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Record Information
Version1.0
Created at2005-11-16 15:48:42 UTC
Updated at2022-01-12 19:25:50 UTC
NP-MRD IDNP0000406
Secondary Accession NumbersNone
Natural Product Identification
Common NameCaprylic acid
DescriptionCaprylic acid is the common name for the eight-carbon straight-chain fatty acid known by the systematic name octanoic acid. It is found naturally in coconuts and breast milk. It is an oily liquid with a slightly unpleasant rancid taste that is minimally soluble in water. Caprylic acid is used commercially in the production of esters used in perfumery and also in the manufacture of dyes (Wikipedia).
Structure
Thumb
Synonyms
ValueSource
1-Heptanecarboxylic acidChEBI
8:0ChEBI
Acide octanoiqueChEBI
Acido octanoicoChEBI
Acidum octanociumChEBI
Acidum octanoicumChEBI
C8:0ChEBI
CH3-[CH2]6-COOHChEBI
KaprylsaeureChEBI
N-Caprylic acidChEBI
N-Octanoic acidChEBI
N-Octoic acidChEBI
N-Octylic acidChEBI
OCTANOIC ACID (caprylIC ACID)ChEBI
OctansaeureChEBI
Octoic acidChEBI
Octylic acidChEBI
OctanoateKegg
1-HeptanecarboxylateGenerator
N-CaprylateGenerator
N-OctanoateGenerator
N-OctoateGenerator
N-OctylateGenerator
OCTANOate (caprylate)Generator
OctoateGenerator
OctylateGenerator
Octanoic acidGenerator
CaprylateGenerator
Emery 657HMDB
Kortacid 0899HMDB
Lunac 8-95HMDB
Lunac 8-98HMDB
Neo-fat 8HMDB
Neo-fat 8SHMDB
Prifac 2901HMDB
Caprylic acid, cadmium saltHMDB
Caprylic acid, cesium saltHMDB
Caprylic acid, manganese saltHMDB
Caprylic acid, nickel(+2) saltHMDB
Caprylic acid, zinc saltHMDB
Caprylic acid, aluminum saltHMDB
Caprylic acid, barium saltHMDB
Caprylic acid, chromium(+2) saltHMDB
Caprylic acid, lead(+2) saltHMDB
Caprylic acid, potassium saltHMDB
Caprylic acid, tin(+2) saltHMDB
Sodium octanoateHMDB
Caprylic acid, 14C-labeledHMDB
Caprylic acid, lithium saltHMDB
Caprylic acid, ruthenium(+3) saltHMDB
Caprylic acid, sodium saltHMDB
Caprylic acid, sodium salt, 11C-labeledHMDB
Caprylic acid, tin saltHMDB
Caprylic acid, zirconium saltHMDB
Sodium caprylateHMDB
Caprylic acid, ammonia saltHMDB
Caprylic acid, calcium saltHMDB
Caprylic acid, cobalt saltHMDB
Caprylic acid, copper saltHMDB
Caprylic acid, copper(+2) saltHMDB
Caprylic acid, iridum(+3) saltHMDB
Caprylic acid, iron(+3) saltHMDB
Caprylic acid, lanthanum(+3) saltHMDB
Caprylic acid, zirconium(+4) saltHMDB
FA(8:0)HMDB
Lithium octanoateHMDB
Chemical FormulaC8H16O2
Average Mass144.2114 Da
Monoisotopic Mass144.11503 Da
IUPAC Nameoctanoic acid
Traditional Namecaprylic acid
CAS Registry Number124-07-2
SMILES
CCCCCCCC(O)=O
InChI Identifier
InChI=1S/C8H16O2/c1-2-3-4-5-6-7-8(9)10/h2-7H2,1H3,(H,9,10)
InChI KeyWWZKQHOCKIZLMA-UHFFFAOYSA-N
Experimental Spectra
Spectrum TypeDescriptionDepositor EmailDepositor OrganizationDepositorDeposition DateView
1D NMR1H NMR Spectrum (1D, 700 MHz, H2O, simulated)Ahselim2022-01-12View Spectrum
1D NMR1H NMR Spectrum (1D, 700 MHz, H2O, experimental)Ahselim2022-01-12View Spectrum
1D NMR1H NMR Spectrum (1D, 500 MHz, H2O, experimental)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, CD3OD, experimental)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
