NP-MRD: Showing NP-Card for 5'-Methylthioadenosine (NP0000972)

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Record Information

Version

1.0

Created at

2005-11-16 15:48:42 UTC

Updated at

2021-08-19 23:58:38 UTC

NP-MRD ID

NP0000972

Secondary Accession Numbers

None

Natural Product Identification

Common Name

5'-Methylthioadenosine

Description

5'-Methylthioadenosine, also known as MTA or thiomethyladenosine, belongs to the class of organic compounds known as 5'-deoxy-5'-thionucleosides. These are 5'-deoxyribonucleosides in which the ribose is thio-substituted at the 5'position by a S-alkyl group. 5'-Methylthioadenosine is metabolized solely by MTA-phosphorylase, to yield 5-methylthioribose-1-phosphate and adenine, a crucial step in the methionine and purine salvage pathways, respectively. 5'-Methylthioadenosine exists in all living species, ranging from bacteria to humans. 5'-Methylthioadenosine (MTA) is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues. Within humans, 5'-methylthioadenosine participates in a number of enzymatic reactions. In particular, 5'-methylthioadenosine and spermidine can be biosynthesized from S-adenosylmethioninamine and putrescine through the action of the enzyme spermidine synthase. In addition, 5'-methylthioadenosine can be converted into 5-methylthioribose 1-phosphate and L-methionine; which is catalyzed by the enzyme S-methyl-5'-thioadenosine phosphorylase. It is produced from S-adenosylmethionine mainly through the polyamine biosynthetic pathway, where it behaves as a powerful inhibitory product. For instance, 5'-Methylthioadenosine has been shown to influence the regulation of gene expression, proliferation, differentiation, and apoptosis (PMID: 15313459 ). In humans, 5'-methylthioadenosine is involved in the metabolic disorder called hypermethioninemia. Outside of the human body, 5'-Methylthioadenosine has been detected, but not quantified in several different foods, such as soursops, allspices, summer grapes, alaska wild rhubarbs, and breadfruits. Elevated excretion appears in children with severe combined immunodeficiency syndrome (SCID) (PMID: 3987052 ). Evidence suggests that 5'-Methylthioadenosine can affect cellular processes in many ways. 5'-Methylthioadenosine can be found in human urine.

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

HMDB0001173
     RDKit          3D
5'-Methylthioadenosine
 35 37  0  0  0  0  0  0  0  0999 V2000
    4.4626    1.1326    1.3832 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4701   -0.6001    0.9338 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8655   -1.3757    0.8284 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0637   -0.9271   -0.3377 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.8087   -1.5720   -0.3589 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0279   -0.8829   -1.2498 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.3744   -0.9365   -0.9378 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2684   -1.8240   -1.3948 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4937   -1.5767   -0.8970 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3660   -0.4975   -0.1001 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2444    0.2267    0.6773 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6099   -0.1528    0.7280 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7931    1.2822    1.3750 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5081    1.6274    1.3173 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6454    0.9388    0.5712 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0495   -0.1107   -0.1338 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5674    0.4833   -1.4099 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.2012    0.5978   -2.6666 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6904    0.5135   -0.3964 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.7396    1.3169   -0.8641 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9580    1.7565    0.5921 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1443    1.3005    2.2829 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5009    1.5396    1.7063 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0524   -2.4881    0.7301 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3110   -1.2830    1.7937 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5917   -1.1499   -1.3126 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1419   -1.4348   -2.2337 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0760   -2.6490   -2.0768 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3164    0.3126    0.1126 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9060   -0.9045    1.3878 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1943    2.5005    1.9096 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1600    1.2984   -1.2586 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5513    0.4632   -3.3993 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3477    0.8291    0.6124 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5092    2.2458   -0.5511 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 11 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
  6 17  1  0
 17 18  1  0
 17 19  1  0
 19 20  1  0
 19  4  1  0
 16  7  1  0
 16 10  1  0
  1 21  1  0
  1 22  1  0
  1 23  1  0
  3 24  1  0
  3 25  1  0
  4 26  1  6
  6 27  1  6
  8 28  1  0
 12 29  1  0
 12 30  1  0
 14 31  1  0
 17 32  1  1
 18 33  1  0
 19 34  1  1
 20 35  1  0
M  END


  Mrv1652309042000182D          

 20 22  0  0  0  0            999 V2000
 9999.8190 9998.0719    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10001.6078 9998.0639    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10002.1173 9999.9242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10002.8310 9999.5108    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
10003.5467 9999.9242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10000.731610000.0051    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10000.3191 9998.7355    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
10001.1441 9998.7355    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
10001.3990 9999.5201    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9996.606710000.3270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9997.2187 9999.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.0472 9998.9672    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9997.6604 9998.4151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.4449 9998.6700    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9998.6167 9999.4774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.003710000.0294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9999.3313 9999.8898    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9999.159810000.6967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.339410000.7830    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
10000.0849 9999.5541    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  6  9  1  0  0  0  0
  8  2  1  1  0  0  0
  9  3  1  6  0  0  0
  7  1  1  1  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 11 10  1  0  0  0  0
 15 16  2  0  0  0  0
 14 15  1  0  0  0  0
 16 11  1  0  0  0  0
 18 19  2  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
 15 17  1  0  0  0  0
 20 17  1  6  0  0  0
  6 20  1  0  0  0  0
 20  7  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0000972

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N

> <INCHI_IDENTIFIER>
InChI=1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1

