NP-MRD: Showing NP-Card for dGTP (NP0000794)

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Record Information

Version

1.0

Created at

2005-11-16 15:48:42 UTC

Updated at

2021-06-29 00:47:04 UTC

NP-MRD ID

NP0000794

Secondary Accession Numbers

None

Natural Product Identification

Common Name

dGTP

Description

Deoxyguanosine triphosphate (dGTP) is a nucleoside triphosphate, and a nucleotide precursor used in cells for DNA synthesis. DGTP is used in the polymerase chain reaction technique, in sequencing, and in cloning. It is also the competitor of inhibition onset by acyclovir in the treatment of HSV virus. Under normal physiologic conditions, deoxyguanosine (dGuo) undergoes phosphorolysis by purine nucleoside phosphorylase (PNP, EC 2.4.2.1, An enzyme involved in the recycling of nucleosides and deoxynucleosides in cellular remodeling). However, when PNP is inhibited, deoxycytidine kinase (dCK, EC 2.7.1.74) Shunts unmetabolized dGuo into deoxyguanosine triphosphate (dGTP), which accumulates and blocks DNA synthesis. Deficiency of purine nucleoside phosphorylase results in defective T-cell immunity. A correlation between the degree of T cell inhibition and the level of dCK activity has been observed. (PMID: 11287638 , 402573 ).

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI


  Mrv1652305271900082D          

 31 33  0  0  1  0            999 V2000
    3.0698    0.0624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4426    0.5058    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8008    0.6063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1494   -0.7796    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6770    0.2529    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.7267    1.3304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5825    1.3270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5457    0.2737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9359   -1.1225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0048    0.7622    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4205   -0.4885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6392   -0.6063    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2040    0.7657    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0260   -1.9437    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3464    0.2876    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.6029   -0.4885    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4366    0.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3361   -1.2681    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0567   -0.0069    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8848   -0.0069    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7129   -0.0069    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8883   -0.8350    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8883    0.8211    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5409   -0.0034    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3724   -0.0034    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5478   -0.8315    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5478    0.8280    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2006    0.0034    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2040   -0.8280    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0286    0.0069    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2040    0.8315    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  5  2  1  1  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  3  8  1  0  0  0  0
  4  9  2  0  0  0  0
  5 10  1  0  0  0  0
  5 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 15 17  1  1  0  0  0
 16 18  1  6  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  2  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 28 31  2  0  0  0  0
  6  7  2  0  0  0  0
  9 12  1  0  0  0  0
 15 16  1  0  0  0  0
M  END

HMDB0001440
     RDKit          3D
dGTP
 47 49  0  0  0  0  0  0  0  0999 V2000
   -3.4750    2.8036   -1.0707 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0976    1.7831   -0.2789 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3609    0.6773   -0.0350 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9306   -0.2878    0.7056 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2127   -0.1540    1.1952 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4473   -1.2930    1.8788 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3714   -2.0914    1.8181 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4116   -1.4896    1.0933 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0887   -1.9925    0.7743 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.0376   -2.7077   -0.5426 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9737   -1.9329   -1.2915 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.2633   -2.7104   -2.1699 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1196   -1.4532   -0.1168 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.7870   -0.3367   -0.5359 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3666    0.1878    0.6329 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4123    1.4533    0.3177 P   0  0  0  0  0  5  0  0  0  0  0  0
    1.8535    2.7591    0.8485 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7311    1.6663   -1.3170 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8610    1.1492    1.1615 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6278   -0.2312    0.5669 P   0  0  0  0  0  5  0  0  0  0  0  0
    4.0490   -1.4674    1.1970 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4603   -0.3621   -1.1128 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2798   -0.1053    0.9407 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8594    1.3358    0.2997 P   0  0  0  0  0  5  0  0  0  0  0  0
    8.1088    1.7054    1.0708 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7434    2.5814    0.4423 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2273    1.1284   -1.3274 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1277   -0.9922    0.7495 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9643    0.9941    0.9362 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1226    1.1012    1.3857 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3453    1.9259    0.1912 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2286    2.6861   -2.0600 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2759    3.7031   -0.5811 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2412   -3.0849    2.2686 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7941   -2.6902    1.6107 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6214   -3.7395   -0.4019 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0053   -2.7328   -1.0775 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3842   -1.0051   -1.7583 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6891   -2.6324   -3.0635 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3846   -2.3306    0.2874 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5896   -0.7772   -1.1633 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2250    0.4041   -1.1029 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5524    0.8777   -1.8675 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3246   -0.3571   -1.5748 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.0981    3.3723   -0.0223 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.9031    1.8603   -1.8987 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8550    2.8016   -0.0341 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 16 19  1  0
 19 20  1  0
 20 21  2  0
 20 22  1  0
 20 23  1  0
 23 24  1  0
 24 25  2  0
 24 26  1  0
 24 27  1  0
 13 28  1  0
  5 29  1  0
 29 30  2  0
 29 31  1  0
 31  2  1  0
  8  4  1  0
 28  9  1  0
  1 32  1  0
  1 33  1  0
  7 34  1  0
  9 35  1  1
 10 36  1  0
 10 37  1  0
 11 38  1  6
 12 39  1  0
 13 40  1  1
 14 41  1  0
 14 42  1  0
 18 43  1  0
 22 44  1  0
 26 45  1  0
 27 46  1  0
 31 47  1  0
M  END