Predicted Spectra
Not Available
Chemical Shift Submissions
Not Available
Species
Species of Origin
Species NameSourceReference
Agave decipiensLOTUS Database
Ailuropoda melanoleucaLOTUS Database
Ajania fastigiataLOTUS Database
Alpinia latilabrisLOTUS Database
Anthemis aciphyllaLOTUS Database
Anthemis aciphylla BOISS.var.discoidea BOISSKNApSAcK Database
Arabidopsis thalianaKNApSAcK Database
Arnica montanaLOTUS Database
Artemisia xerophyticaLOTUS Database
Attalea colendaLOTUS Database
Basella albaLOTUS Database
Bellis perennisLOTUS Database
Brassica hirtaKNApSAcK Database
Bupleurum chinenseKNApSAcK Database
Canarium albumLOTUS Database
Cannabis sativaCannabisDB
      Not Available
Carica papayaLOTUS Database
Cocos nuciferaKNApSAcK Database
Codonopsis pilosulaKNApSAcK Database
Coriandrum sativumLOTUS Database
Cuphea painteriKNApSAcK Database
Cyperus conglomeratusLOTUS Database
Daphne papyraceaLOTUS Database
Deschampsia antarcticaLOTUS Database
Drymaria cordataKNApSAcK Database
Duhaldea cappaLOTUS Database
Erigeron philadelphicusLOTUS Database
Erucaria microcarpaLOTUS Database
Evernia prunastriLOTUS Database
Geum heterocarpumLOTUS Database
Ginkgo bilobaKNApSAcK Database
Glycyrrhiza glabraLOTUS Database
Gossypium hirsutumLOTUS Database
Hippophae rhamnoidesKNApSAcK Database
Homo sapiensLOTUS Database
Hypericum ericoidesLOTUS Database
Ilex paraguariensisLOTUS Database
Inula grandisLOTUS Database
Iris kemaonensisLOTUS Database
Lepidium meyeniiLOTUS Database
Lumbricus terrestrisLOTUS Database
Malva sylvestrisLOTUS Database
Melissa officinalisLOTUS Database
Morinda citrifoliaLOTUS Database
Narthecium ossifragumLOTUS Database
Necrodes surinamensisLOTUS Database
Nymphaea albaKNApSAcK Database
Oecophylla smaragdinaLOTUS Database
Panax quinquefoliumKNApSAcK Database
Panax quinquefoliusPlant
Pelargonium graveolensLOTUS Database
Phaseolus coccineusLOTUS Database
Pinus sibiricaKNApSAcK Database
Plumeria rubraLOTUS Database
Polygala senegaLOTUS Database
Prunus domesticaLOTUS Database
Prunus dulcisLOTUS Database
Psidium guajavaLOTUS Database
Punica granatumKNApSAcK Database
Rehmannia glutinosaKNApSAcK Database
Rhodiola roseaPlant
Rhodiola rosea L.KNApSAcK Database
Rhododendron sichotenseLOTUS Database
Salmonella entericaLOTUS Database
Salvia fruticosaLOTUS Database
Salvia rosmarinusLOTUS Database
Santalum albumKNApSAcK Database
Saussurea involucrataLOTUS Database
Saxifraga stoloniferaLOTUS Database
Saxifraga stolonifera Meerb.KNApSAcK Database
Scolochloa festucaceaLOTUS Database
Scutellaria baicalensisLOTUS Database
Serenoa repensLOTUS Database
Sideritis creticaLOTUS Database
Sinapis albaPlant
Solanum pennelliiLOTUS Database
Spongiporus leucomallellus (Murril)-
Tamarindus indicaLOTUS Database
Thymus longicaulisLOTUS Database
Tordylium apulumLOTUS Database
Tripleurospermum maritimumLOTUS Database
Ventilago denticulataLOTUS Database
Viburnum prunifoliumLOTUS Database
Vitis viniferaLOTUS Database
Wolfiporia cocos-
Species Where Detected
Species NameSourceReference
Escherichia coliKNApSAcK Database
