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Showing NP-Card for 8-oxo-GTP (NP0339717)

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Record Information
Version2.0
Created at2024-09-11 23:12:36 UTC
Updated at2024-09-11 23:12:37 UTC
NP-MRD IDNP0339717
Secondary Accession NumbersNone
Natural Product Identification
Common Name8-oxo-GTP
Description8-Oxo-GTP belongs to the class of organic compounds known as purine ribonucleoside triphosphates. These are purine ribobucleotides with a triphosphate group linked to the ribose moiety. 8-oxo-GTP was first documented in 2013 (PMID: 23463507). Based on a literature review a significant number of articles have been published on 8-oxo-GTP (PMID: 38776712) (PMID: 38657843) (PMID: 36746255) (PMID: 36139879) (PMID: 35809767) (PMID: 33021500).
Structure
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MOLSDFPDBSMILESInChI

MOL for NP0339717 (8-oxo-GTP)


  Mrv2104 05272301442D          

 33 35  0  0  0  0            999 V2000
   -0.5683   -3.7149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4820   -4.5353    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1495   -5.0203    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6646   -5.6877    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6344   -4.3528    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.8169   -5.5052    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7307   -6.3257    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9102   -6.2394    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5512   -6.4119    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.6444   -7.1462    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3119   -7.6311    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9793   -8.1160    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8270   -8.2985    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.7968   -6.9636    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0992   -3.2299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0992   -2.4049    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3687   -2.8174    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1937   -2.8174    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -3.4849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -4.2695    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
  1 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 15 20  1  0  0  0  0
 17 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  2  0  0  0  0
 32 33  1  0  0  0  0
 26 33  2  0  0  0  0
 22 33  1  0  0  0  0
M  CHG  4   5  -1   9  -1  13  -1  14  -1
M  END
Download

3D MOL for NP0339717 (8-oxo-GTP)

Download
3D SDF for NP0339717 (8-oxo-GTP)

  Mrv2104 05272301442D          

 33 35  0  0  0  0            999 V2000
   -0.5683   -3.7149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4820   -4.5353    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1495   -5.0203    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6646   -5.6877    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6344   -4.3528    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.8169   -5.5052    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7307   -6.3257    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9102   -6.2394    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5512   -6.4119    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.6444   -7.1462    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3119   -7.6311    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9793   -8.1160    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8270   -8.2985    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.7968   -6.9636    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0992   -3.2299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0992   -2.4049    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3687   -2.8174    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1937   -2.8174    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -3.4849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -4.2695    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
  1 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 15 20  1  0  0  0  0
 17 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  2  0  0  0  0
 32 33  1  0  0  0  0
 26 33  2  0  0  0  0
 22 33  1  0  0  0  0
M  CHG  4   5  -1   9  -1  13  -1  14  -1
M  END
> <DATABASE_ID>
NP0339717

> <DATABASE_NAME>
NP-MRD

> <SMILES>
NC1=NC2=C(NC(=O)N2C2OC(COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C(O)C2O)C(=O)N1

> <INCHI_IDENTIFIER>
InChI=1/C10H16N5O15P3/c11-9-13-6-3(7(18)14-9)12-10(19)15(6)8-5(17)4(16)2(28-8)1-27-32(23,24)30-33(25,26)29-31(20,21)22/h2,4-5,8,16-17H,1H2,(H,12,19)(H,23,24)(H,25,26)(H2,20,21,22)(H3,11,13,14,18)/p-4

> <INCHI_KEY>
JCHLKIQZUXYLPW-UHFFFAOYNA-J

> <FORMULA>
C10H12N5O15P3

> <MOLECULAR_WEIGHT>
535.149

> <EXACT_MASS>
534.95647002

> <JCHEM_ACCEPTOR_COUNT>
14

> <JCHEM_ATOM_COUNT>
45

> <JCHEM_AVERAGE_POLARIZABILITY>
38.62661826740147

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
5

> <JCHEM_FORMAL_CHARGE>
-4

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
({[5-(2-amino-6,8-dioxo-6,7,8,9-tetrahydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)(phosphonatooxy)phosphinate

> <JCHEM_LOGP>
-4.001478886666666

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-4

> <JCHEM_PKA>
2.531468782594704

> <JCHEM_PKA_STRONGEST_ACIDIC>
0.8952789677228207

> <JCHEM_PKA_STRONGEST_BASIC>
-3.66458978437653

> <JCHEM_POLAR_SURFACE_AREA>
320.65

> <JCHEM_REFRACTIVITY>
102.536

> <JCHEM_ROTATABLE_BOND_COUNT>
8

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
{[5-(2-amino-6,8-dioxo-1,7-dihydropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy(phosphonatooxy)phosphinate