  Mrv1652305271900082D          

 31 33  0  0  1  0            999 V2000
    3.0698    0.0624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4426    0.5058    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8008    0.6063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1494   -0.7796    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6770    0.2529    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.7267    1.3304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5825    1.3270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5457    0.2737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9359   -1.1225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0048    0.7622    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4205   -0.4885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6392   -0.6063    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2040    0.7657    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0260   -1.9437    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3464    0.2876    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.6029   -0.4885    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4366    0.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3361   -1.2681    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0567   -0.0069    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8848   -0.0069    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7129   -0.0069    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8883   -0.8350    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8883    0.8211    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5409   -0.0034    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3724   -0.0034    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5478   -0.8315    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5478    0.8280    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2006    0.0034    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2040   -0.8280    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0286    0.0069    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2040    0.8315    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  5  2  1  1  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  3  8  1  0  0  0  0
  4  9  2  0  0  0  0
  5 10  1  0  0  0  0
  5 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 15 17  1  1  0  0  0
 16 18  1  6  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  2  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 28 31  2  0  0  0  0
  6  7  2  0  0  0  0
  9 12  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0000794

> <DATABASE_NAME>
NP-MRD

> <SMILES>
NC1=NC2=C(N=CN2[C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)N1

> <INCHI_IDENTIFIER>
InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1

> <INCHI_KEY>
HAAZLUGHYHWQIW-KVQBGUIXSA-N

> <FORMULA>
C10H16N5O13P3

> <MOLECULAR_WEIGHT>
507.181

> <EXACT_MASS>
506.995745159

> <JCHEM_ACCEPTOR_COUNT>
13

> <JCHEM_ATOM_COUNT>
47

> <JCHEM_AVERAGE_POLARIZABILITY>
39.091797101174514

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
7

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
({[({[(2R,3S,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid

> <ALOGPS_LOGP>
-0.61

> <JCHEM_LOGP>
-3.231227985703539

> <ALOGPS_LOGS>
-1.96

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-3

> <JCHEM_PKA>
2.534540493596073

> <JCHEM_PKA_STRONGEST_ACIDIC>
1.028110452478031

> <JCHEM_PKA_STRONGEST_BASIC>
0.3262272999808975

> <JCHEM_POLAR_SURFACE_AREA>
274.5799999999999

> <JCHEM_REFRACTIVITY>
95.72909999999997

> <JCHEM_ROTATABLE_BOND_COUNT>
8

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
5.59e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
dGTP

