NP-MRD: Showing NP-Card for (+)-Streptazolin (NP0069393)

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Record Information

Version

2.0

Created at

2022-04-28 14:44:39 UTC

Updated at

2022-04-28 14:44:39 UTC

NP-MRD ID

NP0069393

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(+)-Streptazolin

Description

STREPTAZOLIN, also known as isostreptazolin, belongs to the class of organic compounds known as oxazolidinones. Oxazolidinones are compounds containing an oxazolidinone moiety, which is an oxazolidine bearing a ketone group. (+)-Streptazolin is found in Streptomyces osmaniensis, Streptomyces sannanensis, Streptomyces sp.A1 and Streptomyces viridochromogenes. (+)-Streptazolin was first documented in 2014 (PMID: 24991297). Based on a literature review a small amount of articles have been published on STREPTAZOLIN (PMID: 28767052) (PMID: 31208056) (PMID: 29665368) (PMID: 24984798).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652304282216442D          

 15 17  0  0  1  0            999 V2000
    3.4065   -0.8210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5599   -0.0103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9345    0.5278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1559    0.2553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0025   -0.5554    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.6278   -1.0935    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3093   -1.8545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7378   -2.5595    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4871   -1.7867    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2975   -0.9838    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.6721   -0.4457    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.9907    0.3153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5514    1.0137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2730    0.9825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1308   -0.6353    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  6  0  0  0
  1  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
 10  9  1  6  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  4 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 11 15  1  1  0  0  0
M  END
> <DATABASE_ID>
NP0069393

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C\C=C1/[C@H](O)[C@H]2OC(=O)N3CCC=C1[C@@H]23

> <INCHI_IDENTIFIER>
InChI=1S/C11H13NO3/c1-2-6-7-4-3-5-12-8(7)10(9(6)13)15-11(12)14/h2,4,8-10,13H,3,5H2,1H3/b6-2-/t8-,9-,10-/m0/s1

> <INCHI_KEY>
OJIUACOQFBQCDF-IKXJTIOISA-N

> <FORMULA>
C11H13NO3

> <MOLECULAR_WEIGHT>
207.229

> <EXACT_MASS>
207.089543283

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
28

> <JCHEM_AVERAGE_POLARIZABILITY>
21.0683223679658

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(4S,5S,6Z,11S)-6-ethylidene-5-hydroxy-3-oxa-1-azatricyclo[5.3.1.0^{4,11}]undec-7-en-2-one

> <ALOGPS_LOGP>
0.92

> <JCHEM_LOGP>
0.2501252576666664

> <ALOGPS_LOGS>
-0.26

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.467227273257443

> <JCHEM_PKA_STRONGEST_BASIC>
-3.469234790677194

> <JCHEM_POLAR_SURFACE_AREA>
49.77

> <JCHEM_REFRACTIVITY>
54.717400000000005

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.14e+02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(4S,5S,6Z,11S)-6-ethylidene-5-hydroxy-3-oxa-1-azatricyclo[5.3.1.0^{4,11}]undec-7-en-2-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 28-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   28-APR-22         0                                  
HETATM    1  C   UNK     0       6.359  -1.532   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       6.645  -0.019   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       5.478   0.985   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       4.024   0.477   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       3.738  -1.037   0.000  0.00  0.00           C+0
HETATM    6  N   UNK     0       4.905  -2.041   0.000  0.00  0.00           N+0
HETATM    7  C   UNK     0       4.311  -3.462   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0       5.110  -4.778   0.000  0.00  0.00           O+0
HETATM    9  O   UNK     0       2.776  -3.335   0.000  0.00  0.00           O+0
HETATM   10  C   UNK     0       2.422  -1.836   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       1.255  -0.832   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       1.849   0.589   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       1.029   1.892   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      -0.510   1.834   0.000  0.00  0.00           C+0
HETATM   15  O   UNK     0      -0.244  -1.186   0.000  0.00  0.00           O+0
CONECT    1    2    6                                                       
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5   12                                                  
CONECT    5    4    6   10                                                  
CONECT    6    5    1    7                                                  
CONECT    7    6    8    9                                                  
CONECT    8    7                                                            
CONECT    9    7   10                                                       
CONECT   10    9    5   11                                                  
CONECT   11   10   12   15                                                  
CONECT   12   11    4   13                                                  
CONECT   13   12   14                                                       
CONECT   14   13                                                            
CONECT   15   11                                                            
MASTER        0    0    0    0    0    0    0    0   15    0   34    0
END

View in JSmol

Synonyms

Value	Source
Isostreptazolin	MeSH
Streptazoline	MeSH

Chemical Formula

C₁₁H₁₃NO₃

Average Mass

207.2290 Da

Monoisotopic Mass

207.08954 Da

IUPAC Name

(4S,5S,6Z,11S)-6-ethylidene-5-hydroxy-3-oxa-1-azatricyclo[5.3.1.0^{4,11}]undec-7-en-2-one

