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Showing NP-Card for Azelaic acid (NP0000459)

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Record Information
Version2.0
Created at2005-11-16 15:48:42 UTC
Updated at2024-09-03 04:18:55 UTC
NP-MRD IDNP0000459
Natural Product DOIhttps://doi.org/10.57994/1562
Secondary Accession NumbersNone
Natural Product Identification
Common NameAzelaic acid
DescriptionAzelaic acid (AZA) is a naturally occurring saturated nine-carbon dicarboxylic acid (COOH (CH2)7-COOH). It possesses a variety of biological actions both in vitro and in vivo. Interest in the biological activity of AZA arose originally out of studies of skin surface lipids and the pathogenesis of hypochromia in pityriasis versicolor infection. Later, it was shown that Pityrosporum can oxidize unsaturated fatty acids to C8-C12 dicarboxylic acids that are cornpetitive inhibitors of tyrosinase in vitro. Azelaic acid was chosen for further investigation and development of a new topical drug for treating hyperpigmentary disorders for the following reasons: It possesses a middle-range of antityrosinase activity, is inexpensive, and more soluble to be incorporated into a base cream than other dicarboxylic acids. Azelaic acid is another option for the topical treatment of mild to moderate inflammatory acne vulgaris. It offers effectiveness similar to that of other agents without the systemic side effects of oral antibiotics or the allergic sensitization of topical benzoyl peroxide and with less irritation than tretinoin. Azelaic acid is less expensive than certain other prescription acne preparations, but it is much more expensive than nonprescription benzoyl peroxide preparations. Whether it is safe and effective when used in combination with other agents is not known. (PMID: 7737781 , 8961845 ).
Structure
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MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for NP0000459 (Azelaic acid)


  Mrv1652309272007272D          

 13 12  0  0  0  0            999 V2000
 9987.6752 9986.0223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9988.3888 9985.6105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9989.1045 9986.0223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9989.8202 9985.6105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9989.1045 9986.8479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9986.9575 9985.6105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9986.2428 9986.0223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9985.5279 9985.6105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9984.8130 9986.0223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9984.0979 9985.6105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9983.3831 9986.0223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9982.6682 9985.6105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9983.3831 9986.8479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  6  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
M  END
Download

3D MOL for NP0000459 (Azelaic acid)

HMDB0000784
     RDKit          3D
Azelaic acid
 29 28  0  0  0  0  0  0  0  0999 V2000
   -4.9974    0.0468   -2.2837 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4621    0.1986   -1.1584 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1988    0.8011   -0.1631 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0833   -0.2451   -0.8795 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7426    0.0311    0.5444 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3358   -0.3951    0.9007 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2821    0.3024    0.0843 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0607   -0.2322    0.5627 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2163    0.4026   -0.1915 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4848   -0.1914    0.3559 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6954    0.3346   -0.2836 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6632    1.1937   -1.1957 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9313   -0.1326    0.1317 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9588    0.6277    0.7954 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3524    0.1777   -1.6004 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0602   -1.3448   -1.0431 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4069   -0.6156    1.1734 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9002    1.0654    0.8482 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1763   -0.0857    1.9590 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1735   -1.4713    0.8517 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3834    0.1293   -1.0035 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2740    1.3887    0.3099 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0500   -1.3169    0.3992 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1129   -0.0085    1.6445 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1087    0.1714   -1.2708 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2034    1.5065   -0.1003 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5364    0.0262    1.4497 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4670   -1.2851    0.2610 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.2578   -1.0794   -0.0425 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 11 13  1  0
  3 14  1  0
  4 15  1  0
  4 16  1  0
  5 17  1  0
  5 18  1  0
  6 19  1  0
  6 20  1  0
  7 21  1  0
  7 22  1  0
  8 23  1  0
  8 24  1  0
  9 25  1  0
  9 26  1  0
 10 27  1  0
 10 28  1  0
 13 29  1  0
M  END
Download

3D SDF for NP0000459 (Azelaic acid)