> <JCHEM_VEBER_RULE>
0

$$$$

HMDB0001440
     RDKit          3D
dGTP
 47 49  0  0  0  0  0  0  0  0999 V2000
   -3.4750    2.8036   -1.0707 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0976    1.7831   -0.2789 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3609    0.6773   -0.0350 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9306   -0.2878    0.7056 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2127   -0.1540    1.1952 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4473   -1.2930    1.8788 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3714   -2.0914    1.8181 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4116   -1.4896    1.0933 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0887   -1.9925    0.7743 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.0376   -2.7077   -0.5426 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9737   -1.9329   -1.2915 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.2633   -2.7104   -2.1699 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1196   -1.4532   -0.1168 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.7870   -0.3367   -0.5359 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3666    0.1878    0.6329 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4123    1.4533    0.3177 P   0  0  0  0  0  5  0  0  0  0  0  0
    1.8535    2.7591    0.8485 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7311    1.6663   -1.3170 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8610    1.1492    1.1615 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6278   -0.2312    0.5669 P   0  0  0  0  0  5  0  0  0  0  0  0
    4.0490   -1.4674    1.1970 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4603   -0.3621   -1.1128 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2798   -0.1053    0.9407 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8594    1.3358    0.2997 P   0  0  0  0  0  5  0  0  0  0  0  0
    8.1088    1.7054    1.0708 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7434    2.5814    0.4423 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2273    1.1284   -1.3274 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1277   -0.9922    0.7495 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9643    0.9941    0.9362 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1226    1.1012    1.3857 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3453    1.9259    0.1912 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2286    2.6861   -2.0600 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2759    3.7031   -0.5811 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2412   -3.0849    2.2686 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7941   -2.6902    1.6107 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6214   -3.7395   -0.4019 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0053   -2.7328   -1.0775 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3842   -1.0051   -1.7583 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6891   -2.6324   -3.0635 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3846   -2.3306    0.2874 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5896   -0.7772   -1.1633 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2250    0.4041   -1.1029 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5524    0.8777   -1.8675 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3246   -0.3571   -1.5748 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.0981    3.3723   -0.0223 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.9031    1.8603   -1.8987 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8550    2.8016   -0.0341 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 16 19  1  0
 19 20  1  0
 20 21  2  0
 20 22  1  0
 20 23  1  0
 23 24  1  0
 24 25  2  0
 24 26  1  0
 24 27  1  0
 13 28  1  0
  5 29  1  0
 29 30  2  0
 29 31  1  0
 31  2  1  0
  8  4  1  0
 28  9  1  0
  1 32  1  0
  1 33  1  0
  7 34  1  0
  9 35  1  1
 10 36  1  0
 10 37  1  0
 11 38  1  6
 12 39  1  0
 13 40  1  1
 14 41  1  0
 14 42  1  0
 18 43  1  0
 22 44  1  0
 26 45  1  0
 27 46  1  0
 31 47  1  0
M  END

HEADER    PROTEIN                                 27-MAY-19   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   27-MAY-19         0                                  
HETATM    1  C   UNK     0       5.730   0.116   0.000  0.00  0.00           C+0
HETATM    2  N   UNK     0       4.560   0.944   0.000  0.00  0.00           N+0
HETATM    3  C   UNK     0       7.095   1.132   0.000  0.00  0.00           C+0
HETATM    4  N   UNK     0       5.879  -1.455   0.000  0.00  0.00           N+0
HETATM    5  C   UNK     0       3.130   0.472   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       5.090   2.483   0.000  0.00  0.00           C+0
HETATM    7  N   UNK     0       6.687   2.477   0.000  0.00  0.00           N+0
HETATM    8  C   UNK     0       8.485   0.511   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       7.347  -2.095   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       1.876   1.423   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       2.652  -0.912   0.000  0.00  0.00           C+0
HETATM   12  N   UNK     0       8.660  -1.132   0.000  0.00  0.00           N+0
HETATM   13  O   UNK     0       9.714   1.429   0.000  0.00  0.00           O+0
HETATM   14  N   UNK     0       7.515  -3.628   0.000  0.00  0.00           N+0
HETATM   15  C   UNK     0       0.647   0.537   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       1.125  -0.912   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      -0.815   1.022   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0       0.627  -2.367   0.000  0.00  0.00           O+0
HETATM   19  O   UNK     0      -1.973  -0.013   0.000  0.00  0.00           O+0
HETATM   20  P   UNK     0      -3.518  -0.013   0.000  0.00  0.00           P+0
HETATM   21  O   UNK     0      -5.064  -0.013   0.000  0.00  0.00           O+0
HETATM   22  O   UNK     0      -3.525  -1.559   0.000  0.00  0.00           O+0
HETATM   23  O   UNK     0      -3.525   1.533   0.000  0.00  0.00           O+0
HETATM   24  P   UNK     0      -6.610  -0.006   0.000  0.00  0.00           P+0
HETATM   25  O   UNK     0      -8.162  -0.006   0.000  0.00  0.00           O+0
HETATM   26  O   UNK     0      -6.623  -1.552   0.000  0.00  0.00           O+0
HETATM   27  O   UNK     0      -6.623   1.546   0.000  0.00  0.00           O+0
HETATM   28  P   UNK     0      -9.708   0.006   0.000  0.00  0.00           P+0
HETATM   29  O   UNK     0      -9.714  -1.546   0.000  0.00  0.00           O+0
HETATM   30  O   UNK     0     -11.253   0.013   0.000  0.00  0.00           O+0
HETATM   31  O   UNK     0      -9.714   1.552   0.000  0.00  0.00           O+0
CONECT    1    2    3    4                                                  
CONECT    2    1    5    6                                                  
CONECT    3    1    7    8                                                  
CONECT    4    1    9                                                       
CONECT    5    2   10   11                                                  
CONECT    6    2    7                                                       
CONECT    7    3    6                                                       
CONECT    8    3   12   13                                                  
CONECT    9    4   14   12                                                  
CONECT   10    5   15                                                       
CONECT   11    5   16                                                       
CONECT   12    8    9                                                       
CONECT   13    8                                                            
CONECT   14    9                                                            
CONECT   15   10   17   16                                                  
CONECT   16   11   18   15                                                  
CONECT   17   15   19                                                       
CONECT   18   16                                                            
CONECT   19   17   20                                                       
CONECT   20   19   21   22   23                                             
CONECT   21   20   24                                                       
CONECT   22   20                                                            
CONECT   23   20                                                            
CONECT   24   21   25   26   27                                             
CONECT   25   24   28                                                       
CONECT   26   24                                                            
CONECT   27   24                                                            
CONECT   28   25   29   30   31                                             
CONECT   29   28                                                            
CONECT   30   28                                                            
CONECT   31   28                                                            
MASTER        0    0    0    0    0    0    0    0   31    0   66    0
END