> <INCHI_KEY>
WUUGFSXJNOTRMR-IOSLPCCCSA-N

> <FORMULA>
C11H15N5O3S

> <MOLECULAR_WEIGHT>
297.334

> <EXACT_MASS>
297.089560061

> <JCHEM_ACCEPTOR_COUNT>
7

> <JCHEM_ATOM_COUNT>
35

> <JCHEM_AVERAGE_POLARIZABILITY>
29.256574959298177

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(methylsulfanyl)methyl]oxolane-3,4-diol

> <ALOGPS_LOGP>
-0.14

> <JCHEM_LOGP>
-0.6084927256666669

> <ALOGPS_LOGS>
-1.66

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.012986053228548

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.47183133876813

> <JCHEM_PKA_STRONGEST_BASIC>
3.9212883219836336

> <JCHEM_POLAR_SURFACE_AREA>
119.31

> <JCHEM_REFRACTIVITY>
74.02919999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
6.50e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
methylthioadenosine

> <JCHEM_VEBER_RULE>
0

$$$$

HMDB0001173
     RDKit          3D
5'-Methylthioadenosine
 35 37  0  0  0  0  0  0  0  0999 V2000
    4.4626    1.1326    1.3832 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4701   -0.6001    0.9338 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8655   -1.3757    0.8284 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0637   -0.9271   -0.3377 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.8087   -1.5720   -0.3589 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0279   -0.8829   -1.2498 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.3744   -0.9365   -0.9378 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2684   -1.8240   -1.3948 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4937   -1.5767   -0.8970 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3660   -0.4975   -0.1001 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2444    0.2267    0.6773 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6099   -0.1528    0.7280 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7931    1.2822    1.3750 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5081    1.6274    1.3173 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6454    0.9388    0.5712 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0495   -0.1107   -0.1338 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5674    0.4833   -1.4099 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.2012    0.5978   -2.6666 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6904    0.5135   -0.3964 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.7396    1.3169   -0.8641 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9580    1.7565    0.5921 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1443    1.3005    2.2829 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5009    1.5396    1.7063 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0524   -2.4881    0.7301 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3110   -1.2830    1.7937 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5917   -1.1499   -1.3126 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1419   -1.4348   -2.2337 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0760   -2.6490   -2.0768 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3164    0.3126    0.1126 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9060   -0.9045    1.3878 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1943    2.5005    1.9096 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1600    1.2984   -1.2586 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5513    0.4632   -3.3993 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3477    0.8291    0.6124 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5092    2.2458   -0.5511 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 11 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
  6 17  1  0
 17 18  1  0
 17 19  1  0
 19 20  1  0
 19  4  1  0
 16  7  1  0
 16 10  1  0
  1 21  1  0
  1 22  1  0
  1 23  1  0
  3 24  1  0
  3 25  1  0
  4 26  1  6
  6 27  1  6
  8 28  1  0
 12 29  1  0
 12 30  1  0
 14 31  1  0
 17 32  1  1
 18 33  1  0
 19 34  1  1
 20 35  1  0
M  END

HEADER    PROTEIN                                 04-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-SEP-20         0                                  
HETATM    1  O   UNK     0    8666.3298663.068   0.000  0.00  0.00           O+0
HETATM    2  O   UNK     0    8669.6688663.053   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0    8670.6198666.525   0.000  0.00  0.00           C+0
HETATM    4  S   UNK     0    8671.9518665.753   0.000  0.00  0.00           S+0
HETATM    5  C   UNK     0    8673.2878666.525   0.000  0.00  0.00           C+0
HETATM    6  O   UNK     0    8668.0328666.676   0.000  0.00  0.00           O+0
HETATM    7  C   UNK     0    8667.2628664.306   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0    8668.8028664.306   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0    8669.2788665.771   0.000  0.00  0.00           C+0
HETATM   10  N   UNK     0    8660.3338667.277   0.000  0.00  0.00           N+0
HETATM   11  C   UNK     0    8661.4758666.245   0.000  0.00  0.00           C+0
HETATM   12  N   UNK     0    8661.1558664.739   0.000  0.00  0.00           N+0
HETATM   13  C   UNK     0    8662.2998663.708   0.000  0.00  0.00           C+0
HETATM   14  N   UNK     0    8663.7648664.184   0.000  0.00  0.00           N+0
HETATM   15  C   UNK     0    8664.0858665.691   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0    8662.9408666.722   0.000  0.00  0.00           C+0
HETATM   17  N   UNK     0    8665.4188666.461   0.000  0.00  0.00           N+0
HETATM   18  C   UNK     0    8665.0988667.967   0.000  0.00  0.00           C+0
HETATM   19  N   UNK     0    8663.5678668.128   0.000  0.00  0.00           N+0
HETATM   20  C   UNK     0    8666.8258665.834   0.000  0.00  0.00           C+0
CONECT    1    7                                                            
CONECT    2    8                                                            
CONECT    3    4    9                                                       
CONECT    4    3    5                                                       
CONECT    5    4                                                            
CONECT    6    9   20                                                       
CONECT    7    8    1   20                                                  
CONECT    8    7    9    2                                                  
CONECT    9    8    6    3                                                  
CONECT   10   11                                                            
CONECT   11   12   10   16                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   16   14   17                                                  
CONECT   16   15   11   19                                                  
CONECT   17   18   15   20                                                  
CONECT   18   19   17                                                       
CONECT   19   18   16                                                       
CONECT   20   17    6    7                                                  
MASTER        0    0    0    0    0    0    0    0   20    0   44    0
END

