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Showing NP-Card for Galactonic acid (NP0000595)

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Record Information
Version1.0
Created at2005-11-16 15:48:42 UTC
Updated at2020-11-24 22:16:45 UTC
NP-MRD IDNP0000595
Secondary Accession NumbersNone
Natural Product Identification
Common NameGalactonic acid
DescriptionGalactonic acid is a sugar acid that is a metabolic breakdown product of galactose. Galactose dehydrogenase is responsible for converting galactose to galactonolactone, which then spontaneously or enzymatically converts to galactonic acid. Once formed, galactonic acid may enter the pentose phosphate pathway. Galactonic acid is increased in red blood cells of galactosemic patients, due to a galactose-1-phosphate uridyltransferase (GALT) deficiency (PMID: 14680973 , OMMBID: The Online Metabolic and Molecular Bases of Inherited Disease, Ch.72). When present in sufficiently high levels, galactonic acid can act as an acidogen and a metabotoxin. An acidogen is an acidic compound that induces acidosis, which has multiple adverse effects on many organ systems. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Chronically high levels of galactonic acid are associated with at least two inborn errors of metabolism, including galactosemia and galactosemia type II. Galactonic acid is an organic acid. Abnormally high levels of organic acids in the blood (organic acidemia), urine (organic aciduria), the brain, and other tissues lead to general metabolic acidosis. Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis, the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone (hypotonia), and lack of energy (lethargy). These can progress to heart abnormalities, liver abnormalities (jaundice), kidney abnormalities, seizures, coma, and possibly death. These are also the characteristic symptoms of untreated galactosemia. Many affected children with organic acidemias experience intellectual disability or delayed development. High levels of galactonic acid in infants are specifically associated with hepatomegaly (an enlarged liver), cirrhosis, renal failure, cataracts, vomiting, seizure, hypoglycemia, lethargy, brain damage, and ovarian failure.
Structure
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MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for NP0000595 (Galactonic acid)


  Mrv1652305271900132D          

 13 12  0  0  0  0            999 V2000
 9991.8108 9991.2533    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9991.0969 9991.6652    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
 9990.3821 9991.2533    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9989.6675 9991.6652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9988.9529 9991.2533    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9990.3821 9990.4280    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9991.0969 9992.4899    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9992.5263 9991.6652    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
 9993.2417 9991.2533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9993.9551 9991.6652    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9993.2417 9990.4280    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9992.5263 9992.4899    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9991.8108 9990.4280    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  8  1  0  0  0  0
  1 13  1  1  0  0  0
  2  3  1  0  0  0  0
  2  7  1  6  0  0  0
  3  4  1  0  0  0  0
  3  6  1  6  0  0  0
  4  5  1  0  0  0  0
  8  9  1  0  0  0  0
  8 12  1  1  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
M  END
Download

3D MOL for NP0000595 (Galactonic acid)

HMDB0000565
     RDKit          3D
Galactonic acid
 25 24  0  0  0  0  0  0  0  0999 V2000
   -3.3767    1.0005    1.0256 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1738    0.9302    0.6415 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2542    1.7582    1.2550 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8295   -0.0170   -0.4234 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.9667   -0.7057   -0.8826 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8477   -1.0886   -0.0001 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.6004   -1.8568   -1.1353 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3915   -0.5559    0.6227 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.1911   -1.6563    0.9844 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2286    0.2780   -0.3143 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.6078   -0.4182   -1.4477 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4903    0.7690    0.3584 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2237    1.4865    1.5162 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5507    2.6821    1.5473 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4118    0.5191   -1.3009 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5252   -1.0193   -0.1337 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3791   -1.7497    0.7146 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7726   -1.3570   -1.9698 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1893   -0.0242    1.5652 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6113   -2.4340    1.1917 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6613    1.1754   -0.6212 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0587   -1.2637   -1.1870 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1402   -0.0975    0.6498 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0279    1.4228   -0.3577 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8667    2.2219    1.6815 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  4  6  1  0
  6  7  1  0
  6  8  1  0
  8  9  1  0
  8 10  1  0
 10 11  1  0
 10 12  1  0
 12 13  1  0
  3 14  1  0
  4 15  1  6
  5 16  1  0
  6 17  1  1
  7 18  1  0
  8 19  1  1
  9 20  1  0
 10 21  1  6
 11 22  1  0
 12 23  1  0
 12 24  1  0
 13 25  1  0
M  END
Download

3D SDF for NP0000595 (Galactonic acid)


