NP-MRD: Showing NP-Card for Afzelone D (NP0060864)

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Record Information

Version

2.0

Created at

2022-04-28 05:50:33 UTC

Updated at

2022-04-28 05:50:33 UTC

NP-MRD ID

NP0060864

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Afzelone D

Description

7-Hydroxy-3-[(2S,3S)-1-(2-hydroxy-4-methoxyphenyl)-3-(4-hydroxyphenyl)-3-(4-methoxyphenyl)-1-oxopropan-2-yl]-4H-chromen-4-one belongs to the class of organic compounds known as 2'-hydroxy-dihydrochalcones. These are organic compounds containing dihydrochalcone skeleton that carries a hydroxyl group at the 2'-position. Afzelone D is found in Ochna afzelii . Based on a literature review very few articles have been published on 7-hydroxy-3-[(2S,3S)-1-(2-hydroxy-4-methoxyphenyl)-3-(4-hydroxyphenyl)-3-(4-methoxyphenyl)-1-oxopropan-2-yl]-4H-chromen-4-one.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652304282207502D          

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M  END

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M  END


  Mrv1652304282207502D          

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  7 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 22 23  2  0  0  0  0
 21 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 26 27  1  0  0  0  0
 20 27  2  0  0  0  0
 26 28  1  0  0  0  0
 16 29  1  6  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  2  0  0  0  0
 32 33  1  0  0  0  0
 33 34  2  0  0  0  0
 34 35  1  0  0  0  0
 35 36  2  0  0  0  0
 31 36  1  0  0  0  0
 36 37  1  0  0  0  0
 34 38  1  0  0  0  0
 38 39  1  0  0  0  0
  2 40  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0060864

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC1=CC=C(C=C1)[C@@H]([C@H](C(=O)C1=CC=C(OC)C=C1O)C1=COC2=CC(O)=CC=C2C1=O)C1=CC=C(O)C=C1

> <INCHI_IDENTIFIER>
InChI=1S/C32H26O8/c1-38-22-10-5-19(6-11-22)29(18-3-7-20(33)8-4-18)30(32(37)24-14-12-23(39-2)16-27(24)35)26-17-40-28-15-21(34)9-13-25(28)31(26)36/h3-17,29-30,33-35H,1-2H3/t29-,30+/m0/s1

> <INCHI_KEY>
BDWPTFULLOHIBX-XZWHSSHBSA-N

> <FORMULA>
C32H26O8

> <MOLECULAR_WEIGHT>
538.552

> <EXACT_MASS>
538.162767797

> <JCHEM_ACCEPTOR_COUNT>
8

> <JCHEM_ATOM_COUNT>
66

> <JCHEM_AVERAGE_POLARIZABILITY>
55.47401734479371

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
7-hydroxy-3-[(2S,3S)-1-(2-hydroxy-4-methoxyphenyl)-3-(4-hydroxyphenyl)-3-(4-methoxyphenyl)-1-oxopropan-2-yl]-4H-chromen-4-one

