Showing NP-Card for O-Phosphoethanolamine (NP0000470)

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Record Information
Version2.0
Created at2005-11-16 15:48:42 UTC
Updated at2021-07-01 14:27:27 UTC
NP-MRD IDNP0000470
Secondary Accession NumbersNone
Natural Product Identification
Common NameO-Phosphoethanolamine
DescriptionO-Phosphoethanolamine, also known as PEA, phosphorylethanolamine, colamine phosphoric acid or ethanolamine O-phosphate, belongs to the class of organic compounds known as phosphoethanolamines. Phosphoethanolamines are compounds containing a phosphate linked to the second carbon of an ethanolamine. O-Phosphoethanolamine is used in the biosynthesis of two different types of phospholipids: Glycerophospholipids and sphingolipids. O-Phosphoethanolamine exists in all living species, ranging from bacteria to plants to humans. Within humans, O-phosphoethanolamine participates in a number of enzymatic reactions. In particular, cytidine triphosphate and O-phosphoethanolamine can be converted into CDP-ethanolamine; which is mediated by the enzyme ethanolamine-phosphate cytidylyltransferase. In addition, O-phosphoethanolamine can be biosynthesized from ethanolamine; which is catalyzed by the enzyme choline/ethanolamine kinase. In humans, O-phosphoethanolamine is involved in phosphatidylcholine biosynthesis. O-phosphoethanolamine is also a product of the metabolism of sphingolipids. In particular, sphinglipids are metabolized in vivo to phosphorylethanolamine and a fatty aldehyde, generally palmitaldehyde. Both metabolites are ultimately converted to glycerophospholipids. The lipids are first phosphorylated by a kinase and then cleaved by the pyridoxal-dependent sphinganine-1-phosphate aldolase. Elevated urine levels of O-Phosphoethanolamine or PEA can be used to help in the diagnosis of Hypophosphatasia (HPP). Reference ranges for urinary PEA vary according to age and somewhat by diet, and follow a circadian rhythm. Outside of the human body, O-phosphoethanolamine has been detected, but not quantified in, several different foods, such as oxheart cabbages, anises, shiitakes, abalones, and teffs.
Structure
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MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for NP0000470 (O-Phosphoethanolamine)

  Mrv1652309032023572D          

  8  7  0  0  0  0            999 V2000
   11.8291  -13.0248    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   12.5436  -12.6123    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.1146  -13.4373    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.4166  -12.3103    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.2416  -13.7393    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.6871  -13.0248    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.2581  -13.0248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9725  -12.6123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  1  4  1  0  0  0  0
  1  5  2  0  0  0  0
  2  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  8  1  0  0  0  0
M  END
Download

3D MOL for NP0000470 (O-Phosphoethanolamine)

HMDB0000224
     RDKit          3D
O-Phosphoethanolamine
 16 15  0  0  0  0  0  0  0  0999 V2000
    2.2447    0.7162    0.4850 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6246   -0.2795   -0.3464 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4444   -0.9499    0.3116 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4008   -0.0409    0.9477 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8823   -0.0107    0.1254 P   0  0  0  0  0  5  0  0  0  0  0  0
   -2.2036   -1.4182   -0.2876 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6539    0.9608   -1.2511 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0875    0.6905    1.0659 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6826    1.4208   -0.1661 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0446    0.3483    1.0547 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3459   -1.0701   -0.6277 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2516    0.2174   -1.2690 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0881   -1.5110   -0.4979 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7671   -1.7150    1.0391 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2102    1.7910   -0.9132 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8791    0.8502    0.5133 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  5  7  1  0
  5  8  1  0
  1  9  1  0
  1 10  1  0
  2 11  1  0
  2 12  1  0
  3 13  1  0
  3 14  1  0
  7 15  1  0
  8 16  1  0
M  END
Download

3D SDF for NP0000470 (O-Phosphoethanolamine)

  Mrv1652309032023572D          

  8  7  0  0  0  0            999 V2000
   11.8291  -13.0248    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   12.5436  -12.6123    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.1146  -13.4373    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.4166  -12.3103    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.2416  -13.7393    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.6871  -13.0248    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.2581  -13.0248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9725  -12.6123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  1  4  1  0  0  0  0
  1  5  2  0  0  0  0
  2  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  8  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0000470

> <DATABASE_NAME>
NP-MRD

> <SMILES>
NCCOP(O)(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)

> <INCHI_KEY>
SUHOOTKUPISOBE-UHFFFAOYSA-N

> <FORMULA>
C2H8NO4P

> <MOLECULAR_WEIGHT>
141.063

> <EXACT_MASS>
141.019094261

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
16

> <JCHEM_AVERAGE_POLARIZABILITY>
11.11675089618825

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2-aminoethoxy)phosphonic acid