COMPND    HMDB0001173
HETATM    1  C1  UNL     1       4.463   1.133   1.383  1.00  0.00           C  
HETATM    2  S1  UNL     1       4.470  -0.600   0.934  1.00  0.00           S  
HETATM    3  C2  UNL     1       2.865  -1.376   0.828  1.00  0.00           C  
HETATM    4  C3  UNL     1       2.064  -0.927  -0.338  1.00  0.00           C  
HETATM    5  O1  UNL     1       0.809  -1.572  -0.359  1.00  0.00           O  
HETATM    6  C4  UNL     1       0.028  -0.883  -1.250  1.00  0.00           C  
HETATM    7  N1  UNL     1      -1.374  -0.936  -0.938  1.00  0.00           N  
HETATM    8  C5  UNL     1      -2.268  -1.824  -1.395  1.00  0.00           C  
HETATM    9  N2  UNL     1      -3.494  -1.577  -0.897  1.00  0.00           N  
HETATM   10  C6  UNL     1      -3.366  -0.497  -0.100  1.00  0.00           C  
HETATM   11  C7  UNL     1      -4.244   0.227   0.677  1.00  0.00           C  
HETATM   12  N3  UNL     1      -5.610  -0.153   0.728  1.00  0.00           N  
HETATM   13  N4  UNL     1      -3.793   1.282   1.375  1.00  0.00           N  
HETATM   14  C8  UNL     1      -2.508   1.627   1.317  1.00  0.00           C  
HETATM   15  N5  UNL     1      -1.645   0.939   0.571  1.00  0.00           N  
HETATM   16  C9  UNL     1      -2.049  -0.111  -0.134  1.00  0.00           C  
HETATM   17  C10 UNL     1       0.567   0.483  -1.410  1.00  0.00           C  
HETATM   18  O2  UNL     1       1.201   0.598  -2.667  1.00  0.00           O  
HETATM   19  C11 UNL     1       1.690   0.514  -0.396  1.00  0.00           C  
HETATM   20  O3  UNL     1       2.740   1.317  -0.864  1.00  0.00           O  
HETATM   21  H1  UNL     1       4.958   1.756   0.592  1.00  0.00           H  
HETATM   22  H2  UNL     1       5.144   1.301   2.283  1.00  0.00           H  
HETATM   23  H3  UNL     1       3.501   1.540   1.706  1.00  0.00           H  
HETATM   24  H4  UNL     1       3.052  -2.488   0.730  1.00  0.00           H  
HETATM   25  H5  UNL     1       2.311  -1.283   1.794  1.00  0.00           H  
HETATM   26  H6  UNL     1       2.592  -1.150  -1.313  1.00  0.00           H  
HETATM   27  H7  UNL     1       0.142  -1.435  -2.234  1.00  0.00           H  
HETATM   28  H8  UNL     1      -2.076  -2.649  -2.077  1.00  0.00           H  
HETATM   29  H9  UNL     1      -6.316   0.313   0.113  1.00  0.00           H  
HETATM   30  H10 UNL     1      -5.906  -0.905   1.388  1.00  0.00           H  
HETATM   31  H11 UNL     1      -2.194   2.501   1.910  1.00  0.00           H  
HETATM   32  H12 UNL     1      -0.160   1.298  -1.259  1.00  0.00           H  
HETATM   33  H13 UNL     1       0.551   0.463  -3.399  1.00  0.00           H  
HETATM   34  H14 UNL     1       1.348   0.829   0.612  1.00  0.00           H  
HETATM   35  H15 UNL     1       2.509   2.246  -0.551  1.00  0.00           H  
CONECT    1    2   21   22   23
CONECT    2    3
CONECT    3    4   24   25
CONECT    4    5   19   26
CONECT    5    6
CONECT    6    7   17   27
CONECT    7    8   16
CONECT    8    9    9   28
CONECT    9   10
CONECT   10   11   11   16
CONECT   11   12   13
CONECT   12   29   30
CONECT   13   14   14
CONECT   14   15   31
CONECT   15   16   16
CONECT   17   18   19   32
CONECT   18   33
CONECT   19   20   34
CONECT   20   35
END

HMDB0001173
     RDKit          3D
5'-Methylthioadenosine
 35 37  0  0  0  0  0  0  0  0999 V2000
    4.4626    1.1326    1.3832 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4701   -0.6001    0.9338 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8655   -1.3757    0.8284 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0637   -0.9271   -0.3377 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.8087   -1.5720   -0.3589 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0279   -0.8829   -1.2498 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.3744   -0.9365   -0.9378 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2684   -1.8240   -1.3948 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4937   -1.5767   -0.8970 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3660   -0.4975   -0.1001 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2444    0.2267    0.6773 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6099   -0.1528    0.7280 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7931    1.2822    1.3750 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5081    1.6274    1.3173 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6454    0.9388    0.5712 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0495   -0.1107   -0.1338 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5674    0.4833   -1.4099 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.2012    0.5978   -2.6666 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6904    0.5135   -0.3964 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.7396    1.3169   -0.8641 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9580    1.7565    0.5921 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1443    1.3005    2.2829 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5009    1.5396    1.7063 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0524   -2.4881    0.7301 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3110   -1.2830    1.7937 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5917   -1.1499   -1.3126 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1419   -1.4348   -2.2337 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0760   -2.6490   -2.0768 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3164    0.3126    0.1126 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9060   -0.9045    1.3878 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1943    2.5005    1.9096 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1600    1.2984   -1.2586 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5513    0.4632   -3.3993 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3477    0.8291    0.6124 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5092    2.2458   -0.5511 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 11 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
  6 17  1  0
 17 18  1  0
 17 19  1  0
 19 20  1  0
 19  4  1  0
 16  7  1  0
 16 10  1  0
  1 21  1  0
  1 22  1  0
  1 23  1  0
  3 24  1  0
  3 25  1  0
  4 26  1  6
  6 27  1  6
  8 28  1  0
 12 29  1  0
 12 30  1  0
 14 31  1  0
 17 32  1  1
 18 33  1  0
 19 34  1  1
 20 35  1  0
M  END