COMPND    HMDB0001440
HETATM    1  N1  UNL     1      -3.475   2.804  -1.071  1.00  0.00           N  
HETATM    2  C1  UNL     1      -4.098   1.783  -0.279  1.00  0.00           C  
HETATM    3  N2  UNL     1      -3.361   0.677  -0.035  1.00  0.00           N  
HETATM    4  C2  UNL     1      -3.931  -0.288   0.706  1.00  0.00           C  
HETATM    5  C3  UNL     1      -5.213  -0.154   1.195  1.00  0.00           C  
HETATM    6  N3  UNL     1      -5.447  -1.293   1.879  1.00  0.00           N  
HETATM    7  C4  UNL     1      -4.371  -2.091   1.818  1.00  0.00           C  
HETATM    8  N4  UNL     1      -3.412  -1.490   1.093  1.00  0.00           N  
HETATM    9  C5  UNL     1      -2.089  -1.992   0.774  1.00  0.00           C  
HETATM   10  C6  UNL     1      -2.038  -2.708  -0.543  1.00  0.00           C  
HETATM   11  C7  UNL     1      -0.974  -1.933  -1.291  1.00  0.00           C  
HETATM   12  O1  UNL     1      -0.263  -2.710  -2.170  1.00  0.00           O  
HETATM   13  C8  UNL     1      -0.120  -1.453  -0.117  1.00  0.00           C  
HETATM   14  C9  UNL     1       0.787  -0.337  -0.536  1.00  0.00           C  
HETATM   15  O2  UNL     1       1.367   0.188   0.633  1.00  0.00           O  
HETATM   16  P1  UNL     1       2.412   1.453   0.318  1.00  0.00           P  
HETATM   17  O3  UNL     1       1.854   2.759   0.849  1.00  0.00           O  
HETATM   18  O4  UNL     1       2.731   1.666  -1.317  1.00  0.00           O  
HETATM   19  O5  UNL     1       3.861   1.149   1.161  1.00  0.00           O  
HETATM   20  P2  UNL     1       4.628  -0.231   0.567  1.00  0.00           P  
HETATM   21  O6  UNL     1       4.049  -1.467   1.197  1.00  0.00           O  
HETATM   22  O7  UNL     1       4.460  -0.362  -1.113  1.00  0.00           O  
HETATM   23  O8  UNL     1       6.280  -0.105   0.941  1.00  0.00           O  
HETATM   24  P3  UNL     1       6.859   1.336   0.300  1.00  0.00           P  
HETATM   25  O9  UNL     1       8.109   1.705   1.071  1.00  0.00           O  
HETATM   26  O10 UNL     1       5.743   2.581   0.442  1.00  0.00           O  
HETATM   27  O11 UNL     1       7.227   1.128  -1.327  1.00  0.00           O  
HETATM   28  O12 UNL     1      -1.128  -0.992   0.749  1.00  0.00           O  
HETATM   29  C10 UNL     1      -5.964   0.994   0.936  1.00  0.00           C  
HETATM   30  O13 UNL     1      -7.123   1.101   1.386  1.00  0.00           O  
HETATM   31  N5  UNL     1      -5.345   1.926   0.191  1.00  0.00           N  
HETATM   32  H1  UNL     1      -3.229   2.686  -2.060  1.00  0.00           H  
HETATM   33  H2  UNL     1      -3.276   3.703  -0.581  1.00  0.00           H  
HETATM   34  H3  UNL     1      -4.241  -3.085   2.269  1.00  0.00           H  
HETATM   35  H4  UNL     1      -1.794  -2.690   1.611  1.00  0.00           H  
HETATM   36  H5  UNL     1      -1.621  -3.739  -0.402  1.00  0.00           H  
HETATM   37  H6  UNL     1      -3.005  -2.733  -1.078  1.00  0.00           H  
HETATM   38  H7  UNL     1      -1.384  -1.005  -1.758  1.00  0.00           H  
HETATM   39  H8  UNL     1      -0.689  -2.632  -3.064  1.00  0.00           H  
HETATM   40  H9  UNL     1       0.385  -2.331   0.287  1.00  0.00           H  
HETATM   41  H10 UNL     1       1.590  -0.777  -1.163  1.00  0.00           H  
HETATM   42  H11 UNL     1       0.225   0.404  -1.103  1.00  0.00           H  
HETATM   43  H12 UNL     1       2.552   0.878  -1.867  1.00  0.00           H  
HETATM   44  H13 UNL     1       5.325  -0.357  -1.575  1.00  0.00           H  
HETATM   45  H14 UNL     1       6.098   3.372  -0.022  1.00  0.00           H  
HETATM   46  H15 UNL     1       6.903   1.860  -1.899  1.00  0.00           H  
HETATM   47  H16 UNL     1      -5.855   2.802  -0.034  1.00  0.00           H  
CONECT    1    2   32   33
CONECT    2    3    3   31
CONECT    3    4
CONECT    4    5    5    8
CONECT    5    6   29
CONECT    6    7    7
CONECT    7    8   34
CONECT    8    9
CONECT    9   10   28   35
CONECT   10   11   36   37
CONECT   11   12   13   38
CONECT   12   39
CONECT   13   14   28   40
CONECT   14   15   41   42
CONECT   15   16
CONECT   16   17   17   18   19
CONECT   18   43
CONECT   19   20
CONECT   20   21   21   22   23
CONECT   22   44
CONECT   23   24
CONECT   24   25   25   26   27
CONECT   26   45
CONECT   27   46
CONECT   29   30   30   31
CONECT   31   47
END

