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Record Information
Version1.0
Created at2005-11-16 15:48:42 UTC
Updated at2021-08-15 04:56:43 UTC
NP-MRD IDNP0000052
Secondary Accession NumbersNone
Natural Product Identification
Common Name2-Hydroxybutyric acid
Description2-Hydroxybutyric acid (alpha-hydroxybutyrate) is an organic acid derived from alpha-ketobutyrate. Alpha-Ketobutyrate is produced by amino acid catabolism (threonine and methionine) and glutathione anabolism (cysteine formation pathway) and is metabolized to propionyl-CoA and carbon dioxide (PMID: 20526369 ). 2-Hydroxybutyric acid is formed as a by-product of the formation of alpha-ketobutyrate via a reaction catalyzed by lactate dehydrogenase (LDH) or alpha-hydroxybutyrate dehydrogenase (alphaHBDH). Alpha-Hydroxybutyric acid is primarily produced in mammalian hepatic tissues that catabolize L-threonine or synthesize glutathione. Oxidative stress or detoxification of xenobiotics in the liver can dramatically increase the rate of hepatic glutathione synthesis. Under such metabolic stress conditions, supplies of L-cysteine for glutathione synthesis become limiting, so homocysteine is diverted from the transmethylation pathway (which forms methionine) into the transsulfuration pathway (which forms cystathionine). 2-Hydroxybutyrate is released as a byproduct when cystathionine is cleaved into cysteine that is incorporated into glutathione. Chronic shifts in the rate of glutathione synthesis may be reflected by urinary excretion of 2-hydroxybutyrate. 2-Hydroxybutyrate is an early marker for both insulin resistance and impaired glucose regulation that appears to arise due to increased lipid oxidation and oxidative stress (PMID: 20526369 ). 2-Hydroxybutyric acid is often found in the urine of patients suffering from lactic acidosis and ketoacidosis. 2-Hydroxybutyric acid generally appears at high concentrations in situations related to deficient energy metabolism (e.G. Birth asphyxia) and also in inherited metabolic diseases affecting the central nervous system during neonatal development, such as "cerebral" lactic acidosis, glutaric aciduria type II, dihydrolipoyl dehydrogenase (E3) deficiency, and propionic acidemia. More recently it has been noted that elevated levels of alpha-hydroxybutyrate in the plasma is a good marker for early-stage type II diabetes (PMID: 19166731 ). It was concluded from studies done in the mid-1970's that an increased NADH2/NAD ratio was the most important factor for the production of 2-hydroxybutyric acid (PMID: 168632 ).
Structure
Thumb
Synonyms
ValueSource
(S)-2-Hydroxybutanoic acidChEBI
2-HydroxybutyrateChEBI
2-Hydroxybutyric acidChEBI
L-2-Hydroxybutanoic acidChEBI
L-2-Hydroxybutyric acidChEBI
L-alpha-Hydroxybutanoic acidChEBI
L-alpha-Hydroxybutyric acidChEBI
(S)-2-HydroxybutanoateGenerator
L-2-HydroxybutanoateGenerator
L-2-HydroxybutyrateGenerator
L-a-HydroxybutanoateGenerator
L-a-Hydroxybutanoic acidGenerator
L-alpha-HydroxybutanoateGenerator
L-Α-hydroxybutanoateGenerator
L-Α-hydroxybutanoic acidGenerator
L-a-HydroxybutyrateGenerator
L-a-Hydroxybutyric acidGenerator
L-alpha-HydroxybutyrateGenerator
L-Α-hydroxybutyrateGenerator
L-Α-hydroxybutyric acidGenerator
(S)-2-HydroxybutyrateGenerator
2-HydroxybutanoateGenerator
(+)-2-Hydroxy-n-butyric acidHMDB
(+)-2-Hydroxybutanoic acidHMDB
(+)-2-Hydroxybutyric acidHMDB
(+)-alpha-Hydroxybutyric acidHMDB
(+)-α-Hydroxybutyric acidHMDB
(2S)-2-Hydroxybutanoic acidHMDB
(S)-(+)-2-Hydroxybutanoic acidHMDB
(S)-2-Hydroxybutyric acidHMDB
2-Hydroxybutanoic acidHMDB
alpha-Hydroxy-n-butyric acidHMDB
alpha-Hydroxybutanoic acidHMDB
alpha-Hydroxybutyric acidHMDB
α-Hydroxy-n-butyric acidHMDB
α-Hydroxybutanoic acidHMDB
α-Hydroxybutyric acidHMDB
Chemical FormulaC4H8O3
Average Mass104.1045 Da
Monoisotopic Mass104.04734 Da
IUPAC Name(2S)-2-hydroxybutanoic acid
Traditional Name(S)-2-hydroxybutyric acid
CAS Registry Number600-15-7
SMILES
CCC(O)C(O)=O
InChI Identifier
InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7)
InChI KeyAFENDNXGAFYKQO-UHFFFAOYSA-N
Spectra
Spectrum TypeDescriptionDepositor IDDeposition DateView
1D NMR1H NMR Spectrum (1D, 600 MHz, H2O, experimental)Wishart Lab2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 15.09 MHz, CDCl3, experimental)Wishart Lab2021-06-20View Spectrum
2D NMR[1H, 13C] NMR Spectrum (2D, 600 MHz, H2O, experimental)Wishart Lab2021-06-20View Spectrum
Species
Species of Origin
  • Animalia
  • Chemical Taxonomy
    Description Belongs to the class of organic compounds known as alpha hydroxy acids and derivatives. These are organic compounds containing a carboxylic acid substituted with a hydroxyl group on the adjacent carbon.
