Record Information |
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Version | 2.0 |
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Created at | 2024-09-11 23:10:28 UTC |
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Updated at | 2024-09-11 23:10:28 UTC |
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NP-MRD ID | NP0339710 |
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Secondary Accession Numbers | None |
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Natural Product Identification |
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Common Name | 5-formyl-tetrahydrofolate |
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Description | 5-Formyl-tetrahydrofolate belongs to the class of organic compounds known as tetrahydrofolic acids. These are heterocyclic compounds based on the 5,6,7,8-tetrahydropteroic acid skeleton conjugated with at least one L-glutamic acid unit. 5-formyl-tetrahydrofolate was first documented in 2010 (PMID: 20372793). Based on a literature review very few articles have been published on 5-formyl-tetrahydrofolate (PMID: 24991041) (PMID: 21233333) (PMID: 21036909). |
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Structure | NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)NC(CCC([O-])=O)C([O-])=O)N2C=O)N1 InChI=1/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2 |
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Synonyms | Value | Source |
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5-Formyl-tetrahydrofolic acid | Generator |
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Chemical Formula | C20H21N7O7 |
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Average Mass | 471.4310 Da |
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Monoisotopic Mass | 471.15134 Da |
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IUPAC Name | 2-[(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioate |
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Traditional Name | 2-[(4-{[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioate |
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CAS Registry Number | Not Available |
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SMILES | NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)NC(CCC([O-])=O)C([O-])=O)N2C=O)N1 |
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InChI Identifier | InChI=1/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2 |
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InChI Key | VVIAGPKUTFNRDU-UHFFFAOYNA-L |
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Experimental Spectra |
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| Not Available | Predicted Spectra |
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| Not Available | Chemical Shift Submissions |
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| Not Available | Species |
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Species of Origin | Not Available |
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Chemical Taxonomy |
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Description | This compound belongs to the class of organic compounds known as tetrahydrofolic acids. These are heterocyclic compounds based on the 5,6,7,8-tetrahydropteroic acid skeleton conjugated with at least one L-glutamic acid unit. |
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Kingdom | Organic compounds |
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Super Class | Organoheterocyclic compounds |
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Class | Pteridines and derivatives |
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Sub Class | Pterins and derivatives |
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Direct Parent | Tetrahydrofolic acids |
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Alternative Parents | |
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Substituents | - Tetrahydrofolic acid
- Glutamic acid or derivatives
- Hippuric acid or derivatives
- Hippuric acid
- N-acyl-alpha-amino acid
- N-acyl-alpha amino acid or derivatives
- Alpha-amino acid or derivatives
- Aminobenzamide
- Aminobenzoic acid or derivatives
- Benzoic acid or derivatives
- Benzamide
- Benzoyl
- Phenylalkylamine
- Aniline or substituted anilines
- Aminopyrimidine
- Pyrimidone
- Secondary aliphatic/aromatic amine
- Pyrimidine
- Dicarboxylic acid or derivatives
- Monocyclic benzene moiety
- Benzenoid
- Heteroaromatic compound
- Vinylogous amide
- Tertiary carboxylic acid amide
- Carboxamide group
- Amino acid
- Amino acid or derivatives
- Secondary carboxylic acid amide
- Carboxylic acid derivative
- Azacycle
- Carboxylic acid
- Secondary amine
- Organic nitrogen compound
- Amine
- Carbonyl group
- Organonitrogen compound
- Organooxygen compound
- Primary amine
- Hydrocarbon derivative
- Organic oxide
- Organopnictogen compound
- Organic oxygen compound
- Organic anion
- Aromatic heteropolycyclic compound
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Molecular Framework | Aromatic heteropolycyclic compounds |
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External Descriptors | - an <i>N</i><sup>5</sup>-formyl-tetrahydrofolate (5-FORMYL-THF )
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Physical Properties |
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State | Not Available |
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Experimental Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Predicted Properties | |
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General References | - Hartman BA, Fazili Z, Pfeiffer CM, O'Connor DL: Neither folic acid supplementation nor pregnancy affects the distribution of folate forms in the red blood cells of women. J Nutr. 2014 Sep;144(9):1364-9. doi: 10.3945/jn.113.189233. Epub 2014 Jul 2. [PubMed:24991041 ]
- Srivastava AC, Ramos-Parra PA, Bedair M, Robledo-Hernandez AL, Tang Y, Sumner LW, Diaz de la Garza RI, Blancaflor EB: The folylpolyglutamate synthetase plastidial isoform is required for postembryonic root development in Arabidopsis. Plant Physiol. 2011 Mar;155(3):1237-51. doi: 10.1104/pp.110.168278. Epub 2011 Jan 13. [PubMed:21233333 ]
- Chae H, Han K, Kim KS, Park H, Lee J, Lee Y: Rho-dependent termination of ssrS (6S RNA) transcription in Escherichia coli: implication for 3' processing of 6S RNA and expression of downstream ygfA (putative 5-formyl-tetrahydrofolate cyclo-ligase). J Biol Chem. 2011 Jan 7;286(1):114-22. doi: 10.1074/jbc.M110.150201. Epub 2010 Oct 29. [PubMed:21036909 ]
- Matsushita S, Ikeda R, Nishizawa Y, Che XF, Furukawa T, Miyadera K, Tabata S, Ushiyama M, Tajitsu Y, Yamamoto M, Takeda Y, Minami K, Mataki H, Kanzaki T, Yamada K, Kanekura T, Akiyama S: The role of thymidine phosphorylase in the induction of early growth response protein-1 and thrombospondin-1 by 5-fluorouracil in human cancer carcinoma cells. Int J Oncol. 2010 May;36(5):1193-200. doi: 10.3892/ijo_00000602. [PubMed:20372793 ]
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