View in JSmol

Synonyms

Value	Source
5'-Deoxy-5'-(methylthio)adenosine	ChEBI
5-Methylthioadenosine	ChEBI
9-(5-S-Methyl-5-thio-beta-D-ribofuranosyl)-9H-purin-6-amine	ChEBI
Methylthioadenosine	ChEBI
MTA	ChEBI
S-Methyl-5'-thioadenosine	ChEBI
Thiomethyladenosine	ChEBI
5'-Deoxy-5'-(methylsulfanyl)adenosine	Kegg
9-(5-S-Methyl-5-thio-b-D-ribofuranosyl)-9H-purin-6-amine	Generator
9-(5-S-Methyl-5-thio-β-D-ribofuranosyl)-9H-purin-6-amine	Generator
5'-Deoxy-5'-(methylsulphanyl)adenosine	Generator
1-(6-Amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-beta-D-ribofuranose	HMDB
1-(6-Amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-beta-delta-ribofuranose	HMDB
5'-(Methylthio)-5'-deoxyadenosine	HMDB
5'-(Methylthio)adenosine	HMDB
5'-S-Methyl-5'-thio-adenosine	HMDB
5'-S-Methyl-5'-thioadenosine	HMDB
S-Methyl-5-thioadenosine	HMDB
Adenine(5'-deoxy-5'-methylthio)9-beta-D-furanoriboside	HMDB
5-MTDA	HMDB
5'-Methylthio-5'-deoxyadenosine	HMDB
5'-Deoxy-5'-methylthioadenosine	HMDB
5'-Methylthioadenosine, methyl-(14)C-labeled	HMDB
5'-Methylthioadenosine	ChEBI

Chemical Formula

C₁₁H₁₅N₅O₃S

Average Mass

297.3340 Da

Monoisotopic Mass

297.08956 Da

IUPAC Name

(2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(methylsulfanyl)methyl]oxolane-3,4-diol

Traditional Name

methylthioadenosine

CAS Registry Number

2457-80-9

SMILES

CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N

InChI Identifier

InChI=1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1

InChI Key

WUUGFSXJNOTRMR-IOSLPCCCSA-N

Experimental Spectra

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, 100%_DMSO, experimental)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Predicted Spectra