> <ALOGPS_LOGP>
-1.54

> <JCHEM_LOGP>
-2.4512986210264835

> <ALOGPS_LOGS>
-0.74

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
6.565826815298373

> <JCHEM_PKA_STRONGEST_ACIDIC>
1.5391795005429323

> <JCHEM_PKA_STRONGEST_BASIC>
10.017192603268537

> <JCHEM_POLAR_SURFACE_AREA>
92.77999999999999

> <JCHEM_REFRACTIVITY>
27.084

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.58e+01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
phosphorylethanolamine

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for NP0000470 (O-Phosphoethanolamine)

HMDB0000224
     RDKit          3D
O-Phosphoethanolamine
 16 15  0  0  0  0  0  0  0  0999 V2000
    2.2447    0.7162    0.4850 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6246   -0.2795   -0.3464 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4444   -0.9499    0.3116 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4008   -0.0409    0.9477 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8823   -0.0107    0.1254 P   0  0  0  0  0  5  0  0  0  0  0  0
   -2.2036   -1.4182   -0.2876 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6539    0.9608   -1.2511 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0875    0.6905    1.0659 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6826    1.4208   -0.1661 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0446    0.3483    1.0547 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3459   -1.0701   -0.6277 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2516    0.2174   -1.2690 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0881   -1.5110   -0.4979 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7671   -1.7150    1.0391 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2102    1.7910   -0.9132 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8791    0.8502    0.5133 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  5  7  1  0
  5  8  1  0
  1  9  1  0
  1 10  1  0
  2 11  1  0
  2 12  1  0
  3 13  1  0
  3 14  1  0
  7 15  1  0
  8 16  1  0
M  END
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PDB for NP0000470 (O-Phosphoethanolamine)

HEADER    PROTEIN                                 03-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   03-SEP-20         0                                  
HETATM    1  P   UNK     0      22.081 -24.313   0.000  0.00  0.00           P+0
HETATM    2  O   UNK     0      23.415 -23.543   0.000  0.00  0.00           O+0
HETATM    3  O   UNK     0      20.747 -25.083   0.000  0.00  0.00           O+0
HETATM    4  O   UNK     0      21.311 -22.979   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0      22.851 -25.647   0.000  0.00  0.00           O+0
HETATM    6  N   UNK     0      27.416 -24.313   0.000  0.00  0.00           N+0
HETATM    7  C   UNK     0      24.748 -24.313   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      26.082 -23.543   0.000  0.00  0.00           C+0
CONECT    1    2    3    4    5                                             
CONECT    2    1    7                                                       
CONECT    3    1                                                            
CONECT    4    1                                                            
CONECT    5    1                                                            
CONECT    6    8                                                            
CONECT    7    2    8                                                       
CONECT    8    6    7                                                       
MASTER        0    0    0    0    0    0    0    0    8    0   14    0
END
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3D PDB for NP0000470 (O-Phosphoethanolamine)

COMPND    HMDB0000224
HETATM    1  N1  UNL     1       2.245   0.716   0.485  1.00  0.00           N  
HETATM    2  C1  UNL     1       1.625  -0.279  -0.346  1.00  0.00           C  
HETATM    3  C2  UNL     1       0.444  -0.950   0.312  1.00  0.00           C  
HETATM    4  O1  UNL     1      -0.401  -0.041   0.948  1.00  0.00           O  
HETATM    5  P1  UNL     1      -1.882  -0.011   0.125  1.00  0.00           P  
HETATM    6  O2  UNL     1      -2.204  -1.418  -0.288  1.00  0.00           O  
HETATM    7  O3  UNL     1      -1.654   0.961  -1.251  1.00  0.00           O  
HETATM    8  O4  UNL     1      -3.087   0.691   1.066  1.00  0.00           O  
HETATM    9  H1  UNL     1       2.683   1.421  -0.166  1.00  0.00           H  
HETATM   10  H2  UNL     1       3.045   0.348   1.055  1.00  0.00           H  
HETATM   11  H3  UNL     1       2.346  -1.070  -0.628  1.00  0.00           H  
HETATM   12  H4  UNL     1       1.252   0.217  -1.269  1.00  0.00           H  
HETATM   13  H5  UNL     1      -0.088  -1.511  -0.498  1.00  0.00           H  
HETATM   14  H6  UNL     1       0.767  -1.715   1.039  1.00  0.00           H  
HETATM   15  H7  UNL     1      -1.210   1.791  -0.913  1.00  0.00           H  
HETATM   16  H8  UNL     1      -3.879   0.850   0.513  1.00  0.00           H  
CONECT    1    2    9   10
CONECT    2    3   11   12
CONECT    3    4   13   14
CONECT    4    5
CONECT    5    6    6    7    8
CONECT    7   15
CONECT    8   16
END
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SMILES for NP0000470 (O-Phosphoethanolamine)