HMDB0001440
     RDKit          3D
dGTP
 47 49  0  0  0  0  0  0  0  0999 V2000
   -3.4750    2.8036   -1.0707 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0976    1.7831   -0.2789 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3609    0.6773   -0.0350 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9306   -0.2878    0.7056 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2127   -0.1540    1.1952 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4473   -1.2930    1.8788 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3714   -2.0914    1.8181 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4116   -1.4896    1.0933 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0887   -1.9925    0.7743 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.0376   -2.7077   -0.5426 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9737   -1.9329   -1.2915 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.2633   -2.7104   -2.1699 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1196   -1.4532   -0.1168 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.7870   -0.3367   -0.5359 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3666    0.1878    0.6329 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4123    1.4533    0.3177 P   0  0  0  0  0  5  0  0  0  0  0  0
    1.8535    2.7591    0.8485 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7311    1.6663   -1.3170 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8610    1.1492    1.1615 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6278   -0.2312    0.5669 P   0  0  0  0  0  5  0  0  0  0  0  0
    4.0490   -1.4674    1.1970 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4603   -0.3621   -1.1128 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2798   -0.1053    0.9407 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8594    1.3358    0.2997 P   0  0  0  0  0  5  0  0  0  0  0  0
    8.1088    1.7054    1.0708 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7434    2.5814    0.4423 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2273    1.1284   -1.3274 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1277   -0.9922    0.7495 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9643    0.9941    0.9362 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1226    1.1012    1.3857 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3453    1.9259    0.1912 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2286    2.6861   -2.0600 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2759    3.7031   -0.5811 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2412   -3.0849    2.2686 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7941   -2.6902    1.6107 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6214   -3.7395   -0.4019 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0053   -2.7328   -1.0775 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3842   -1.0051   -1.7583 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6891   -2.6324   -3.0635 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3846   -2.3306    0.2874 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5896   -0.7772   -1.1633 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2250    0.4041   -1.1029 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5524    0.8777   -1.8675 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3246   -0.3571   -1.5748 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.0981    3.3723   -0.0223 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.9031    1.8603   -1.8987 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8550    2.8016   -0.0341 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 16 18  1  0
 16 19  1  0
 19 20  1  0
 20 21  2  0
 20 22  1  0
 20 23  1  0
 23 24  1  0
 24 25  2  0
 24 26  1  0
 24 27  1  0
 13 28  1  0
  5 29  1  0
 29 30  2  0
 29 31  1  0
 31  2  1  0
  8  4  1  0
 28  9  1  0
  1 32  1  0
  1 33  1  0
  7 34  1  0
  9 35  1  1
 10 36  1  0
 10 37  1  0
 11 38  1  6
 12 39  1  0
 13 40  1  1
 14 41  1  0
 14 42  1  0
 18 43  1  0
 22 44  1  0
 26 45  1  0
 27 46  1  0
 31 47  1  0
M  END

