Record Information |
---|
Version | 1.0 |
---|
Created at | 2005-11-16 15:48:42 UTC |
---|
Updated at | 2022-02-09 16:31:25 UTC |
---|
NP-MRD ID | NP0000718 |
---|
Secondary Accession Numbers | None |
---|
Natural Product Identification |
---|
Common Name | 3-Hydroxybutyric acid |
---|
Description | 3-Hydroxybutyric acid (or beta-hydroxybutyrate) is a ketone body. Like the other ketone bodies (acetoacetate and acetone), levels of 3-hydroxybutyrate in blood and urine are raised in ketosis. In humans, 3-hydroxybutyrate is synthesized in the liver from acetyl-CoA and can be used as an energy source by the brain when blood glucose is low. Blood levels of 3-hydroxybutyric acid levels may be monitored in diabetic patients to look for diabetic ketoacidosis. Persistent mild hyperketonemia is a common finding in newborns. Ketone bodies serve as an indispensable source of energy for extrahepatic tissues, especially the brain and lung of developing mammals. Another important function of ketone bodies is to provide acetoacetyl-CoA and acetyl-CoA for the synthesis of cholesterol, fatty acids, and complex lipids. During the early postnatal period, acetoacetate (AcAc) and beta-hydroxybutyrate are preferred over glucose as substrates for synthesis of phospholipids and sphingolipids in accord with requirements for brain growth and myelination. Thus, during the first 2 weeks of postnatal development, when the accumulation of cholesterol and phospholipids accelerates, the proportion of ketone bodies incorporated into these lipids increases. On the other hand, an increased proportion of ketone bodies is utilized for cerebroside synthesis during the period of active myelination. In the lung, AcAc serves better than glucose as a precursor for the synthesis of lung phospholipids. The synthesized lipids, particularly dipalmitoylphosphatidylcholine, are incorporated into surfactant, and thus have a potential role in supplying adequate surfactant lipids to maintain lung function during the early days of life (PMID: 3884391 ). 3-Hydroxybutyric acid is found to be associated with fumarase deficiency and medium-chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism. |
---|
Structure | InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/t3-/m1/s1 |
---|
Synonyms | Value | Source |
---|
(R)-(-)-beta-Hydroxybutyric acid | ChEBI | (R)-3-Hydroxybutanoic acid | ChEBI | 3-D-Hydroxybutyric acid | ChEBI | D-3-Hydroxybutyric acid | ChEBI | (R)-3-Hydroxybutyric acid | Kegg | D-beta-Hydroxybutyric acid | Kegg | (R)-(-)-b-Hydroxybutyrate | Generator | (R)-(-)-b-Hydroxybutyric acid | Generator | (R)-(-)-beta-Hydroxybutyrate | Generator | (R)-(-)-Β-hydroxybutyrate | Generator | (R)-(-)-Β-hydroxybutyric acid | Generator | (R)-3-Hydroxybutanoate | Generator | 3-D-Hydroxybutyrate | Generator | D-3-Hydroxybutyrate | Generator | (R)-3-Hydroxybutyrate | Generator | D-b-Hydroxybutyrate | Generator | D-b-Hydroxybutyric acid | Generator | D-beta-Hydroxybutyrate | Generator | D-Β-hydroxybutyrate | Generator | D-Β-hydroxybutyric acid | Generator | 3-Hydroxybutyrate | Generator | 3-delta-Hydroxybutyrate | HMDB | 3-delta-Hydroxybutyric acid | HMDB | BHIB | HMDB | D-(-)-3-Hydroxybutyrate | HMDB | delta-(-)-3-Hydroxybutyrate | HMDB | delta-3-Hydroxybutyrate | HMDB | delta-3-Hydroxybutyric acid | HMDB | delta-beta-Hydroxybutyrate | HMDB | 3R-Hydroxy-butanoate | HMDB | (-)-3-Hydroxy-N-butyric acid | HMDB | (-)-3-Hydroxybutyric