  Mrv1652305271900132D          

 13 12  0  0  0  0            999 V2000
 9991.8108 9991.2533    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9991.0969 9991.6652    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
 9990.3821 9991.2533    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9989.6675 9991.6652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9988.9529 9991.2533    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9990.3821 9990.4280    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9991.0969 9992.4899    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9992.5263 9991.6652    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
 9993.2417 9991.2533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9993.9551 9991.6652    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9993.2417 9990.4280    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9992.5263 9992.4899    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9991.8108 9990.4280    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  8  1  0  0  0  0
  1 13  1  1  0  0  0
  2  3  1  0  0  0  0
  2  7  1  6  0  0  0
  3  4  1  0  0  0  0
  3  6  1  6  0  0  0
  4  5  1  0  0  0  0
  8  9  1  0  0  0  0
  8 12  1  1  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0000595

> <DATABASE_NAME>
NP-MRD

> <SMILES>
OC[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/t2-,3+,4+,5-/m1/s1

> <INCHI_KEY>
RGHNJXZEOKUKBD-MGCNEYSASA-N

> <FORMULA>
C6H12O7

> <MOLECULAR_WEIGHT>
196.1553

> <EXACT_MASS>
196.058302738

> <JCHEM_ACCEPTOR_COUNT>
7

> <JCHEM_ATOM_COUNT>
25

> <JCHEM_AVERAGE_POLARIZABILITY>
17.069696029240205

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
6

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2R,3S,4S,5R)-2,3,4,5,6-pentahydroxyhexanoic acid

> <ALOGPS_LOGP>
-2.57

> <JCHEM_LOGP>
-3.4097443106666665

> <ALOGPS_LOGS>
-0.09

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
12.593710458724516

> <JCHEM_PKA_STRONGEST_ACIDIC>
3.388205574321856

> <JCHEM_PKA_STRONGEST_BASIC>
-2.974220927705365

> <JCHEM_POLAR_SURFACE_AREA>
138.45

> <JCHEM_REFRACTIVITY>
38.271

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
1.59e+02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
galactonic acid

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for NP0000595 (Galactonic acid)

HMDB0000565
     RDKit          3D
Galactonic acid
 25 24  0  0  0  0  0  0  0  0999 V2000
   -3.3767    1.0005    1.0256 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1738    0.9302    0.6415 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2542    1.7582    1.2550 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8295   -0.0170   -0.4234 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.9667   -0.7057   -0.8826 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8477   -1.0886   -0.0001 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.6004   -1.8568   -1.1353 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3915   -0.5559    0.6227 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.1911   -1.6563    0.9844 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2286    0.2780   -0.3143 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.6078   -0.4182   -1.4477 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4903    0.7690    0.3584 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2237    1.4865    1.5162 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5507    2.6821    1.5473 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4118    0.5191   -1.3009 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5252   -1.0193   -0.1337 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3791   -1.7497    0.7146 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7726   -1.3570   -1.9698 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1893   -0.0242    1.5652 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6113   -2.4340    1.1917 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6613    1.1754   -0.6212 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0587   -1.2637   -1.1870 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1402   -0.0975    0.6498 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0279    1.4228   -0.3577 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8667    2.2219    1.6815 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  4  6  1  0
  6  7  1  0
  6  8  1  0
  8  9  1  0
  8 10  1  0
 10 11  1  0
 10 12  1  0
 12 13  1  0
  3 14  1  0
  4 15  1  6
  5 16  1  0
  6 17  1  1
  7 18  1  0
  8 19  1  1
  9 20  1  0
 10 21  1  6
 11 22  1  0
 12 23  1  0
 12 24  1  0
 13 25  1  0
M  END
Download

PDB for NP0000595 (Galactonic acid)

HEADER    PROTEIN                                 27-MAY-19   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   27-MAY-19         0                                  
HETATM    1  C   UNK     0    8651.3808650.339   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0    8650.0488651.108   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0    8648.7138650.339   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0    8647.3798651.108   0.000  0.00  0.00           C+0
HETATM    5  O   UNK     0    8646.0458650.339   0.000  0.00  0.00           O+0
HETATM    6  O   UNK     0    8648.7138648.799   0.000  0.00  0.00           O+0
HETATM    7  O   UNK     0    8650.0488652.648   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0    8652.7168651.108   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0    8654.0518650.339   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0    8655.3838651.108   0.000  0.00  0.00           O+0
HETATM   11  O   UNK     0    8654.0518648.799   0.000  0.00  0.00           O+0
HETATM   12  O   UNK     0    8652.7168652.648   0.000  0.00  0.00           O+0
HETATM   13  O   UNK     0    8651.3808648.799   0.000  0.00  0.00           O+0
CONECT    1    2    8   13                                                  
CONECT    2    1    3    7                                                  
CONECT    3    2    4    6                                                  
CONECT    4    3    5                                                       
CONECT    5    4                                                            
CONECT    6    3                                                            
CONECT    7    2                                                            
CONECT    8    1    9   12                                                  
CONECT    9    8   10   11                                                  
CONECT   10    9                                                            
CONECT   11    9                                                            
CONECT   12    8                                                            
CONECT   13    1                                                            
MASTER        0    0    0    0    0    0    0    0   13    0   24    0
END
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3D PDB for NP0000595 (Galactonic acid)