Traditional Name

(4S,5S,6Z,11S)-6-ethylidene-5-hydroxy-3-oxa-1-azatricyclo[5.3.1.0^{4,11}]undec-7-en-2-one

CAS Registry Number

Not Available

SMILES

C\C=C1/[C@H](O)[C@H]2OC(=O)N3CCC=C1[C@@H]23

InChI Identifier

InChI=1S/C11H13NO3/c1-2-6-7-4-3-5-12-8(7)10(9(6)13)15-11(12)14/h2,4,8-10,13H,3,5H2,1H3/b6-2-/t8-,9-,10-/m0/s1

InChI Key

OJIUACOQFBQCDF-IKXJTIOISA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Streptomyces osmaniensis	LOTUS Database	35616633
Streptomyces sannanensis	LOTUS Database	35616633
Streptomyces sp.A1	Bacteria	KNApSAcK
Streptomyces viridochromogenes	Bacteria	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as oxazolidinones. Oxazolidinones are compounds containing an oxazolidinone moiety, which is an oxazolidine bearing a ketone group.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Azolidines

Sub Class

Oxazolidines

Direct Parent

Oxazolidinones

Alternative Parents

Substituents

Oxazolidinone
Cyclic alcohol
Carbamic acid ester
Carbonic acid derivative
Secondary alcohol
Oxacycle
Azacycle
Organopnictogen compound
Organic oxygen compound
Organooxygen compound
Organonitrogen compound
Alcohol
Organic nitrogen compound
Carbonyl group
Hydrocarbon derivative
Organic oxide
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	0.92	ALOGPS
logP	0.25	ChemAxon
logS	-0.26	ALOGPS
pKa (Strongest Acidic)	13.47	ChemAxon
pKa (Strongest Basic)	-3.5	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	49.77 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	54.72 m³·mol⁻¹	ChemAxon
Polarizability	21.07 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00027639

Chemspider ID

9944359

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

11769676

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Yang CL, Wang YS, Liu CL, Zeng YJ, Cheng P, Jiao RH, Bao SX, Huang HQ, Tan RX, Ge HM: Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069. Mar Drugs. 2017 Aug 2;15(8). pii: md15080244. doi: 10.3390/md15080244. [PubMed:28767052 ]
Samy MN, Le Goff G, Lopes P, Georgousaki K, Gumeni S, Almeida C, Gonzalez I, Genilloud O, Trougakos I, Fokialakis N, Ouazzani J: Osmanicin, a Polyketide Alkaloid Isolated from Streptomyces osmaniensis CA-244599 Inhibits Elastase in Human Fibroblasts. Molecules. 2019 Jun 15;24(12). pii: molecules24122239. doi: 10.3390/molecules24122239. [PubMed:31208056 ]
Djinni I, Djoudi W, Souagui S, Rabia F, Rahmouni S, Mancini I, Kecha M: Streptomyces thermoviolaceus SRC3 strain as a novel source of the antibiotic adjuvant streptazolin: A statistical approach toward the optimized production. J Microbiol Methods. 2018 May;148:161-168. doi: 10.1016/j.mimet.2018.04.008. Epub 2018 Apr 14. [PubMed:29665368 ]
Groenhagen U, Maczka M, Dickschat JS, Schulz S: Streptopyridines, volatile pyridine alkaloids produced by Streptomyces sp. FORM5. Beilstein J Org Chem. 2014 Jun 24;10:1421-32. doi: 10.3762/bjoc.10.146. eCollection 2014. [PubMed:24991297 ]
Perry JA, Koteva K, Verschoor CP, Wang W, Bowdish DM, Wright GD: A macrophage-stimulating compound from a screen of microbial natural products. J Antibiot (Tokyo). 2015 Jan;68(1):40-6. doi: 10.1038/ja.2014.83. Epub 2014 Jul 2. [PubMed:24984798 ]

Showing NP-Card for (+)-Streptazolin (NP0069393)

MOL for NP0069393 ((+)-Streptazolin)

3D MOL for NP0069393 ((+)-Streptazolin)

3D SDF for NP0069393 ((+)-Streptazolin)

3D-SDF for NP0069393 ((+)-Streptazolin)

PDB for NP0069393 ((+)-Streptazolin)

3D PDB for NP0069393 ((+)-Streptazolin)

SMILES for NP0069393 ((+)-Streptazolin)

INCHI for NP0069393 ((+)-Streptazolin)

Structure for NP0069393 ((+)-Streptazolin)

3D Structure for NP0069393 ((+)-Streptazolin)