acid | HMDB | (3R)-3-Hydroxybutanoic acid | HMDB | (3R)-3-Hydroxybutyric acid | HMDB | (3R)-Hydroxybutyrate | HMDB | (R)-(-)-3-Hydroxybutyric acid | HMDB | (R)-beta-Hydroxybutanoic acid | HMDB | (R)-beta-Hydroxybutyric acid | HMDB | (R)-Β-hydroxybutanoic acid | HMDB | (R)-Β-hydroxybutyric acid | HMDB | 3-Hydroxy-N-butyric acid | HMDB | 3-Hydroxybutanoic acid | HMDB | 3R-Hydroxybutanoic acid | HMDB | D-(-)-3-Hydroxybutanoic acid | HMDB | D-(-)-3-Hydroxybutyric acid | HMDB | D-(-)-beta-Hydroxybutyric acid | HMDB | D-(-)-Β-hydroxybutyric acid | HMDB | beta-Hydroxy-N-butyric acid | HMDB | beta-Hydroxybutanoic acid | HMDB | beta-Hydroxybutyric acid | HMDB | Β-hydroxy-N-butyric acid | HMDB | Β-hydroxybutanoic acid | HMDB | Β-hydroxybutyric acid | HMDB | 3-Hydroxybutyric acid | HMDB |
|
---|
Chemical Formula | C4H8O3 |
---|
Average Mass | 104.1045 Da |
---|
Monoisotopic Mass | 104.04734 Da |
---|
IUPAC Name | (3R)-3-hydroxybutanoic acid |
---|
Traditional Name | (-)-3-hydroxybutyric acid |
---|
CAS Registry Number | 300-85-6 |
---|
SMILES | CC(O)CC(O)=O |
---|
InChI Identifier | InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7) |
---|
InChI Key | WHBMMWSBFZVSSR-UHFFFAOYSA-N |
---|
Experimental Spectra |
---|
|
| Spectrum Type | Description | Depositor Email | Depositor Organization | Depositor | Deposition Date | View |
---|
1D NMR | 1H NMR Spectrum (1D, 700 MHz, H2O, simulated) | Ahselim | | | 2022-02-09 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 700 MHz, H2O, experimental) | Ahselim | | | 2022-02-09 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 600 MHz, H2O, experimental) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 2D NMR | [1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum |
| Predicted Spectra |
---|
|
| Not Available | Chemical Shift Submissions |
---|
|
| Not Available | Species |
---|
Species of Origin | |
---|
Species Where Detected | |
---|
Chemical Taxonomy |
---|
Description | Belongs to the class of organic compounds known as beta hydroxy acids and derivatives. Beta hydroxy acids and derivatives are compounds containing a carboxylic acid substituted with a hydroxyl group on the C3 carbon atom. |
---|
Kingdom | Organic compounds |
---|
Super Class | Organic acids and derivatives |
---|
Class | Hydroxy acids and derivatives |
---|
Sub Class | Beta hydroxy acids and derivatives |
---|
Direct Parent | Beta hydroxy acids and derivatives |
---|
Alternative Parents | |
---|
Substituents | - Short-chain hydroxy acid
- Beta-hydroxy acid
- Fatty acid
- Secondary alcohol
- Monocarboxylic acid or derivatives
- Carboxylic acid
- Carboxylic acid derivative
- Organic oxygen compound
- Organic oxide
- Hydrocarbon derivative
- Organooxygen compound
- Carbonyl group
- Alcohol
- Aliphatic acyclic compound
|
---|
Molecular Framework | Aliphatic acyclic compounds |
---|
External Descriptors | |
---|
Physical Properties |
---|
State | Solid |
---|
Experimental Properties | Property | Value | Reference |
---|
Melting Point | 46 °C | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | 444 mg/mL | Not Available | LogP | Not Available | Not Available |
|
---|
Predicted Properties | |
---|
General References | - Pan JW, Rothman TL, Behar KL, Stein DT, Hetherington HP: Human brain beta-hydroxybutyrate and lactate increase in fasting-induced ketosis. J Cereb Blood Flow Metab. 2000 Oct;20(10):1502-7. [PubMed:11043913 ]
