Record Information |
---|
Version | 1.0 |
---|
Created at | 2005-11-16 15:48:42 UTC |
---|
Updated at | 2022-02-09 16:06:27 UTC |
---|
NP-MRD ID | NP0000398 |
---|
Secondary Accession Numbers | None |
---|
Natural Product Identification |
---|
Common Name | Tyramine |
---|
Description | Tyramine is a monoamine compound derived from the amino acid tyrosine. Tyramine is metabolized by the enzyme monoamine oxidase. In foods, it is often produced by the decarboxylation of tyrosine during fermentation or decay. Foods containing considerable amounts of tyramine include fish, chocolate, alcoholic beverages, cheese, soy sauce, sauerkraut, and processed meat. A large dietary intake of tyramine can cause an increase in systolic blood pressure of 30 mmHg or more. Tyramine acts as a neurotransmitter via a G protein-coupled receptor with high affinity for tyramine called TA1. The TA1 receptor is found in the brain as well as peripheral tissues including the kidney. An indirect sympathomimetic, Tyramine can also serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine is a biomarker for the consumption of cheese |
---|
Structure | InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 |
---|
Synonyms | Value | Source |
---|
2-(p-Hydroxyphenyl)ethylamine | ChEBI | 4-Hydroxy-beta-phenylethylamine | ChEBI | 4-Hydroxyphenethylamine | ChEBI | 4-Hydroxyphenylethylamine | ChEBI | beta-(4-Hydroxyphenyl)ethylamine | ChEBI | p-(2-Aminoethyl)phenol | ChEBI | p-Hydroxyphenethylamine | ChEBI | p-Hydroxyphenylethylamine | ChEBI | p-Tyramine | ChEBI | Tyramin | ChEBI | 4-Hydroxy-b-phenylethylamine | Generator | 4-Hydroxy-β-phenylethylamine | Generator | b-(4-Hydroxyphenyl)ethylamine | Generator | Β-(4-hydroxyphenyl)ethylamine | Generator | 2-(4'-Hydroxyphenyl)ethylamine | HMDB | 2-(4-Hydroxyphenyl)ethylamine | HMDB | 4-(2-Aminoethyl)-phenol | HMDB | 4-(2-Aminoethyl)-phenol(thyramin) | HMDB | 4-(2-Aminoethyl)phenol | HMDB | 4-Hydroxy-benzeneethanamine | HMDB | a-(4-Hydroxyphenyl)-b-aminoethane | HMDB | alpha-(4-Hydroxyphenyl)-beta-aminoethane | HMDB | p-(2-Aminoethyl)-phenol | HMDB | p-beta-Aminoethylphenol | HMDB | p-Hydroxy-b-phenethylamine | HMDB | p-Hydroxy-b-phenylethylamine | HMDB | p-Hydroxy-beta-phenethylamine | HMDB | p-Hydroxy-beta-phenylethylamine | HMDB | Systogene | HMDB | Tenosin-wirkstoff | HMDB | Tocosine | HMDB | Tyramine base | HMDB | Tyrosamine | HMDB | Uteramine | HMDB | Para-tyramine | HMDB | 4 Hydroxyphenethylamine | HMDB | 2-(4-Hydroxyphenyl)ethanamine | HMDB | 2-(4’-hydroxyphenyl)ethylamine | HMDB | p-Hydroxy-β-phenylethylamine | HMDB | p-Β-aminoethylphenol | HMDB | Α-(4-hydroxyphenyl)-β-aminoethane | HMDB |
|
---|
Chemical Formula | C8H11NO |
---|
Average Mass | 137.1790 Da |
---|
Monoisotopic Mass | 137.08406 Da |
---|
IUPAC Name | 4-(2-aminoethyl)phenol |
---|
Traditional Name | tyramine |
---|
CAS Registry Number | 51-67-2 |
---|
SMILES | NCCC1=CC=C(O)C=C1 |
---|
InChI Identifier | InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 |
---|
InChI Key | DZGWFCGJZKJUFP-UHFFFAOYSA-N |
---|
Experimental Spectra |
---|
|
| Spectrum Type | Description | Depositor Email | Depositor Organization | Depositor | Deposition Date | View |
---|
1D NMR | 1H NMR Spectrum (1D, 700 MHz, H2O, simulated) | Ahselim | | | 2022-02-09 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 700 MHz, H2O, experimental) | Ahselim | | | 2022-02-09 | View Spectrum | 2D NMR | [1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum |
| Predicted Spectra |
---|
|
| Not Available | Chemical Shift Submissions |
---|
|
| Spectrum Type | Description | Depositor ID | Depositor Organization | Depositor | Deposition Date | View |
---|
1D NMR | 1H NMR Spectrum (1D, 500 MHz, H2O, simulated) | V.dorna83 | | | 2021-08-09 | View Spectrum |
| Species |
---|
Species of Origin | |
---|
Species Where Detected | |
---|
Chemical Taxonomy |
---|
Description | Belongs to the class of organic compounds known as phenethylamines. Phenethylamines are compounds containing a phenethylamine moiety, which consists of a phenyl group substituted at the second position by an ethan-1-amine. |
---|
Kingdom | Organic compounds |
---|
Super Class | Benzenoids |
---|
Class | Benzene and substituted derivatives |
---|
Sub Class | Phenethylamines |
---|
Direct Parent | Phenethylamines |
---|
Alternative Parents | |
---|
Substituents | - Phenethylamine
- 2-arylethylamine
- 1-hydroxy-2-unsubstituted benzenoid
- Aralkylamine
- Phenol
- Organic nitrogen compound
- Organic oxygen compound
- Organopnictogen compound
- Hydrocarbon derivative
- Primary amine
- Organooxygen compound