View in JSmol

Synonyms

Value	Source
2'-Deoxy-GTP	ChEBI
2'-Deoxyguanosine 5'-triphosphate	ChEBI
2'-Deoxyguanosine triphosphate	ChEBI
Deoxy-GTP	ChEBI
Deoxyguanosine 5'-triphosphate	ChEBI
Deoxyguanosine triphosphate	ChEBI
2'-Deoxyguanosine 5'-triphosphoric acid	Generator
2'-Deoxyguanosine triphosphoric acid	Generator
Deoxyguanosine 5'-triphosphoric acid	Generator
Deoxyguanosine triphosphoric acid	Generator
Deoxyguanosine triphosphate, 3H-labeled	HMDB

Chemical Formula

C₁₀H₁₆N₅O₁₃P₃

Average Mass

507.1810 Da

Monoisotopic Mass

506.99575 Da

IUPAC Name

({[({[(2R,3S,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid

Traditional Name

dGTP

CAS Registry Number

2564-35-4

SMILES

NC1=NC2=C(N=CN2[C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)N1

InChI Identifier

InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1

InChI Key

HAAZLUGHYHWQIW-KVQBGUIXSA-N

Experimental Spectra

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Predicted Spectra

Not Available

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Anas platyrhynchos	FooDB	FooDB
Anatidae	FooDB	FooDB
Anser anser	FooDB	FooDB
Bison bison	FooDB	FooDB
Bos taurus	FooDB	FooDB
Bos taurus X Bison bison	FooDB	FooDB
Bubalus bubalis	FooDB	FooDB
Capra aegagrus hircus	FooDB	FooDB
Cervidae	FooDB	FooDB
Cervus canadensis	FooDB	FooDB
Columba	FooDB	FooDB
Columbidae	FooDB	FooDB
Dromaius novaehollandiae	FooDB	FooDB
Equus caballus	FooDB	FooDB
Gallus gallus	FooDB	FooDB
Homo sapiens	LOTUS Database	35616633
Lagopus muta	FooDB	FooDB
Leporidae	FooDB	FooDB
Lepus timidus	FooDB	FooDB
Melanitta fusca	FooDB	FooDB
Meleagris gallopavo	FooDB	FooDB
Mus musculus	LOTUS Database	35616633
Numida meleagris	FooDB	FooDB
Odocoileus	FooDB	FooDB
Oryctolagus	FooDB	FooDB
Ovis aries	FooDB	FooDB
Phasianidae	FooDB	FooDB
Phasianus colchicus	FooDB	FooDB
Struthio camelus	FooDB	FooDB
Sus scrofa	FooDB	FooDB
Sus scrofa domestica	FooDB	FooDB

