Record Information |
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Version | 1.0 |
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Created at | 2006-08-12 20:38:19 UTC |
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Updated at | 2021-06-29 00:47:47 UTC |
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NP-MRD ID | NP0000515 |
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Secondary Accession Numbers | None |
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Natural Product Identification |
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Common Name | L-Histidinol |
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Description | L-Histidinol, a structural analogue of the essential amino acid L-histidine, enhances the toxicity of a variety of anticancer drugs for many tumour cells of animal origin (PMID: 8297120 ). L-Histidinol inhibits human myristoyl-CoA:Protein-myristoyltransferase (hNMT), an essential eukaryotic enzyme that catalyzes the cotranslational transfer of myristate into the NH2-terminal glycine residue of a number of important proteins of diverse function (PMID: 9778369 ). |
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Structure | InChI=1S/C6H11N3O/c7-5(3-10)1-6-2-8-4-9-6/h2,4-5,10H,1,3,7H2,(H,8,9)/t5-/m0/s1 |
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Synonyms | Value | Source |
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4-[(S)-2-Amino-3-hydroxypropyl]imidazole | ChEBI | (S)-beta-Amino-1H-imidazole-4-propanol | HMDB | Histidinol | HMDB | HSO | HMDB | Imidazole C-4(5) deriv. 4 | HMDB | Histidol | HMDB | (2S)-2-Amino-3-(1H-imidazol-4-yl)propan-1-ol | HMDB | (S)-Histidinol | HMDB | (BetaS)-beta-amino-1H-imidazole-5-propanol | HMDB | (ΒS)-β-amino-1H-imidazole-5-propanol | HMDB | beta-Amino-1H-imidazole-5-propanol | HMDB | Β-amino-1H-imidazole-5-propanol | HMDB | L-Histidinol | HMDB |
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Chemical Formula | C6H11N3O |
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Average Mass | 141.1710 Da |
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Monoisotopic Mass | 141.09021 Da |
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IUPAC Name | (2S)-2-amino-3-(1H-imidazol-5-yl)propan-1-ol |
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Traditional Name | HSO |
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CAS Registry Number | 4836-52-6 |
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SMILES | N[C@H](CO)CC1=CN=CN1 |
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InChI Identifier | InChI=1S/C6H11N3O/c7-5(3-10)1-6-2-8-4-9-6/h2,4-5,10H,1,3,7H2,(H,8,9)/t5-/m0/s1 |
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InChI Key | ZQISRDCJNBUVMM-YFKPBYRVSA-N |
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Experimental Spectra |
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| Spectrum Type | Description | Depositor Email | Depositor Organization | Depositor | Deposition Date | View |
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1D NMR | 1H NMR Spectrum (1D, 600 MHz, H2O, experimental) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 2D NMR | [1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum |
| Predicted Spectra |
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| Not Available | Chemical Shift Submissions |
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| Not Available | Species |
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Species of Origin | |
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Species Where Detected | |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as aralkylamines. These are alkylamines in which the alkyl group is substituted at one carbon atom by an aromatic hydrocarbyl group. |
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Kingdom | Organic compounds |
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Super Class | Organic nitrogen compounds |
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Class | Organonitrogen compounds |
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Sub Class | Amines |
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Direct Parent | Aralkylamines |
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Alternative Parents | |
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Substituents | - Aralkylamine
- Azole
- Imidazole
- Heteroaromatic compound
- 1,2-aminoalcohol
- Azacycle
- Organoheterocyclic compound
- Organic oxygen compound
- Primary amine
- Primary alcohol
- Organooxygen compound
- Primary aliphatic amine
- Alcohol
- Hydrocarbon derivative
- Organopnictogen compound
- Aromatic heteromonocyclic compound
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Molecular Framework | Aromatic heteromonocyclic compounds |
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External Descriptors | |
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Physical Properties |
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State | Solid |
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Experimental Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Predicted Properties | |
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General References | - Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762. [PubMed:19212411 ]
- Raju RV, Datla RS, Warrington RC, Sharma RK: Effects of L-histidine and its structural analogues on human N-myristoyltransferase activity and importance of EEVEH amino acid sequence for enzyme activity. Biochemistry. 1998 Oct 20;37(42):14928-36. [PubMed:9778369 ]
- Warrington RC, Cheng I, Zhang L, Fang WD: L-histidinol increases the vulnerability of cultured human leukemia and lymphoma cells to anticancer drugs. Anticancer Res. 1993 Nov-Dec;13(6A):2107-12. [PubMed:8297120 ]
- Warrington RC, Norum JN, Hilchey JL, Watt C, Fang WD: A simple, informative, and quantitative flow cytometric method for assessing apoptosis in cultured cells. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Apr;27(2):231-43. [PubMed:12657362 ]
- Pan L, Yu J, Mi Z, Mo L, Jin H, Yao C, Ren D, Menghe B: A Metabolomics Approach Uncovers Differences between Traditional and Commercial Dairy Products in Buryatia (Russian Federation). Molecules. 2018 Mar 22;23(4). pii: molecules23040735. doi: 10.3390/molecules23040735. [PubMed:29565828 ]
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