NCCOP(O)(O)=O
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INCHI for NP0000470 (O-Phosphoethanolamine)

InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)
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View in JSmol
Synonyms
Chemical FormulaC2H8NO4P
Average Mass141.0630 Da
Monoisotopic Mass141.01909 Da
IUPAC Name(2-aminoethoxy)phosphonic acid
Traditional Namephosphorylethanolamine
CAS Registry Number1071-23-4
SMILES
NCCOP(O)(O)=O
InChI Identifier
InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)
InChI KeySUHOOTKUPISOBE-UHFFFAOYSA-N
Experimental Spectra
Spectrum TypeDescriptionDepositor EmailDepositor OrganizationDepositorDeposition DateView
1D NMR1H NMR Spectrum (1D, 500 MHz, H2O, experimental)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
Predicted Spectra
Not Available
Chemical Shift Submissions
Not Available
Species
Species of Origin
Chemical Taxonomy
Description Belongs to the class of organic compounds known as phosphoethanolamines. Phosphoethanolamines are compounds containing a phosphate linked to the second carbon of an ethanolamine.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassOrganic phosphoric acids and derivatives
Sub ClassPhosphate esters
Direct ParentPhosphoethanolamines
Alternative Parents
Substituents
  • Phosphoethanolamine
  • Monoalkyl phosphate
  • Alkyl phosphate
  • Organic nitrogen compound
  • Organic oxygen compound
  • Organopnictogen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Amine
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point241 - 243 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility72 mg/mLNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
Water Solubility25.8 g/LALOGPS
logP-1.5ALOGPS
logP-2.5ChemAxon
logS-0.74ALOGPS
pKa (Strongest Acidic)1.54ChemAxon
pKa (Strongest Basic)10.02ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area92.78 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity27.08 m³·mol⁻¹ChemAxon
Polarizability11.12 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
HMDB IDHMDB0000224
DrugBank IDDB01738
Phenol Explorer Compound IDNot Available
FoodDB IDFDB031115
KNApSAcK IDNot Available
Chemspider ID990
KEGG Compound IDC00346
BioCyc IDPHOSPHORYL-ETHANOLAMINE
BiGG ID1485304
Wikipedia LinkPhosphorylethanolamine
METLIN ID5233
PubChem Compound1015
PDB IDNot Available
ChEBI ID17553
Good Scents IDNot Available
References
General References
  1. Silwood CJ, Lynch E, Claxson AW, Grootveld MC: 1H and (13)C NMR spectroscopic analysis of human saliva. J Dent Res. 2002 Jun;81(6):422-7. [PubMed:12097436 ]
  2. Seki Y, Kimura M, Mizutani N, Fujita M, Aimi Y, Suzuki Y: Cerebrospinal fluid taurine after traumatic brain injury. Neurochem Res. 2005 Jan;30(1):123-8. [PubMed:15756940 ]
  3. Thiele I, Swainston N, Fleming RM, Hoppe A, Sahoo S, Aurich MK, Haraldsdottir H, Mo ML, Rolfsson O, Stobbe MD, Thorleifsson SG, Agren R, Bolling C, Bordel S, Chavali AK, Dobson P, Dunn WB, Endler L, Hala D, Hucka M, Hull D, Jameson D, Jamshidi N, Jonsson JJ, Juty N, Keating S, Nookaew I, Le Novere N, Malys N, Mazein A, Papin JA, Price ND, Selkov E Sr, Sigurdsson MI, Simeonidis E, Sonnenschein N, Smallbone K, Sorokin A, van Beek JH, Weichart D, Goryanin I, Nielsen J, Westerhoff HV, Kell DB, Mendes P, Palsson BO: A community-driven global reconstruction of human metabolism. Nat Biotechnol. 2013 May;31(5):419-25. doi: 10.1038/nbt.2488. Epub 2013 Mar 3. [PubMed:23455439 ]
  4. Klunk WE, Debnath ML, McClure RJ, Pettegrew JW: Inactivity of phosphoethanolamine, an endogenous GABA analog decreased in Alzheimer's disease, at GABA binding sites. Life Sci. 1995;56(26):2377-83. [PubMed:7791524 ]
  5. Klunk WE, McClure RJ, Xu CJ, Pettegrew JW: Structural determinants of activity at the GABAB receptor. A comparison of phosphoethanolamine and related GABA analogs. Mol Chem Neuropathol. 1995 Sep;26(1):15-30. [PubMed:8588821 ]
  6. Li G, Foote C, Alexander S, Alexander H: Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum. Development. 2001 Sep;128(18):3473-83. [PubMed:11566853 ]