Species Where Detected

Species Name	Source	Reference
Escherichia coli	KNApSAcK Database	22123792

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as purine 2'-deoxyribonucleoside triphosphates. These are purine nucleotides with triphosphate group linked to the ribose moiety lacking a hydroxyl group at position 2.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

Purine nucleotides

Sub Class

Purine deoxyribonucleotides

Direct Parent

Purine 2'-deoxyribonucleoside triphosphates

Alternative Parents

Substituents

Purine 2'-deoxyribonucleoside triphosphate
Imidazopyrimidine
Purine
Hydroxypyrimidine
Monoalkyl phosphate
N-substituted imidazole
Organic phosphoric acid derivative
Phosphoric acid ester
Alkyl phosphate
Pyrimidine
Azole
Imidazole
Heteroaromatic compound
Tetrahydrofuran
Secondary alcohol
Organoheterocyclic compound
Azacycle
Oxacycle
Organooxygen compound
Organonitrogen compound
Hydrocarbon derivative
Organic oxide
Organopnictogen compound
Organic oxygen compound
Organic nitrogen compound
Alcohol
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

deoxyguanosine phosphate (CHEBI:16497 )
guanyl deoxyribonucleotide (CHEBI:16497 )
purine 2'-deoxyribonucleoside 5'-triphosphate (CHEBI:16497 )
Deoxyribonucleotides (C00286 )

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
Water Solubility	5.59 g/L	ALOGPS
logP	-0.61	ALOGPS
logP	-3.2	ChemAxon
logS	-2	ALOGPS
pKa (Strongest Acidic)	1.03	ChemAxon
pKa (Strongest Basic)	0.33	ChemAxon
Physiological Charge	-3	ChemAxon
Hydrogen Acceptor Count	13	ChemAxon
Hydrogen Donor Count	7	ChemAxon
Polar Surface Area	274.58 Å²	ChemAxon
Rotatable Bond Count	8	ChemAxon
Refractivity	95.73 m³·mol⁻¹	ChemAxon
Polarizability	39.09 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

HMDB0001440

DrugBank ID

DB02181

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

Deoxyguanosine_triphosphate

METLIN ID

6248

PubChem Compound

65103

PDB ID

Not Available

ChEBI ID

16497

Good Scents ID

Not Available

References

General References

Kicska GA, Long L, Horig H, Fairchild C, Tyler PC, Furneaux RH, Schramm VL, Kaufman HL: Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes. Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4593-8. Epub 2001 Apr 3. [PubMed:11287638 ]
Stoop JW, Zegers BJ, Hendrickx GF, van Heukelom LH, Staal GE, de Bree PK, Wadman SK, Ballieux RE: Purine nucleoside phosphorylase deficiency associated with selective cellular immunodeficiency. N Engl J Med. 1977 Mar 24;296(12):651-5. [PubMed:402573 ]
Hardy CD, Schultz CS, Collins K: Requirements for the dGTP-dependent repeat addition processivity of recombinant Tetrahymena telomerase. J Biol Chem. 2001 Feb 16;276(7):4863-71. doi: 10.1074/jbc.M005158200. Epub 2000 Nov 28. [PubMed:11096070 ]
Torti A, Lossani A, Savi L, Focher F, Wright GE, Brown NC, Xu WC: Clostridium difficile DNA polymerase IIIC: basis for activity of antibacterial compounds. Curr Enzym Inhib. 2011 Oct;7(3):147-153. doi: 10.2174/157340811798807597. [PubMed:22844265 ]
Muller EG: Deoxyribonucleotides are maintained at normal levels in a yeast thioredoxin mutant defective in DNA synthesis. J Biol Chem. 1994 Sep 30;269(39):24466-71. [PubMed:7929110 ]

Showing NP-Card for dGTP (NP0000794)

MOL for NP0000794 (dGTP)

3D MOL for NP0000794 (dGTP)

3D SDF for NP0000794 (dGTP)

3D-SDF for NP0000794 (dGTP)

PDB for NP0000794 (dGTP)

3D PDB for NP0000794 (dGTP)

SMILES for NP0000794 (dGTP)

INCHI for NP0000794 (dGTP)

Structure for NP0000794 (dGTP)

3D Structure for NP0000794 (dGTP)