Slazyk WE, Spierto FW: Liquid-chromatographic measurement of biopterin and neopterin in serum and urine. Clin Chem. 1990 Jul;36(7):1364-8. [PubMed:2372953 ]
Dhondt JL, Hayte JM, Forzy G, Delcroix M, Farriaux JP: Unconjugated pteridines in amniotic fluid during gestation. Clin Chim Acta. 1986 Dec 30;161(3):269-73. [PubMed:3802534 ]
Iizuka T, Sasaki M, Oishi K, Uemura S, Koike M, Minatogawa Y: Nitric oxide may trigger lactation in humans. J Pediatr. 1997 Dec;131(6):839-43. [PubMed:9427887 ]
Zoghbi HY, Milstien S, Butler IJ, Smith EO, Kaufman S, Glaze DG, Percy AK: Cerebrospinal fluid biogenic amines and biopterin in Rett syndrome. Ann Neurol. 1989 Jan;25(1):56-60. [PubMed:2913929 ]
Kaufman S: Hyperphenylalaninaemia caused by defects in biopterin metabolism. J Inherit Metab Dis. 1985;8 Suppl 1:20-7. [PubMed:3930837 ]
(). Nagatsu T, Ichinose H, Mogi M, Togari A (1999) Neopterin and cytokines in hereditary dystonia and Parkinson’s disease. Pteridines 10: 5–13.. .

Showing NP-Card for Biopterin (NP0001044)

MOL for NP0001044 (Biopterin)

3D MOL for NP0001044 (Biopterin)

3D SDF for NP0001044 (Biopterin)

3D-SDF for NP0001044 (Biopterin)

PDB for NP0001044 (Biopterin)

3D PDB for NP0001044 (Biopterin)

SMILES for NP0001044 (Biopterin)

INCHI for NP0001044 (Biopterin)

Structure for NP0001044 (Biopterin)

3D Structure for NP0001044 (Biopterin)