Record Information |
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Version | 1.0 |
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Created at | 2005-11-16 15:48:42 UTC |
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Updated at | 2021-08-19 23:58:33 UTC |
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NP-MRD ID | NP0000897 |
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Secondary Accession Numbers | None |
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Natural Product Identification |
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Common Name | D-alpha-Aminobutyric acid |
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Description | D-alpha-Aminobutyric acid (AABA), also known as alpha-aminobutyrate, (R)-2-aminobutanoic acid or D-homoalanine, belongs to the class of organic compounds known as D-alpha-amino acids. These are alpha amino acids which have the D-configuration of the alpha-carbon atom. D-alpha-aminobutyric acid is an optically active form of alpha-aminobutyric acid having D-configuration. It is an enantiomer of a L-alpha-aminobutyric acid and a non-proteinogenic amino acid. Alpha-aminobutyric acid is one of the three isomers of aminobutyric acid. The two others are the neurotransmitter Gamma-Aminobutyric acid (GABA) and Beta-Aminobutyric acid (BABA) which is known for inducing plant disease resistance. Optically active organic compounds found in meteorites typically exist in racemic form, yet life on Earth has almost exclusively selected for L- over D-enantiomers of amino acids. D-enantiomers of non-proteinogenic amino acids are known to inhibit aerobic microorganisms. D-alpha-aminobutyric acid has been shown to inhibit microbial iron reduction by a number of Geobacter strains including Geobacter bemidjiensis, Geobacter metallireducens and Geopsychrobacter electrodiphilus (PMID: 25695622 ). D-alpha-Aminobutyric acid is a known substrate of D-amino acid oxidase (PMID: 6127341 ). |
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Structure | InChI=1S/C4H9NO2/c1-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 |
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Synonyms | Value | Source |
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(2R)-2-Aminobutyric acid | ChEBI | (R)-2-Aminobutanoic acid | ChEBI | (R)-2-Aminobutyric acid | ChEBI | alpha-Aminobutyric acid | ChEBI | D-(-)-2-Aminobutyric acid | ChEBI | D-2-Aminobutanoic acid | ChEBI | D-2-Aminobuttersaeure | ChEBI | D-2-Aminobutyrate | ChEBI | D-2-Aminobutyric acid | ChEBI | (2R)-2-Aminobutyrate | Generator | (R)-2-Aminobutanoate | Generator | (R)-2-Aminobutyrate | Generator | a-Aminobutyrate | Generator | a-Aminobutyric acid | Generator | alpha-Aminobutyrate | Generator | Α-aminobutyrate | Generator | Α-aminobutyric acid | Generator | D-(-)-2-Aminobutyrate | Generator | D-2-Aminobutanoate | Generator | D-a-Aminobutyrate | Generator | D-a-Aminobutyric acid | Generator | D-alpha-Aminobutyrate | Generator | D-Α-aminobutyrate | Generator | D-Α-aminobutyric acid | Generator | (2R)-2-Aminobutanoate | HMDB | (2R)-2-Aminobutanoic acid | HMDB | (R)-2-Amino-butanoate | HMDB | (R)-2-Amino-butanoic acid | HMDB | delta-(-)-2-Aminobutyric acid | HMDB | delta-2-Aminobutanoate | HMDB | delta-2-Aminobutanoic acid | HMDB | delta-2-Aminobuttersaeure | HMDB | delta-2-Aminobutyrate | HMDB | delta-2-Aminobutyric acid | HMDB | delta-alpha-Aminobutyric acid | HMDB | 2R-Amino-butanoate | HMDB | (2S)-2-Aminobutanoic acid | HMDB | alpha-Aminobutyric acid, (S)-isomer | HMDB | Butyrine, (S)-isomer | HMDB | L-2-Aminobutyric acid | HMDB | Homoalanine | HMDB | 2-Aminobutyric acid | HMDB | 2-Aminobutanoic acid | HMDB | alpha-Aminobutyric acid, (+-)-isomer | HMDB | Butyrine, (R)-isomer | HMDB | Butyrine | HMDB | Butyrine, (+-)-isomer | HMDB | L-Homoalanine | HMDB | alpha-Aminobutyric acid, (R)-isomer | HMDB |
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Chemical Formula | C4H9NO2 |
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Average Mass | 103.1198 Da |
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Monoisotopic Mass | 103.06333 Da |
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IUPAC Name | (2R)-2-aminobutanoic acid |
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Traditional Name | D-2-aminobutyric acid |
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CAS Registry Number | 2623-91-8 |
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SMILES | CC[C@@H](N)C(O)=O |