> <JCHEM_VEBER_RULE>
0

$$$$

Download
3D-SDF for NP0339717 (8-oxo-GTP)
Download
PDB for NP0339717 (8-oxo-GTP)
HEADER    PROTEIN                                 27-MAY-23   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   27-MAY-23         0                                  
HETATM    1  C   UNK     0      -1.061  -6.934   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0      -0.900  -8.466   0.000  0.00  0.00           O+0
HETATM    3  P   UNK     0      -2.146  -9.371   0.000  0.00  0.00           P+0
HETATM    4  O   UNK     0      -1.241 -10.617   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0      -3.051  -8.125   0.000  0.00  0.00           O-1
HETATM    6  O   UNK     0      -3.392 -10.276   0.000  0.00  0.00           O+0
HETATM    7  P   UNK     0      -3.231 -11.808   0.000  0.00  0.00           P+0
HETATM    8  O   UNK     0      -1.699 -11.647   0.000  0.00  0.00           O+0
HETATM    9  O   UNK     0      -4.762 -11.969   0.000  0.00  0.00           O-1
HETATM   10  O   UNK     0      -3.070 -13.339   0.000  0.00  0.00           O+0
HETATM   11  P   UNK     0      -4.316 -14.245   0.000  0.00  0.00           P+0
HETATM   12  O   UNK     0      -5.561 -15.150   0.000  0.00  0.00           O+0
HETATM   13  O   UNK     0      -3.410 -15.491   0.000  0.00  0.00           O-1
HETATM   14  O   UNK     0      -5.221 -12.999   0.000  0.00  0.00           O-1
HETATM   15  C   UNK     0       0.185  -6.029   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0       0.185  -4.489   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0       1.650  -4.013   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       2.555  -5.259   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0       4.095  -5.259   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0       1.650  -6.505   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0       2.126  -7.970   0.000  0.00  0.00           O+0
HETATM   22  N   UNK     0       2.126  -2.549   0.000  0.00  0.00           N+0
HETATM   23  C   UNK     0       1.220  -1.303   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0      -0.320  -1.303   0.000  0.00  0.00           O+0
HETATM   25  N   UNK     0       2.126  -0.057   0.000  0.00  0.00           N+0
HETATM   26  C   UNK     0       3.590  -0.533   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       4.924   0.237   0.000  0.00  0.00           C+0
HETATM   28  O   UNK     0       4.924   1.777   0.000  0.00  0.00           O+0
HETATM   29  N   UNK     0       6.258  -0.533   0.000  0.00  0.00           N+0
HETATM   30  C   UNK     0       6.258  -2.073   0.000  0.00  0.00           C+0
HETATM   31  N   UNK     0       7.591  -2.843   0.000  0.00  0.00           N+0
HETATM   32  N   UNK     0       4.924  -2.843   0.000  0.00  0.00           N+0
HETATM   33  C   UNK     0       3.590  -2.073   0.000  0.00  0.00           C+0
CONECT    1    2   15                                                       
CONECT    2    1    3                                                       
CONECT    3    2    4    5    6                                             
CONECT    4    3                                                            
CONECT    5    3                                                            
CONECT    6    3    7                                                       
CONECT    7    6    8    9   10                                             
CONECT    8    7                                                            
CONECT    9    7                                                            
CONECT   10    7   11                                                       
CONECT   11   10   12   13   14                                             
CONECT   12   11                                                            
CONECT   13   11                                                            
CONECT   14   11                                                            
CONECT   15    1   16   20                                                  
CONECT   16   15   17                                                       
CONECT   17   16   18   22                                                  
CONECT   18   17   19   20                                                  
CONECT   19   18                                                            
CONECT   20   18   21   15                                                  
CONECT   21   20                                                            
CONECT   22   17   23   33                                                  
CONECT   23   22   24   25                                                  
CONECT   24   23                                                            
CONECT   25   23   26                                                       
CONECT   26   25   27   33                                                  
CONECT   27   26   28   29                                                  
CONECT   28   27                                                            
CONECT   29   27   30                                                       
CONECT   30   29   31   32                                                  
CONECT   31   30                                                            
CONECT   32   30   33                                                       
CONECT   33   32   26   22                                                  
MASTER        0    0    0    0    0    0    0    0   33    0   70    0
END