COMPND    HMDB0000565
HETATM    1  O1  UNL     1      -3.377   1.000   1.026  1.00  0.00           O  
HETATM    2  C1  UNL     1      -2.174   0.930   0.641  1.00  0.00           C  
HETATM    3  O2  UNL     1      -1.254   1.758   1.255  1.00  0.00           O  
HETATM    4  C2  UNL     1      -1.830  -0.017  -0.423  1.00  0.00           C  
HETATM    5  O3  UNL     1      -2.967  -0.706  -0.883  1.00  0.00           O  
HETATM    6  C3  UNL     1      -0.848  -1.089  -0.000  1.00  0.00           C  
HETATM    7  O4  UNL     1      -0.600  -1.857  -1.135  1.00  0.00           O  
HETATM    8  C4  UNL     1       0.392  -0.556   0.623  1.00  0.00           C  
HETATM    9  O5  UNL     1       1.191  -1.656   0.984  1.00  0.00           O  
HETATM   10  C5  UNL     1       1.229   0.278  -0.314  1.00  0.00           C  
HETATM   11  O6  UNL     1       1.608  -0.418  -1.448  1.00  0.00           O  
HETATM   12  C6  UNL     1       2.490   0.769   0.358  1.00  0.00           C  
HETATM   13  O7  UNL     1       2.224   1.487   1.516  1.00  0.00           O  
HETATM   14  H1  UNL     1      -1.551   2.682   1.547  1.00  0.00           H  
HETATM   15  H2  UNL     1      -1.412   0.519  -1.301  1.00  0.00           H  
HETATM   16  H3  UNL     1      -3.525  -1.019  -0.134  1.00  0.00           H  
HETATM   17  H4  UNL     1      -1.379  -1.750   0.715  1.00  0.00           H  
HETATM   18  H5  UNL     1      -0.773  -1.357  -1.970  1.00  0.00           H  
HETATM   19  H6  UNL     1       0.189  -0.024   1.565  1.00  0.00           H  
HETATM   20  H7  UNL     1       0.611  -2.434   1.192  1.00  0.00           H  
HETATM   21  H8  UNL     1       0.661   1.175  -0.621  1.00  0.00           H  
HETATM   22  H9  UNL     1       2.059  -1.264  -1.187  1.00  0.00           H  
HETATM   23  H10 UNL     1       3.140  -0.097   0.650  1.00  0.00           H  
HETATM   24  H11 UNL     1       3.028   1.423  -0.358  1.00  0.00           H  
HETATM   25  H12 UNL     1       2.867   2.222   1.681  1.00  0.00           H  
CONECT    1    2    2
CONECT    2    3    4
CONECT    3   14
CONECT    4    5    6   15
CONECT    5   16
CONECT    6    7    8   17
CONECT    7   18
CONECT    8    9   10   19
CONECT    9   20
CONECT   10   11   12   21
CONECT   11   22
CONECT   12   13   23   24
CONECT   13   25
END
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SMILES for NP0000595 (Galactonic acid)

OC[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)C(O)=O
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INCHI for NP0000595 (Galactonic acid)

InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/t2-,3+,4+,5-/m1/s1
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View in JSmol
Synonyms
ValueSource
D-Galactonic acidKegg
D-GalactonateGenerator
GalactonateGenerator
Galactonic acid, (D)-isomerHMDB
Galactonic acid, monopotassium saltHMDB
Galactonic acid, (L)-isomerHMDB
Chemical FormulaC6H12O7
Average Mass196.1553 Da
Monoisotopic Mass196.05830 Da
IUPAC Name(2R,3S,4S,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
Traditional Namegalactonic acid
CAS Registry Number13382-27-9
SMILES
OC[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)C(O)=O
InChI Identifier
InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/t2-,3+,4+,5-/m1/s1
InChI KeyRGHNJXZEOKUKBD-MGCNEYSASA-N
Experimental Spectra
Spectrum TypeDescriptionDepositor EmailDepositor OrganizationDepositorDeposition DateView
1D NMR1H NMR Spectrum (1D, 600 MHz, H2O, simulated)Varshavi.d262021-08-17View Spectrum
1D NMR1H NMR Spectrum (1D, 600 MHz, H2O, experimental)Varshavi.d262021-08-17View Spectrum
2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, 5%_DMSO, experimental)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
Predicted Spectra
Not Available
Chemical Shift Submissions
Not Available
Species
Species of Origin
Species NameSourceReference
Anas platyrhynchosFooDB
AnatidaeFooDB
Anser anserFooDB
Arabidopsis thalianaLOTUS Database
Bison bisonFooDB
Bos taurusFooDB
Bos taurus X Bison bisonFooDB
Bubalus bubalisFooDB
Capra aegagrus hircusFooDB
CervidaeFooDB
Cervus canadensisFooDB
ColumbaFooDB
ColumbidaeFooDB
Dromaius novaehollandiaeFooDB
Equus caballusFooDB
Gallus gallusFooDB
Lagopus mutaFooDB
LeporidaeFooDB
Lepus timidusFooDB
Lotus corniculatusLOTUS Database
Melanitta fuscaFooDB
Meleagris gallopavoFooDB
Numida meleagrisFooDB
OdocoileusFooDB
OryctolagusFooDB
Ovis ariesFooDB
PhasianidaeFooDB
Phasianus colchicusFooDB
Prunus aviumPlant
Struthio camelusFooDB
Sus scrofaFooDB
Sus scrofa domesticaFooDB
Triticum aestivumKNApSAcK Database
Chemical Taxonomy
Description Belongs to the class of organic compounds known as medium-chain hydroxy acids and derivatives. These are hydroxy acids with a 6 to 12 carbon atoms long side chain.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassHydroxy acids and derivatives
Sub ClassMedium-chain hydroxy acids and derivatives
Direct ParentMedium-chain hydroxy acids and derivatives
Alternative Parents
Substituents
  • Medium-chain hydroxy acid
  • Medium-chain fatty acid
  • Beta-hydroxy acid
  • Hydroxy fatty acid
  • Alpha-hydroxy acid
  • Monosaccharide
  • Fatty acyl
  • Fatty acid
  • Secondary alcohol
  • Polyol
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Carboxylic acid derivative
  • Organooxygen compound
  • Hydrocarbon derivative
  • Organic oxide
  • Carbonyl group
  • Primary alcohol
  • Alcohol
  • Organic oxygen compound
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point133 - 136 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
Water Solubility159 g/LALOGPS
logP-2.6ALOGPS
logP-3.4ChemAxon
logS-0.09ALOGPS
pKa (Strongest Acidic)3.39ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count6ChemAxon
Polar Surface Area138.45 ŲChemAxon
Rotatable Bond Count5ChemAxon
Refractivity38.27 m³·mol⁻¹ChemAxon
Polarizability17.07 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
HMDB IDHMDB0000565
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDFDB022122
KNApSAcK IDC00053191
Chemspider ID114198
KEGG Compound IDC00880
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN ID3336
PubChem Compound128869
PDB IDNot Available
ChEBI ID16534
Good Scents IDNot Available
References
General References
  1. Shoemaker JD, Elliott WH: Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease. J Chromatogr. 1991 Jan 2;562(1-2):125-38. [PubMed:2026685 ]
  2. Shinka T, Inoue Y, Peng H, Zhen-Wei X, Ose M, Kuhara T: Urine screening of five-day-old newborns: metabolic profiling of neonatal galactosuria. J Chromatogr B Biomed Sci Appl. 1999 Sep 24;732(2):469-77. [PubMed:10517369 ]
  3. Yager CT, Chen J, Reynolds R, Segal S: Galactitol and galactonate in red blood cells of galactosemic patients. Mol Genet Metab. 2003 Nov;80(3):283-9. [PubMed:14680973 ]
  4. Tian W, Xiang X, Wang H: Differential Impacts of Water Table and Temperature on Bacterial Communities in Pore Water From a Subalpine Peatland, Central China. Front Microbiol. 2021 May 28;12:649981. doi: 10.3389/fmicb.2021.649981. eCollection 2021. [PubMed:34122363 ]
  5. Sodeyama T, Nishikawa H, Harai K, Takeshima D, Sawa Y, Maruta T, Ishikawa T: The d-mannose/l-galactose pathway is the dominant ascorbate biosynthetic route in the moss Physcomitrium patens. Plant J. 2021 Sep;107(6):1724-1738. doi: 10.1111/tpj.15413. Epub 2021 Aug 10. [PubMed:34245628 ]