Not Available

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Abelmoschus esculentus	FooDB	FooDB
Actinidia chinensis	FooDB	FooDB
Agaricus bisporus	FooDB	FooDB
Agave	FooDB	FooDB
Allium ampeloprasum	FooDB	FooDB
Allium ascalonicum	FooDB	FooDB
Allium cepa	FooDB	FooDB
Allium cepa L.	FooDB	FooDB
Allium fistulosum	FooDB	FooDB
Allium sativum	FooDB	FooDB
Allium schoenoprasum	FooDB	FooDB
Allium tuberosum	FooDB	FooDB
Aloysia triphylla	FooDB	FooDB
Amaranthus	FooDB	FooDB
Amelanchier alnifolia	FooDB	FooDB
Anacardium occidentale	FooDB	FooDB
Ananas comosus	FooDB	FooDB
Anas platyrhynchos	FooDB	FooDB
Anatidae	FooDB	FooDB
Anethum graveolens	FooDB	FooDB
Angelica keiskei	FooDB	FooDB
Annona cherimola	FooDB	FooDB
Annona muricata	FooDB	FooDB
Annona reticulata	FooDB	FooDB
Annona squamosa	FooDB	FooDB
Anser anser	FooDB	FooDB
Anthriscus cerefolium	FooDB	FooDB
Apis cerana	LOTUS Database	35616633
Apium graveolens	FooDB	FooDB
Apium graveolens var. dulce	FooDB	FooDB
Apium graveolens var. rapaceum	FooDB	FooDB
Apium graveolens var. secalinum	FooDB	FooDB
Arachis hypogaea	FooDB	FooDB
Arctium lappa	FooDB	FooDB
Armoracia rusticana	FooDB	FooDB
Artemisia dracunculus	FooDB	FooDB
Artemisia vulgaris	FooDB	FooDB
Artocarpus altilis	FooDB	FooDB
Artocarpus heterophyllus	FooDB	FooDB
Asparagus officinalis	FooDB	FooDB
Attalea speciosa	FooDB	FooDB
Auricularia auricula-judae	FooDB	FooDB
Auricularia polytricha	FooDB	FooDB
Avena sativa L.	FooDB	FooDB
Averrhoa carambola	FooDB	FooDB
Basella alba	FooDB	FooDB
Benincasa hispida	FooDB	FooDB
Bertholletia excelsa	FooDB	FooDB
Beta vulgaris	FooDB	FooDB
Beta vulgaris ssp. cicla	FooDB	FooDB
Bison bison	FooDB	FooDB
Borago officinalis	FooDB	FooDB
Bos taurus	FooDB	FooDB
Bos taurus X Bison bison	FooDB	FooDB
Brassica alboglabra	FooDB	FooDB
Brassica juncea	FooDB	FooDB
Brassica napus	FooDB	FooDB
Brassica napus var. napus	FooDB	FooDB
Brassica oleracea	FooDB	FooDB
Brassica oleracea var. botrytis	FooDB	FooDB
Brassica oleracea var. capitata	FooDB	FooDB
Brassica oleracea var. gemmifera	FooDB	FooDB
Brassica oleracea var. gongylodes	FooDB	FooDB
Brassica oleracea var. italica	FooDB	FooDB
Brassica oleracea var. sabauda	FooDB	FooDB
Brassica oleracea var. viridis	FooDB	FooDB
Brassica rapa	FooDB	FooDB
Brassica rapa ssp. chinensis	FooDB	FooDB
Brassica rapa var. pekinensis	FooDB	FooDB
Brassica rapa var. rapa	FooDB	FooDB
Brassica ruvo	FooDB	FooDB
Brosimum alicastrum	FooDB	FooDB
Bubalus bubalis	FooDB	FooDB
Byrsonima crassifolia	FooDB	FooDB
Cajanus cajan	FooDB	FooDB
Canarium ovatum	FooDB	FooDB
Cannabis sativa	CannabisDB	Not Available
Cantharellus cibarius	FooDB	FooDB
Capparis spinosa	FooDB	FooDB
Capra aegagrus hircus	FooDB	FooDB
Capsicum annuum	FooDB	FooDB
Capsicum annuum L.	FooDB	FooDB
Capsicum annuum var. annuum	FooDB	FooDB
Capsicum chinense	FooDB	FooDB
Capsicum pubescens	FooDB	FooDB
Carica papaya L.	FooDB	FooDB
Carissa macrocarpa	FooDB	FooDB
Carthamus tinctorius	FooDB	FooDB
Carum carvi	FooDB	FooDB
Carya	FooDB	FooDB
Carya illinoinensis	FooDB	FooDB
Castanea	FooDB	FooDB
Castanea crenata	FooDB	FooDB
Castanea mollissima	FooDB	FooDB
Castanea sativa	FooDB	FooDB
Ceratonia siliqua	FooDB	FooDB
Cervidae	FooDB	FooDB
Cervus canadensis	FooDB	FooDB
Chamaemelum nobile	FooDB	FooDB
Chamerion angustifolium	FooDB	FooDB
Chenopodium album	FooDB	FooDB
Chenopodium quinoa	FooDB	FooDB
Chlamydomonas reinhardtii	LOTUS Database	35616633
Chrysanthemum coronarium	FooDB	FooDB
Cicer arietinum	FooDB	FooDB
Cichorium endivia	FooDB	FooDB
Cichorium intybus	FooDB	FooDB
Cinnamomum	FooDB	FooDB
Cinnamomum aromaticum	FooDB	FooDB
Cinnamomum verum	FooDB	FooDB
Cirsium	FooDB	FooDB
Citrullus lanatus	FooDB	FooDB
Citrus ×limon (L.) Burm. f. (pro sp.)	FooDB	FooDB
Citrus aurantiifolia	FooDB	FooDB
Citrus latifolia	FooDB	FooDB
Citrus limon	FooDB	FooDB
Citrus maxima	FooDB	FooDB
Citrus paradisi	FooDB	FooDB
Citrus reticulata	FooDB	FooDB
Citrus X sinensis (L.) Osbeck (pro. sp.)	FooDB	FooDB
Cocos nucifera	FooDB	FooDB
Coffea arabica L.	FooDB	FooDB
Coffea canephora	FooDB	FooDB
Colocasia esculenta	FooDB	FooDB
Columba	FooDB	FooDB
Columbidae	FooDB	FooDB
Corchorus olitorius	FooDB	FooDB
Coriandrum sativum L.	FooDB	FooDB
Corylus	FooDB	FooDB
Corylus avellana	FooDB	FooDB
Crateva religiosa	FooDB	FooDB
Crocus sativus	FooDB	FooDB
Cucumis melo	FooDB	FooDB
Cucumis metuliferus	FooDB	FooDB
Cucumis sativus L.	FooDB	FooDB
Cucurbita	FooDB	FooDB
Cucurbita maxima	FooDB	FooDB
Cucurbita moschata	FooDB	FooDB
Cuminum cyminum	FooDB	FooDB