  Mrv1652309272007272D          

 13 12  0  0  0  0            999 V2000
 9987.6752 9986.0223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9988.3888 9985.6105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9989.1045 9986.0223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9989.8202 9985.6105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9989.1045 9986.8479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9986.9575 9985.6105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9986.2428 9986.0223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9985.5279 9985.6105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9984.8130 9986.0223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9984.0979 9985.6105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9983.3831 9986.0223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9982.6682 9985.6105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9983.3831 9986.8479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  6  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0000459

> <DATABASE_NAME>
NP-MRD

> <SMILES>
OC(=O)CCCCCCCC(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)

> <INCHI_KEY>
BDJRBEYXGGNYIS-UHFFFAOYSA-N

> <FORMULA>
C9H16O4

> <MOLECULAR_WEIGHT>
188.2209

> <EXACT_MASS>
188.104859

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
29

> <JCHEM_AVERAGE_POLARIZABILITY>
20.504953678260282

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
nonanedioic acid

> <ALOGPS_LOGP>
1.37

> <JCHEM_LOGP>
1.8243603576666663

> <ALOGPS_LOGS>
-1.92

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-2

> <JCHEM_PKA>
4.9803358868575005

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.147810514884144

> <JCHEM_POLAR_SURFACE_AREA>
74.6

> <JCHEM_REFRACTIVITY>
46.542

> <JCHEM_ROTATABLE_BOND_COUNT>
8

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.28e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
azelaic acid

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for NP0000459 (Azelaic acid)

HMDB0000784
     RDKit          3D
Azelaic acid
 29 28  0  0  0  0  0  0  0  0999 V2000
   -4.9974    0.0468   -2.2837 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4621    0.1986   -1.1584 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1988    0.8011   -0.1631 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0833   -0.2451   -0.8795 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7426    0.0311    0.5444 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3358   -0.3951    0.9007 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2821    0.3024    0.0843 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0607   -0.2322    0.5627 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2163    0.4026   -0.1915 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4848   -0.1914    0.3559 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6954    0.3346   -0.2836 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6632    1.1937   -1.1957 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9313   -0.1326    0.1317 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9588    0.6277    0.7954 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3524    0.1777   -1.6004 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0602   -1.3448   -1.0431 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4069   -0.6156    1.1734 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9002    1.0654    0.8482 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1763   -0.0857    1.9590 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1735   -1.4713    0.8517 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3834    0.1293   -1.0035 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2740    1.3887    0.3099 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0500   -1.3169    0.3992 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1129   -0.0085    1.6445 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1087    0.1714   -1.2708 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2034    1.5065   -0.1003 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5364    0.0262    1.4497 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4670   -1.2851    0.2610 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.2578   -1.0794   -0.0425 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 11 13  1  0
  3 14  1  0
  4 15  1  0
  4 16  1  0
  5 17  1  0
  5 18  1  0
  6 19  1  0
  6 20  1  0
  7 21  1  0
  7 22  1  0
  8 23  1  0
  8 24  1  0
  9 25  1  0
  9 26  1  0
 10 27  1  0
 10 28  1  0
 13 29  1  0
M  END
Download

PDB for NP0000459 (Azelaic acid)

HEADER    PROTEIN                                 27-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   27-SEP-20         0                                  
HETATM    1  C   UNK     0    8643.6608640.575   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0    8644.9928639.806   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0    8646.3288640.575   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0    8647.6648639.806   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0    8646.3288642.116   0.000  0.00  0.00           O+0
HETATM    6  C   UNK     0    8642.3218639.806   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0    8640.9878640.575   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0    8639.6528639.806   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0    8638.3188640.575   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0    8636.9838639.806   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0    8635.6488640.575   0.000  0.00  0.00           C+0
HETATM   12  O   UNK     0    8634.3148639.806   0.000  0.00  0.00           O+0
HETATM   13  O   UNK     0    8635.6488642.116   0.000  0.00  0.00           O+0
CONECT    1    2    6                                                       
CONECT    2    1    3                                                       
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3                                                            
CONECT    6    1    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12   13                                                  
CONECT   12   11                                                            
CONECT   13   11                                                            
MASTER        0    0    0    0    0    0    0    0   13    0   24    0
END
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3D PDB for NP0000459 (Azelaic acid)