Ganoderma lucidumKNApSAcK Database
Chemical Taxonomy
Description Belongs to the class of organic compounds known as medium-chain fatty acids. These are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassFatty Acyls
Sub ClassFatty acids and conjugates
Direct ParentMedium-chain fatty acids
Alternative Parents
Substituents
  • Medium-chain fatty acid
  • Straight chain fatty acid
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Carboxylic acid derivative
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Physical Properties
StateLiquid
Experimental Properties
PropertyValueReference
Melting Point16.5 °CNot Available
Boiling Point237.00 to 239.00 °C. @ 760.00 mm HgThe Good Scents Company Information System
Water Solubility0.79 mg/mLNot Available
LogP3.05Hansch CH, Leo A and Hoekman DH. "Exploring QSAR: Hydrophobic, Electronic, and Steric Constraints. Volume 1" ACS Publications (1995).
Predicted Properties
PropertyValueSource
Water Solubility0.91 g/LALOGPS
logP2.92ALOGPS
logP2.7ChemAxon
logS-2.2ALOGPS
pKa (Strongest Acidic)5.19ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area37.3 ŲChemAxon
Rotatable Bond Count6ChemAxon
Refractivity40.28 m³·mol⁻¹ChemAxon
Polarizability17.4 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
HMDB IDHMDB0000482
DrugBank IDDB04519
Phenol Explorer Compound IDNot Available
FoodDB IDFDB006235
KNApSAcK IDC00001231
Chemspider ID370
KEGG Compound IDC06423
BioCyc IDCPD-195
BiGG ID48223
Wikipedia LinkCaprylic_acid
METLIN ID5469
PubChem Compound379
PDB IDNot Available
ChEBI ID28837
Good Scents IDrw1009091
References
General References
  1. Hoffmann GF, Meier-Augenstein W, Stockler S, Surtees R, Rating D, Nyhan WL: Physiology and pathophysiology of organic acids in cerebrospinal fluid. J Inherit Metab Dis. 1993;16(4):648-69. [PubMed:8412012 ]
  2. Giannakou SA, Dallas PP, Rekkas DM, Choulis NH: In vitro evaluation of nimodipine permeation through human epidermis using response surface methodology. Int J Pharm. 2002 Jul 8;241(1):27-34. [PubMed:12086718 ]
  3. Dieterle F, Muller-Hagedorn S, Liebich HM, Gauglitz G: Urinary nucleosides as potential tumor markers evaluated by learning vector quantization. Artif Intell Med. 2003 Jul;28(3):265-79. [PubMed:12927336 ]
  4. Nair MK, Joy J, Venkitanarayanan KS: Inactivation of Enterobacter sakazakii in reconstituted infant formula by monocaprylin. J Food Prot. 2004 Dec;67(12):2815-9. [PubMed:15633694 ]
  5. Habeeb AF, Francis RD: Preparation of human immunoglobulin by caprylic acid precipitation. Prep Biochem. 1984;14(1):1-17. [PubMed:6718324 ]
  6. Leon G, Herrera M, Vargas M, Arguedas M, Sanchez A, Segura A, Gomez A, Solano G, Corrales-Aguilar E, Risner K, Narayanan A, Bailey C, Villalta M, Hernandez A, Sanchez A, Cordero D, Solano D, Duran G, Segura E, Cerdas M, Umana D, Moscoso E, Estrada R, Gutierrez J, Mendez M, Castillo AC, Sanchez L, Sanchez R, Gutierrez JM, Diaz C, Alape A: Development and characterization of two equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19. Sci Rep. 2021 May 10;11(1):9825. doi: 10.1038/s41598-021-89242-z. [PubMed:33972631 ]