Curcuma longa	FooDB	FooDB
Cydonia oblonga	FooDB	FooDB
Cymbopogon citratus	FooDB	FooDB
Cynara cardunculus	FooDB	FooDB
Cynara scolymus	FooDB	FooDB
Daucus carota	FooDB	FooDB
Daucus carota ssp. sativus	FooDB	FooDB
Dimocarpus longan	FooDB	FooDB
Dioscorea	FooDB	FooDB
Dioscorea pentaphylla	FooDB	FooDB
Diospyros	FooDB	FooDB
Diospyros kaki	FooDB	FooDB
Diospyros virginiana	FooDB	FooDB
Dromaius novaehollandiae	FooDB	FooDB
Durio zibethinus	FooDB	FooDB
Dysphania ambrosioides	FooDB	FooDB
Elaeis	FooDB	FooDB
Eleocharis dulcis	FooDB	FooDB
Elettaria cardamomum	FooDB	FooDB
Empetrum nigrum	FooDB	FooDB
Ephedra distachya	LOTUS Database	35616633
Equus caballus	FooDB	FooDB
Eragrostis tef	FooDB	FooDB
Eriobotrya japonica	FooDB	FooDB
Eruca vesicaria subsp. Sativa	FooDB	FooDB
Eugenia javanica	FooDB	FooDB
Eugenia uniflora	FooDB	FooDB
Euphorbia tithymaloides	LOTUS Database	35616633
Eutrema japonicum	FooDB	FooDB
Fagopyrum esculentum	FooDB	FooDB
Fagopyrum tataricum	FooDB	FooDB
Fagus	FooDB	FooDB
Feijoa sellowiana	FooDB	FooDB
Ficus carica	FooDB	FooDB
Flammulina velutipes	FooDB	FooDB
Foeniculum vulgare	FooDB	FooDB
Fragaria x ananassa	FooDB	FooDB
Gallus gallus	FooDB	FooDB
Garcinia mangostana	FooDB	FooDB
Gaylussacia baccata	FooDB	FooDB
Ginkgo biloba	FooDB	FooDB
Glycine max	FooDB	FooDB
Gossypium	FooDB	FooDB
Grifola frondosa	FooDB	FooDB
Hedysarum alpinum	FooDB	FooDB
Helianthus annuus L.	FooDB	FooDB
Helianthus tuberosus	FooDB	FooDB
Hibiscus sabbariffa	FooDB	FooDB
Hippophae rhamnoides	FooDB	FooDB
Homo sapiens	LOTUS Database	35616633
Hordeum vulgare	FooDB	FooDB
Hyacinthoides non-scripta	LOTUS Database	35616633
Hyssopus officinalis L.	FooDB	FooDB
Illicium verum	FooDB	FooDB
Ipomoea aquatica	FooDB	FooDB
Ipomoea batatas	FooDB	FooDB
Juglans	FooDB	FooDB
Juglans ailanthifolia	FooDB	FooDB
Juglans cinerea	FooDB	FooDB
Juglans nigra L.	FooDB	FooDB
Juglans regia	FooDB	FooDB
Lablab purpureus	FooDB	FooDB
Lactuca sativa	FooDB	FooDB
Lagenaria siceraria	FooDB	FooDB
Lagopus muta	FooDB	FooDB
Lathyrus sativus	FooDB	FooDB
Laurus nobilis L.	FooDB	FooDB
Lens culinaris	FooDB	FooDB
Lentinus edodes	FooDB	FooDB
Lepidium sativum	FooDB	FooDB
Leporidae	FooDB	FooDB
Lepus timidus	FooDB	FooDB
Levisticum officinale	FooDB	FooDB
Linum usitatissimum	FooDB	FooDB
Litchi chinensis	FooDB	FooDB
Luffa aegyptiaca	FooDB	FooDB
Lupinus	FooDB	FooDB
Lupinus albus	FooDB	FooDB
Macadamia	FooDB	FooDB
Macadamia tetraphylla	FooDB	FooDB
Malpighia emarginata	FooDB	FooDB
Malus	FooDB	FooDB
Malus pumila	FooDB	FooDB
Mammea americana	FooDB	FooDB
Mangifera indica	FooDB	FooDB
Manihot esculenta	FooDB	FooDB
Manilkara zapota	FooDB	FooDB
Maranta arundinacea	FooDB	FooDB
Matricaria recutita	FooDB	FooDB
Matteuccia struthiopteris	FooDB	FooDB
Medicago sativa	FooDB	FooDB
Melanitta fusca	FooDB	FooDB
Meleagris gallopavo	FooDB	FooDB
Melissa officinalis L.	FooDB	FooDB
Mentha	FooDB	FooDB
Mentha aquatica	FooDB	FooDB
Mentha arvensis	FooDB	FooDB
Mentha spicata	FooDB	FooDB
Mentha x piperita	FooDB	FooDB
Mespilus germanica	FooDB	FooDB
Metroxylon sagu	FooDB	FooDB
Momordica charantia	FooDB	FooDB
Morchellaceae	FooDB	FooDB
Morella rubra	FooDB	FooDB
Moringa oleifera	FooDB	FooDB
Morus	FooDB	FooDB
Morus nigra	FooDB	FooDB
Mus musculus	LOTUS Database	35616633
Musa acuminata	FooDB	FooDB
Musa x paradisiaca	FooDB	FooDB
Myrica	FooDB	FooDB
Myristica fragrans	FooDB	FooDB
Nelumbo	FooDB	FooDB
Nelumbo nucifera	FooDB	FooDB
Nephelium lappaceum	FooDB	FooDB
Numida meleagris	FooDB	FooDB
Nuphar lutea	FooDB	FooDB
Ocimum basilicum	FooDB	FooDB
Odocoileus	FooDB	FooDB
Oenothera biennis	FooDB	FooDB
Olea europaea	FooDB	FooDB
Opuntia	FooDB	FooDB
Opuntia cochenillifera	FooDB	FooDB
Opuntia macrorhiza	FooDB	FooDB
Origanum majorana	FooDB	FooDB
Origanum onites	FooDB	FooDB
Origanum vulgare	FooDB	FooDB
Origanum X majoricum	FooDB	FooDB
Oryctolagus	FooDB	FooDB
Oryza rufipogon	FooDB	FooDB
Oryza sativa	FooDB	FooDB
Ovis aries	FooDB	FooDB
Pachyrhizus erosus	FooDB	FooDB
Panax ginseng	FooDB	FooDB
Pangium edule	FooDB	FooDB
Panicum miliaceum	FooDB	FooDB
Passiflora edulis	FooDB	FooDB
Pastinaca sativa	FooDB	FooDB
Pediomelum esculentum	FooDB	FooDB
Perideridia oregana	FooDB	FooDB
Persea americana	FooDB	FooDB
Petasites japonicus	FooDB	FooDB
Petroselinum crispum	FooDB	FooDB
Phaseolus coccineus	FooDB	FooDB
Phaseolus lunatus	FooDB	FooDB
Phaseolus vulgaris	FooDB	FooDB
Phasianidae	FooDB	FooDB
Phasianus colchicus	FooDB	FooDB
Phoenix dactylifera	FooDB	FooDB
Photinia melanocarpa	FooDB	FooDB
Phyllostachys edulis	FooDB	FooDB