COMPND    HMDB0000784
HETATM    1  O1  UNL     1      -4.997   0.047  -2.284  1.00  0.00           O  
HETATM    2  C1  UNL     1      -4.462   0.199  -1.158  1.00  0.00           C  
HETATM    3  O2  UNL     1      -5.199   0.801  -0.163  1.00  0.00           O  
HETATM    4  C2  UNL     1      -3.083  -0.245  -0.880  1.00  0.00           C  
HETATM    5  C3  UNL     1      -2.743   0.031   0.544  1.00  0.00           C  
HETATM    6  C4  UNL     1      -1.336  -0.395   0.901  1.00  0.00           C  
HETATM    7  C5  UNL     1      -0.282   0.302   0.084  1.00  0.00           C  
HETATM    8  C6  UNL     1       1.061  -0.232   0.563  1.00  0.00           C  
HETATM    9  C7  UNL     1       2.216   0.403  -0.192  1.00  0.00           C  
HETATM   10  C8  UNL     1       3.485  -0.191   0.356  1.00  0.00           C  
HETATM   11  C9  UNL     1       4.695   0.335  -0.284  1.00  0.00           C  
HETATM   12  O3  UNL     1       4.663   1.194  -1.196  1.00  0.00           O  
HETATM   13  O4  UNL     1       5.931  -0.133   0.132  1.00  0.00           O  
HETATM   14  H1  UNL     1      -4.959   0.628   0.795  1.00  0.00           H  
HETATM   15  H2  UNL     1      -2.352   0.178  -1.600  1.00  0.00           H  
HETATM   16  H3  UNL     1      -3.060  -1.345  -1.043  1.00  0.00           H  
HETATM   17  H4  UNL     1      -3.407  -0.616   1.173  1.00  0.00           H  
HETATM   18  H5  UNL     1      -2.900   1.065   0.848  1.00  0.00           H  
HETATM   19  H6  UNL     1      -1.176  -0.086   1.959  1.00  0.00           H  
HETATM   20  H7  UNL     1      -1.174  -1.471   0.852  1.00  0.00           H  
HETATM   21  H8  UNL     1      -0.383   0.129  -1.004  1.00  0.00           H  
HETATM   22  H9  UNL     1      -0.274   1.389   0.310  1.00  0.00           H  
HETATM   23  H10 UNL     1       1.050  -1.317   0.399  1.00  0.00           H  
HETATM   24  H11 UNL     1       1.113  -0.009   1.645  1.00  0.00           H  
HETATM   25  H12 UNL     1       2.109   0.171  -1.271  1.00  0.00           H  
HETATM   26  H13 UNL     1       2.203   1.506  -0.100  1.00  0.00           H  
HETATM   27  H14 UNL     1       3.536   0.026   1.450  1.00  0.00           H  
HETATM   28  H15 UNL     1       3.467  -1.285   0.261  1.00  0.00           H  
HETATM   29  H16 UNL     1       6.258  -1.079  -0.042  1.00  0.00           H  
CONECT    1    2    2
CONECT    2    3    4
CONECT    3   14
CONECT    4    5   15   16
CONECT    5    6   17   18
CONECT    6    7   19   20
CONECT    7    8   21   22
CONECT    8    9   23   24
CONECT    9   10   25   26
CONECT   10   11   27   28
CONECT   11   12   12   13
CONECT   13   29
END
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SMILES for NP0000459 (Azelaic acid)

OC(=O)CCCCCCCC(O)=O
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INCHI for NP0000459 (Azelaic acid)

InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
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View in JSmol
Synonyms
ValueSource
1,7-DicarboxyheptaneChEBI
1,7-Heptanedicarboxylic acidChEBI
1,9-Nonanedioic acidChEBI
Acide azelaiqueChEBI
Acidum azelaicumChEBI
Anchoic acidChEBI
AzelainsaeureChEBI
AzelexChEBI
FinaceaChEBI
Lepargylic acidChEBI
N-Nonanedioic acidChEBI
NonandisaeureChEBI
SkinorenChEBI
Nonanedioic acidKegg
1,7-HeptanedicarboxylateGenerator
1,9-NonanedioateGenerator
AnchoateGenerator
LepargylateGenerator
N-NonanedioateGenerator
NonanedioateGenerator
AzelaateGenerator
Azalaic acidHMDB
AzelaicacidtechHMDB
Azelainic acidHMDB
AzelateHMDB
Emerox 1110HMDB
Emerox 1144HMDB
Emery'S L-110HMDB
FinevinHMDB
Heptanedicarboxylic acidHMDB
Nonanedioic acid azelaic acidHMDB
Nonanedioic acid homopolymerHMDB
Poly(azelaic anhydride)HMDB
Polyazelaic anhydrideHMDB
SkinoremHMDB
Azelaic acid, dilithium saltHMDB
Azelaic acid, dipotassium saltHMDB
Azelaic acid, disodium saltHMDB
Azelaic acid, monosodium saltHMDB
Azelaic acid, potassium saltHMDB
Azelaic acid, sodium saltHMDB
Monosodium azelateHMDB
Azelic acidHMDB
alpha,Omega-nonanedioic acidHMDB
Α,ω-nonanedioic acidHMDB
Azelaic acidPhytoBank
Chemical FormulaC9H16O4
Average Mass188.2209 Da
Monoisotopic Mass188.10486 Da
IUPAC Namenonanedioic acid
Traditional Nameazelaic acid
CAS Registry Number123-99-9
SMILES
OC(=O)CCCCCCCC(O)=O
InChI Identifier
InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
InChI KeyBDJRBEYXGGNYIS-UHFFFAOYSA-N
Experimental Spectra
Spectrum TypeDescriptionDepositor EmailDepositor OrganizationDepositorDeposition DateView
HSQC NMR[1H, 13C] NMR Spectrum (2D, 600 MHz, CD3OD, experimental)Not AvailableSumner lab, University of MissouriZach Tretter2024-01-10View Spectrum
HMBC NMR[1H, 13C] NMR Spectrum (2D, 600 MHz, CD3OD, experimental)Not AvailableSumner lab, University of MissouriZach Tretter2024-01-10View Spectrum
COSY NMR[1H, 1H] NMR Spectrum (2D, 600 MHz, CD3OD, experimental)Not AvailableSumner lab, University of MissouriZach Tretter2024-01-10View Spectrum
1D NMR1H NMR Spectrum (1D, 600 MHz, CD3OD, experimental)Not AvailableSumner lab, University of MissouriZach Tretter2024-01-10View Spectrum
1D NMR13C NMR Spectrum (1D, 201 MHz, CD3OD, experimental)Not AvailableSumner lab, University of MissouriZach Tretter2024-01-10View Spectrum
1D NMR1H NMR Spectrum (1D, 600 MHz, H2O, experimental)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, CD3OD, experimental)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
Predicted Spectra
Spectrum TypeDescriptionDepositor IDDepositor OrganizationDepositorDeposition DateView
Chemical Shift Submissions
Not Available
Species
Species of Origin
Species NameSourceReference
Acorus calamusLOTUS Database
Aloe africanaLOTUS Database
Anas platyrhynchosFooDB
AnatidaeFooDB
Anser anserFooDB
Averrhoa carambolaKNApSAcK Database
Bison bisonFooDB
Bos taurusFooDB
Bos taurus X Bison bisonFooDB
Brucea javanicaLOTUS Database
Bubalus bubalisFooDB
Cannabis sativaCannabisDB
      Not Available
Capra aegagrus hircusFooDB
Carthamus oxyacanthusLOTUS Database
CervidaeFooDB
Cervus canadensisFooDB