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InChI Identifier | InChI=1S/C4H9NO2/c1-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 |
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InChI Key | QWCKQJZIFLGMSD-GSVOUGTGSA-N |
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Experimental Spectra |
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| Spectrum Type | Description | Depositor Email | Depositor Organization | Depositor | Deposition Date | View |
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1D NMR | 1H NMR Spectrum (1D, 500 MHz, H2O, experimental) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 500 MHz, D2O, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 500 MHz, D2O, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 500 MHz, D2O, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 500 MHz, D2O, experimental) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 2D NMR | [1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum |
| Predicted Spectra |
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| Not Available | Chemical Shift Submissions |
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Species of Origin | |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as d-alpha-amino acids. These are alpha amino acids which have the D-configuration of the alpha-carbon atom. |
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Kingdom | Organic compounds |
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Super Class | Organic acids and derivatives |
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Class | Carboxylic acids and derivatives |
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Sub Class | Amino acids, peptides, and analogues |
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Direct Parent | D-alpha-amino acids |
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Alternative Parents | |
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Substituents | - D-alpha-amino acid
- Fatty acid
- Amino acid
- Carboxylic acid
- Monocarboxylic acid or derivatives
- Amine
- Hydrocarbon derivative
- Organic oxide
- Organopnictogen compound
- Primary amine
- Organooxygen compound
- Organonitrogen compound
- Organic oxygen compound
- Primary aliphatic amine
- Organic nitrogen compound
- Carbonyl group
- Aliphatic acyclic compound
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Molecular Framework | Aliphatic acyclic compounds |
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External Descriptors | |
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Physical Properties |
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State | Solid |
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Experimental Properties | |
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Predicted Properties | |
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General References | - Ohdoi C, Nyhan WL, Kuhara T: Chemical diagnosis of Lesch-Nyhan syndrome using gas chromatography-mass spectrometry detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 15;792(1):123-30. [PubMed:12829005 ]
- Ketting D, Wadman SK, Spaapen LJ, Van der Meer SB, Duran M: Gas chromatography method for the separation of amino acids enantiomers in plasma and urine. Application in a case of short bowel syndrome. Clin Chim Acta. 1991 Dec 31;204(1-3):79-86. [PubMed:1819475 ]
- Lange R, Hui Bon Hoa G, Douzou P, Yagi K: Kinetics of primary interaction of D-amino acid oxidase with its substrate. Biochem Int. 1983 May;6(5):693-8. [PubMed:6148943 ]
- Mung D, Li L: Development of Chemical Isotope Labeling LC-MS for Milk Metabolomics: Comprehensive and Quantitative Profiling of the Amine/Phenol Submetabolome. Anal Chem. 2017 Apr 18;89(8):4435-4443. doi: 10.1021/acs.analchem.6b03737. Epub 2017 Mar 28. [PubMed:28306241 ]
- Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]
- Nixon SL, Cockell CS: Nonproteinogenic D-amino acids at millimolar concentrations are a toxin for anaerobic microorganisms relevant to early Earth and other anoxic planets. Astrobiology. 2015 Mar;15(3):238-46. doi: 10.1089/ast.2014.1252. Epub 2015 Feb 19. [PubMed:25695622 ]
- Fitzpatrick PF, Massey V: The kinetic mechanism of D-amino acid oxidase with D-alpha-aminobutyrate as substrate. Effect of enzyme concentration on the kinetics. J Biol Chem. 1982 Nov 10;257(21):12916-23. [PubMed:6127341 ]
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