Physalis	FooDB	FooDB
Physalis philadelphica var. immaculata	FooDB	FooDB
Phytolacca americana	FooDB	FooDB
Pimenta dioica	FooDB	FooDB
Pimpinella anisum	FooDB	FooDB
Pinus	FooDB	FooDB
Pinus edulis	FooDB	FooDB
Piper nigrum L.	FooDB	FooDB
Pistacia vera	FooDB	FooDB
Pisum sativum	FooDB	FooDB
Pleurotus ostreatus	FooDB	FooDB
Polygonum alpinum	FooDB	FooDB
Portulaca oleracea	FooDB	FooDB
Pouteria sapota	FooDB	FooDB
Prunus armeniaca	FooDB	FooDB
Prunus avium	FooDB	FooDB
Prunus avium L.	FooDB	FooDB
Prunus cerasus	FooDB	FooDB
Prunus domestica	FooDB	FooDB
Prunus dulcis	FooDB	FooDB
Prunus persica	FooDB	FooDB
Prunus persica var. nucipersica	FooDB	FooDB
Prunus persica var. persica	FooDB	FooDB
Prunus tomentosa	FooDB	FooDB
Prunus virginiana	FooDB	FooDB
Psidium cattleianum	FooDB	FooDB
Psidium guajava	FooDB	FooDB
Psophocarpus tetragonolobus	FooDB	FooDB
Punica granatum	FooDB	FooDB
Pyrus communis	FooDB	FooDB
Pyrus pyrifolia	FooDB	FooDB
Quercus	FooDB	FooDB
Raphanus sativus	FooDB	FooDB
Raphanus sativus var. longipinnatus	FooDB	FooDB
Raphanus sativus var. sativus	FooDB	FooDB
Rheum rhabarbarum	FooDB	FooDB
Ribes aureum	FooDB	FooDB
Ribes glandulosum	FooDB	FooDB
Ribes nigrum	FooDB	FooDB
Ribes rubrum	FooDB	FooDB
Ribes uva-crispa	FooDB	FooDB
Rosa	FooDB	FooDB
Rubus arcticus	FooDB	FooDB
Rubus chamaemorus	FooDB	FooDB
Rubus idaeus	FooDB	FooDB
Rubus occidentalis	FooDB	FooDB
Rubus spectabilis	FooDB	FooDB
Rumex	FooDB	FooDB
Rumex acetosa	FooDB	FooDB
Rumex articus	FooDB	FooDB
Sagittaria latifolia	FooDB	FooDB
Salix pulchra	FooDB	FooDB
Salvia elegans	FooDB	FooDB
Salvia hispanica	FooDB	FooDB
Salvia officinalis	FooDB	FooDB
Salvia rosmarinus	FooDB	FooDB
Sambucus nigra	FooDB	FooDB
Sambucus nigra L.	FooDB	FooDB
Satureja hortensis L.	FooDB	FooDB
Satureja montana	FooDB	FooDB
Scorzonera hispanica	FooDB	FooDB
Secale cereale	FooDB	FooDB
Sechium edule	FooDB	FooDB
Sesamum indicum	FooDB	FooDB
Sesbania bispinosa	FooDB	FooDB
Sinapis alba	FooDB	FooDB
Sisymbrium	FooDB	FooDB
Solanum lycopersicum	FooDB	FooDB
Solanum lycopersicum var. cerasiforme	FooDB	FooDB
Solanum lycopersicum var. lycopersicum	FooDB	FooDB
Solanum melongena	FooDB	FooDB
Solanum quitoense	FooDB	FooDB
Solanum tuberosum	FooDB	FooDB
Sorbus aucuparia	FooDB	FooDB
Sorghum bicolor	FooDB	FooDB
Spinacia oleracea	FooDB	FooDB
Struthio camelus	FooDB	FooDB
Sus scrofa	FooDB	FooDB
Sus scrofa domestica	FooDB	FooDB
Synechococcus elongatus	LOTUS Database	35616633
Syzygium aromaticum	FooDB	FooDB
Syzygium cumini	FooDB	FooDB
Syzygium jambos	FooDB	FooDB
Tamarindus indica	FooDB	FooDB
Taraxacum officinale	FooDB	FooDB
Tetragonia tetragonioides	FooDB	FooDB
Thalassiosira pseudonana	LOTUS Database	35616633
Thelesperma	FooDB	FooDB
Thymus pulegioides	FooDB	FooDB
Thymus vulgaris	FooDB	FooDB
Tilia cordata	FooDB	FooDB
Tilia L.	FooDB	FooDB
Tragopogon porrifolius	FooDB	FooDB
Trigonella foenum-graecum	FooDB	FooDB
Triticum	FooDB	FooDB
Triticum aestivum	FooDB	FooDB
Triticum durum	FooDB	FooDB
Triticum spelta	FooDB	FooDB
Triticum turanicum	FooDB	FooDB
Trypanosoma brucei	LOTUS Database	35616633
Typha angustifolia	FooDB	FooDB
Vaccinium	FooDB	FooDB
Vaccinium angustifolium	FooDB	FooDB
Vaccinium angustifolium X Vaccinium corymbosum	FooDB	FooDB
Vaccinium arboreum	FooDB	FooDB
Vaccinium corymbosum	FooDB	FooDB
Vaccinium deliciosum	FooDB	FooDB
Vaccinium elliottii	FooDB	FooDB
Vaccinium macrocarpon	FooDB	FooDB
Vaccinium myrtilloides	FooDB	FooDB
Vaccinium myrtillus	FooDB	FooDB
Vaccinium ovalifolium	FooDB	FooDB
Vaccinium ovatum	FooDB	FooDB
Vaccinium oxycoccos	FooDB	FooDB
Vaccinium parvifolium	FooDB	FooDB
Vaccinium reticulatum	FooDB	FooDB
Vaccinium stamineum	FooDB	FooDB
Vaccinium uliginosum	FooDB	FooDB
Vaccinium vitis-idaea	FooDB	FooDB
Valerianella locusta	FooDB	FooDB
Vanilla	FooDB	FooDB
Verbena officinalis	FooDB	FooDB
Viburnum edule	FooDB	FooDB
Vicia faba	FooDB	FooDB
Vigna aconitifolia	FooDB	FooDB
Vigna angularis	FooDB	FooDB
Vigna mungo	FooDB	FooDB
Vigna radiata	FooDB	FooDB
Vigna umbellata	FooDB	FooDB
Vigna unguiculata	FooDB	FooDB
Vigna unguiculata ssp. cylindrica	FooDB	FooDB
Vigna unguiculata ssp. unguiculata	FooDB	FooDB
Vigna unguiculata var. sesquipedalis	FooDB	FooDB
Vitis	FooDB	FooDB
Vitis aestivalis	FooDB	FooDB
Vitis labrusca	FooDB	FooDB
Vitis rotundifolia	FooDB	FooDB
Vitis vinifera L.	FooDB	FooDB
Xanthosoma sagittifolium	FooDB	FooDB
Zea mays L.	FooDB	FooDB
Zingiber officinale	FooDB	FooDB
Zizania	FooDB	FooDB
Zizania aquatica	FooDB	FooDB
Ziziphus zizyphus	FooDB	FooDB