- Organonitrogen compound
- Primary aliphatic amine
- Amine
- Aromatic homomonocyclic compound
|
---|
Molecular Framework | Aromatic homomonocyclic compounds |
---|
External Descriptors | |
---|
Physical Properties |
---|
State | Solid |
---|
Experimental Properties | |
---|
Predicted Properties | |
---|
General References | - Tyce GM, Stockard J, Sharpless NS, Muenter MD: Excretion of amines and their metabolites by two patients in hepatic coma treated with L-dopa. Clin Pharmacol Ther. 1983 Sep;34(3):390-8. [PubMed:6883916 ]
- Jacob G, Costa F, Vincent S, Robertson D, Biaggioni I: Neurovascular dissociation with paradoxical forearm vasodilation during systemic tyramine administration. Circulation. 2003 May 20;107(19):2475-9. Epub 2003 Apr 21. [PubMed:12707242 ]
- Nakai T, Yamada R: Basic and clinical reevaluation of tyramine and histamine tests for the investigation of adrenomedullary sympathetic functions. J Clin Endocrinol Metab. 1983 Jul;57(1):19-23. [PubMed:6853676 ]
- Jayanthi LD, Balasubramanian N, Balasubramanian AS: Cholinesterases exhibiting aryl acylamidase activity in human amniotic fluid. Clin Chim Acta. 1992 Feb 14;205(3):157-66. [PubMed:1349516 ]
- Watson DG, Midgley JM, Chen RN, Huang W, Bain GM, McDonald NM, Reid JL, McGhee CN: Analysis of biogenic amines and their metabolites in biological tissues and fluids by gas chromatography-negative ion chemical ionization mass spectrometry (GC-NICIMS). J Pharm Biomed Anal. 1990;8(8-12):899-904. [PubMed:2100639 ]
- Chalon SA, Granier LA, Vandenhende FR, Bieck PR, Bymaster FP, Joliat MJ, Hirth C, Potter WZ: Duloxetine increases serotonin and norepinephrine availability in healthy subjects: a double-blind, controlled study. Neuropsychopharmacology. 2003 Sep;28(9):1685-93. Epub 2003 May 28. [PubMed:12784100 ]
- Yin SJ, Lee SC: Tyramine interference in assay of serum dopamine-beta-hydroxylase. Clin Chem. 1977 Mar;23(3):617-8. [PubMed:319927 ]
- Andrew R, Watson DG, Best SA, Midgley JM, Wenlong H, Petty RK: The determination of hydroxydopamines and other trace amines in the urine of parkinsonian patients and normal controls. Neurochem Res. 1993 Nov;18(11):1175-7. [PubMed:8255370 ]
- Markianos E, Backman H: Diurnal changes in dopamine-beta-hydroxylase, homovanillic acid and 3-methoxy-4-hydroxyphenylglycol in serum of man. J Neural Transm. 1976;39(1-2):79-93. [PubMed:988114 ]
- Causon RC, Brown MJ: Measurement of tyramine in human plasma, utilising ion-pair extraction and high-performance liquid chromatography with amperometric detection. J Chromatogr. 1984 Sep 14;310(1):11-7. [PubMed:6501508 ]
- Lin J, Cashman JR: Detoxication of tyramine by the flavin-containing monooxygenase: stereoselective formation of the trans oxime. Chem Res Toxicol. 1997 Aug;10(8):842-52. [PubMed:9282832 ]
- Wolrath H, Forsum U, Larsson PG, Boren H: Analysis of bacterial vaginosis-related amines in vaginal fluid by gas chromatography and mass spectrometry. J Clin Microbiol. 2001 Nov;39(11):4026-31. [PubMed:11682525 ]
- Varma DR, Chemtob S: Endothelium- and beta-2 adrenoceptor-independent relaxation of rat aorta by tyramine and certain other phenylethylamines. J Pharmacol Exp Ther. 1993 Jun;265(3):1096-104. [PubMed:8389852 ]
- Gabastou JM, Nugon-Baudon L, Robert Y, Manuel C, Vaissade P, Bourgeon E, Sibeud M, Szylit O, Bourlioux P: [Digestive amines of bacterial origin and behavior disorders. Apropos of a case]. Pathol Biol (Paris). 1996 Apr;44(4):275-81. [PubMed:8763591 ]
- Hiroi T, Imaoka S, Funae Y: Dopamine formation from tyramine by CYP2D6. Biochem Biophys Res Commun. 1998 Aug 28;249(3):838-43. [PubMed:9731223 ]
- Watson DG, McGhee CN, Midgley JM, Zhou P, Doig WM: Determination of acidic metabolites of biogenic amines in human aqueous humour by gas chromatography--negative ion chemical ionisation mass spectrometry. J Neurochem. 1992 Jan;58(1):116-20. [PubMed:1727423 ]
- Antal EJ, Hendershot PE, Batts DH, Sheu WP, Hopkins NK, Donaldson KM: Linezolid, a novel oxazolidinone antibiotic: assessment of monoamine oxidase inhibition using pressor response to oral tyramine. J Clin Pharmacol. 2001 May;41(5):552-62. [PubMed:11361052 ]
- Balbi T, Fusco M, Vasapollo D, Boschetto R, Cocco P, Leon A, Farruggio A: The presence of trace amines in postmortem cerebrospinal fluid in humans. J Forensic Sci. 2005 May;50(3):630-2. [PubMed:15932098 ]
- Di Stefano AF, Rusca A: Pressor response to oral tyramine during co-administration with safinamide in healthy volunteers. Naunyn Schmiedebergs Arch Pharmacol. 2011 Dec;384(6):505-15. doi: 10.1007/s00210-011-0674-2. Epub 2011 Aug 19. [PubMed:21850574 ]
|
---|