> <ALOGPS_LOGP>
5.57

> <JCHEM_LOGP>
5.909740486333335

> <ALOGPS_LOGS>
-5.29

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
8.886533540664207

> <JCHEM_PKA_STRONGEST_ACIDIC>
6.496006804920322

> <JCHEM_PKA_STRONGEST_BASIC>
-4.470649114614857

> <JCHEM_POLAR_SURFACE_AREA>
122.52000000000002

> <JCHEM_REFRACTIVITY>
148.51189999999997

> <JCHEM_ROTATABLE_BOND_COUNT>
8

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
2.79e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
7-hydroxy-3-[(2S,3S)-1-(2-hydroxy-4-methoxyphenyl)-3-(4-hydroxyphenyl)-3-(4-methoxyphenyl)-1-oxopropan-2-yl]chromen-4-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 28-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   28-APR-22         0                                  
HETATM    1  C   UNK     0      -7.827   0.338   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -7.767   1.877   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -6.404   2.594   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -5.101   1.773   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -5.161   0.234   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -6.524  -0.484   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -3.859  -0.588   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -3.919  -2.126   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -2.616  -2.948   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -2.676  -4.487   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      -4.039  -5.204   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      -5.341  -4.383   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      -5.281  -2.844   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0      -4.099  -6.743   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0      -5.462  -7.460   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      -2.496   0.130   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      -1.193  -0.692   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      -1.253  -2.230   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0       0.049  -3.052   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0       1.412  -2.334   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       1.472  -0.796   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      -0.024  -0.598   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0       1.122   1.235   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0       2.835  -0.078   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       4.137  -0.900   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       4.077  -2.438   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       2.715  -3.156   0.000  0.00  0.00           C+0
HETATM   28  O   UNK     0       5.380  -3.260   0.000  0.00  0.00           O+0
HETATM   29  C   UNK     0      -2.436   1.669   0.000  0.00  0.00           C+0
HETATM   30  O   UNK     0      -3.739   2.490   0.000  0.00  0.00           O+0
HETATM   31  C   UNK     0      -1.073   2.386   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0      -1.013   3.925   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       0.349   4.642   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0       1.652   3.821   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0       1.592   2.282   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0       0.229   1.565   0.000  0.00  0.00           C+0
HETATM   37  O   UNK     0       0.169   0.026   0.000  0.00  0.00           O+0
HETATM   38  O   UNK     0       3.015   4.538   0.000  0.00  0.00           O+0
HETATM   39  C   UNK     0       3.075   6.077   0.000  0.00  0.00           C+0
HETATM   40  O   UNK     0      -9.069   2.698   0.000  0.00  0.00           O+0
CONECT    1    2    6                                                       
CONECT    2    1    3   40                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6    7                                                  
CONECT    6    5    1                                                       
CONECT    7    5    8   16                                                  
CONECT    8    7    9   13                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12   14                                                  
CONECT   12   11   13                                                       
CONECT   13   12    8                                                       
CONECT   14   11   15                                                       
CONECT   15   14                                                            
CONECT   16    7   17   29                                                  
CONECT   17   16   18   22                                                  
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   21   27                                                  
CONECT   21   20   22   24                                                  
CONECT   22   21   17   23                                                  
CONECT   23   22                                                            
CONECT   24   21   25                                                       
CONECT   25   24   26                                                       
CONECT   26   25   27   28                                                  
CONECT   27   26   20                                                       
CONECT   28   26                                                            
CONECT   29   16   30   31                                                  
CONECT   30   29                                                            
CONECT   31   29   32   36                                                  
CONECT   32   31   33                                                       
CONECT   33   32   34                                                       
CONECT   34   33   35   38                                                  
CONECT   35   34   36                                                       
CONECT   36   35   31   37                                                  
CONECT   37   36                                                            
CONECT   38   34   39                                                       
CONECT   39   38                                                            
CONECT   40    2                                                            
MASTER        0    0    0    0    0    0    0    0   40    0   88    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₃₂H₂₆O₈

Average Mass

538.5520 Da

Monoisotopic Mass

538.16277 Da

IUPAC Name

7-hydroxy-3-[(2S,3S)-1-(2-hydroxy-4-methoxyphenyl)-3-(4-hydroxyphenyl)-3-(4-methoxyphenyl)-1-oxopropan-2-yl]-4H-chromen-4-one

Traditional Name

7-hydroxy-3-[(2S,3S)-1-(2-hydroxy-4-methoxyphenyl)-3-(4-hydroxyphenyl)-3-(4-methoxyphenyl)-1-oxopropan-2-yl]chromen-4-one

CAS Registry Number

Not Available

SMILES

COC1=CC=C(C=C1)[C@@H]([C@H](C(=O)C1=CC=C(OC)C=C1O)C1=COC2=CC(O)=CC=C2C1=O)C1=CC=C(O)C=C1

InChI Identifier

InChI=1S/C32H26O8/c1-38-22-10-5-19(6-11-22)29(18-3-7-20(33)8-4-18)30(32(37)24-14-12-23(39-2)16-27(24)35)26-17-40-28-15-21(34)9-13-25(28)31(26)36/h3-17,29-30,33-35H,1-2H3/t29-,30+/m0/s1

InChI Key

BDWPTFULLOHIBX-XZWHSSHBSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Ochna afzelii	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as 2'-hydroxy-dihydrochalcones. These are organic compounds containing dihydrochalcone skeleton that carries a hydroxyl group at the 2'-position.

Kingdom

Organic compounds

Super Class

Phenylpropanoids and polyketides

Class

Linear 1,3-diarylpropanoids

Sub Class

Chalcones and dihydrochalcones

Direct Parent

2'-Hydroxy-dihydrochalcones

Alternative Parents

Substituents

2'-hydroxy-dihydrochalcone
Cinnamylphenol
Alkyl-phenylketone
Diphenylmethane
Chromone
Butyrophenone
1-benzopyran
Methoxyphenol
Benzopyran
Phenylketone
Phenoxy compound
Methoxybenzene
Aryl alkyl ketone
Aryl ketone
Phenol ether
Benzoyl
Anisole
1-hydroxy-4-unsubstituted benzenoid
1-hydroxy-2-unsubstituted benzenoid
Pyranone
Phenol
Alkyl aryl ether
Benzenoid
Pyran
Monocyclic benzene moiety
Heteroaromatic compound
Vinylogous acid
Ketone
Oxacycle
Organoheterocyclic compound
Ether
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	5.57	ALOGPS
logP	5.91	ChemAxon
logS	-5.3	ALOGPS
pKa (Strongest Acidic)	6.5	ChemAxon
pKa (Strongest Basic)	-4.5	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	8	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	122.52 Å²	ChemAxon
Rotatable Bond Count	8	ChemAxon
Refractivity	148.51 m³·mol⁻¹	ChemAxon
Polarizability	55.47 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

163067772

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Showing NP-Card for Afzelone D (NP0060864)

MOL for NP0060864 (Afzelone D)

3D MOL for NP0060864 (Afzelone D)

3D SDF for NP0060864 (Afzelone D)

3D-SDF for NP0060864 (Afzelone D)

PDB for NP0060864 (Afzelone D)

3D PDB for NP0060864 (Afzelone D)

SMILES for NP0060864 (Afzelone D)

INCHI for NP0060864 (Afzelone D)

Structure for NP0060864 (Afzelone D)

3D Structure for NP0060864 (Afzelone D)