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as 5'-deoxy-5'-thionucleosides. These are 5'-deoxyribonucleosides in which the ribose is thio-substituted at the 5'position by a S-alkyl group.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

5'-deoxyribonucleosides

Sub Class

5'-deoxy-5'-thionucleosides

Direct Parent

5'-deoxy-5'-thionucleosides

Alternative Parents

Substituents

5'-deoxy-5'-thionucleoside
Glycosyl compound
N-glycosyl compound
6-aminopurine
Pentose monosaccharide
Imidazopyrimidine
Purine
Aminopyrimidine
Monosaccharide
N-substituted imidazole
Pyrimidine
Imidolactam
Azole
Tetrahydrofuran
Imidazole
Heteroaromatic compound
Secondary alcohol
1,2-diol
Organoheterocyclic compound
Dialkylthioether
Sulfenyl compound
Thioether
Azacycle
Oxacycle
Organic oxygen compound
Alcohol
Hydrocarbon derivative
Organopnictogen compound
Amine
Primary amine
Organic nitrogen compound
Organonitrogen compound
Organooxygen compound
Organosulfur compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

thioadenosine (CHEBI:17509 )

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	3607 mg/L @ 25 °C (est)	The Good Scents Company Information System
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
Water Solubility	6.5 g/L	ALOGPS
logP	-0.14	ALOGPS
logP	-0.61	ChemAxon
logS	-1.7	ALOGPS
pKa (Strongest Acidic)	12.47	ChemAxon
pKa (Strongest Basic)	3.92	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	7	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	119.31 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	74.03 m³·mol⁻¹	ChemAxon
Polarizability	29.26 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

HMDB0001173

DrugBank ID

DB02282

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB031156

KNApSAcK ID

Not Available

Chemspider ID

388321

KEGG Compound ID

C00170

BioCyc ID

5-METHYLTHIOADENOSINE

BiGG ID

34127

Wikipedia Link

Not Available

METLIN ID

3425

PubChem Compound

439176

PDB ID

Not Available

ChEBI ID

17509

Good Scents ID

rw1207471

References

General References

Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762. [PubMed:19212411 ]
Liebich HM, Di Stefano C, Wixforth A, Schmid HR: Quantitation of urinary nucleosides by high-performance liquid chromatography. J Chromatogr A. 1997 Feb 28;763(1-2):193-7. [PubMed:9129323 ]
Avila MA, Garcia-Trevijano ER, Lu SC, Corrales FJ, Mato JM: Methylthioadenosine. Int J Biochem Cell Biol. 2004 Nov;36(11):2125-30. [PubMed:15313459 ]
Gerasimovskaya EV, Ahmad S, White CW, Jones PL, Carpenter TC, Stenmark KR: Extracellular ATP is an autocrine/paracrine regulator of hypoxia-induced adventitial fibroblast growth. Signaling through extracellular signal-regulated kinase-1/2 and the Egr-1 transcription factor. J Biol Chem. 2002 Nov 22;277(47):44638-50. Epub 2002 Sep 18. [PubMed:12244041 ]
Mills GC, Mills JS: Urinary excretion of methylthioadenosine in immunodeficient children. Clin Chim Acta. 1985 Mar 30;147(1):15-23. [PubMed:3987052 ]
Contreres JO, Dupuy E, Job B, Habib A, Bryckaert M, Rosa JP, Simoneau G, Herbert JM, Savi P, Levy-Toledano S: Effect of clopidogrel administration to healthy volunteers on platelet phosphorylation events triggered by ADP. Br J Haematol. 2003 Feb;120(4):633-42. [PubMed:12588350 ]
Mills GC, Schmalstieg FC, Goldblum RM: Urinary excretion of modified purines and nucleosides in immunodeficient children. Biochem Med. 1985 Aug;34(1):37-51. [PubMed:4052062 ]

Showing NP-Card for 5'-Methylthioadenosine (NP0000972)

MOL for NP0000972 (5'-Methylthioadenosine)

3D MOL for NP0000972 (5'-Methylthioadenosine)

3D SDF for NP0000972 (5'-Methylthioadenosine)

3D-SDF for NP0000972 (5'-Methylthioadenosine)

PDB for NP0000972 (5'-Methylthioadenosine)

3D PDB for NP0000972 (5'-Methylthioadenosine)

SMILES for NP0000972 (5'-Methylthioadenosine)

INCHI for NP0000972 (5'-Methylthioadenosine)

Structure for NP0000972 (5'-Methylthioadenosine)

3D Structure for NP0000972 (5'-Methylthioadenosine)