- Pan JW, Telang FW, Lee JH, de Graaf RA, Rothman DL, Stein DT, Hetherington HP: Measurement of beta-hydroxybutyrate in acute hyperketonemia in human brain. J Neurochem. 2001 Nov;79(3):539-44. [PubMed:11701757 ]
- Plecko B, Stoeckler-Ipsiroglu S, Schober E, Harrer G, Mlynarik V, Gruber S, Moser E, Moeslinger D, Silgoner H, Ipsiroglu O: Oral beta-hydroxybutyrate supplementation in two patients with hyperinsulinemic hypoglycemia: monitoring of beta-hydroxybutyrate levels in blood and cerebrospinal fluid, and in the brain by in vivo magnetic resonance spectroscopy. Pediatr Res. 2002 Aug;52(2):301-6. [PubMed:12149510 ]
- Shoemaker JD, Elliott WH: Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease. J Chromatogr. 1991 Jan 2;562(1-2):125-38. [PubMed:2026685 ]
- Hoffmann GF, Meier-Augenstein W, Stockler S, Surtees R, Rating D, Nyhan WL: Physiology and pathophysiology of organic acids in cerebrospinal fluid. J Inherit Metab Dis. 1993;16(4):648-69. [PubMed:8412012 ]
- Zupke C, Sinskey AJ, Stephanopoulos G: Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl Microbiol Biotechnol. 1995 Dec;44(1-2):27-36. [PubMed:8579834 ]
- Redjems-Bennani N, Jeandel C, Lefebvre E, Blain H, Vidailhet M, Gueant JL: Abnormal substrate levels that depend upon mitochondrial function in cerebrospinal fluid from Alzheimer patients. Gerontology. 1998;44(5):300-4. [PubMed:9693263 ]
- Frenkel G, Peterson RN, Freund M: Oxidative and glycolytic metabolism of semen components by washed guinea pig spermatozoa. Fertil Steril. 1975 Feb;26(2):144-7. [PubMed:1126459 ]
- Abrahamsson K, Eriksson BO, Holme E, Jodal U, Jonsson A, Lindstedt S: Pivalic acid-induced carnitine deficiency and physical exercise in humans. Metabolism. 1996 Dec;45(12):1501-7. [PubMed:8969283 ]
- Teresinski G, Buszewicz G, Madro R: The influence of ethanol on the level of ketone bodies in hypothermia. Forensic Sci Int. 2002 Jun 25;127(1-2):88-96. [PubMed:12098531 ]
- Nalecz KA, Miecz D, Berezowski V, Cecchelli R: Carnitine: transport and physiological functions in the brain. Mol Aspects Med. 2004 Oct-Dec;25(5-6):551-67. [PubMed:15363641 ]
- Blomqvist G, Alvarsson M, Grill V, Von Heijne G, Ingvar M, Thorell JO, Stone-Elander S, Widen L, Ekberg K: Effect of acute hyperketonemia on the cerebral uptake of ketone bodies in nondiabetic subjects and IDDM patients. Am J Physiol Endocrinol Metab. 2002 Jul;283(1):E20-8. [PubMed:12067838 ]
- Krotkiewski M: Value of VLCD supplementation with medium chain triglycerides. Int J Obes Relat Metab Disord. 2001 Sep;25(9):1393-400. [PubMed:11571605 ]
- Kamijo T, Indo Y, Souri M, Aoyama T, Hara T, Yamamoto S, Ushikubo S, Rinaldo P, Matsuda I, Komiyama A, Hashimoto T: Medium chain 3-ketoacyl-coenzyme A thiolase deficiency: a new disorder of mitochondrial fatty acid beta-oxidation. Pediatr Res. 1997 Nov;42(5):569-76. [PubMed:9357925 ]
- Geary N, Grotschel H, Scharrer E: Blood metabolites and feeding during postinsulin hypophagia. Am J Physiol. 1982 Sep;243(3):R304-11. [PubMed:7051864 ]
- Yeh YY, Sheehan PM: Preferential utilization of ketone bodies in the brain and lung of newborn rats. Fed Proc. 1985 Apr;44(7):2352-8. [PubMed:3884391 ]
- Shi D, Yan R, Lv L, Jiang H, Lu Y, Sheng J, Xie J, Wu W, Xia J, Xu K, Gu S, Chen Y, Huang C, Guo J, Du Y, Li L: The serum metabolome of COVID-19 patients is distinctive and predictive. Metabolism. 2021 May;118:154739. doi: 10.1016/j.metabol.2021.154739. Epub 2021 Mar 2. [PubMed:33662365 ]
|
---|