ColumbaFooDB
ColumbidaeFooDB
Dromaius novaehollandiaeFooDB
Equus caballusFooDB
Fritillaria hupehensisLOTUS Database
Fritillaria monanthaLOTUS Database
Gallus gallusFooDB
Hibiscus syriacusLOTUS Database
Homo sapiensLOTUS Database
Hyacinthoides non-scriptaLOTUS Database
Isatis tinctoriaLOTUS Database
Lagopus mutaFooDB
LeporidaeFooDB
Lepus timidusFooDB
Lotus burttiiLOTUS Database
Melanitta fuscaFooDB
Meleagris gallopavoFooDB
Numida meleagrisFooDB
OdocoileusFooDB
OryctolagusFooDB
Ovis ariesFooDB
Peucedanum praeruptorumLOTUS Database
Phaseolus vulgarisFooDB
PhasianidaeFooDB
Phasianus colchicusFooDB
Ranunculus ternatusLOTUS Database
Salmonella entericaLOTUS Database
Saussurea medusaLOTUS Database
Schnabelia tetradontaKNApSAcK Database
Solanum lycopersicumLOTUS Database
Solanum tuberosumKNApSAcK Database
Streptomyces nigraLOTUS Database
Struthio camelusFooDB
Sus scrofaFooDB
Sus scrofa domesticaFooDB
Tuber indicumLOTUS Database
Vincetoxicum atratumLOTUS Database
Vitis viniferaLOTUS Database
Species Where Detected
Species NameSourceReference
Homo sapiens (Urine)KNApSAcK Database
Chemical Taxonomy
Description Belongs to the class of organic compounds known as medium-chain fatty acids. These are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassFatty Acyls
Sub ClassFatty acids and conjugates
Direct ParentMedium-chain fatty acids
Alternative Parents
Substituents
  • Medium-chain fatty acid
  • Dicarboxylic acid or derivatives
  • Carboxylic acid
  • Carboxylic acid derivative
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point106.5 °CNot Available
Boiling Point356.00 to 357.00 °C. @ 760.00 mm HgThe Good Scents Company Information System
Water Solubility2.4 mg/mLNot Available
LogP1.57Hansch CH, Leo A and Hoekman DH. "Exploring QSAR: Hydrophobic, Electronic, and Steric Constraints. Volume 1" ACS Publications (1995).
Predicted Properties
PropertyValueSource
Water Solubility2.28 g/LALOGPS
logP1.37ALOGPS
logP1.82ChemAxon
logS-1.9ALOGPS
pKa (Strongest Acidic)4.15ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area74.6 ŲChemAxon
Rotatable Bond Count8ChemAxon
Refractivity46.54 m³·mol⁻¹ChemAxon
Polarizability20.5 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
HMDB IDHMDB0000784
DrugBank IDDB00548
Phenol Explorer Compound IDNot Available
FoodDB IDFDB012192
KNApSAcK IDC00045634
Chemspider ID2179
KEGG Compound IDC08261
BioCyc IDCPD0-1265
BiGG IDNot Available
Wikipedia LinkAzelaic_Acid
METLIN ID5750
PubChem Compound2266
PDB IDNot Available
ChEBI ID48131
Good Scents IDrw1220821
References
General References
  1. Mayer-da-Silva A, Gollnick H, Detmar M, Gassmuller J, Parry A, Muller R, Orfanos CE: Effects of azelaic acid on sebaceous gland, sebum excretion rate and keratinization pattern in human skin. An in vivo and in vitro study. Acta Derm Venereol Suppl (Stockh). 1989;143:20-30. [PubMed:2475995 ]
  2. Hermanns JF, Petit L, Martalo O, Pierard-Franchimont C, Cauwenbergh G, Pierard GE: Unraveling the patterns of subclinical pheomelanin-enriched facial hyperpigmentation: effect of depigmenting agents. Dermatology. 2000;201(2):118-22. [PubMed:11053913 ]
