Record Information |
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Version | 1.0 |
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Created at | 2009-01-29 12:14:58 UTC |
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Updated at | 2021-06-30 02:06:18 UTC |
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NP-MRD ID | NP0000353 |
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Secondary Accession Numbers | None |
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Natural Product Identification |
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Common Name | 3-Methyladenine |
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Description | 3-Methyladenine, also known as 3-ma nucleobase, belongs to the class of organic compounds known as 6-aminopurines. These are purines that carry an amino group at position 6. Purine is a bicyclic aromatic compound made up of a pyrimidine ring fused to an imidazole ring. 3-Methyladenine exists in all living species, ranging from bacteria to humans. 3-Methyladenine has been detected, but not quantified, in several different foods, such as soft-necked garlics, chinese bayberries, burbots, amaranths, and tea. This could make 3-methyladenine a potential biomarker for the consumption of these foods. 3-Methyladenine is one of the purines damaged by alkylation and oxidation which can be recognized and excised by the human 3-methyladenine DNA glycosylase (AAG) (EC: EC3.2.2.21). |
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Structure | InChI=1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3 |
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Synonyms | Value | Source |
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3-Methyl-3H-adenine | ChEBI | 3-METHYL-3H-purin-6-ylamine | ChEBI | 6-Amino-3-methylpurine | ChEBI | 3-Methyl-3H-purin-6-amine | HMDB | 3-Methyl-3H-purin-6-amine (acd/name 4.0) | HMDB | 3-Methyl-3H-purin-6-ylamine (acd/name 4.0) | HMDB | 3-Methyl-adenine | HMDB | 3-MA nucleobase | HMDB | N(3)-Methyladenine | HMDB |
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Chemical Formula | C6H7N5 |
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Average Mass | 149.1533 Da |
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Monoisotopic Mass | 149.07015 Da |
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IUPAC Name | 3-methyl-3H-purin-6-amine |
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Traditional Name | 3-methyladenine |
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CAS Registry Number | 5142-23-4 |
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SMILES | CN1C=NC(N)=C2N=CN=C12 |
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InChI Identifier | InChI=1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3 |
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InChI Key | FSASIHFSFGAIJM-UHFFFAOYSA-N |
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Experimental Spectra |
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| Spectrum Type | Description | Depositor Email | Depositor Organization | Depositor | Deposition Date | View |
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2D NMR | [1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum |
| Predicted Spectra |
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| Not Available | Chemical Shift Submissions |
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| Spectrum Type | Description | Depositor ID | Depositor Organization | Depositor | Deposition Date | View |
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1D NMR | 1H NMR Spectrum (1D, 600 MHz, H2O, simulated) | V.dorna83 | | | 2021-08-08 | View Spectrum |
| Species |
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Species of Origin | |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as 6-aminopurines. These are purines that carry an amino group at position 6. Purine is a bicyclic aromatic compound made up of a pyrimidine ring fused to an imidazole ring. |
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Kingdom | Organic compounds |
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Super Class | Organoheterocyclic compounds |
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Class | Imidazopyrimidines |
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Sub Class | Purines and purine derivatives |
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Direct Parent | 6-aminopurines |
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Alternative Parents | |
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Substituents | - 6-aminopurine
- Aminopyrimidine
- Imidolactam
- Pyrimidine
- Heteroaromatic compound
- Imidazole
- Azole
- Azacycle
- Organic nitrogen compound
- Organopnictogen compound
- Hydrocarbon derivative
- Primary amine
- Organonitrogen compound
- Amine
- Aromatic heteropolycyclic compound
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Molecular Framework | Aromatic heteropolycyclic compounds |
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External Descriptors | |
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Physical Properties |
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State | Solid |
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Experimental Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Predicted Properties | |
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External Links |
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HMDB ID | HMDB0011600 |
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DrugBank ID | DB04104 |
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Phenol Explorer Compound ID | Not Available |
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FoodDB ID | FDB028311 |
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KNApSAcK ID | Not Available |
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Chemspider ID | 1610 |
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KEGG Compound ID | C00913 |
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BioCyc ID | 3-Methyl-Adenines |
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BiGG ID | Not Available |
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Wikipedia Link | Not Available |
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METLIN ID | Not Available |
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PubChem Compound | 1673 |
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PDB ID | ADK |
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ChEBI ID | 38635 |
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Good Scents ID | Not Available |
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References |
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General References | - Tavazzi B, Lazzarino G, Leone P, Amorini AM, Bellia F, Janson CG, Di Pietro V, Ceccarelli L, Donzelli S, Francis JS, Giardina B: Simultaneous high performance liquid chromatographic separation of purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis of inborn errors of metabolism. Clin Biochem. 2005 Nov;38(11):997-1008. Epub 2005 Sep 1. [PubMed:16139832 ]
- Roux A, Xu Y, Heilier JF, Olivier MF, Ezan E, Tabet JC, Junot C: Annotation of the human adult urinary metabolome and metabolite identification using ultra high performance liquid chromatography coupled to a linear quadrupole ion trap-Orbitrap mass spectrometer. Anal Chem. 2012 Aug 7;84(15):6429-37. doi: 10.1021/ac300829f. Epub 2012 Jul 17. [PubMed:22770225 ]
- Li M, Yang X, Wang H, Xu E, Xi Z: Inhibition of androgen induces autophagy in benign prostate epithelial cells. Int J Urol. 2014 Feb;21(2):195-9. doi: 10.1111/iju.12210. Epub 2013 Jul 2. [PubMed:23819759 ]
- Huang YT, Cheng CC, Lin TC, Chiu TH, Lai PC: Therapeutic potential of sepantronium bromide YM155 in gemcitabine-resistant human urothelial carcinoma cells. Oncol Rep. 2014 Feb;31(2):771-80. doi: 10.3892/or.2013.2882. Epub 2013 Nov 28. [PubMed:24297644 ]
- Pickard RD, Spencer BH, McFarland AJ, Bernaitis N, Davey AK, Perkins AV, Chess-Williams R, McDermott CM, Forbes A, Christie D, Anoopkumar-Dukie S: Paradoxical effects of the autophagy inhibitor 3-methyladenine on docetaxel-induced toxicity in PC-3 and LNCaP prostate cancer cells. Naunyn Schmiedebergs Arch Pharmacol. 2015 Jul;388(7):793-9. doi: 10.1007/s00210-015-1104-7. Epub 2015 Feb 24. [PubMed:25708950 ]
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