Download
3D PDB for NP0339717 (8-oxo-GTP)
Download
SMILES for NP0339717 (8-oxo-GTP)
NC1=NC2=C(NC(=O)N2C2OC(COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C(O)C2O)C(=O)N1
Download
INCHI for NP0339717 (8-oxo-GTP)
InChI=1/C10H16N5O15P3/c11-9-13-6-3(7(18)14-9)12-10(19)15(6)8-5(17)4(16)2(28-8)1-27-32(23,24)30-33(25,26)29-31(20,21)22/h2,4-5,8,16-17H,1H2,(H,12,19)(H,23,24)(H,25,26)(H2,20,21,22)(H3,11,13,14,18)/p-4
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View in JSmol
SynonymsNot Available
Chemical FormulaC10H12N5O15P3
Average Mass535.1490 Da
Monoisotopic Mass534.95647 Da
IUPAC Name({[5-(2-amino-6,8-dioxo-6,7,8,9-tetrahydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)(phosphonatooxy)phosphinate
Traditional Name{[5-(2-amino-6,8-dioxo-1,7-dihydropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy(phosphonatooxy)phosphinate
CAS Registry NumberNot Available
SMILES
NC1=NC2=C(NC(=O)N2C2OC(COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C(O)C2O)C(=O)N1
InChI Identifier
InChI=1/C10H16N5O15P3/c11-9-13-6-3(7(18)14-9)12-10(19)15(6)8-5(17)4(16)2(28-8)1-27-32(23,24)30-33(25,26)29-31(20,21)22/h2,4-5,8,16-17H,1H2,(H,12,19)(H,23,24)(H,25,26)(H2,20,21,22)(H3,11,13,14,18)/p-4
InChI KeyJCHLKIQZUXYLPW-UHFFFAOYNA-J
Experimental Spectra
Not Available
Predicted Spectra
Not Available
Chemical Shift Submissions
Not Available
Species
Species of OriginNot Available
Chemical Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as purine ribonucleoside triphosphates. These are purine ribobucleotides with a triphosphate group  linked to the ribose moiety.
KingdomOrganic compounds  
Super ClassNucleosides, nucleotides, and analogues  
ClassPurine nucleotides  
Sub ClassPurine ribonucleotides  
Direct ParentPurine ribonucleoside triphosphates  
Alternative Parents
Substituents
  • Purine ribonucleoside triphosphate
    • 