  3. Rocamora V, Puig L, Romani J, de Moragas JM: Amelanotic lentigo maligna melanoma: report of a case and review of the literature. Cutis. 1999 Jul;64(1):53-6. [PubMed:10431675 ]
  4. Russell JJ: Topical therapy for acne. Am Fam Physician. 2000 Jan 15;61(2):357-66. [PubMed:10670502 ]
  5. Webster G: Combination azelaic acid therapy for acne vulgaris. J Am Acad Dermatol. 2000 Aug;43(2 Pt 3):S47-50. [PubMed:10898830 ]
  6. Del Rosso JQ: Medical treatment of rosacea with emphasis on topical therapies. Expert Opin Pharmacother. 2004 Jan;5(1):5-13. [PubMed:14680431 ]
  7. Frampton JE, Wagstaff AJ: Azelaic acid 15% gel: in the treatment of papulopustular rosacea. Am J Clin Dermatol. 2004;5(1):57-64. [PubMed:14979745 ]
  8. Halder RM, Richards GM: Topical agents used in the management of hyperpigmentation. Skin Therapy Lett. 2004 Jun-Jul;9(6):1-3. [PubMed:15334278 ]
  9. Wolf JE Jr: Present and future rosacea therapy. Cutis. 2005 Mar;75(3 Suppl):4-7; discussion 33-6. [PubMed:15810803 ]
  10. van Zuuren EJ, Graber MA: The rigor of trials evaluating Rosacea treatments. Cutis. 2005 Mar;75(3 Suppl):13-6; discussion 33-6. [PubMed:15810805 ]
  11. Nally JB, Berson DS: Topical therapies for rosacea. J Drugs Dermatol. 2006 Jan;5(1):23-6. [PubMed:16468288 ]
  12. Fleischer AB Jr: The evolution of azelaic acid. Cutis. 2006 Feb;77(2 Suppl):4-6. [PubMed:16566281 ]
  13. Draelos ZD: The rationale for advancing the formulation of azelaic acid vehicles. Cutis. 2006 Feb;77(2 Suppl):7-11. [PubMed:16566282 ]
  14. Elewski B, Thiboutot D: A clinical overview of azelaic acid. Cutis. 2006 Feb;77(2 Suppl):12-6. [PubMed:16566283 ]
  15. Del Rosso JQ: The use of topical azelaic acid for common skin disorders other than inflammatory rosacea. Cutis. 2006 Feb;77(2 Suppl):22-4. [PubMed:16566285 ]
  16. Worret WI, Fluhr JW: [Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid]. J Dtsch Dermatol Ges. 2006 Apr;4(4):293-300. [PubMed:16638058 ]
  17. Liu RH, Smith MK, Basta SA, Farmer ER: Azelaic acid in the treatment of papulopustular rosacea: a systematic review of randomized controlled trials. Arch Dermatol. 2006 Aug;142(8):1047-52. [PubMed:16924055 ]
  18. Gupta AK, Gover MD, Nouri K, Taylor S: The treatment of melasma: a review of clinical trials. J Am Acad Dermatol. 2006 Dec;55(6):1048-65. Epub 2006 Sep 28. [PubMed:17097400 ]
  19. Fitton A, Goa KL: Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders. Drugs. 1991 May;41(5):780-98. [PubMed:1712709 ]
  20. van Zuuren EJ, Gupta AK, Gover MD, Graber M, Hollis S: Systematic review of rosacea treatments. J Am Acad Dermatol. 2007 Jan;56(1):107-15. Epub 2006 Nov 7. [PubMed:17190628 ]
  21. Gupta AK, Gover MD: Azelaic acid (15% gel) in the treatment of acne rosacea. Int J Dermatol. 2007 May;46(5):533-8. [PubMed:17472690 ]
  22. Nguyen QH, Bui TP: Azelaic acid: pharmacokinetic and pharmacodynamic properties and its therapeutic role in hyperpigmentary disorders and acne. Int J Dermatol. 1995 Feb;34(2):75-84. [PubMed:7737781 ]
  23. Mackrides PS, Shaughnessy AF: Azelaic acid therapy for acne. Am Fam Physician. 1996 Dec;54(8):2457-9. [PubMed:8961845 ]