    KingdomOrganic compounds
    Super ClassOrganic acids and derivatives
    ClassHydroxy acids and derivatives
    Sub ClassAlpha hydroxy acids and derivatives
    Direct ParentAlpha hydroxy acids and derivatives
    Alternative Parents
    Substituents
    • Fatty acid
    • Alpha-hydroxy acid
    • Secondary alcohol
    • Monocarboxylic acid or derivatives
    • Carboxylic acid
    • Carboxylic acid derivative
    • Organic oxygen compound
    • Organic oxide
    • Hydrocarbon derivative
    • Organooxygen compound
    • Carbonyl group
    • Alcohol
    • Aliphatic acyclic compound
    Molecular FrameworkAliphatic acyclic compounds
    External Descriptors
    Physical Properties
    StateSolid
    Experimental Properties
    PropertyValueReference
    Melting Point44.2 °CNot Available
    Boiling Point118-120 °CNot Available
    Water SolubilityNot AvailableNot Available
    LogPNot AvailableNot Available
    Predicted Properties
    PropertyValueSource
    Water Solubility484 g/LALOGPS
    logP-0.16ALOGPS
    logP0.051ChemAxon
    logS0.67ALOGPS
    pKa (Strongest Acidic)3.99ChemAxon
    pKa (Strongest Basic)-3.8ChemAxon
    Physiological Charge-1ChemAxon
    Hydrogen Acceptor Count3ChemAxon
    Hydrogen Donor Count2ChemAxon
    Polar Surface Area57.53 ŲChemAxon
    Rotatable Bond Count2ChemAxon
    Refractivity23.36 m³·mol⁻¹ChemAxon
    Polarizability9.98 ųChemAxon
    Number of Rings0ChemAxon
    BioavailabilityYesChemAxon
    Rule of FiveYesChemAxon
    Ghose FilterNoChemAxon
    Veber's RuleNoChemAxon
    MDDR-like RuleNoChemAxon
    External Links
    HMDB IDHMDB0000008
    DrugBank IDNot Available
    Phenol Explorer Compound IDNot Available
    FoodDB IDFDB021867
    KNApSAcK IDNot Available
    Chemspider ID389701
    KEGG Compound IDC05984
    BioCyc IDCPD-3564
    BiGG IDNot Available
    Wikipedia Link2-Hydroxybutyric_acid
    METLIN IDNot Available
    PubChem Compound440864
    PDB IDNot Available
    ChEBI ID50613
    Good Scents IDNot Available
    References
    General References
    1. Sweatman BC, Farrant RD, Holmes E, Ghauri FY, Nicholson JK, Lindon JC: 600 MHz 1H-NMR spectroscopy of human cerebrospinal fluid: effects of sample manipulation and assignment of resonances. J Pharm Biomed Anal. 1993 Aug;11(8):651-64. [PubMed:8257730 ]
    2. Landaas S, Pettersen JE: Clinical conditions associated with urinary excretion of 2-hydroxybutyric acid. Scand J Clin Lab Invest. 1975 May;35(3):259-66. [PubMed:168632 ]
    3. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762. [PubMed:19212411 ]
    4. Li X, Xu Z, Lu X, Yang X, Yin P, Kong H, Yu Y, Xu G: Comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry for metabonomics: Biomarker discovery for diabetes mellitus. Anal Chim Acta. 2009 Feb 9;633(2):257-62. doi: 10.1016/j.aca.2008.11.058. Epub 2008 Dec 3. [PubMed:19166731 ]
    5. Gall WE, Beebe K, Lawton KA, Adam KP, Mitchell MW, Nakhle PJ, Ryals JA, Milburn MV, Nannipieri M, Camastra S, Natali A, Ferrannini E: alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population. PLoS One. 2010 May 28;5(5):e10883. doi: 10.1371/journal.pone.0010883. [PubMed:20526369 ]
    6. (). Aldrich Library of FT-IR Spectra, 1st edn., 1985, 1, 548D. .
    7. (). Mori, K. et al., Tetrahedron, 1979, 35, 1601. .
    8. (). Levene, P.A. et al., J. Biol. Chem., 1941, 141, 391. .
    9. (). Duvillier, E., Ann. Chim. Phys., 1879, 17, 532. .
    10. (). Chenault, H.K. et al., J.O.C., 1987, 52, 2608. .
    11. (). Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 1, 854B. .
    12. (). Horn, D.H.S. et al., J.C.S., 1954, 1460. .
    13. (). Wong, C.H. et al., J.O.C., 1985, 50, 1992. .