  • Purine ribonucleoside monophosphate
    • 

  • Pentose phosphate
    • 

  • Pentose-5-phosphate
    • 

  • Glycosyl compound
    • 

  • N-glycosyl compound
    • 

  • 6-oxopurine
    • 

  • Hypoxanthine
    • 

  • Monosaccharide phosphate
    • 

  • Pentose monosaccharide
    • 

  • Purinone
    • 

  • Imidazopyrimidine
    • 

  • Purine
    • 

  • Aminopyrimidine
    • 

  • Pyrimidone
    • 

  • Monosaccharide
    • 

  • N-substituted imidazole
    • 

  • Organic phosphoric acid derivative
    • 

  • Phosphoric acid ester
    • 

  • Alkyl phosphate
    • 

  • Pyrimidine
    • 

  • Tetrahydrofuran
    • 

  • Azole
    • 

  • Vinylogous amide
    • 

  • Imidazole
    • 

  • Heteroaromatic compound
    • 

  • Secondary alcohol
    • 

  • Urea
    • 

  • Lactam
    • 

  • 1,2-diol
    • 

  • Oxacycle
    • 

  • Azacycle
    • 

  • Organoheterocyclic compound
    • 

  • Primary amine
    • 

  • Hydrocarbon derivative
    • 

  • Organic oxide
    • 

  • Organopnictogen compound
    • 

  • Amine
    • 

  • Organic oxygen compound
    • 

  • Organic nitrogen compound
    • 

  • Alcohol
    • 

  • Organonitrogen compound
    • 

  • Organooxygen compound
    • 

  • Organic anion
    • 

  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Physical Properties
StateNot Available
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-4ChemAxon
pKa (Strongest Acidic)0.9ChemAxon
pKa (Strongest Basic)-3.7ChemAxon
Physiological Charge-4ChemAxon
Hydrogen Acceptor Count14ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area320.65 ŲChemAxon
Rotatable Bond Count8ChemAxon
Refractivity102.54 m³·mol⁻¹ChemAxon
Polarizability38.63 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
HMDB IDNot Available
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDNot Available
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem CompoundNot Available
PDB IDNot Available
ChEBI IDNot Available
Good Scents IDNot Available
References
General References
  1. Emam EAF, Roy K, Varshney U: An exchange of single amino acid between the phosphohydrolase modules of Escherichia coli MutT and Mycobacterium smegmatis MutT1 switches their cleavage specificities. DNA Repair (Amst). 2024 Jul;139:103693. doi: 10.1016/j.dnarep.2024.103693. Epub  2024 May 15. [PubMed:38776712  ] 
  2. Li Y, Wang X: The role of DNA and RNA guanosine oxidation in cardiovascular diseases. Pharmacol Res. 2024 Jun;204:107187. doi: 10.1016/j.phrs.2024.107187. Epub 2024  Apr 23. [PubMed:38657843  ] 
  3. Nigo F, Nakagawa R, Hirai Y, Imai L, Suzuki Y, Furuta K, Kaito C: Staphylococcus aureus MazG hydrolyzes oxidized guanine nucleotides and contributes to oxidative stress resistance. Biochimie. 2023 Jun;209:52-60. doi: 10.1016/j.biochi.2023.02.001. Epub 2023 Feb  4. [PubMed:36746255  ] 
  4. Kondo Y, Rikiishi K, Sugimoto M: Rice Nudix Hydrolase OsNUDX2 Sanitizes Oxidized Nucleotides. Antioxidants (Basel). 2022 Sep 13;11(9):1805. doi: 10.3390/antiox11091805. [PubMed:36139879  ] 
  5. Li J, Wang ZH, Dang YM, Li DN, Liu Z, Dai DP, Cai JP: MTH1 suppression enhances the stemness of MCF7 through upregulation of STAT3. Free Radic Biol Med. 2022 Aug 1;188:447-458. doi:  10.1016/j.freeradbiomed.2022.06.240. Epub 2022 Jul 6. [PubMed:35809767  ] 
  6. Raj P, Karthik S, Arif SM, Varshney U, Vijayan M: Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1. Acta Crystallogr D Struct Biol. 2020 Oct 1;76(Pt 10):982-992. doi:  10.1107/S2059798320010992. Epub 2020 Sep 16. [PubMed:33021500  ] 
  7. Samaan GN, Paranagama N, Haque A, Hecht DA, Swairjo MA, Purse BW: Structure-based design of guanosine analogue inhibitors targeting GTP cyclohydrolase IB towards a new class of antibiotics. Bioorg Med Chem Lett. 2020 Jan 15;30(2):126818. doi: 10.1016/j.bmcl.2019.126818.  Epub 2019 Nov 12. [PubMed:31771800  ] 
  8. Arif SM, Patil AG, Varshney U, Vijayan M: Biochemical and structural studies of Mycobacterium smegmatis MutT1, a sanitization enzyme with unusual modes of association. Acta Crystallogr D Struct Biol. 2017 Apr 1;73(Pt 4):349-364. doi:  10.1107/S2059798317002534. Epub 2017 Mar 31. [PubMed:28375146  ] 
  9. Paranagama N, Bonnett SA, Alvarez J, Luthra A, Stec B, Gustafson A, Iwata-Reuyl D, Swairjo MA: Mechanism and catalytic strategy of the prokaryotic-specific GTP cyclohydrolase-IB. Biochem J. 2017 Mar 7;474(6):1017-1039. doi: 10.1042/BCJ20161025. [PubMed:28126741  ] 
  10. Tanaka S, Kihara M, Sugimoto M: Structure and molecular characterization of barley nudix hydrolase genes. Biosci Biotechnol Biochem. 2015;79(3):394-401. doi: 10.1080/09168451.2014.978259.  Epub 2014 Nov 7. [PubMed:25379607  ] 
  11. Gordon AJ, Satory D, Wang M, Halliday JA, Golding I, Herman C: Removal of 8-oxo-GTP by MutT hydrolase is not a major contributor to transcriptional fidelity. Nucleic Acids Res. 2014 Oct 29;42(19):12015-26. doi: 10.1093/nar/gku912. Epub  2014 Oct 7. [PubMed:25294823  ] 
  12. Kumpornsin K, Kotanan N, Chobson P, Kochakarn T, Jirawatcharadech P, Jaru-ampornpan P, Yuthavong Y, Chookajorn T: Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I. Malar J. 2014 Apr 19;13:150. doi: 10.1186/1475-2875-13-150. [PubMed:24745605  ] 
  13. Patil AG, Sang PB, Govindan A, Varshney U: Mycobacterium tuberculosis MutT1 (Rv2985) and ADPRase (Rv1700) proteins constitute a two-stage mechanism of 8-oxo-dGTP and 8-oxo-GTP detoxification and adenosine to cytidine mutation avoidance. J Biol Chem. 2013 Apr 19;288(16):11252-62. doi: 10.1074/jbc.M112.442566. Epub  2013 Mar 5. [PubMed:23463507  ] 
  14. Sekiguchi T, Ito R, Hayakawa H, Sekiguchi M: Elimination and utilization of oxidized guanine nucleotides in the synthesis of RNA and its precursors. J Biol Chem. 2013 Mar 22;288(12):8128-8135. doi: 10.1074/jbc.M112.418723. Epub  2013 Feb 3. [PubMed:23376345  ] 
  15. Sang PB, Varshney U: Biochemical properties of MutT2 proteins from Mycobacterium tuberculosis and M. smegmatis and their contrasting antimutator roles in Escherichia coli. J Bacteriol. 2013 Apr;195(7):1552-60. doi: 10.1128/JB.02102-12. Epub 2013 Jan 25. [PubMed:23354752  ]